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USP22 Gene

protein-coding   GIFtS: 61
GCID: GC17M020902

Ubiquitin Specific Peptidase 22

(Previous names: ubiquitin specific protease 22, ubiquitin specific peptidase...)
(Previous symbol: USP3L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 221 2     Ubiquitin Carboxyl-Terminal Hydrolase 222
USP3L1 2 3     Ubiquitin Thiolesterase 222
Ubiquitin Specific Protease 221 2     Ubiquitin-Specific Processing Protease 222
Deubiquitinating Enzyme 222 3     EC 3.4.19.123
Ubiquitin Thioesterase 222 3     KIAA10633
Ubiquitin-Specific-Processing Protease 222 3     KIAA10645
Ubiquitin Specific Peptidase 3-Like1     EC 3.1.2.158

External Ids:    HGNC: 126211   Entrez Gene: 233262   Ensembl: ENSG000001244227   OMIM: 6121165   UniProtKB: Q9UPT93   

Export aliases for USP22 gene to outside databases

Previous GC identifers: GC17P020956 GC17M022551 GC17M020808 GC17M021064 GC17M020843 GC17M020106


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP22 Gene:
USP22 (ubiquitin specific peptidase 22) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and transcription coactivator activity. An important paralog of this gene is USP17L13.

UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex
SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to
specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear
receptor-mediated transactivation and cell cycle progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP22 gene promoter:
         AP-2rep   Pax-5   ATF-2   LCR-F1   E47   YY1   AREB6   CREB   CRE-BP1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for USP22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

USP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP22 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M020902:  view genomic region     (about GC identifiers)

Start:
20,902,906 bp from pter      End:
20,947,073 bp from pter
Size:
44,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 22  
Size: 525 amino acids; 59961 Da
Subunit: Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3,
ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex
required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA
complex
Sequence caution: Sequence=AAH25317.1; Type=Frameshift; Positions=355; Sequence=BAA83015.1; Type=Erroneous
initiation;
Secondary accessions: A0JNS3 Q2NLE2 Q6MZY4 Q8TBS8 Q96IW5
Alternative splicing: 2 isoforms:  Q9UPT9-1   Q9UPT9-2   (Ref.2 (AAI10500) sequence differs from that shown due to a frameshift in position 3)

Explore the universe of human proteins at neXtProt for USP22: NX_Q9UPT9

Explore proteomics data for USP22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys144, Lys166, Lys382, Lys442, Lys505
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP22 (Q9UPT9) (see all 19)
     TIGLRGL  CVFFGCF  VSTTIDP  NLGNTCF 


    See USP22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056091.1  
    ENSEMBL proteins: 
     ENSP00000261497   ENSP00000440950   ENSP00000464398   ENSP00000464499   ENSP00000468457  
     ENSP00000468748  
    Reactome Protein details: Q9UPT9

    USP22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for USP22
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP22
    GenScript Custom Purified and Recombinant Proteins Services for USP22
    Novus Biologicals USP22 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP22

     
    Search eBioscience for Proteins for USP22 

     
    antibodies-online proteins for USP22 (2 products) 

     
    antibodies-online peptides for USP22

    USP22 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP22
    OriGene Custom Antibody Services for USP22
    Novus Biologicals USP22 Antibodies
    Abcam antibodies for USP22
    Cloud-Clone Corp. Antibodies for USP22
    ThermoFisher Antibodies for USP22
    antibodies-online antibodies for USP22 (47 products) 

    USP22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP22
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP22
    Cloud-Clone Corp. CLIAs for USP22
    Search eBioscience for ELISAs for USP22 
    antibodies-online kits for USP22 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q9UPT9

    ProtoNet protein and cluster: Q9UPT9

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
    Similarity: Belongs to the peptidase C19 family. UBP8 subfamily
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP22_HUMAN, Q9UPT9
    Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex
    SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to
    specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear
    receptor-mediated transactivation and cell cycle progression
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA18206972
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843contributes to ubiquitin-specific protease activity IMP18206973
    GO:0005515protein binding IPI18206972
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with USP22           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for USP22:
     Decreased DCP1a protein expres 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Usp22):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with USP22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Usp22tm1Dfan for USP22

       genOway: Develop your customized and physiologically relevant rodent model for USP22

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP22:
    hsa-mir-361-5p (MIRT044092), hsa-mir-346 (MIRT042724), hsa-let-7b-5p (MIRT052073), hsa-mir-183-5p (MIRT047140), hsa-mir-365a-3p (MIRT044046), hsa-mir-125b-2-3p (MIRT038630), hsa-mir-200c-3p (MIRT044385), hsa-mir-29c-5p (MIRT038544), hsa-mir-320a (MIRT044650)

    Block miRNA regulation of human, mouse, rat USP22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP22 (see all 9):
    hsa-miR-922 hsa-miR-4268 hsa-miR-513a-3p hsa-miR-3133 hsa-miR-3190 hsa-miR-1912 hsa-miR-4316 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP22
    Predesigned siRNA for gene silencing in human, mouse, rat USP22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP22

    Clone
    Products:
         
    OriGene clones in human, mouse for USP22 (see all 9)
    OriGene ORF clones in mouse, rat for USP22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP22 (NM_015276)
    Sino Biological Human cDNA Clone for USP22
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP22
    Addgene plasmids for USP22 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP22
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP22_HUMAN, Q9UPT9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000124SAGA complex IDA18206972
    GO:0070461colocalizes with SAGA-type complex IDA18838386

    Find genes that share ontologies with USP22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP22 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with USP22           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for USP22
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Array including USP22: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP22 (Q9UPT91, 2, 3 ENSP000002614974) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4FP628053, ENSP000003669744I2D: score=1 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=1 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007049cell cycle IEA--
    GO:0009790embryo development NAS16378762

    Find genes that share ontologies with USP22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP22 (UBP22)

    1 HMDB Compound for USP22    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP22 gene: 
    NM_015276.1  

    Unigene Cluster for USP22:

    Ubiquitin specific peptidase 22
    Hs.462492  [show with all ESTs]
    Unigene Representative Sequence: AB028986
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261497(uc002gym.4) ENST00000537526(uc002gyn.4 uc002gyl.4)
    ENST00000455117 ENST00000579645 ENST00000463692 ENST00000478443 ENST00000582335
    ENST00000577610 ENST00000578446 ENST00000476111 ENST00000584538
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP22 (see all 9):
    hsa-miR-922 hsa-miR-4268 hsa-miR-513a-3p hsa-miR-3133 hsa-miR-3190 hsa-miR-1912 hsa-miR-4316 hsa-miR-4325
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP22
    Predesigned siRNA for gene silencing in human, mouse, rat USP22
    Clone
    Products:
         
    OriGene clones in human, mouse for USP22 (see all 9)
    OriGene ORF clones in mouse, rat for USP22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP22 (NM_015276)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP22
    Addgene plasmids for USP22 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP22
      QuantiTect SYBR Green Assays in human, mouse, rat USP22
      QuantiFast Probe-based Assays in human, mouse, rat USP22

    Additional mRNA sequence: 

    AB028986.1 AK025331.1 AK130677.1 AL049258.1 AL110213.1 BC007196.1 BC013364.2 BC025317.1 
    BC050994.1 BC084550.1 BC110499.1 BC126897.1 BC126898.1 BX640815.1 

    Selected DOTS entries (see all 28):

    DT.100661813  DT.100859449  DT.40217429  DT.92459034  DT.100661806  DT.91694319  DT.92459044  DT.92459033 
    DT.97862469  DT.121013189  DT.95275660  DT.86844614  DT.97776493  DT.97777524  DT.100661807  DT.100763760 
    DT.121013190  DT.121013197  DT.121013238  DT.121013385  DT.428942  DT.91654792  DT.91873243  DT.95275653 

    Selected AceView cDNA sequences (see all 891):

    AA995186 BG675938 F09541 AL574141 BE701552 AI499258 CA314544 CA396028 
    BM706065 AI925821 AI127160 BI711250 BU155590 BU167986 AI073543 BQ878519 
    BM554901 T09466 AI241870 BU196993 BE701537 BE701532 AA351117 BF993829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTTCCCT
    USP22 Expression
    About this image


    USP22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Lung (Respiratory System)
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
     
     Uterus (Reproductive System)
    USP22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462492

    UniProtKB/Swiss-Prot: UBP22_HUMAN, Q9UPT9
    Tissue specificity: Moderately expressed in various tissues including heart and skeletal muscle, and weakly
    expressed in lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including USP22: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP22
    QuantiTect SYBR Green Assays in human, mouse, rat USP22
    QuantiFast Probe-based Assays in human, mouse, rat USP22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP22 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp221 , 5 ubiquitin specific peptidase 221, 5 89.21(n)1
    97.9(a)1
      11 (37.96 cM)5
    2168251  NM_001004143.41  NP_001004143.21 
     611517855 
    chicken
    (Gallus gallus)
    Aves USP221 ubiquitin specific peptidase 22 83.44(n)
    96.38(a)
      416501  XM_004945181.1  XP_004945238.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254812 Xenopus laevis transcribed sequence with strong similarity more 78.94(n)    BU914152.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp221 ubiquitin specific peptidase 22 80.02(n)
    91.07(a)
      692275  NM_001045248.1  NP_001038713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta not1 , 3 axon target recognition
    ubiquitin-specific protease3
    non-stop1
    54(a)3
    60.69(n)1
    57.17(a)1
      3 75D43
    400301  NM_079416.41  NP_524140.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP8(YMR223W)4
    UBP81
    Ubiquitin-specific protease that is a component of more4
    UBP81
    45.68(n)1
    37.56(a)1
      13(716715-718130)4
    8552631, 4  NP_013950.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os04g06473001 Os04g0647300 50(n)
    43.39(a)
      4337205  NM_001060605.2  NP_001054070.2 


    ENSEMBL Gene Tree for USP22 (if available)
    TreeFam Gene Tree for USP22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for USP22 gene
    USP17L132  USP17L282  USP17L242  USP17L302  USP17L122  USP17L172  USP17L232  USP17L262  
    USP17L182  USP512  USP422  USP17L252  USP17L152  USP17L202  USP17L192  USP17L212  
    USP17L102  USP17L272  USP362  USP27X2  USP17L222  USP17L22  USP17L292  USP17L52  
    USP17L112  
    6 SIMAP similar genes for USP22 using alignment to 5 protein entries:     UBP22_HUMAN (see all proteins):
    DKFZp434K1822    USP27X    USP51    USP36    USP11    USP15

    Find genes that share paralogs with USP22           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for USP22
    PGOHUM00000232645 PGOHUM00000233154 PGOHUM00000241752


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP22 (see all 1101)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405550661,2
    --20906846(+) GGGTCC/TCCCTG 1 -- int10--------
    rs1827077531,2
    --20906884(+) ATGCCA/TTGAAG 1 -- int10--------
    rs1869913331,2
    --20906942(+) GGGCCC/TGGTGG 1 -- int10--------
    rs1456304041,2
    --20906974(+) CTTTGA/GGAGGC 1 -- int10--------
    rs1915119411,2
    --20906993(+) GAGGAC/TTGCCT 1 -- int10--------
    rs1481214181,2
    C--20906997(+) ATTGCC/TTGAAG 1 -- int10--------
    rs1410025721,2
    --20907006(+) AGTCAA/GGAGTT 1 -- int10--------
    rs80663931,2
    C,F,H--20907074(+) caggcG/Atgatg 1 -- int15Minor allele frequency- A:0.00NS EA WA 522
    rs1502107741,2
    --20907088(+) CATGCC/TTATAA 1 -- int10--------
    rs1836528811,2
    --20907092(+) CCTATA/GATCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for USP22 (20902906 - 20947073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for USP22:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715749CNV Deletion23290073
    esv2103773CNV Deletion18987734
    esv2715750CNV Deletion23290073
    esv28319CNV Loss19812545
    dgv515n67CNV Gain20364138
    esv2751619CNV Gain17911159
    nsv827917CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP22
    DNA2.0 Custom Variant and Variant Library Synthesis for USP22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612116    OMIM disorders: --


    Find genes that share disorders with USP22           About GenesLikeMe

    Genetic Association Database (GAD): USP22

    Export disorders for USP22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP22 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with USP22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (Mol. Cell 2008)
    2. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. (PubMed id 18206973)1, 2 Zhang X.-Y.... McMahon S.B. (Mol. Cell 2008)
    3. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. (PubMed id 18469533)1, 2 Zhang X.-Y.... McMahon S.B. (Cell Cycle 2008)
    4. The expression patterns of deubiquitinating enzymes, USP22 and Usp22. (PubMed id 16378762)1, 2 Lee H.-J.... Baek K.-H. (Gene Expr. Patterns 2006)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    7. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    8. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    9. Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma. (PubMed id 23412977)1 Wang H....Ling R. (Tumour Biol. 2013)
    10. Increased expression of USP22 is associated with disease progression and patient prognosis of salivary duct carcinoma. (PubMed id 23664741)1 Piao S....Guo F. (Oral Oncol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23326 HGNC: 12621 AceView: USP22 Ensembl:ENSG00000124422 euGenes: HUgn23326
    ECgene: USP22 H-InvDB: USP22

    (According to HUGE)
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    HUGE: KIAA1063 KIAA1064

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP22 gene:
    Search GeneIP for patents involving USP22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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