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USP26 Gene

protein-coding   GIFtS: 54
GCID: GC0XM132158

Ubiquitin Specific Peptidase 26

(Previous name: ubiquitin specific protease 26)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin Specific Peptidase 261 2     Ubiquitin Carboxyl-Terminal Hydrolase 262
Ubiquitin Specific Protease 261 2     Ubiquitin Thiolesterase 262
Deubiquitinating Enzyme 262 3     Ubiquitin-Specific Processing Protease 262
Ubiquitin Thioesterase 262 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 262 3     

External Ids:    HGNC: 134851   Entrez Gene: 838442   Ensembl: ENSG000001345887   OMIM: 3003095   UniProtKB: Q9BXU73   
ORGUL members:         

Export aliases for USP26 gene to outside databases

Previous GC identifers: GC0XM126805 GC0XM129005 GC0XM130104 GC0XM130865 GC0XM131885 GC0XM131986 GC0XM121562


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP26 Gene:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a
deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations
in this gene have been associated with Sertoli cell-only syndrome and male infertility. (provided by RefSeq, Jul
2008)

GeneCards Summary for USP26 Gene:
USP26 (ubiquitin specific peptidase 26) is a protein-coding gene. Diseases associated with USP26 include sertoli cell-only syndrome, and male infertility. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP37.

UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7
Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP26 gene promoter:
         ER-alpha   FOXF2   Pax-2   FOXO3   CUTL1   Pax-2a   FOXO3b   Pax-2b   FOXO3a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP26 promoter sequence
   Search Chromatin IP Primers for USP26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.2

USP26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP26 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM132158:  view genomic region     (about GC identifiers)

Start:
132,158,659 bp from pter      End:
132,231,137 bp from pter
Size:
72,479 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 26  
Size: 913 amino acids; 104047 Da
Subunit: Interacts with AR
Secondary accessions: B9WRT6 Q5H9H4

Explore the universe of human proteins at neXtProt for USP26: NX_Q9BXU7

Explore proteomics data for USP26 at MOPED


See USP26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_114113.1  
ENSEMBL proteins: 
 ENSP00000359869   ENSP00000423390   ENSP00000384360  

USP26 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for USP26

USP26 Antibody Products:

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LSBio Antibodies in human, mouse, rat for USP26

USP26 Assay Products:

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Cloud-Clone Corp. CLIAs for USP26


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
USP: Ubiquitin-specific peptidases

3 InterPro protein domains:
 IPR001394 Peptidase_C19_UCH
 IPR018200 Pept_C19ubi-hydrolase_C_CS
 IPR028889 UCH/PAN2

Graphical View of Domain Structure for InterPro Entry Q9BXU7

ProtoNet protein and cluster: Q9BXU7

1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

UniProtKB/Swiss-Prot: UBP26_HUMAN, Q9BXU7
Similarity: Belongs to the peptidase C19 family
Similarity: Contains 1 USP domain


USP26 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UBP26_HUMAN, Q9BXU7
Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

     Enzyme Number (IUBMB): EC 3.4.19.121

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004221ubiquitin thiolesterase activity ----
GO:0005515protein binding IPI--
GO:0008234cysteine-type peptidase activity IEA--
     
USP26 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for USP26:
 Decreased Tat-dependent transc  Decreased p24 protein expressi 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP26
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP26
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP26

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat USP26

Gene Editing
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GenScript: all cDNA clones in your preferred vector: USP26 (NM_024025)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP26
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP26

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP26


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UBP26_HUMAN, Q9BXU7: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol1
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--

USP26 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for USP26 About    
See pathways by source

SuperPathContained pathways About
1Ubiquitin-Proteasome Dependent Proteolysis
Ubiquitin-Proteasome Dependent Proteolysis

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP26
    Ubiquitin-Proteasome Dependent Proteolysis


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP26
Interactions:

    Search GeneGlobe Interaction Network for USP26

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

Selected Interacting proteins for USP26 (Q9BXU73 ENSP000003598694) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
InteractantInteraction Details
GeneCardExternal ID(s)
CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
USP17L7P0C7H93I2D: score=1 
S100A4ENSP000003462944STRING: ENSP00000346294
CNOT4ENSP000003546734STRING: ENSP00000354673
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006511ubiquitin-dependent protein catabolic process IEA--
GO:0016579protein deubiquitination IDA--

USP26 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
9 ApexBio Compounds for USP26     About this table
CompoundAction CAS #
IU1potent and selective small-molecule inhibitor of Usp14[314245-33-5]
LDN 57444Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity[668467-91-2]
NSC 632839 hydrochlorideInhibitor of ubiquitin isopeptidase activity[157654-67-6]
P 22077Inhibitor of ubiquitin-specific protease (USP) 7[1247819-59-5]
P005091Ubiquitin-specific protease 7 (USP7) inhibitor[882257-11-6]
PR-619Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor[2645-32-1]
SJB2-043novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
Vialinin AInhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity[858134-23-3]
WP1130Cell permeable deubiquitinase (DUB) inhibitor[856243-80-6]

Browse Tocris compounds for USP26 (UBP26)

1 HMDB Compound for USP26    About this table
CompoundSynonyms CAS #PubMed Ids
WaterDihydrogen oxide (see all 2)7732-18-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for USP26 gene: 
NM_031907.1  

Unigene Cluster for USP26:

Ubiquitin specific peptidase 26
Hs.333137  [show with all ESTs]
Unigene Representative Sequence: AK292527
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370832(uc011mvf.2) ENST00000511190(uc010nrm.1) ENST00000417459
ENST00000406273

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat USP26 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate USP26
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for USP26
Predesigned siRNA for gene silencing in human, mouse, rat USP26
Clone
Products:
     
OriGene clones in human, mouse for USP26 (see all 6)
OriGene ORF clones in mouse, rat for USP26
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: USP26 (NM_024025)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP26
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP26
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for USP26
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP26
  QuantiTect SYBR Green Assays in human, mouse, rat USP26
  QuantiFast Probe-based Assays in human, mouse, rat USP26

Additional mRNA sequence: 

AF285593.1 AK292527.1 BC069073.1 BC101189.2 BC101190.2 BC101191.2 BC101192.1 

3 DOTS entries:

DT.95302363  DT.99969062  DT.97765880 

3 AceView cDNA sequences:

NM_031907 AF285593 BC069073 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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USP26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CATAATGAGA
USP26 Expression
About this image


USP26 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)
         XY Germ Cells Testis Cord
 
 Gonad
         XY Germ Cells Testis Cord
USP26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

USP26 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.333137
    Custom PCR Arrays for USP26
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for USP26
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP26
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP26

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for USP26 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Usp261 , 5 ubiquitin specific peptidase 261, 5 61.44(n)1
41.62(a)1
  X (28.31 cM)5
835631  NM_031388.21  NP_113565.21 
 517539595 
zebrafish
(Danio rerio)
Actinopterygii USP296
ubiquitin specific peptidase 29
29(a)
1 → many
7(6411831-6414502) ENSDARG00000093835


ENSEMBL Gene Tree for USP26 (if available)
TreeFam Gene Tree for USP26 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for USP26 gene
USP372  USP292  
2 SIMAP similar genes for USP26 using alignment to 2 protein entries:     UBP26_HUMAN (see all proteins):
USP29    USP37

USP26 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for USP26
PGOHUM00000240704


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for USP26 (see all 117)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs795838491,2
C--132116255(+) AAAAAA/TAGCTA 1 -- ds50010--------
rs1830289261,2
--132116285(+) ATAGTC/TCCATC 1 -- ds50010--------
rs1871225461,2
C--132116483(+) GGATGC/TTCATC 1 -- ds50010--------
rs413003031,2
C--132116609(+) GTTCAT/CAGTTT 1 -- ds50012Minor allele frequency- C:0.25CSA 4
rs1918179951,2
--132116616(+) GTTTTC/TCTTCC 1 -- ds50010--------
rs1843619971,2
--132116623(+) TTCCAG/TGGAGG 1 -- ds50010--------
rs1393504771,2
C,F--132116689(+) CTTATT/CCCTTC 2 /E /G mis11Minor allele frequency- C:0.00NA 4538
rs2004769981,2
--132116691(+) TATTCC/TTTCTG 2 K syn10--------
rs1891587781,2
--132116803(+) TGCAAC/GGCCTA 2 P R mis10--------
rs1440969911,2
C--132117108(+) GGTCTT/CAGGAG 2 /L syn11Minor allele frequency- C:0.00NA 4472

HapMap Linkage Disequilibrium report for USP26 (132158659 - 132231137 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for USP26: --
Human Gene Mutation Database (HGMD): USP26
Locus Specific Mutation Databases (LSDB): USP26

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing USP26
DNA2.0 Custom Variant and Variant Library Synthesis for USP26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300309    OMIM disorders: --

7 diseases for USP26:    
About MalaCards
sertoli cell-only syndrome    male infertility    infertility    azoospermia
conjunctivitis    hypogonadism    hiv-1

2 diseases from the University of Copenhagen DISEASES database for USP26:
Male infertility     Infertility

USP26 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

2 Novoseek inferred disease relationships for USP26 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
infertility male 81.4 10 17968467 (2), 18377898 (1), 15970005 (1), 16888075 (1) (see all 5)
azoospermia 73.6 1 18958354 (1)

Genetic Association Database (GAD): USP26
Human Genome Epidemiology (HuGE) Navigator: USP26 (10 documents)

Export disorders for USP26 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for USP26 gene, integrated from 10 sources (see all 26):
(articles sorted by number of sources associating them with USP26)
    Utopia: connect your pdf to the dynamic
world of online information

  1. USP26 gene variations in fertile and infertile men. (PubMed id 18927127)1, 2, 4, 9 Ribarski I.... Kleiman S.E. (Hum. Reprod. 2009)
  2. Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism. (PubMed id 15970005)1, 2, 4, 9 Paduch D.A.... Schlegel P.N. (Reprod. BioMed. Online 2005)
  3. Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls. (PubMed id 18377898)1, 2, 4, 9 Christensen G.L.... Carrell D.T. (Fertil. Steril. 2008)
  4. Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility. (PubMed id 17968467)1, 4, 9 Zhang J....Zhang Q.Y. (Asian J. Androl. 2007)
  5. Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. (PubMed id 18958354)1, 4, 9 Lee I.W....Teng Y.N. (Asian J. Androl. 2008)
  6. Possible role of USP26 in patients with severely impaired spermatogenesis. (PubMed id 15562280)1, 4, 9 Stouffs K....Liebaers I. (Eur. J. Hum. Genet. 2005)
  7. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
  8. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling. (PubMed id 20501646)1, 2 Dirac A.M. and Bernards R. (Mol. Cancer Res. 2010)
  9. Gene polymorphisms and male infertility--a meta-analysis and literature review. (PubMed id 18062861)1, 4 TA1ttelmann F....Simoni M. (Reprod. Biomed. Online 2007)
  10. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83844 HGNC: 13485 AceView: USP26 Ensembl:ENSG00000134588 euGenes: HUgn83844
ECgene: USP26 H-InvDB: USP26

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for USP26 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for USP26 gene:
Search GeneIP for patents involving USP26

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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