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Aliases for USP24 Gene

Aliases for USP24 Gene

  • Ubiquitin Specific Peptidase 24 2 3 5
  • Ubiquitin-Specific-Processing Protease 24 4
  • Ubiquitin Specific Protease 24 2
  • Deubiquitinating Enzyme 24 4
  • Ubiquitin Thioesterase 24 4
  • EC 3.4.19.12 4
  • KIAA1057 4

External Ids for USP24 Gene

Previous GeneCards Identifiers for USP24 Gene

  • GC01M055368
  • GC01M054433
  • GC01M054889
  • GC01M054901
  • GC01M055244
  • GC01M055533
  • GC01M053645
  • GC01M055536
  • GC01M055543

Summaries for USP24 Gene

Entrez Gene Summary for USP24 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP24 Gene

USP24 (Ubiquitin Specific Peptidase 24) is a Protein Coding gene. GO annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP24 Gene

  • Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Gene Wiki entry for USP24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP24 Gene

Genomics for USP24 Gene

Regulatory Elements for USP24 Gene

Promoters for USP24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP24 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP24 Gene

Chromosome:
1
Start:
55,066,359 bp from pter
End:
55,215,368 bp from pter
Size:
149,010 bases
Orientation:
Minus strand

Genomic View for USP24 Gene

Genes around USP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP24 Gene

Proteins for USP24 Gene

  • Protein details for USP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPU5-UBP24_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 24
    Protein Accession:
    Q9UPU5
    Secondary Accessions:
    • Q6ZSY2
    • Q8N2Y4
    • Q9NXD1

    Protein attributes for USP24 Gene

    Size:
    2620 amino acids
    Molecular mass:
    294365 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29660.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91084.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP24 Gene

Proteomics data for USP24 Gene at MOPED

Post-translational modifications for USP24 Gene

  • Ubiquitination at Lys 275, Lys 369, Lys 421, Lys 620, Lys 648, Lys 1764, and Lys 2097
  • Modification sites at PhosphoSitePlus

Other Protein References for USP24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for USP24 Gene

Domains & Families for USP24 Gene

Gene Families for USP24 Gene

Suggested Antigen Peptide Sequences for USP24 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPU5

UniProtKB/Swiss-Prot:

UBP24_HUMAN :
  • Contains 1 UBA domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 UBA domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP24: view

Function for USP24 Gene

Molecular function for USP24 Gene

GENATLAS Biochemistry:
uiquitin specific protease 24 (ubiquitin thiolesterase),carboxyterminal hydrolase,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.

Enzyme Numbers (IUBMB) for USP24 Gene

Gene Ontology (GO) - Molecular Function for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP24: view
genes like me logo Genes that share phenotypes with USP24: view

Animal Models for USP24 Gene

MGI Knock Outs for USP24:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP24

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP24 Gene

Localization for USP24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP24 Gene COMPARTMENTS Subcellular localization image for USP24 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP24 Gene

Pathways & Interactions for USP24 Gene

SuperPathways for USP24 Gene

No Data Available

SIGNOR curated interactions for USP24 Gene

Activates:

Gene Ontology (GO) - Biological Process for USP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP24: view

No data available for Pathways by source for USP24 Gene

Drugs & Compounds for USP24 Gene

No Compound Related Data Available

Transcripts for USP24 Gene

Unigene Clusters for USP24 Gene

Ubiquitin specific peptidase 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP24 Gene

No ASD Table

Relevant External Links for USP24 Gene

GeneLoc Exon Structure for
USP24
ECgene alternative splicing isoforms for
USP24

Expression for USP24 Gene

mRNA expression in normal human tissues for USP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP24 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for USP24 Gene

This gene is overexpressed in Breast (23.8) and Peripheral blood mononuclear cells (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP24 Gene



SOURCE GeneReport for Unigene cluster for USP24 Gene Hs.477009

genes like me logo Genes that share expression patterns with USP24: view

Protein tissue co-expression partners for USP24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for USP24 Gene

Orthologs for USP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP24 36
  • 100 (a)
OneToOne
USP24 35
  • 99.65 (n)
  • 99.92 (a)
cow
(Bos Taurus)
Mammalia USP24 36
  • 99 (a)
OneToOne
USP24 35
  • 92.52 (n)
  • 98.47 (a)
dog
(Canis familiaris)
Mammalia USP24 35
  • 92.77 (n)
  • 99.04 (a)
USP24 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp24 16
Usp24 35
  • 89.68 (n)
  • 97.06 (a)
Usp24 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP24 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP24 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp24 35
  • 90.12 (n)
  • 96.87 (a)
chicken
(Gallus gallus)
Aves USP24 35
  • 82.34 (n)
  • 92.07 (a)
USP24 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP24 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7973 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4161 35
usp24 35
  • 78.35 (n)
  • 88.63 (a)
zebrafish
(Danio rerio)
Actinopterygii usp24 36
  • 83 (a)
OneToOne
usp24 35
  • 72.95 (n)
  • 82.91 (a)
worm
(Caenorhabditis elegans)
Secernentea F37B12.4 37
  • 29 (a)
T24B8.7 36
  • 15 (a)
OneToMany
Species with no ortholog for USP24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP24 Gene

ENSEMBL:
Gene Tree for USP24 (if available)
TreeFam:
Gene Tree for USP24 (if available)

Paralogs for USP24 Gene

Paralogs for USP24 Gene

(1) SIMAP similar genes for USP24 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for USP24 Gene

genes like me logo Genes that share paralogs with USP24: view

Variants for USP24 Gene

Sequence variations from dbSNP and Humsavar for USP24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1165222 - 55,172,402(-) TCCCA(C/T)TGGTC nc-transcript-variant, reference, missense
rs2274540 - 55,097,070(-) AGGGC(A/G)GTGGA reference, missense
rs12753590 - 55,092,870(-) TACTG(A/C/G/T)ATACA reference, missense
rs487230 - 55,075,501(-) ACAAG(C/T)AGAGC reference, missense
rs12455 -- 55,068,244(+) ATTTT(A/G)CTGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP24 Gene

Variant ID Type Subtype PubMed ID
nsv817614 CNV Gain 22305530
nsv518539 CNV Loss 19592680
nsv870896 CNV Gain 21882294
nsv525879 CNV Loss 19592680
nsv921 CNV Insertion 18451855
esv2496177 CNV Deletion 19546169

Variation tolerance for USP24 Gene

Residual Variation Intolerance Score: 1.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP24 Gene

HapMap Linkage Disequilibrium report
USP24
Human Gene Mutation Database (HGMD)
USP24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP24 Gene

Disorders for USP24 Gene

Relevant External Links for USP24

Genetic Association Database (GAD)
USP24
Human Genome Epidemiology (HuGE) Navigator
USP24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP24

No disorders were found for USP24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP24 Gene

Publications for USP24 Gene

  1. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PMID: 16917932) Li Y. … Grupe A. (Hum. Mutat. 2006) 3 23 48 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. (PMID: 25814533) Peterson L.F. … Donato N.J. (Blood 2015) 3

Products for USP24 Gene

Sources for USP24 Gene

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