USP28 Gene
protein-coding GIFtS: 54
GCID: GC11M113668
|
|
ubiquitin specific peptidase 28(Previous name: ubiquitin specific protease 28 )
| |
Aliases
for USP28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 281 2 | | Ubiquitin-Specific-Processing Protease 282 3 | | KIAA15151 3 5 | | Ubiquitin Carboxyl-Terminal Hydrolase 282 | | Ubiquitin Specific Protease 281 2 | | Ubiquitin Thiolesterase 282 | | Deubiquitinating Enzyme 282 3 | | EC 3.4.19.123 | | Ubiquitin Thioesterase 282 3 | | EC 3.1.2.158 |
Export aliases for USP28 gene to outside databasesPrevious GC identifers: GC11M116021 GC11M115180 GC11M113702 GC11M113206 GC11M113173 GC11M109597 |
Summaries
for USP28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP28:
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins andpeptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate anddegradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al.,2001).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2Function: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNAdamage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Alsoinvolved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphasepromoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC inthe nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast,it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining theselective MYC degradation in the nucleolus
|
Genomic Views
for USP28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP28 gene promoter:
Max1 USF1 p53 Nkx2-5 LCR-F1 GATA-1 N-Myc S8 USF-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23USP28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M113668: view genomic region
(about GC identifiers)
Start:
|
113,668,596 bp from pter |
End:
|
113,746,292 bp from pter |
Size:
|
77,697 bases |
Orientation:
|
minus strand |
|
Proteins
for USP28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 28 Size: 1077 amino acids; 122491 Da
Subunit: Interacts with isoform 1 of FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of MYC
Subcellular location: Nucleus, nucleoplasm
1 PDB 3D structure from  and Proteopedia  for USP28:2LVA (3D)
Secondary accessions: B0YJC0 B0YJC1 Q9P213Alternative splicing: 2 isoforms: Q96RU2-1 Q96RU2-2 Explore the universe of human proteins at neXtProt for USP28: NX_Q96RU2
Post-translational modifications:
Degradaded upon nickel ion level or hypoxia exposure1
Phosphorylated upon DNA damage at Ser-67 and Ser-714, by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RU2
4/5 DME Specific Peptides for USP28 (Q96RU2) (see all 5)
USP28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065937.1
ENSEMBL proteins: ENSP00000003302 ENSP00000442431 ENSP00000444991 ENSP00000441513 ENSP00000440260 ENSP00000442257 ENSP00000445743 ENSP00000438050 ENSP00000437688 ENSP00000445722 ENSP00000440799 ENSP00000446284 ENSP00000437450 ENSP00000260188
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
USP28 for ontologies About GeneDecksing
USP28 Antibody Products:
Assay Products for USP28: |
Protein
Domains /
Families
for USP28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP28 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RU2ProtoNet protein and cluster: Q96RU2 2 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB003903 Ubiquitin interacting motif
UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2Similarity: Belongs to the peptidase C19 family. USP28 subfamilySimilarity: Contains 1 UIM (ubiquitin-interacting motif) repeat |
Function
for USP28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP28_HUMAN, Q96RU2Function: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNAdamage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Alsoinvolved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphasepromoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC inthe nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast,it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining theselective MYC degradation in the nucleolusCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Induction: Down-regulated upon hypoxiaEnzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP28 (NM_020886) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP28 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
USP28 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for USP28:
Animal Models:
1 MGI phenotypic allele  for Usp28 (no phenotypes)
USP28 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | | | 2 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP28
1 
Cell Signaling Technology (CST) Pathway for USP28
USP28 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP28
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/63 Interacting proteins for USP28 (Q96RU22, 3 ENSP000000033024) via UniProtKB, MINT, STRING, and/or I2D (see all 63)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
USP28 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP28
1 HMDB Compound for USP28 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP28 / UBP28
|
Transcripts
for USP28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP28 gene: NM_020886.2 Unigene Cluster for USP28: Ubiquitin specific peptidase 28 Hs.503891 [show with all ESTs]Unigene Representative Sequence: NM_02088616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000003302(uc001pog.3 uc001poh.3 uc010rwy.2 uc001poi.3)
ENST00000544967 ENST00000545540 ENST00000544272 ENST00000540438(uc010rwz.1)
ENST00000538224 ENST00000538475 ENST00000537706(uc001poj.3) ENST00000545608
ENST00000535607 ENST00000537490 ENST00000537642 ENST00000542033 ENST00000540925
ENST00000544750 ENST00000260188
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP28 (NM_020886) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP28 |
Additional cDNA sequence: AB040948.1 AF266283.1 AK027521.1 AK097623.1 AK123255.1 AK304376.1 AK304770.1 BC035986.1 BC065928.1 11 DOTS entries: DT.40196816 DT.436446 DT.100020054 DT.99940140 DT.100020055 DT.101962320 DT.100020052 DT.101964560 DT.120727912 DT.40310650 DT.100671162 24/100 AceView cDNA sequences (see all 100): AI368173 AF266283 BG289257 AA490857 AW025713 AK097623 BC065928 AW515403 AI923030 AA348047 BX951921 AB040948 AW769730 CA448327 BE672125 NM_020886 BQ421081 BU187516 AI273067 AW316631 AI609285 BX505753 CD630451 AL707545
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USP28 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | · | 28c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP28
|
Expression
for USP28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See USP28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP28
SOURCE GeneReport for Unigene cluster: Hs.503891
SABiosciences Custom PCR Arrays for USP28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP28 |
Orthologs
for USP28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP28 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP281 |
ubiquitin specific peptidase 28 |
68.73(n)
68.7(a) |
|
428246 NM_001031496.1 NP_001026667.1 |
lizard
(Anolis carolinensis) |
Reptilia |
USP286 |
-- |
63(a) |
1 ↔ 1 |
GL343354.1(239105-257631) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.120442 |
Transcribed sequence with moderate similarity to protein more |
76.22(n) |
|
BX703329.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
usp286 |
ubiquitin specific peptidase 28 |
50(a) |
1 ↔ 1 |
21(22165897-22225823) |
worm
(Caenorhabditis elegans) |
Secernentea |
K02C4.36 |
Probable ubiquitin carboxyl-terminal hydrolase K02... |
14(a) |
1 → many |
II(8080737-8086797) |
ENSEMBL Gene Tree for USP28 (if available)
TreeFam Gene Tree for USP28 (if available) |
Paralogs
for USP28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP28 gene
- USP252
1 SIMAP similar gene for USP28 using alignment to 14 protein entries: UBP28_HUMAN (see all proteins):USP25
USP28 for paralogs About GeneDecksing
|
Genomic Variants
for USP28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP28 (113668596 - 113746292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP28: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP28 |
|
Disorders
/ Diseases
for USP28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP28 for disorders About GeneDecksing
OMIM gene information: 610748
OMIM disorders: --
3  diseases for USP28: About MalaCardsfanconi's anemia anemia hypoxia
Export disorders for USP28 gene to outside databases
|
Publications
for USP28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP28 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with USP28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of alternatively spliced products and tissue- specific isoforms of USP28 and USP25. (PubMed id 11597335)1, 2, 3, 9 Valero R.... Marfany G. (2001)
- The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)1, 2 Bassermann F....Pagano M. (2008)
- The ubiquitin-specific protease USP28 is required for MYC stability. (PubMed id 17558397)1, 2 Popov N....Eilers M. (2007)
- Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. (PubMed id 17873522)1, 2 Popov N....Eilers M. (2007)
- A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. (PubMed id 16901786)1, 2 Zhang D....Elledge S.J. (2006)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
- GSK-3b regulates cell growth, migration, and angiogene sis via Fbw7 and USP28-dependent degradation of HIF-1a. (PubMed id 22144179)1 Flugel D....Kietzmann T. (2012)
|
External Searches for USP28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP28 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP28 gene:
Search GeneIP for patents involving USP28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for USP28 | | OriGene shRNA RFP for USP28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP28 | | | OriGene Protein Over-expression Lysate for USP28 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP28 | | OriGene 3'-UTR Clone for USP28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP28 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP28 | | OriGene Custom Protein Services for USP28 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP28 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP28 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP28 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP28 |
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| | Antibodies & Assays for USP28 |
| | | | Search Tocris compounds for USP28 |
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 | | | USP28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP28 |
|  |  |  | | | | ThermoFisher Antibodies for USP28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP28 |
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