Aliases for USP26 Gene
External Ids for USP26 Gene
Previous GeneCards Identifiers for USP26 Gene
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]
GeneCards Summary for USP26 Gene
USP26 (Ubiquitin Specific Peptidase 26) is a Protein Coding gene. Diseases associated with USP26 include Male Infertility and Azoospermia. Among its related pathways are Metabolism of proteins and Ubiquitin-Proteasome Dependent Proteolysis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.
UniProtKB/Swiss-Prot for USP26 Gene
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.