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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP22 Gene

protein-coding   GIFtS: 56
GCID: GC17M020902

Ubiquitin Specific Peptidase 22

(Previous names: ubiquitin specific protease 22, ubiquitin specific peptidase...)
(Previous symbol: USP3L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 221 2     Ubiquitin Carboxyl-Terminal Hydrolase 222
USP3L1 2 3     Ubiquitin Thiolesterase 222
Ubiquitin Specific Protease 221 2     Ubiquitin-Specific Processing Protease 222
Deubiquitinating Enzyme 222 3     EC 3.4.19.123
Ubiquitin Thioesterase 222 3     KIAA10633
Ubiquitin-Specific-Processing Protease 222 3     KIAA10645
Ubiquitin Specific Peptidase 3-Like1     EC 3.1.2.158

External Ids:    HGNC: 126211   Entrez Gene: 233262   Ensembl: ENSG000001244227   OMIM: 6121165   UniProtKB: Q9UPT93   

Export aliases for USP22 gene to outside databases

Previous GC identifers: GC17P020956 GC17M022551 GC17M020808 GC17M021064 GC17M020843 GC17M020106


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP22 Gene: 
USP22 (ubiquitin specific peptidase 22) is a protein-coding gene. Diseases associated with USP22 include oral squamous cell carcinoma, and colorectal cancer. GO annotations related to this gene include ubiquitin-specific protease activity and transcription coactivator activity. An important paralog of this gene is USP3.

UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex
SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to
specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear
receptor-mediated transactivation and cell cycle progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP22 gene promoter:
         AP-2rep   Pax-5   ATF-2   LCR-F1   E47   YY1   AREB6   CREB   CRE-BP1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

USP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP22 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M020902:  view genomic region     (about GC identifiers)

Start:
20,902,906 bp from pter      End:
20,947,073 bp from pter
Size:
44,168 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 22  
Size: 525 amino acids; 59961 Da
Subunit: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3,
ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex
required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA
complex
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH25317.1; Type=Frameshift; Positions=355; Sequence=BAA83015.1; Type=Erroneous
initiation;
Secondary accessions: A0JNS3 Q2NLE2 Q6MZY4 Q8TBS8 Q96IW5
Alternative splicing: 2 isoforms:  Q9UPT9-1   Q9UPT9-2   (Ref.2 (AAI10500) sequence differs from that shown due to a frameshift in position 3)

Explore the universe of human proteins at neXtProt for USP22: NX_Q9UPT9

Explore proteomics data for USP22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPT9

  • 4/19 DME Specific Peptides for USP22 (Q9UPT9) (see all 19)
     TIGLRGL  CVFFGCF  VSTTIDP  NLGNTCF 

    USP22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP22 Protein Expression
    REFSEQ proteins: NP_056091.1  
    ENSEMBL proteins: 
     ENSP00000261497   ENSP00000440950   ENSP00000464398   ENSP00000464499   ENSP00000468457  
     ENSP00000468748  

    Human Recombinant Protein Products for USP22: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP22
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP22
    GenScript Custom Purified and Recombinant Proteins Services for USP22
    Novus Biologicals USP22 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP22 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000124SAGA complex IDA18206972
    GO:0070461colocalizes with SAGA-type complex IDA18838386

    USP22 for ontologies           About GeneDecksing



    USP22 Antibody Products: 
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    Novus Biologicals USP22 Antibodies
    Abcam antibodies for USP22
    Cloud-Clone Corp. Antibodies for USP22 
    ThermoFisher Antibodies for USP22
    LSBio Antibodies in human, mouse, rat for USP22 

    Assay Products for USP22: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP22
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    Cloud-Clone Corp. ELISAs for USP22 
    Cloud-Clone Corp. CLIAs for USP22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR001607 Znf_UBP
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPT9

    ProtoNet protein and cluster: Q9UPT9

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
    Similarity: Belongs to the peptidase C19 family. UBP8 subfamily
    Similarity: Contains 1 UBP-type zinc finger


    USP22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP22_HUMAN, Q9UPT9
    Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex
    SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to
    specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear
    receptor-mediated transactivation and cell cycle progression
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA18206972
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0004843contributes to ubiquitin-specific protease activity IMP18206973
    GO:0005515protein binding IPI18206972
    GO:0008270zinc ion binding IEA--
         
    USP22 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP22:
     Decreased DCP1a protein expres 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp22):
     cellular  embryogenesis  growth/size  mortality/aging 

    USP22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usp22tm1Dfan for USP22

       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP22 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP22 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP22
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP22 (see all 9):
    hsa-miR-922 hsa-miR-4268 hsa-miR-513a-3p hsa-miR-3133 hsa-miR-3190 hsa-miR-1912 hsa-miR-4316 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP22

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of USP22

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP22 (see all 9)
    OriGene ORF clones in mouse, rat for USP22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP22 (NM_015276)
    Sino Biological Human cDNA Clone for USP22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP22
    Sirion Biotech Customized lentivirus for stable overexpression of USP22 
                         Customized lentivirus expression plasmids for stable overexpression of USP22 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP22
    Search LifeMap BioReagents cell lines for USP22
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for USP22 (Q9UPT92, 3 ENSP000002614974) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007049cell cycle IEA--
    GO:0009790embryo development NAS16378762
    GO:0016574histone ubiquitination IDA18469533

    USP22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP22 (UBP22)

    1 HMDB Compound for USP22    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP22 / UBP22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP22 gene: 
    NM_015276.1  

    Unigene Cluster for USP22:

    Ubiquitin specific peptidase 22
    Hs.462492  [show with all ESTs]
    Unigene Representative Sequence: AB028986
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261497(uc002gym.4) ENST00000537526(uc002gyn.4 uc002gyl.4)
    ENST00000455117 ENST00000579645 ENST00000463692 ENST00000478443 ENST00000582335
    ENST00000577610 ENST00000578446 ENST00000476111 ENST00000584538
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP22
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP22 (see all 9):
    hsa-miR-922 hsa-miR-4268 hsa-miR-513a-3p hsa-miR-3133 hsa-miR-3190 hsa-miR-1912 hsa-miR-4316 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP22
    Clone
    Products:
         
    OriGene clones in human, mouse for USP22 (see all 9)
    OriGene ORF clones in mouse, rat for USP22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP22 (NM_015276)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP22
    Sirion Biotech Customized lentivirus for stable overexpression of USP22 
                         Customized lentivirus expression plasmids for stable overexpression of USP22 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP22
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP22

    Additional mRNA sequence: 

    AB028986.1 AK025331.1 AK130677.1 AL049258.1 AL110213.1 BC007196.1 BC013364.2 BC025317.1 
    BC050994.1 BC084550.1 BC110499.1 BC126897.1 BC126898.1 BX640815.1 

    24/28 DOTS entries (see all 28):

    DT.100661813  DT.100859449  DT.40217429  DT.92459034  DT.100661806  DT.91694319  DT.92459044  DT.92459033 
    DT.97862469  DT.121013189  DT.95275660  DT.86844614  DT.97776493  DT.97777524  DT.100661807  DT.100763760 
    DT.121013190  DT.121013197  DT.121013238  DT.121013385  DT.428942  DT.91654792  DT.91873243  DT.95275653 

    24/891 AceView cDNA sequences (see all 891):

    BI711250 BM554901 BE701537 AI127160 AA351117 CR602078 BU155590 BM451998 
    AI570695 BF338579 AI338010 BU617301 CA418482 AA281450 BQ671234 BE079289 
    CK429203 BX954920 BU183210 AA045456 BX957125 CB118636 T33860 BQ775745 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTTCCCT
    USP22 Expression
    About this image


    See USP22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP22

    SOURCE GeneReport for Unigene cluster: Hs.462492

    UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
    Tissue specificity: Moderately expressed in various tissues including heart and skeletal muscle, and weakly
    expressed in lung and liver

        SABiosciences Expression via Pathway-Focused PCR Array including USP22: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP22 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp221 , 5 ubiquitin specific peptidase 221, 5 89.21(n)1
    97.9(a)1
      11 (37.96 cM)5
    2168251  NM_001004143.41  NP_001004143.21 
     611517855 
    chicken
    (Gallus gallus)
    Aves USP221 ubiquitin specific peptidase 22 83.37(n)
    96.18(a)
      416501  XM_414805.3  XP_414805.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    89(a)
    1 → many
    GL343385.1(764731-818871)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254812 Xenopus laevis transcribed sequence with strong similarity more 78.94(n)    BU914152.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp221 ubiquitin specific peptidase 22 80.02(n)
    91.07(a)
      692275  NM_001045248.1  NP_001038713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta not1 , 3 axon target recognition
    ubiquitin-specific protease3
    non-stop1
    54(a)3
    60.99(n)1
    57.66(a)1
      3 75D43
    400301  NM_079416.31  NP_524140.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP8(YMR223W)4
    UBP81
    Ubiquitin-specific protease that is a component of more4
    Ubp8p1
    45.51(n)1
    37.56(a)1
      13(716715-718130)4
    8552631, 4  NP_013950.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os04g06473001 hypothetical protein 50(n)
    43.39(a)
      4337205  NM_001060605.2  NP_001054070.2 


    ENSEMBL Gene Tree for USP22 (if available)
    TreeFam Gene Tree for USP22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP22 gene
    USP32  USP442  USP27X2  USP512  USP492  
    6 SIMAP similar genes for USP22 using alignment to 5 protein entries:     UBP22_HUMAN (see all proteins):
    DKFZp434K1822    USP27X    USP51    USP36    USP11    USP15

    USP22 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for USP22
    PGOHUM00000232645 PGOHUM00000233154 PGOHUM00000241752


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1101 SNPs in USP22 are shown (see all 1101)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405550661,2
    --20906846(+) GGGTCC/TCCCTG 1 -- int10--------
    rs1827077531,2
    --20906884(+) ATGCCA/TTGAAG 1 -- int10--------
    rs1869913331,2
    --20906942(+) GGGCCC/TGGTGG 1 -- int10--------
    rs1456304041,2
    --20906974(+) CTTTGA/GGAGGC 1 -- int10--------
    rs1915119411,2
    --20906993(+) GAGGAC/TTGCCT 1 -- int10--------
    rs1481214181,2
    C--20906997(+) ATTGCC/TTGAAG 1 -- int10--------
    rs1410025721,2
    --20907006(+) AGTCAA/GGAGTT 1 -- int10--------
    rs80663931,2
    C,F,H--20907074(+) caggcG/Atgatg 1 -- int15Minor allele frequency- A:0.00NS EA WA 522
    rs1502107741,2
    --20907088(+) CATGCC/TTATAA 1 -- int10--------
    rs1836528811,2
    --20907092(+) CCTATA/GATCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for USP22 (20902906 - 20947073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for USP22:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715749CNV Deletion23290073
    esv2103773CNV Deletion18987734
    esv2715750CNV Deletion23290073
    esv28319CNV Loss19812545
    dgv515n67CNV Gain20364138
    esv2751619CNV Gain17911159
    nsv827917CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612116    OMIM disorders: --

    5 diseases for USP22:    About MalaCards
    oral squamous cell carcinoma    colorectal cancer    esophagitis    squamous cell carcinoma
    breast cancer


    USP22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP22

    Export disorders for USP22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP22 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with USP22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (2008)
    2. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. (PubMed id 18206973)1, 2 Zhang X.Y....McMahon S.B. (2008)
    3. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. (PubMed id 18469533)1, 2 Zhang X.Y....McMahon S.B. (2008)
    4. The expression patterns of deubiquitinating enzymes, USP22 and Usp22. (PubMed id 16378762)1, 2 Lee H.J....Baek K.H. (2006)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    7. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (2013)
    8. Prognostic significance of USP22 as an oncogene in pap illary thyroid carcinoma. (PubMed id 23412977)1 Wang H....Ling R. (2013)
    9. USP22 antagonizes p53 transcriptional activation by de ubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryo nic development. (PubMed id 22542455)1 Lin Z....Fang D. (2012)
    10. USP22 is useful as a novel molecular marker for predic ting disease progression and patient prognosis of oral squamous cell carcinoma. (PubMed id 22880026)1 Piao S....Zhang B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23326 HGNC: 12621 AceView: USP22 Ensembl:ENSG00000124422 euGenes: HUgn23326
    ECgene: USP22 H-InvDB: USP22

    (According to HUGE)
    About This Section
    HUGE: KIAA1063 KIAA1064

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP22 gene:
    Search GeneIP for patents involving USP22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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