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USP25 Gene

protein-coding   GIFtS: 59
GCID: GC21P017102

Ubiquitin Specific Peptidase 25

(Previous name: ubiquitin specific protease 25)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Ubiquitin Specific Peptidase 251 2     Ubiquitin Carboxyl-Terminal Hydrolase 252
Deubiquitinating Enzyme 252 3     Ubiquitin Thiolesterase 252
Ubiquitin Thioesterase 252 3     Ubiquitin-Specific Processing Protease 252
USP212 3     EC 3.4.19.123
USP On Chromosome 212 3     Ubiquitin-Specific-Processing Protease 253
Ubiquitin Specific Protease 251     EC 3.1.2.158
Ubiquitin Specific Protease USP2511     

External Ids:    HGNC: 126241   Entrez Gene: 297612   Ensembl: ENSG000001553137   OMIM: 6047365   UniProtKB: Q9UHP33   

Export aliases for USP25 gene to outside databases

Previous GC identifers: GC21P013766 GC21P016024 GC21P002481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP25 Gene:
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein
breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by
disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25
(Valero et al., 1999 (PubMed 10644437)).(supplied by OMIM, Mar 2008)

GeneCards Summary for USP25 Gene:
USP25 (ubiquitin specific peptidase 25) is a protein-coding gene. Diseases associated with USP25 include panic disorder, and acne. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP28.

UniProtKB/Swiss-Prot: UBP25_HUMAN, Q9UHP3
Function: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions
to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and
prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin
chains
Function: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and
function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the USP25 gene promoter:
         STAT5B   STAT1   AML1a   STAT4   STAT2   STAT3   STAT1beta   STAT6   STAT5A   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP25 promoter sequence

   Search Chromatin IP Primers for USP25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q11.2
Nature(405: 311-319) cytogenetic band:   21q11
USP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP25 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P017102:   GeneLoc Nature:405,311-319
Start:
17,102,344 bp from pter       2,766,805 bp from centromere
End:
17,252,377 bp from pter 2,915,540 bp from centromere
Size:
150,034 bases 148,736 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF170562
genomic clones: P111K10 to P135E14


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP25_HUMAN, Q9UHP3 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 25  
Size: 1055 amino acids; 122218 Da
Subunit: Homodimer or oligomer. Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms
but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1;
the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via
filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates
efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the
interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25
intracellular levels
Secondary accessions: C0LSZ0 Q6DHZ9 Q9H9W1
Alternative splicing: 3 isoforms:  Q9UHP3-2   Q9UHP3-1   Q9UHP3-3   

Explore the universe of human proteins at neXtProt for USP25: NX_Q9UHP3

Explore proteomics data for USP25 at MOPED

Post-translational modifications: 

  • Acetylated1
  • Sumoylation impairs binding to and hydrolysis of ubiquitin chains. Sumoylated preferentially with SUMO2 or SUMO3.
    Desumoylated by SENP1. Regulated by ubiquitination on the same residue1
  • Preferentially monoubiquitinated but can also be polyubiquitinated. Autodeubiquitinated. Ubiquitination activates
    the enzymatic activity either by preventing sumoylation or by allowing novel interactions1
  • Phosphorylation in the C-terminal by SYK regulates USP25 cellular levels1
  • Ubiquitination2 at Lys15, Lys201, Lys250, Lys254, Lys312, Lys313, Lys392, Lys444, Lys520, Lys584,
                                 Lys630, Lys698, Lys715, Lys721
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for USP25 (Q9UHP3)
     LHAVLVH  FGQYPLQVNG  LPPVLTFELSRFEFNQ  QQQDVSEFTHKLLDWLEDAFQ 


    See USP25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269970.1  NP_001269971.1  NP_037528.3  

    ENSEMBL proteins: 
     ENSP00000285679   ENSP00000299574   ENSP00000285681   ENSP00000404086   ENSP00000402354  
     ENSP00000383044  

    USP25 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for USP25
    OriGene Purified Protein for USP25
    OriGene Protein Over-expression Lysate for USP25
    OriGene MassSpec for USP25
    OriGene Custom Protein Services for USP25
    GenScript Custom Purified and Recombinant Proteins Services for USP25
    Novus Biologicals USP25 Protein
    Novus Biologicals USP25 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP25

    USP25 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for USP25
    Novus Biologicals USP25 Antibodies
    Abcam antibodies for USP25
    Cloud-Clone Corp. Antibodies for USP25
    ThermoFisher Antibodies for USP25
    LSBio Antibodies in human, mouse, rat for USP25

    USP25 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP25
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP25
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP25
    Cloud-Clone Corp. CLIAs for USP25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR003903 Ubiquitin-int_motif
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9UHP3

    ProtoNet protein and cluster: Q9UHP3

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB003903 Ubiquitin interacting motif


    UniProtKB/Swiss-Prot: UBP25_HUMAN, Q9UHP3
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBA-like domain
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats
    Similarity: Contains 1 USP domain


    USP25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP25_HUMAN, Q9UHP3
    Function: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions
    to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and
    prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin
    chains
    Function: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and
    function
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: The muscle-specific isoform (USP25m) is up-regulated during myocyte differentiation. Levels increase up
    to 100-fold towards completion of differentiation

         Genatlas biochemistry entry for USP25:
    ubiquitin specific protease 25,expressed in testis,pancreas,kidney,liver,lung,brain,heart,skeletal muscle,encoding
    two alternatively spliced isoforms,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IMP18538659
    GO:0005515protein binding IPI18538659
    GO:0008233peptidase activity TAS10644437
    GO:0032183SUMO binding IDA18538659
         
    USP25 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP25:
     Increased cell death in HCT116  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Usp25):
     hematopoietic system  immune system  respiratory system 

    USP25 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP25
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP25

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP25:
    hsa-mir-128-3p (MIRT022093), hsa-mir-454-5p (MIRT039252), hsa-mir-27a-3p (MIRT028715), hsa-mir-101-3p (MIRT027319)

    Block miRNA regulation of human, mouse, rat USP25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP25 (see all 60):
    hsa-miR-579 hsa-miR-548j hsa-miR-300 hsa-miR-429 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-875-5p hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidUSP25 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP25
    Predesigned siRNA for gene silencing in human, mouse, rat USP25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP25

    Clone
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    OriGene clones in human, mouse for USP25 (see all 7)
    OriGene ORF clones in mouse, rat for USP25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP25 (NM_013396)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP25

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP25
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP25 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP25_HUMAN, Q9UHP3: Cytoplasm
    UBP25_HUMAN, Q9UHP3: Isoform USP25m: Cytoplasm (By similarity). Nucleus (By similarity). Note=Some transient
    punctuate nuclear location in myotubes during myocyte development (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    USP25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP25 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP25
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP25
    Interactions:

        Search GeneGlobe Interaction Network for USP25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP25 (Q9UHP32, 3 ENSP000002856794) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61673 I2D: score=3 
    BTBD9Q96Q073, ENSP000003861214I2D: score=2 STRING: ENSP00000386121
    KCTD10Q9H3F63, ENSP000002284954I2D: score=2 STRING: ENSP00000228495
    KCTD13Q8WZ193, ENSP000003112024I2D: score=2 STRING: ENSP00000311202
    KLHL9Q9P2J33, ENSP000003519334I2D: score=2 STRING: ENSP00000351933
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10644437
    GO:0006508proteolysis TAS10644437
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0070536protein K63-linked deubiquitination IMP18538659
    GO:0071108protein K48-linked deubiquitination IMP18538659

    USP25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP25 (UBP25)

    1 HMDB Compound for USP25    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP25 gene (3 alternative transcripts): 
    NM_001283041.1  NM_001283042.1  NM_013396.4  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285679 ENST00000351097 ENST00000285681(uc002yjz.1) ENST00000547201
    ENST00000549362 ENST00000464435 ENST00000453553 ENST00000449491 ENST00000478932
    ENST00000400183(uc002yjy.1 uc011aby.1 uc010gla.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat USP25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP25 (see all 60):
    hsa-miR-579 hsa-miR-548j hsa-miR-300 hsa-miR-429 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-875-5p hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidUSP25 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP25
    Predesigned siRNA for gene silencing in human, mouse, rat USP25
    Clone
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    OriGene clones in human, mouse for USP25 (see all 7)
    OriGene ORF clones in mouse, rat for USP25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP25 (NM_013396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP25
    Primer
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    OriGene qPCR primer pairs and template standards for USP25
    OriGene qSTAR qPCR primer pairs in human, mouse for USP25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP25
      QuantiTect SYBR Green Assays in human, mouse, rat USP25
      QuantiFast Probe-based Assays in human, mouse, rat USP25

    Selected AceView cDNA sequences (see all 137):

    H01462 BC075792 AI283888 BI964840 BU569569 CA397664 T36007 AU122556 
    AI985497 AA307805 AW316869 BQ215557 NM_013396 AK022574 AA731841 AA644617 
    BC015930 AA382386 AW264420 Z40738 AI554234 CK903453 BG567138 AL833500 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP25 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
    SP1:                                                        -                                                                                               -   
    SP2:                                                        -                                                                                         -     -   
    SP3:                                                  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                        -                                                   

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
    SP1:                          -                     
    SP2:                          -                     
    SP3:  -     -                 -                     
    SP4:                          -                     
    SP5:                                                


    ECgene alternative splicing isoforms for USP25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    USP25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP25 Expression
    About this image


    USP25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Thymus (Hematopoietic System)
             Thymus
    USP25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP25 Protein Expression

    UniProtKB/Swiss-Prot: UBP25_HUMAN, Q9UHP3
    Tissue specificity: Isoform USB25a is found in most adult and fetal tissues; expression is moderately high in
    testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood,
    colon, small intestine, ovary, prostate, thymus and spleen. Isoform USB25b is found in all tissues except heart
    and skeletal muscle. Isoform USB25m is heart and skeletal muscle specific

        Custom PCR Arrays for USP25
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP25
    QuantiTect SYBR Green Assays in human, mouse, rat USP25
    QuantiFast Probe-based Assays in human, mouse, rat USP25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP25 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp251 , 5 ubiquitin specific peptidase 251, 5 86.9(n)1
    92.57(a)1
      16 (44.40 cM)5
    309401  NM_013918.21  NP_038946.21 
     770140695 
    chicken
    (Gallus gallus)
    Aves USP251 ubiquitin specific peptidase 25 81.97(n)
    85.92(a)
      418471  XM_004938353.1  XP_004938410.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP256
    ubiquitin specific peptidase 25
    65(a)
    1 ↔ 1
    3(154400131-154477727)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.180742 Xenopus laevis transcribed sequence with weak similarity more 81.17(n)    CA790722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120452 Danio rerio mRNA similar to ubiquitin specific protease more 75.72(n)    BC045454.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K02C4.36
    Protein K02C4.3 (K02C4.3) mRNA, complete cds
    17(a)
    1 → many
    II(8080789-8086849) WBGene00010502


    ENSEMBL Gene Tree for USP25 (if available)
    TreeFam Gene Tree for USP25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP25 gene
    USP282  
    1 SIMAP similar gene for USP25 using alignment to 4 protein entries:     UBP25_HUMAN (see all proteins):
    USP28

    USP25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP25 (see all 3014)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881470831,2
    C--17100555(+) AGAAAC/TGCTGA 1 -- us2k10--------
    rs799677121,2
    C,F--17100557(+) AAATGC/TTGAGT 1 -- us2k12Minor allele frequency- T:0.18CSA WA 120
    rs1391173801,2
    C--17100597(+) AATGA-/ACAGTCT 1 -- us2k10--------
    rs1156541091,2
    C,F--17100807(+) AATTTT/GCTTGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs2009507671,2
    --17100841(+) CTAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs1496862011,2
    --17100897(+) GTTAGC/TATATA 1 -- us2k10--------
    rs1467008231,2
    --17100971(+) GACAGC/GTCACC 1 -- us2k10--------
    rs1812303301,2
    --17101058(+) CAACCC/GTTTCA 1 -- us2k10--------
    rs99745701,2
    C,F,H--17101120(+) TGCAAT/GTTGTT 1 -- us2k1 tfbs38Minor allele frequency- G:0.19NS NA WA 1088
    rs1152558261,2
    F--17101132(+) AATATC/GAAATG 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for USP25 (17102344 - 17252377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USP25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3461CNV Insertion18451855
    nsv3462CNV Insertion18451855
    nsv459099CNV Gain19166990
    nsv834050CNV Gain17160897
    esv275197CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP25
    DNA2.0 Custom Variant and Variant Library Synthesis for USP25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604736    OMIM disorders: --

    8 diseases for USP25:    
    About MalaCards
    panic disorder    acne    crohn's disease    parkinson's disease
    type 1 diabetes    inflammatory bowel disease    lung cancer    prostatitis


    USP25 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): USP25
    Human Genome Epidemiology (HuGE) Navigator: USP25 (2 documents)

    Export disorders for USP25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP25 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with USP25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Narrowing of the region of allelic loss in 21q11-21 in squamous non- small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. (PubMed id 10612803)1, 2, 3 Groet J.... Nizetic D. (Genes Chromosomes Cancer 2000)
    2. Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. (PubMed id 19909739)1, 2, 9 Cholay M.... Daviet L. (Exp. Cell Res. 2010)
    3. Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. (PubMed id 18538659)1, 2, 9 Meulmeester E.... Melchior F. (Mol. Cell 2008)
    4. Characterization of alternatively spliced products and tissue- specific isoforms of USP28 and USP25. (PubMed id 11597335)1, 2, 9 Valero R.... Marfany G. (Genome Biol. 2001)
    5. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. (PubMed id 10644437)1, 2, 9 Valero R.... Gonzalez-Duarte R. (Genomics 1999)
    6. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. (PubMed id 16501887)1, 2, 9 Bosch-Comas A....Marfany G. (Cell. Mol. Life Sci. 2006)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (Inflamm. Bowel Dis. 2010)
    9. The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition. (PubMed id 19440361)1, 2 Denuc A.... Marfany G. (PLoS ONE 2009)
    10. Genome-wide association study of panic disorder in the Japanese population. (PubMed id 19165232)1, 4 Otowa T....Okazaki Y. (J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29761 HGNC: 12624 AceView: USP25 Ensembl:ENSG00000155313 euGenes: HUgn29761
    ECgene: USP25 H-InvDB: USP25

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP25 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP25 gene:
    Search GeneIP for patents involving USP25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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