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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP28 Gene

protein-coding   GIFtS: 56
GCID: GC11M113668

Ubiquitin Specific Peptidase 28

(Previous name: ubiquitin specific protease 28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 281 2     Ubiquitin Carboxyl-Terminal Hydrolase 282
Ubiquitin Specific Protease 281 2     Ubiquitin Carboxyl-Terminal Hydrolase 28 Variant 12
Deubiquitinating Enzyme 282 3     Ubiquitin Thiolesterase 282
Ubiquitin Thioesterase 282 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 282 3     EC 3.1.2.158
KIAA15153 5     

External Ids:    HGNC: 126251   Entrez Gene: 576462   Ensembl: ENSG000000480287   OMIM: 6107485   UniProtKB: Q96RU23   

Export aliases for USP28 gene to outside databases

Previous GC identifers: GC11M116021 GC11M115180 GC11M113702 GC11M113206 GC11M113173 GC11M109597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP28 Gene:
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and
peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and
degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et
al., 2001).(supplied by OMIM, Mar 2008)

GeneCards Summary for USP28 Gene: 
USP28 (ubiquitin specific peptidase 28) is a protein-coding gene. Diseases associated with USP28 include fanconi's anemia, and anemia. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP25.

UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2
Function: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in
DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN.
Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the
anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically
deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by
specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination
of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the
nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP28 gene promoter:
         Max1   USF1   p53   Nkx2-5   LCR-F1   GATA-1   N-Myc   S8   USF-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23

USP28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP28 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M113668:  view genomic region     (about GC identifiers)

Start:
113,668,596 bp from pter      End:
113,746,292 bp from pter
Size:
77,697 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 28  
Size: 1077 amino acids; 122491 Da
Subunit: Interacts with isoform 1 of FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of
MYC
Subcellular location: Nucleus, nucleoplasm
1 PDB 3D structure from and Proteopedia for USP28:
2LVA (3D)    
Secondary accessions: B0YJC0 B0YJC1 Q9P213
Alternative splicing: 2 isoforms:  Q96RU2-1   Q96RU2-2   

Explore the universe of human proteins at neXtProt for USP28: NX_Q96RU2

Explore proteomics data for USP28 at MOPED 

Post-translational modifications:

  • UniProtKB: Degradaded upon nickel ion level or hypoxia exposure
  • UniProtKB: Phosphorylated upon DNA damage at Ser-67 and Ser-714, by ATM or ATR
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RU2

  • 4/5 DME Specific Peptides for USP28 (Q96RU2) (see all 5)
     LQYLFAL  LHAVLVH  FGQYPLQVNG  LPPVLTFELSRFEFNQ 

    USP28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP28 Protein Expression
    REFSEQ proteins: NP_065937.1  
    ENSEMBL proteins: 
     ENSP00000003302   ENSP00000442431   ENSP00000444991   ENSP00000441513   ENSP00000440260  
     ENSP00000442257   ENSP00000445743   ENSP00000438050   ENSP00000437688   ENSP00000445722  
     ENSP00000440799   ENSP00000446284   ENSP00000437450   ENSP00000260188  

    Human Recombinant Protein Products for USP28: 
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    Novus Biologicals USP28 Proteins
    Novus Biologicals USP28 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP28 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA17558397
    GO:0005730NOT nucleolus IDA--
    GO:0043234protein complex IDA17873522

    USP28 for ontologies           About GeneDecksing



    USP28 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for USP28 

    Assay Products for USP28: 
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    Cloud-Clone Corp. ELISAs for USP28 
    Cloud-Clone Corp. CLIAs for USP28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR003903 Ubiquitin-int_motif
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q96RU2

    ProtoNet protein and cluster: Q96RU2

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB003903 Ubiquitin interacting motif


    UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2
    Similarity: Belongs to the peptidase C19 family. USP28 subfamily
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat


    USP28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP28_HUMAN, Q96RU2
    Function: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in
    DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN.
    Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the
    anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically
    deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by
    specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination
    of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the
    nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Down-regulated upon hypoxia

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP16901786
    GO:0004843ubiquitin-specific protease activity IDA16901786
    GO:0005515protein binding IPI16901786
    GO:0008234cysteine-type peptidase activity ----
         
    USP28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP28:
     Increased resistance to MDM2 i 

         1 MGI phenotypic allele for Usp28 (no phenotypes)

    USP28 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP28 
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    hsa-miR-26a-2* hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-29b-1* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidUSP28 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP28


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP28 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP28
        Ubiquitin-Proteasome Dependent Proteolysis

    1 Cell Signaling Technology (CST) Pathway for USP28
        Protein Stability



    USP28 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/82 Interacting proteins for USP28 (Q96RU22, 3 ENSP000000033024) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146763, ENSP000003730604I2D: score=2 STRING: ENSP00000373060
    MDC1Q146763, ENSP000003655884I2D: score=2 STRING: ENSP00000365588
    ENSG00000224587Q146763I2D: score=2 
    ENSG00000225589Q146763I2D: score=2 
    ENSG00000228575Q146763I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP18662541
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006974response to DNA damage stimulus IDA17873522
    GO:0008283cell proliferation IMP17558397

    USP28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP28 (UBP28)

    1 HMDB Compound for USP28    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP28 / UBP28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP28 gene: 
    NM_020886.2  

    Unigene Cluster for USP28:

    Ubiquitin specific peptidase 28
    Hs.503891  [show with all ESTs]
    Unigene Representative Sequence: NM_020886
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000003302(uc001pog.3 uc001poh.3 uc010rwy.2 uc001poi.3)
    ENST00000544967 ENST00000545540 ENST00000544272 ENST00000540438(uc010rwz.1)
    ENST00000538224 ENST00000538475 ENST00000537706(uc001poj.3) ENST00000545608
    ENST00000535607 ENST00000537490 ENST00000537642 ENST00000542033 ENST00000540925
    ENST00000544750 ENST00000260188
    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate USP28 (see all 39):
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    SwitchGear 3'UTR luciferase reporter plasmidUSP28 3' UTR sequence
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    Additional mRNA sequence: 

    AB040948.1 AF266283.1 AK027521.1 AK097623.1 AK123255.1 AK304376.1 AK304770.1 BC035986.1 
    BC065928.1 

    11 DOTS entries:

    DT.40196816  DT.436446  DT.100020054  DT.99940140  DT.100020055  DT.101962320  DT.100020052  DT.101964560 
    DT.120727912  DT.40310650  DT.100671162 

    24/100 AceView cDNA sequences (see all 100):

    BG289257 AW025713 BE672125 AI923030 AI368173 BU187516 AK097623 AW316631 
    AA490857 NM_020886 AI273067 CA448327 BC065928 AF266283 AW769730 BX951921 
    AW515403 BQ421081 AA348047 AB040948 AK027521 AI026007 BX503219 BQ228828 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USP28 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
    SP1:                    -     -                                   -                                   -                       -                       -         
    SP2:                    -     -                                                                       -                             -     -     -     -     -   
    SP3:                    -     -                                   -                                   -                       -                                 
    SP4:                                                                                                                          -                       -         
    SP5:                                                                                                  -                       -     -                           

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -                                                   
    SP5:                                                                        


    ECgene alternative splicing isoforms for USP28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP28 expression in normal human tissues (normalized intensities)      USP28 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP28 Expression
    About this image


    USP28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             skeletal muscle ; myocytes   
             vastus lateralis   

    See USP28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP28

    SOURCE GeneReport for Unigene cluster: Hs.503891
        SABiosciences Custom PCR Arrays for USP28
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP28 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp281 , 5 ubiquitin specific peptidase 281, 5 87.02(n)1
    90.72(a)1
      9 (26.56 cM)5
    2353231  NM_175482.31  NP_780691.21 
     489853855 
    chicken
    (Gallus gallus)
    Aves USP281 ubiquitin specific peptidase 28 68.73(n)
    68.7(a)
      428246  NM_001031496.1  NP_001026667.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP286
    ubiquitin specific peptidase 28
    58(a)
    1 ↔ 1
    GL343354.1(235562-260196)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120442 Transcribed sequence with moderate similarity to protein more 76.22(n)    BX703329.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp286
    ubiquitin specific peptidase 28
    50(a)
    1 ↔ 1
    21(22165897-22225823)
    worm
    (Caenorhabditis elegans)
    Secernentea K02C4.36
    Probable ubiquitin carboxyl-terminal hydrolase K02...
    15(a)
    1 → many
    II(8080789-8086849)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP2(YOR124C)4 Ubiquitin-specific protease that removes ubiquitin more   --   15(558642-554824) 854291  NP_014767.1 


    ENSEMBL Gene Tree for USP28 (if available)
    TreeFam Gene Tree for USP28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP28 gene
    USP252  
    1 SIMAP similar gene for USP28 using alignment to 14 protein entries:     UBP28_HUMAN (see all proteins):
    USP25

    USP28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1629 SNPs in USP28 are shown (see all 1629)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411345271,2
    --113668240(+) TTTTGA/GTATAT 1 -- int10--------
    rs454802911,2
    C,F--113668314(+) GAAAAT/CTGCTG 1 -- int14Minor allele frequency- C:0.11NS WA NA EA 396
    rs1447246361,2
    --113668437(+) CTTTTA/GTTTCA 1 -- int10--------
    rs1386780251,2
    --113668452(+) CTGGCA/GCGTCA 1 -- int10--------
    rs735529401,2
    C--113668752(+) TCTACA/CTATAC 1 -- ut312Minor allele frequency- C:0.10WA 120
    rs1397478961,2
    C--113668757(+) TATAC-/ATATATA 1 -- ut310--------
    rs2015737191,2
    --113668783(+) ATGTA-/TGCTGGTT 1 -- cds10--------
    rs30745601,2
    C--113668802(+) TTTTT-/T/TTTT
    T
    /TTTTTT
    TTTTT
    3 -- ut311NA 2
    rs124168541,2
    C,F,H--113668857(+) AAGGCC/GGGGTA 1 -- ut31 ese36Minor allele frequency- G:0.14NS EA WA 530
    rs1402822711,2
    C--113668946(+) AGCCTC/GGCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP28 (113668596 - 113746292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP28:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv497CNV Insertion18451855
    nsv832273CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610748    OMIM disorders: --

    3 diseases for USP28:    About MalaCards
    fanconi's anemia    anemia    hypoxia


    USP28 for disorders           About GeneDecksing


    Export disorders for USP28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP28 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with USP28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of alternatively spliced products and tissue- specific isoforms of USP28 and USP25. (PubMed id 11597335)1, 2, 3, 9 Valero R.... Marfany G. (2001)
    2. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)1, 2 Bassermann F....Pagano M. (2008)
    3. The ubiquitin-specific protease USP28 is required for MYC stability. (PubMed id 17558397)1, 2 Popov N....Eilers M. (2007)
    4. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. (PubMed id 17873522)1, 2 Popov N....Eilers M. (2007)
    5. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. (PubMed id 16901786)1, 2 Zhang D....Elledge S.J. (2006)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    8. The E3 ligase PIRH2 polyubiquitylates CHK2 and regulat es its turnover. (PubMed id 23449389)1 Bohgaki M....Hakem R. (2013)
    9. A c-Myc-MicroRNA functional feedback loop affects hepa tocarcinogenesis. (PubMed id 23389829)1 Han H....Li Y. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57646 HGNC: 12625 AceView: USP28 Ensembl:ENSG00000048028 euGenes: HUgn57646
    ECgene: USP28 H-InvDB: USP28

    (According to HUGE)
    About This Section
    HUGE: KIAA1515

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP28 gene:
    Search GeneIP for patents involving USP28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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