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USP24 Gene

protein-coding   GIFtS: 59
GCID: GC01M055543

Ubiquitin Specific Peptidase 24

(Previous name: ubiquitin specific protease 24)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 241 2     KIAA10573 5
Ubiquitin Specific Protease 241 2     Ubiquitin Carboxyl-Terminal Hydrolase 242
Deubiquitinating Enzyme 242 3     Ubiquitin Thiolesterase 242
Ubiquitin Thioesterase 242 3     Ubiquitin-Specific Processing Protease 242
Ubiquitin-Specific-Processing Protease 242 3     EC 3.4.19.123

External Ids:    HGNC: 126231   Entrez Gene: 233582   Ensembl: ENSG000001624027   OMIM: 6105695   UniProtKB: Q9UPU53   

Export aliases for USP24 gene to outside databases

Previous GC identifers: GC01M055368 GC01M054433 GC01M054889 GC01M054901 GC01M055244 GC01M055533 GC01M053645 GC01M055536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP24 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for USP24 Gene:
USP24 (ubiquitin specific peptidase 24) is a protein-coding gene. Diseases associated with USP24 include conjunctivitis, and brain cancer. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP18.

UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5
Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
similarity)

Gene Wiki entry for USP24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP24 gene promoter:
         AML1a   AP-1   Olf-1   Pax-2   Pax-2a   GATA-1   MEF-2A   c-Jun   aMEF-2   TGIF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for USP24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

USP24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP24 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M055543:  view genomic region     (about GC identifiers)

Start:
55,532,032 bp from pter      End:
55,681,039 bp from pter
Size:
149,008 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 24  
Size: 2620 amino acids; 294365 Da
Sequence caution: Sequence=AAH29660.1; Type=Erroneous initiation; Sequence=BAA91084.1; Type=Erroneous initiation;
Secondary accessions: Q6ZSY2 Q8N2Y4 Q9NXD1

Explore the universe of human proteins at neXtProt for USP24: NX_Q9UPU5

Explore proteomics data for USP24 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys275, Lys369, Lys421, Lys620, Lys648, Lys1764, Lys2097
  • Modification sites at PhosphoSitePlus

  • See USP24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056121.2  
    ENSEMBL proteins: 
     ENSP00000294383   ENSP00000385700  

    USP24 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for USP24
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    GenScript Custom Purified and Recombinant Proteins Services for USP24
    Novus Biologicals USP24 Protein
    Novus Biologicals USP24 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP24

    USP24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP24
    OriGene Custom Antibody Services for USP24
    Novus Biologicals USP24 Antibodies
    Abcam antibodies for USP24
    Cloud-Clone Corp. Antibodies for USP24
    ThermoFisher Antibodies for USP24
    LSBio Antibodies in human, mouse, rat for USP24

    USP24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP24
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP24
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP24
    Cloud-Clone Corp. CLIAs for USP24


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR009060 UBA-like
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q9UPU5

    ProtoNet protein and cluster: Q9UPU5

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 USP domain


    USP24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP24_HUMAN, Q9UPU5
    Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By
    similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP24:
    uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP24 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for USP24:
     Decreased Wnt reporter activit  Increased G1 DNA content  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Usp24):
     homeostasis/metabolism 

    USP24 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP24
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP24

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP24
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP24

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP24:
    hsa-mir-193b-3p (MIRT041365), hsa-mir-181b-5p (MIRT047289), hsa-mir-1226-3p (MIRT036516), hsa-let-7d-5p (MIRT032176), hsa-mir-196a-5p (MIRT026075), hsa-mir-935 (MIRT036649)

    Block miRNA regulation of human, mouse, rat USP24 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP24 (see all 90):
    hsa-miR-549 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-208b hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP24
    Predesigned siRNA for gene silencing in human, mouse, rat USP24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP24

    Clone
    Products:
         
    OriGene clones in human, mouse for USP24 (see all 8)
    OriGene ORF clones in mouse, rat for USP24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP24 (NM_015306)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP24

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP24
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP24
    Interactions:

        Search GeneGlobe Interaction Network for USP24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP24 (Q9UPU52, 3 ENSP000003857004) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ECT2Q9H8V32, ENSP000002324584MINT-7947479 STRING: ENSP00000232458
    JUNBP172753, ENSP000003033154I2D: score=1 STRING: ENSP00000303315
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    HIP1RO751462, ENSP000002530834MINT-7947479 STRING: ENSP00000253083
    ETV6P412122, ENSP000002664274MINT-7947479 STRING: ENSP00000266427
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP24 (UBP24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP24 gene: 
    NM_015306.2  

    Unigene Cluster for USP24:

    Ubiquitin specific peptidase 24
    Hs.477009  [show with all ESTs]
    Unigene Representative Sequence: NM_015306
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294383(uc001cyg.4 uc021onw.1) ENST00000484447 ENST00000480962
    ENST00000472566 ENST00000512504 ENST00000482197 ENST00000407756
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP24 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP24 (see all 90):
    hsa-miR-549 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-208b hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP24
    Predesigned siRNA for gene silencing in human, mouse, rat USP24
    Clone
    Products:
         
    OriGene clones in human, mouse for USP24 (see all 8)
    OriGene ORF clones in mouse, rat for USP24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP24 (NM_015306)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP24
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP24
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat USP24
      QuantiTect SYBR Green Assays in human, mouse, rat USP24
      QuantiFast Probe-based Assays in human, mouse, rat USP24

    Additional mRNA sequence: 

    AB028980.1 AK000321.1 AK127075.1 AL832370.1 BC029660.1 

    12 DOTS entries:

    DT.452003  DT.314989  DT.40278164  DT.92447844  DT.95271434  DT.426888  DT.121348422  DT.91811229 
    DT.95331858  DT.100724033  DT.121348490  DT.435023 

    Selected AceView cDNA sequences (see all 266):

    BX461410 N93325 AI707634 N74015 BM978780 AA699524 BU630057 AI185986 
    AI564374 BU619449 AI138729 BU156226 BE328889 AW467609 AW779532 BU581296 
    T33405 T23694 AK055871 BU631500 AW271327 BX280203 AI263096 BQ213462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGCAAAG
    USP24 Expression
    About this image

    USP24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477009
        Custom PCR Arrays for USP24
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP24
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat USP24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP24 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp241 , 5 ubiquitin specific peptidase 241, 5 89.68(n)1
    97.06(a)1
      4 (49.44 cM)5
    3299081  NM_183225.21  NP_899048.21 
     1063162205 
    chicken
    (Gallus gallus)
    Aves USP241 ubiquitin specific peptidase 24 82.34(n)
    92.07(a)
      424665  XM_422499.4  XP_422499.4 
    lizard
    (Anolis carolinensis)
    Reptilia USP246
    ubiquitin specific peptidase 24
    91(a)
    1 ↔ 1
    4(104183166-104272080)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79732 Xenopus laevis transcribed sequence with moderate similarity more 81.35(n)    BI477525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp241 ubiquitin specific peptidase 24 72.95(n)
    82.91(a)
      325631  XM_002665668.3  XP_002665714.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F37B12.43 ubiquitin carboxyl-terminal hydrolase 29(a)   II(9042685-9047401)   --


    ENSEMBL Gene Tree for USP24 (if available)
    TreeFam Gene Tree for USP24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP24 gene
    USP182  USP482  USP412  USP402  USP72  USP472  USP9Y2  USP342  
    USP9X2  
    1 SIMAP similar gene for USP24 using alignment to 2 protein entries:     UBP24_HUMAN (see all proteins):
    USP9X

    USP24 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for USP24
    PGOHUM00000248301 PGOHUM00000234275


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP24 (see all 2922)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340301211,2
    C--53727063(+) TAAAC-/AT/TA 
            
    AAAGA
    1 -- int10--------
    rs98040321,2
    C,F,H--55531635(+) GAAGGC/TGAAAA 1 -- ds500114Minor allele frequency- T:0.03NA NS EA CSA WA 1528
    rs283622961,2
    C,F--55531742(+) ACCAGA/C/TGACAC 1 -- ds50014NS 846
    rs283622971,2
    C--55531771(+) CTTGGG/CAGAGC 1 -- ds50013Minor allele frequency- C:0.01NS 132
    rs287425701,2
    C,F--55531794(+) TGGAGA/GTGAAT 1 -- ds50014Minor allele frequency- G:0.00NS 846
    rs1910292631,2
    --55531919(+) TTTATA/TAGTGT 1 -- ds50010--------
    rs283857141,2
    C--55531989(+) CACTAC/TGGCTG 1 -- ds50014Minor allele frequency- T:0.02NS 886
    rs283622991,2
    C--55532112(+) GGTTCT/CTCCCT 1 -- ut315Minor allele frequency- C:0.00NS WA 1006
    rs283857151,2
    C--55532142(+) GAAATT/GTTATA 1 -- ut316Minor allele frequency- G:0.01NS NA 1012
    rs1840666091,2
    --55532160(+) TTTTAC/TACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP24 (55532032 - 55681039 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USP24:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2496177CNV Deletion19546169
    nsv921CNV Insertion18451855
    nsv518539CNV Loss19592680
    nsv525879CNV Loss19592680
    nsv817614CNV Gain22305530
    nsv870896CNV Gain21882294

    Human Gene Mutation Database (HGMD): USP24
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP24
    DNA2.0 Custom Variant and Variant Library Synthesis for USP24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610569    OMIM disorders: --

    5 diseases for USP24:    
    About MalaCards
    conjunctivitis    brain cancer    coronary heart disease    parkinson's disease
    atherosclerosis


    USP24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP24
    Human Genome Epidemiology (HuGE) Navigator: USP24 (4 documents)

    Export disorders for USP24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP24 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with USP24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PubMed id 16917932)1, 4, 9 Li Y....Grupe A. (Hum. Mutat. 2006)
    2. Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. (PubMed id 20302855)1, 4 Wu Y.R....Lee-Chen G.J. ( international journal of clinical chemistry 2010)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    9. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. (PubMed id 23726366)1 Coram M.A....Tang H. (Am. J. Hum. Genet. 2013)
    10. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23358 HGNC: 12623 AceView: USP24 Ensembl:ENSG00000162402 euGenes: HUgn23358
    ECgene: USP24 H-InvDB: USP24

    (According to HUGE)
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    HUGE: KIAA1057

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP24 gene:
    Search GeneIP for patents involving USP24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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