USP24 Gene
protein-coding GIFtS: 56
GCID: GC01M055536
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|
ubiquitin specific peptidase 24(Previous name: ubiquitin specific protease 24 )
| |
Aliases
for USP24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 241 2 | | Ubiquitin-Specific-Processing Protease 242 3 | | KIAA10571 3 5 | | Ubiquitin Carboxyl-Terminal Hydrolase 242 | | Ubiquitin Specific Protease 241 2 | | Ubiquitin Thiolesterase 242 | | Deubiquitinating Enzyme 242 3 | | Ubiquitin-Specific Processing Protease 242 | | Ubiquitin Thioesterase 242 3 | | EC 3.4.19.123 |
Export aliases for USP24 gene to outside databasesPrevious GC identifers: GC01M055368 GC01M054433 GC01M054889 GC01M054901 GC01M055244 GC01M055533 GC01M053645 |
Summaries
for USP24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP24:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinatedaction of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteineproteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (Bysimilarity)
Gene Wiki entry for USP24
|
Genomic Views
for USP24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP24 gene promoter:
AML1a AP-1 Olf-1 Pax-2 Pax-2a GATA-1 MEF-2A c-Jun aMEF-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3USP24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M055536: view genomic region
(about GC identifiers)
Start:
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55,532,032 bp from pter |
End:
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55,681,039 bp from pter |
Size:
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149,008 bases |
Orientation:
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minus strand |
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Proteins
for USP24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 24 Size: 2620 amino acids; 294365 Da
Sequence caution: Sequence=AAH29660.1; Type=Erroneous initiation; Sequence=BAA91084.1; Type=Erroneous initiation;
Secondary accessions: Q6ZSY2 Q8N2Y4 Q9NXD1Explore the universe of human proteins at neXtProt for USP24: NX_Q9UPU5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPU5
USP24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056121.2
ENSEMBL proteins: ENSP00000294383 ENSP00000385700
Human Recombinant Protein Products:
USP24 Antibody Products:
Assay Products for USP24: |
Protein
Domains /
Families
for USP24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP24 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UPU5ProtoNet protein and cluster: Q9UPU5 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 UBA domain |
Function
for USP24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP24_HUMAN, Q9UPU5Function: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (Bysimilarity)Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Genatlas biochemistry entry for USP24:uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family
Enzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for USP24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP24 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP24 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for USP24:
|
Pathways & Interactions
for USP24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP24
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/530 Interacting proteins for USP24 (Q9UPU52, 3 ENSP000003857004) via UniProtKB, MINT, STRING, and/or I2D (see all 530)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP24 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP24
Search CenterWatch for drugs/clinical trials and news about USP24 / UBP24
|
Transcripts
for USP24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP24 gene: NM_015306.2 Unigene Cluster for USP24: Ubiquitin specific peptidase 24 Hs.477009 [show with all ESTs]Unigene Representative Sequence: NM_0153067 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294383(uc001cyg.4 uc021onw.1) ENST00000484447 ENST00000480962
ENST00000472566 ENST00000512504 ENST00000482197 ENST00000407756
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP24 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP24 (NM_015306) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP24 |
Additional cDNA sequence: AB028980.1 AK000321.1 AK127075.1 AL832370.1 BC029660.1 13 DOTS entries: DT.452003 DT.92447844 DT.314989 DT.40278164 DT.95271434 DT.95335467 DT.426888 DT.121348422 DT.121348490 DT.91811229 DT.95331858 DT.100724033 DT.435023 24/266 AceView cDNA sequences (see all 266): BX281951 BM978780 BU430305 BI816698 BM797987 W86608 AI185986 BU630057 BU619449 AI138729 BU581631 CA395325 AI359835 BU156226 BQ009554 AI571993 W69135 AI650699 BC029660 CR604309 AA382228 AW270985 BU520901 BU618748
GeneLoc Exon Structure
|
Expression
for USP24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGCAAAG
About this image
See USP24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP24
SOURCE GeneReport for Unigene cluster: Hs.477009
SABiosciences Custom PCR Arrays for USP24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP24
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP24 |
Orthologs
for USP24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP24 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP241 |
ubiquitin specific peptidase 24 |
82.85(n)
93.04(a) |
|
424665 XM_422499.3 XP_422499.3 |
lizard
(Anolis carolinensis) |
Reptilia |
USP246 |
-- |
90(a) |
1 ↔ 1 |
4(104183480-104272080) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.79732 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.35(n) |
|
BI477525.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
usp241 |
ubiquitin specific peptidase 24 |
73.26(n)
83.37(a) |
|
325631 XM_002665668.2 XP_002665714.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F37B12.43
T24B8.71 |
ubiquitin carboxyl-terminal hydrolase3
Protein T24B8.71 |
29(a)3
40.36(n)1
24.97(a)1 |
|
II(9042685-9047401)3
1744401 NM_063531.21 NP_495932.21 |
ENSEMBL Gene Tree for USP24 (if available)
TreeFam Gene Tree for USP24 (if available) |
Paralogs
for USP24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP24 gene
- USP182 USP412 USP482 USP402 USP72 USP472 USP9Y2 USP342
- USP9X2
2 SIMAP similar genes for USP24 using alignment to 2 protein entries: UBP24_HUMAN (see all proteins):USP9X USP9Y
USP24 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for USP24
PGOHUM00000248301 PGOHUM00000234275
|
Genomic Variants
for USP24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP24 (55532032 - 55681039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for USP24
1 CNV: 97358
Human Gene Mutation Database (HGMD): USP24
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP24 |
|
Disorders
/ Diseases
for USP24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP24 for disorders About GeneDecksing
OMIM gene information: 610569
OMIM disorders: --
3  diseases for USP24: About MalaCardsparkinson's disease conjunctivitis malaria
Human Genome Epidemiology (HuGE) Navigator: USP24 (4 documents)
Export disorders for USP24 gene to outside databases
|
Publications
for USP24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP24 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with USP24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PubMed id 16917932)1, 9 Li Y....Grupe A. (2006)
- Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
|
External Searches for USP24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP24 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP24 gene:
Search GeneIP for patents involving USP24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | USP24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP24 |
|  |  |  | | | | ThermoFisher Antibodies for USP24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP24 |
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