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Aliases for USP24 Gene

Aliases for USP24 Gene

  • Ubiquitin Specific Peptidase 24 2 3
  • KIAA1057 4 6
  • Ubiquitin-Specific-Processing Protease 24 4
  • Ubiquitin Specific Protease 24 2
  • Deubiquitinating Enzyme 24 4
  • Ubiquitin Thioesterase 24 4
  • EC 4

External Ids for USP24 Gene

Previous GeneCards Identifiers for USP24 Gene

  • GC01M055368
  • GC01M054433
  • GC01M054889
  • GC01M054901
  • GC01M055244
  • GC01M055533
  • GC01M053645
  • GC01M055536
  • GC01M055543

Summaries for USP24 Gene

Entrez Gene Summary for USP24 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP24 Gene

USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP24 Gene

  • Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Gene Wiki entry for USP24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP24 Gene

Genomics for USP24 Gene

Regulatory Elements for USP24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP24 Gene

55,066,359 bp from pter
55,215,366 bp from pter
149,008 bases
Minus strand

Genomic View for USP24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP24 Gene

Proteins for USP24 Gene

  • Protein details for USP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 24
    Protein Accession:
    Secondary Accessions:
    • Q6ZSY2
    • Q8N2Y4
    • Q9NXD1

    Protein attributes for USP24 Gene

    2620 amino acids
    Molecular mass:
    294365 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29660.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91084.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP24 Gene

Proteomics data for USP24 Gene at MOPED

Post-translational modifications for USP24 Gene

  • Ubiquitination at Lys275, Lys369, Lys421, Lys620, Lys648, Lys1764, and Lys2097
  • Modification sites at PhosphoSitePlus

Other Protein References for USP24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for USP24 Gene

Domains for USP24 Gene

Gene Families for USP24 Gene

  • USP :Ubiquitin-specific peptidases

Suggested Antigen Peptide Sequences for USP24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UPU5
  • Contains 1 UBA domain.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP24: view

Function for USP24 Gene

Molecular function for USP24 Gene

GENATLAS Biochemistry:
uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function:
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Enzyme Numbers (IUBMB) for USP24 Gene

Gene Ontology (GO) - Molecular Function for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with USP24: view

Phenotypes for USP24 Gene

genes like me logo Genes that share phenotypes with USP24: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP24

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP24 Gene

Localization for USP24 Gene

Subcellular locations from

Jensen Localization Image for USP24 Gene COMPARTMENTS Subcellular localization image for USP24 gene
Compartment Confidence
nucleus 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP24 Gene

Pathways for USP24 Gene

SuperPathways for USP24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP24: view

No data available for Pathways by source for USP24 Gene

Transcripts for USP24 Gene

Unigene Clusters for USP24 Gene

Ubiquitin specific peptidase 24:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP24

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP24 Gene

No ASD Table

Relevant External Links for USP24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP24 Gene

mRNA expression in normal human tissues for USP24 Gene

mRNA differential expression in normal tissues according to GTEx for USP24 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Protein differential expression in normal tissues for USP24 Gene

This gene is overexpressed in Breast (23.8) and Peripheral blood mononuclear cells (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP24 Gene

SOURCE GeneReport for Unigene cluster for USP24 Gene Hs.477009

genes like me logo Genes that share expressions with USP24: view

Expression partners for USP24 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for USP24 Gene

Orthologs for USP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP24 35
  • 92.52 (n)
  • 98.47 (a)
USP24 36
  • 99 (a)
(Canis familiaris)
Mammalia USP24 35
  • 92.77 (n)
  • 99.04 (a)
USP24 36
  • 99 (a)
(Mus musculus)
Mammalia Usp24 35
  • 89.68 (n)
  • 97.06 (a)
Usp24 16
Usp24 36
  • 98 (a)
(Pan troglodytes)
Mammalia USP24 35
  • 99.65 (n)
  • 99.92 (a)
USP24 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp24 35
  • 90.12 (n)
  • 96.87 (a)
(Monodelphis domestica)
Mammalia USP24 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia USP24 36
  • 87 (a)
(Gallus gallus)
Aves USP24 35
  • 82.34 (n)
  • 92.07 (a)
USP24 36
  • 94 (a)
(Anolis carolinensis)
Reptilia USP24 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4161 35
usp24 35
  • 78.35 (n)
  • 88.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7973 35
(Danio rerio)
Actinopterygii usp24 35
  • 72.95 (n)
  • 82.91 (a)
usp24 36
  • 83 (a)
(Caenorhabditis elegans)
Secernentea F37B12.4 37
  • 29 (a)
T24B8.7 36
  • 15 (a)
Species with no ortholog for USP24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP24 Gene

Gene Tree for USP24 (if available)
Gene Tree for USP24 (if available)

Paralogs for USP24 Gene

Paralogs for USP24 Gene

Selected SIMAP similar genes for USP24 Gene using alignment to 2 proteins: Pseudogenes for USP24 Gene

genes like me logo Genes that share paralogs with USP24: view

Variants for USP24 Gene

Sequence variations from dbSNP and Humsavar for USP24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12455 -- 55,068,244(+) ATTTT(A/G)CTGTT utr-variant-3-prime
rs13312 -- 55,067,069(+) ATGAA(C/G)CTTTA utr-variant-3-prime
rs287227 -- 55,190,402(+) GGTTG(G/T)TTTGA intron-variant
rs287228 -- 55,191,651(+) ACGTC(C/T)GGCTA intron-variant
rs287229 -- 55,194,146(+) CACTA(G/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP24 Gene

Variant ID Type Subtype PubMed ID
nsv817614 CNV Gain 22305530
nsv518539 CNV Loss 19592680
nsv870896 CNV Gain 21882294
nsv525879 CNV Loss 19592680
nsv921 CNV Insertion 18451855
esv2496177 CNV Deletion 19546169

Relevant External Links for USP24 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP24 Gene

Disorders for USP24 Gene

Relevant External Links for USP24

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for USP24 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for USP24 Gene

Publications for USP24 Gene

  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PMID: 16917932) Li Y. … Grupe A. (Hum. Mutat. 2006) 3 23 48
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for USP24 Gene

Sources for USP24 Gene

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