Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP26 Gene

protein-coding   GIFtS: 55
GCID: GC0XM132158

Ubiquitin Specific Peptidase 26

(Previous name: ubiquitin specific protease 26)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 261 2     Ubiquitin Carboxyl-Terminal Hydrolase 262
Ubiquitin Specific Protease 261 2     Ubiquitin Thiolesterase 262
Deubiquitinating Enzyme 262 3     Ubiquitin-Specific Processing Protease 262
Ubiquitin Thioesterase 262 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 262 3     

External Ids:    HGNC: 134851   Entrez Gene: 838442   Ensembl: ENSG000001345887   OMIM: 3003095   UniProtKB: Q9BXU73   

Export aliases for USP26 gene to outside databases

Previous GC identifers: GC0XM126805 GC0XM129005 GC0XM130104 GC0XM130865 GC0XM131885 GC0XM131986 GC0XM121562


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP26 Gene:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a
deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations
in this gene have been associated with Sertoli cell-only syndrome and male infertility. (provided by RefSeq, Jul
2008)

GeneCards Summary for USP26 Gene: 
USP26 (ubiquitin specific peptidase 26) is a protein-coding gene. Diseases associated with USP26 include male infertility, and sertoli cell-only syndrome. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP37.

UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7
Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP26 gene promoter:
         ER-alpha   FOXF2   Pax-2   FOXO3   CUTL1   Pax-2a   FOXO3b   Pax-2b   FOXO3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP26 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.2

USP26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP26 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132158:  view genomic region     (about GC identifiers)

Start:
132,158,659 bp from pter      End:
132,231,137 bp from pter
Size:
72,479 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 26  
Size: 913 amino acids; 104047 Da
Subunit: Interacts with AR
Subcellular location: Nucleus
Secondary accessions: B9WRT6 Q5H9H4

Explore the universe of human proteins at neXtProt for USP26: NX_Q9BXU7

Explore proteomics data for USP26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXU7

  • USP26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP26 Protein Expression
    REFSEQ proteins: NP_114113.1  
    ENSEMBL proteins: 
     ENSP00000359869   ENSP00000423390   ENSP00000384360  

    Human Recombinant Protein Products for USP26: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP26
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP26
    GenScript Custom Purified and Recombinant Proteins Services for USP26
    Novus Biologicals USP26 Protein
    Novus Biologicals USP26 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP26 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    USP26 for ontologies           About GeneDecksing



    USP26 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP26
    GenScript Custom Superior Antibodies Services for USP26
    Novus Biologicals USP26 Antibodies
    Abcam antibodies for USP26
    Cloud-Clone Corp. Antibodies for USP26 
    ThermoFisher Antibodies for USP26
    LSBio Antibodies in human, mouse, rat for USP26 

    Assay Products for USP26: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP26
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP26
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP26 
    Cloud-Clone Corp. CLIAs for USP26


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q9BXU7

    ProtoNet protein and cluster: Q9BXU7

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7
    Similarity: Belongs to the peptidase C19 family


    USP26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP26_HUMAN, Q9BXU7
    Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
    similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP26:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP26 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP26 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP26 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP26
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP26

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP26
    Sirion Biotech Customized adenovirus for overexpression of USP26

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP26 (see all 6)
    OriGene ORF clones in mouse, rat for USP26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP26 (NM_024025)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP26
    Sirion Biotech Customized lentivirus for stable overexpression of USP26 
                         Customized lentivirus expression plasmids for stable overexpression of USP26 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP26
    Search LifeMap BioReagents cell lines for USP26
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP26


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP26 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP26
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP26

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for USP26 (Q9BXU73 ENSP000003598694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    USP17L7P0C7H93I2D: score=1 
    S100A4ENSP000003462944STRING: ENSP00000346294
    --ENSP000003922494STRING: ENSP00000392249
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA--

    USP26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP26 (UBP26)

    1 HMDB Compound for USP26    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP26 / UBP26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP26 gene: 
    NM_031907.1  

    Unigene Cluster for USP26:

    Ubiquitin specific peptidase 26
    Hs.333137  [show with all ESTs]
    Unigene Representative Sequence: AK292527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370832(uc011mvf.2) ENST00000511190(uc010nrm.1) ENST00000417459
    ENST00000406273
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP26
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP26
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP26
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP26
    Clone
    Products:
         
    OriGene clones in human, mouse for USP26 (see all 6)
    OriGene ORF clones in mouse, rat for USP26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP26 (NM_024025)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP26
    Sirion Biotech Customized lentivirus for stable overexpression of USP26 
                         Customized lentivirus expression plasmids for stable overexpression of USP26 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP26
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP26
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP26
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP26

    Additional mRNA sequence: 

    AF285593.1 AK292527.1 BC069073.1 BC101189.2 BC101190.2 BC101191.2 BC101192.1 

    3 DOTS entries:

    DT.95302363  DT.99969062  DT.97765880 

    3 AceView cDNA sequences:

    NM_031907 AF285593 BC069073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP26 expression in normal human tissues (normalized intensities)      USP26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAATGAGA
    USP26 Expression
    About this image


    USP26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See USP26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP26

    SOURCE GeneReport for Unigene cluster: Hs.333137
        SABiosciences Custom PCR Arrays for USP26
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP26
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP26
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP26
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP26
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for USP26 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp261 , 5 ubiquitin specific peptidase 261, 5 61.4(n)1
    41.62(a)1
      X (28.31 cM)5
    835631  NM_031388.21  NP_113565.21 
     517539595 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-165f21.46
    si:ch211-165f21.4
    31(a)
    possible ortholog
    7(6411831-6414502)


    ENSEMBL Gene Tree for USP26 (if available)
    TreeFam Gene Tree for USP26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP26 gene
    USP372  USP292  
    2 SIMAP similar genes for USP26 using alignment to 2 protein entries:     UBP26_HUMAN (see all proteins):
    USP29    USP37

    USP26 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USP26
    PGOHUM00000240704


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in USP26 are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634174
    ----see VAR_0634172 L F mis40--------
    rs795838491,2
    C--132116255(+) AAAAAA/TAGCTA 1 -- ds50010--------
    rs1830289261,2
    --132116285(+) ATAGTC/TCCATC 1 -- ds50010--------
    rs1871225461,2
    C--132116483(+) GGATGC/TTCATC 1 -- ds50010--------
    rs413003031,2
    C--132116609(+) GTTCAT/CAGTTT 1 -- ds50012Minor allele frequency- C:0.25CSA 4
    rs1918179951,2
    --132116616(+) GTTTTC/TCTTCC 1 -- ds50010--------
    rs1843619971,2
    --132116623(+) TTCCAG/TGGAGG 1 -- ds50010--------
    rs1393504771,2
    C,F--132116689(+) CTTATT/CCCTTC 2 /E /G mis11Minor allele frequency- C:0.00NA 4538
    rs2004769981,2
    --132116691(+) TATTCC/TTTCTG 2 K syn10--------
    rs1891587781,2
    --132116803(+) TGCAAC/GGCCTA 2 P R mis10--------

    HapMap Linkage Disequilibrium report for USP26 (132158659 - 132231137 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP26: --

    Human Gene Mutation Database (HGMD): USP26

    Locus Specific Mutation Databases (LSDB): USP26
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP26
    DNA2.0 Custom Variant and Variant Library Synthesis for USP26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300309    OMIM disorders: --

    6 diseases for USP26:    About MalaCards
    male infertility    sertoli cell-only syndrome    infertility    azoospermia
    hypogonadism    conjunctivitis

    2 diseases from the University of Copenhagen DISEASES database for USP26:
    Male infertility     Infertility

    USP26 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for USP26 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility male 81.4 10 17968467 (2), 18377898 (1), 15970005 (1), 16888075 (1) (see all 5)
    azoospermia 73.6 1 18958354 (1)

    Genetic Association Database (GAD): USP26
    Human Genome Epidemiology (HuGE) Navigator: USP26 (10 documents)

    Export disorders for USP26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP26 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with USP26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. USP26 gene variations in fertile and infertile men. (PubMed id 18927127)1, 2, 4, 9 Ribarski I....Kleiman S.E. (2008)
    2. Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. (PubMed id 15970005)1, 2, 4, 9 Paduch D.A....Schlegel P.N. (2005)
    3. Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. (PubMed id 18377898)1, 2, 4, 9 Christensen G.L....Carrell D.T. (2008)
    4. Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility. (PubMed id 17968467)1, 4, 9 Zhang J....Zhang Q.Y. (2007)
    5. Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. (PubMed id 18958354)1, 4, 9 Lee I.W....Teng Y.N. (2008)
    6. Possible role of USP26 in patients with severely impaired spermatogenesis. (PubMed id 15562280)1, 4, 9 Stouffs K....Liebaers I. (2005)
    7. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    8. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. (PubMed id 20501646)1, 2 Dirac A.M. and Bernards R. (2010)
    9. Gene polymorphisms and male infertility--a meta-analysis and literature review. (PubMed id 18062861)1, 4 Tuttelmann F....Simoni M. (2007)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83844 HGNC: 13485 AceView: USP26 Ensembl:ENSG00000134588 euGenes: HUgn83844
    ECgene: USP26 H-InvDB: USP26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP26 gene:
    Search GeneIP for patents involving USP26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for USP26  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for USP26  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for USP26  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP26   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for USP26   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP26   OriGene Custom Protein Services for USP26  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP26
     QIAGEN SeqTarget long-range PCR primers for resequencing USP26
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP26
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP26
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP26
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP26
     GenScript Custom Purified and Recombinant Proteins Services for USP26 GenScript cDNA clones with any tag delivered in your preferred vector for USP26
     GenScript Custom Assay Services for USP26 GenScript Custom Superior Antibodies Services for USP26
     GenScript Custom overexpressing Cell Line Services for USP26 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP26 promoter
     Search Chromatin IP Primers for USP26
     RT2 qPCR Primer Assay in human, mouse, rat USP26
     Search GNC Networks for USP26
     SABiosciences PCR Arrays including human, mouse, rat USP26
     Search Tocris compounds for USP26 (UBP26)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP26 antibodies
     USP26 proteins
     USP26 lysates
     Antibodies for USP26
     See all of Abcam's Antibodies, Kits and Proteins for USP26
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for USP26
     Antibodies for USP26
     ELISAs for USP26
     CLIAs for USP26
     Search LifeMap BioReagents cell lines for USP26
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP26
     Browse SwitchGear 3'UTR luciferase reporter plasmids for USP26
     SwitchGear Promoter luciferase reporter plasmids for USP26
     ThermoFisher Antibodies for USP26
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP26
     inGenious Targeting Laboratory - Custom generated mouse model solutions for USP26
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP26
    Customized:
     lentivirus for stable overexpression of USP26
     lentivirus expression plasmids for stable overexpression of USP26
     adenovirus for overexpression of USP26
     LSBio Antibodies in human, mouse, rat for USP26
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP26 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4