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Aliases for USP26 Gene

Aliases for USP26 Gene

  • Ubiquitin Specific Peptidase 26 2 3
  • Ubiquitin-Specific-Processing Protease 26 4
  • Ubiquitin Specific Protease 26 2
  • Deubiquitinating Enzyme 26 4
  • Ubiquitin Thioesterase 26 4
  • EC 3.4.19.12 4

External Ids for USP26 Gene

Summaries for USP26 Gene

Entrez Gene Summary for USP26 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP26 Gene

USP26 (Ubiquitin Specific Peptidase 26) is a Protein Coding gene. Diseases associated with USP26 include sertoli cell-only syndrome and male infertility. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP29.

UniProtKB/Swiss-Prot for USP26 Gene

  • Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP26 Gene

Genomics for USP26 Gene

Genomic Location for USP26 Gene

Start:
133,024,631 bp from pter
End:
133,097,109 bp from pter
Size:
72,479 bases
Orientation:
Minus strand

Genomic View for USP26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP26 Gene

Regulatory Elements for USP26 Gene

Proteins for USP26 Gene

  • Protein details for USP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXU7-UBP26_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26
    Protein Accession:
    Q9BXU7
    Secondary Accessions:
    • B9WRT6
    • Q5H9H4

    Protein attributes for USP26 Gene

    Size:
    913 amino acids
    Molecular mass:
    104047 Da
    Quaternary structure:
    • Interacts with AR.

neXtProt entry for USP26 Gene

Proteomics data for USP26 Gene at MOPED

Post-translational modifications for USP26 Gene

No Post-translational modifications

Other Protein References for USP26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP26 Gene

Domains for USP26 Gene

Gene Families for USP26 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP26 Gene

UniProtKB/Swiss-Prot:

UBP26_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q9BXU7
Family:
  • Belongs to the peptidase C19 family.:
    • Q9BXU7
genes like me logo Genes that share domains with USP26: view

Function for USP26 Gene

Molecular function for USP26 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

Enzyme Numbers (IUBMB) for USP26 Gene

Gene Ontology (GO) - Molecular Function for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0005515 protein binding IPI 20501646
GO:0008234 cysteine-type peptidase activity --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP26: view

Phenotypes for USP26 Gene

genes like me logo Genes that share phenotypes with USP26: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP26 Gene

Localization for USP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP26 Gene COMPARTMENTS Subcellular localization image for USP26 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20501646
genes like me logo Genes that share ontologies with USP26: view

Pathways for USP26 Gene

genes like me logo Genes that share pathways with USP26: view

Pathways by source for USP26 Gene

1 Qiagen pathway for USP26 Gene

Gene Ontology (GO) - Biological Process for USP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 20501646
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP26: view

Compounds for USP26 Gene

(9) ApexBio Compounds for USP26 Gene

Compound Action Cas Number
IU1 potent and selective small-molecule inhibitor of Usp14 [314245-33-5]
LDN 57444 Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity [668467-91-2]
NSC 632839 hydrochloride Inhibitor of ubiquitin isopeptidase activity [157654-67-6]
P 22077 Inhibitor of ubiquitin-specific protease (USP) 7. [1247819-59-5]
P005091 Ubiquitin-specific protease 7 (USP7) inhibitor [882257-11-6]
PR-619 Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor [2645-32-1]
SJB2-043 novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
Vialinin A Inhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity [858134-23-3]
WP1130 Cell permeable deubiquitinase (DUB) inhibitor [856243-80-6]

(1) HMDB Compounds for USP26 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP26: view

Transcripts for USP26 Gene

mRNA/cDNA for USP26 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP26 Gene

Ubiquitin specific peptidase 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP26 Gene

No ASD Table

Relevant External Links for USP26 Gene

GeneLoc Exon Structure for
USP26
ECgene alternative splicing isoforms for
USP26

Expression for USP26 Gene

mRNA expression in normal human tissues for USP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP26 Gene

This gene is overexpressed in Testis (36.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP26 Gene

SOURCE GeneReport for Unigene cluster for USP26 Gene Hs.333137

genes like me logo Genes that share expressions with USP26: view

Orthologs for USP26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP26 36
  • 96.61 (n)
  • 93.87 (a)
USP26 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP26 36
  • 70.1 (n)
  • 49.13 (a)
USP26 37
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP26 36
  • 74.28 (n)
  • 58.51 (a)
USP26 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp26 36
  • 61.44 (n)
  • 41.62 (a)
Usp26 16
Usp26 37
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 18 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Usp26 36
  • 61.44 (n)
  • 40.89 (a)
zebrafish
(Danio rerio)
Actinopterygii USP29 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 37
  • 25 (a)
OneToMany
Species with no ortholog for USP26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP26 Gene

ENSEMBL:
Gene Tree for USP26 (if available)
TreeFam:
Gene Tree for USP26 (if available)

Paralogs for USP26 Gene

Paralogs for USP26 Gene

Selected SIMAP similar genes for USP26 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for USP26 Gene

genes like me logo Genes that share paralogs with USP26: view

Variants for USP26 Gene

Sequence variations from dbSNP and Humsavar for USP26 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3840975 -- 133,027,857(-) CAACA(-/ACA)CAGAA cds-indel
rs4582709 -- 133,027,622(+) CTACA(A/G)AATTA reference, missense
rs5933260 -- 133,029,675(+) GCAGC(C/T)TATTT upstream-variant-2KB
rs35348009 -- 133,025,032(+) AAGCA(-/A)AAAAA downstream-variant-500B
rs35397110 - 133,027,131(-) TGAAT(C/T)TTAAA reference, missense

Relevant External Links for USP26 Gene

HapMap Linkage Disequilibrium report
USP26
Human Gene Mutation Database (HGMD)
USP26
Locus Specific Mutation Databases (LSDB)
USP26

No data available for Structural Variations from Database of Genomic Variants (DGV) for USP26 Gene

Disorders for USP26 Gene

(2) University of Copenhagen DISEASES for USP26 Gene

(2) Novoseek inferred disease relationships for USP26 Gene

Disease -log(P) Hits PubMed IDs
infertility male 81.4 6
azoospermia 73.6 1

Relevant External Links for USP26

Genetic Association Database (GAD)
USP26
Human Genome Epidemiology (HuGE) Navigator
USP26
genes like me logo Genes that share disorders with USP26: view

No data available for UniProtKB/Swiss-Prot for USP26 Gene

Publications for USP26 Gene

  1. Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. (PMID: 15970005) Paduch D.A. … Schlegel P.N. (Reprod. BioMed. Online 2005) 3 4 23 49
  2. Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. (PMID: 18377898) Christensen G.L. … Carrell D.T. (Fertil. Steril. 2008) 3 4 23 49
  3. USP26 gene variations in fertile and infertile men. (PMID: 18927127) Ribarski I. … Kleiman S.E. (Hum. Reprod. 2009) 3 4 23 49
  4. Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. (PMID: 18958354) Lee I.W. … Teng Y.N. (Asian J. Androl. 2008) 3 23 49
  5. Possible role of USP26 in patients with severely impaired spermatogenesis. (PMID: 15562280) Stouffs K. … Liebaers I. (Eur. J. Hum. Genet. 2005) 3 23 49

Products for USP26 Gene

  • Addgene plasmids for USP26

Sources for USP26 Gene

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