Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP26 Gene

Aliases for USP26 Gene

  • Ubiquitin Specific Peptidase 26 2 3 5
  • Ubiquitin-Specific-Processing Protease 26 4
  • Ubiquitin Specific Protease 26 2
  • Deubiquitinating Enzyme 26 4
  • Ubiquitin Thioesterase 26 4
  • EC 4

External Ids for USP26 Gene

Previous GeneCards Identifiers for USP26 Gene

  • GC0XM126805
  • GC0XM129005
  • GC0XM130104
  • GC0XM130865
  • GC0XM131885
  • GC0XM131986
  • GC0XM132158
  • GC0XM121562

Summaries for USP26 Gene

Entrez Gene Summary for USP26 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP26 Gene

USP26 (Ubiquitin Specific Peptidase 26) is a Protein Coding gene. Diseases associated with USP26 include male infertility and sertoli cell-only syndrome. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.

UniProtKB/Swiss-Prot for USP26 Gene

  • Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP26 Gene

Genomics for USP26 Gene

Regulatory Elements for USP26 Gene

Genomic Location for USP26 Gene

133,024,631 bp from pter
133,097,109 bp from pter
72,479 bases
Minus strand

Genomic View for USP26 Gene

Genes around USP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP26 Gene

Proteins for USP26 Gene

  • Protein details for USP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26
    Protein Accession:
    Secondary Accessions:
    • B9WRT6
    • Q5H9H4

    Protein attributes for USP26 Gene

    913 amino acids
    Molecular mass:
    104047 Da
    Quaternary structure:
    • Interacts with AR.

neXtProt entry for USP26 Gene

Proteomics data for USP26 Gene at MOPED

Post-translational modifications for USP26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP26 Gene

Domains & Families for USP26 Gene

Gene Families for USP26 Gene

Protein Domains for USP26 Gene

Suggested Antigen Peptide Sequences for USP26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP26: view

Function for USP26 Gene

Molecular function for USP26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

Enzyme Numbers (IUBMB) for USP26 Gene

Gene Ontology (GO) - Molecular Function for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP26: view
genes like me logo Genes that share phenotypes with USP26: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP26 Gene

Localization for USP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP26 Gene

Subcellular locations from

Jensen Localization Image for USP26 Gene COMPARTMENTS Subcellular localization image for USP26 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for USP26 Gene

Pathways & Interactions for USP26 Gene

genes like me logo Genes that share pathways with USP26: view

Pathways by source for USP26 Gene

1 Qiagen pathway for USP26 Gene

Gene Ontology (GO) - Biological Process for USP26 Gene


No data available for SIGNOR curated interactions for USP26 Gene

Drugs & Compounds for USP26 Gene

(1) Additional Compounds for USP26 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with USP26: view

Transcripts for USP26 Gene

mRNA/cDNA for USP26 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP26 Gene

Ubiquitin specific peptidase 26:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP26 Gene

No ASD Table

Relevant External Links for USP26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP26 Gene

mRNA expression in normal human tissues for USP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP26 Gene

This gene is overexpressed in Testis (x36.3).

Protein differential expression in normal tissues from HIPED for USP26 Gene

This gene is overexpressed in Serum (58.7) and Placenta (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP26 Gene

SOURCE GeneReport for Unigene cluster for USP26 Gene Hs.333137

genes like me logo Genes that share expression patterns with USP26: view

Protein tissue co-expression partners for USP26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for USP26 Gene

Orthologs for USP26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP26 35
  • 70.1 (n)
  • 49.13 (a)
USP26 36
  • 47 (a)
(Canis familiaris)
Mammalia USP26 35
  • 74.28 (n)
  • 58.51 (a)
USP26 36
  • 58 (a)
(Mus musculus)
Mammalia Usp26 35
  • 61.44 (n)
  • 41.62 (a)
Usp26 16
Usp26 36
  • 38 (a)
(Pan troglodytes)
Mammalia USP26 35
  • 96.61 (n)
  • 93.87 (a)
USP26 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Usp26 35
  • 61.44 (n)
  • 40.89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
(Danio rerio)
Actinopterygii USP29 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 36
  • 25 (a)
Species with no ortholog for USP26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP26 Gene

Gene Tree for USP26 (if available)
Gene Tree for USP26 (if available)

Paralogs for USP26 Gene

Paralogs for USP26 Gene

(2) SIMAP similar genes for USP26 Gene using alignment to 2 proteins: Pseudogenes for USP26 Gene

genes like me logo Genes that share paralogs with USP26: view

Variants for USP26 Gene

Sequence variations from dbSNP and Humsavar for USP26 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs61741870 - 133,027,727(+) GTGTC(A/G)ATTTT reference, missense
rs35397110 - 133,027,131(-) TGAAT(C/T)TTAAA reference, missense
rs41299088 - 133,026,798(+) AGGAT(A/G)TGCTT reference, missense
VAR_063417 -
rs138385391 - 133,026,484(+) GAAGT(C/T)ATCTT reference, missense

Variation tolerance for USP26 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP26 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP26 Gene

Disorders for USP26 Gene

MalaCards: The human disease database

(5) MalaCards diseases for USP26 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
sertoli cell-only syndrome
  • del castillo syndrome
  • spermatogenic failure
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search USP26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with USP26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP26 Gene

Publications for USP26 Gene

  1. USP26 gene variations in fertile and infertile men. (PMID: 18927127) Ribarski I. … Kleiman S.E. (Hum. Reprod. 2009) 3 4 23 48 67
  2. Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. (PMID: 18377898) Christensen G.L. … Carrell D.T. (Fertil. Steril. 2008) 3 23
  3. Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. (PMID: 18958354) Lee I.W. … Teng Y.N. (Asian J. Androl. 2008) 3 23
  4. Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility. (PMID: 17968467) Zhang J. … Zhang Q.Y. (Asian J. Androl. 2007) 3 23
  5. Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26. (PMID: 16888075) Ravel C. … McElreavey K. (Mol. Hum. Reprod. 2006) 3 23

Products for USP26 Gene

Sources for USP26 Gene

Back to Top