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Aliases for USP27X Gene

Aliases for USP27X Gene

  • Ubiquitin Specific Peptidase 27, X-Linked 2 3 5
  • X-Linked Ubiquitin Carboxyl-Terminal Hydrolase 27 3 4
  • Ubiquitin Specific Protease 27, X Chromosome 2 3
  • Ubiquitin-Specific-Processing Protease 27 3 4
  • Deubiquitinating Enzyme 27 3 4
  • Ubiquitin Thioesterase 27 3 4
  • USP22L 3 4
  • USP27 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 22-Like 4
  • Ubiquitin Specific Protease 27, X-Linked 2
  • Ubiquitin Carboxyl-Terminal Hydrolase 27 3
  • EC 4
  • EC 61

External Ids for USP27X Gene

Previous GeneCards Identifiers for USP27X Gene

  • GC0XU900508
  • GC0XP049348
  • GC0XP049531
  • GC0XP049646
  • GC0XP047113

Summaries for USP27X Gene

GeneCards Summary for USP27X Gene

USP27X (Ubiquitin Specific Peptidase 27, X-Linked) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP22.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP27X Gene

Genomics for USP27X Gene

Regulatory Elements for USP27X Gene

Promoters for USP27X Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for USP27X Gene

49,879,867 bp from pter
49,882,565 bp from pter
2,699 bases
Plus strand

Genomic View for USP27X Gene

Genes around USP27X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP27X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP27X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP27X Gene

Proteins for USP27X Gene

  • Protein details for USP27X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 27
    Protein Accession:

    Protein attributes for USP27X Gene

    438 amino acids
    Molecular mass:
    49630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP27X Gene

Post-translational modifications for USP27X Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP27X Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP27X Gene

Gene Families for USP27X Gene

Protein Domains for USP27X Gene


Suggested Antigen Peptide Sequences for USP27X Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP27X: view

Function for USP27X Gene

Molecular function for USP27X Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP27X Gene

Gene Ontology (GO) - Molecular Function for USP27X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP27X: view
genes like me logo Genes that share phenotypes with USP27X: view

Animal Model Products

CRISPR Products

miRNA for USP27X Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP27X Gene

Localization for USP27X Gene

Gene Ontology (GO) - Cellular Components for USP27X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
genes like me logo Genes that share ontologies with USP27X: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for USP27X Gene

Pathways & Interactions for USP27X Gene

SuperPathways for USP27X Gene

No Data Available

Interacting Proteins for USP27X Gene

Selected Interacting proteins: A6NNY8-UBP27_HUMAN for USP27X Gene via IID

Gene Ontology (GO) - Biological Process for USP27X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016578 histone deubiquitination IBA --
genes like me logo Genes that share ontologies with USP27X: view

No data available for Pathways by source and SIGNOR curated interactions for USP27X Gene

Drugs & Compounds for USP27X Gene

No Compound Related Data Available

Transcripts for USP27X Gene

mRNA/cDNA for USP27X Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP27X Gene

Ubiquitin specific peptidase 27, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP27X Gene

No ASD Table

Relevant External Links for USP27X Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP27X Gene

mRNA expression in normal human tissues for USP27X Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP27X Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1) and Brain - Cerebellum (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for USP27X Gene

NURSA nuclear receptor signaling pathways regulating expression of USP27X Gene:


SOURCE GeneReport for Unigene cluster for USP27X Gene:

genes like me logo Genes that share expression patterns with USP27X: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USP27X Gene

Orthologs for USP27X Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP27X Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP27X 34
  • 94.14 (n)
  • 98.17 (a)
(Canis familiaris)
Mammalia LOC100686687 34
  • 92.77 (n)
  • 98.63 (a)
(Mus musculus)
Mammalia Usp27x 34
  • 91.86 (n)
  • 96.35 (a)
Usp27x 16
(Pan troglodytes)
Mammalia LOC100614099 34
  • 98.74 (n)
  • 97.96 (a)
(Rattus norvegicus)
Mammalia Usp27x 34
  • 91.25 (n)
  • 96.58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7153 34
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP22 34
  • 47.3 (n)
  • 40.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9273 34
Species where no ortholog for USP27X was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for USP27X Gene

Gene Tree for USP27X (if available)
Gene Tree for USP27X (if available)

Paralogs for USP27X Gene

(5) SIMAP similar genes for USP27X Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP27X: view

Variants for USP27X Gene

Sequence variations from dbSNP and Humsavar for USP27X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs45487097 -- 49,881,486(+) TGGTT(C/T)AAGTG reference, synonymous-codon
rs58638582 -- 49,882,257(+) GCCGT(C/T)GCTCC utr-variant-3-prime
rs73487840 -- 49,882,672(+) ACATT(C/T)TCCAC downstream-variant-500B
rs111441955 -- 49,882,855(+) TGATT(C/T)AGATC downstream-variant-500B
rs112059598 -- 49,882,415(+) TTTGC(A/G)ATTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP27X Gene

Variant ID Type Subtype PubMed ID
nsv6902 CNV insertion 18451855

Variation tolerance for USP27X Gene

Gene Damage Index Score: 0.24; 5.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP27X Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP27X Gene

Disorders for USP27X Gene

Relevant External Links for USP27X

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP27X Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP27X Gene

Publications for USP27X Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 65
  2. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. (PMID: 27013495) Weber A. … HAocker G. (EMBO Rep. 2016) 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 65
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 65

Products for USP27X Gene

Sources for USP27X Gene

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