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Aliases for USP22 Gene

Aliases for USP22 Gene

  • Ubiquitin Specific Peptidase 22 2 3 5
  • Ubiquitin-Specific-Processing Protease 22 3 4
  • Ubiquitin Specific Protease 22 2 3
  • Deubiquitinating Enzyme 22 3 4
  • Ubiquitin Thioesterase 22 3 4
  • USP3L 3 4
  • Ubiquitin-Specific Processing Protease 22 3
  • Ubiquitin Specific Peptidase 3-Like 2
  • Ubiquitin Thiolesterase 22 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • KIAA1063 4

External Ids for USP22 Gene

Previous HGNC Symbols for USP22 Gene

  • USP3L

Previous GeneCards Identifiers for USP22 Gene

  • GC17P020956
  • GC17M022551
  • GC17M020808
  • GC17M021064
  • GC17M020843
  • GC17M020106
  • GC17M020902

Summaries for USP22 Gene

GeneCards Summary for USP22 Gene

USP22 (Ubiquitin Specific Peptidase 22) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include enzyme binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP49.

UniProtKB/Swiss-Prot for USP22 Gene

  • Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP22 Gene

Genomics for USP22 Gene

Regulatory Elements for USP22 Gene

Enhancers for USP22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP22 on UCSC Golden Path with GeneCards custom track

Promoters for USP22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP22 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP22 Gene

Chromosome:
17
Start:
20,999,593 bp from pter
End:
21,043,760 bp from pter
Size:
44,168 bases
Orientation:
Minus strand

Genomic View for USP22 Gene

Genes around USP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP22 Gene

Proteins for USP22 Gene

  • Protein details for USP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT9-UBP22_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 22
    Protein Accession:
    Q9UPT9
    Secondary Accessions:
    • A0JNS3
    • Q2NLE2
    • Q6MZY4
    • Q8TBS8
    • Q96IW5

    Protein attributes for USP22 Gene

    Size:
    525 amino acids
    Molecular mass:
    59961 Da
    Quaternary structure:
    • Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex.
    SequenceCaution:
    • Sequence=AAH25317.1; Type=Frameshift; Positions=355; Evidence={ECO:0000305}; Sequence=BAA83015.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP22 Gene

Proteomics data for USP22 Gene at MOPED

Post-translational modifications for USP22 Gene

  • Ubiquitination at Lys 144, Lys 166, Lys 382, and Lys 442
  • Modification sites at PhosphoSitePlus

Other Protein References for USP22 Gene

Antibody Products

Domains & Families for USP22 Gene

Gene Families for USP22 Gene

Suggested Antigen Peptide Sequences for USP22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPT9

UniProtKB/Swiss-Prot:

UBP22_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. UBP8 subfamily.
  • Contains 1 UBP-type zinc finger.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. UBP8 subfamily.
Similarity:
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP22: view

Function for USP22 Gene

Molecular function for USP22 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Enzyme Numbers (IUBMB) for USP22 Gene

Gene Ontology (GO) - Molecular Function for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 18206972
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IMP 18206973
GO:0008270 zinc ion binding IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP22: view
genes like me logo Genes that share phenotypes with USP22: view

Animal Models for USP22 Gene

MGI Knock Outs for USP22:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP22

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP22 Gene

Localization for USP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP22 Gene COMPARTMENTS Subcellular localization image for USP22 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IDA 18206972
genes like me logo Genes that share ontologies with USP22: view

Pathways & Interactions for USP22 Gene

genes like me logo Genes that share pathways with USP22: view

Pathways by source for USP22 Gene

Gene Ontology (GO) - Biological Process for USP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0009790 embryo development NAS 16378762
GO:0016574 histone ubiquitination IDA 18469533
GO:0016578 histone deubiquitination IDA 18206972
genes like me logo Genes that share ontologies with USP22: view

No data available for SIGNOR curated interactions for USP22 Gene

Drugs & Compounds for USP22 Gene

(1) Additional Compounds for USP22 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP22: view

Transcripts for USP22 Gene

Unigene Clusters for USP22 Gene

Ubiquitin specific peptidase 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP22 Gene

No ASD Table

Relevant External Links for USP22 Gene

GeneLoc Exon Structure for
USP22
ECgene alternative splicing isoforms for
USP22

Expression for USP22 Gene

mRNA expression in normal human tissues for USP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.9), Fetal heart (25.8), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP22 Gene



SOURCE GeneReport for Unigene cluster for USP22 Gene Hs.462492

mRNA Expression by UniProt/SwissProt for USP22 Gene

Q9UPT9-UBP22_HUMAN
Tissue specificity: Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.
genes like me logo Genes that share expression patterns with USP22: view

Protein tissue co-expression partners for USP22 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for USP22 Gene

Orthologs for USP22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP22 35
  • 88.39 (n)
  • 97.47 (a)
USP22 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP22 35
  • 89.48 (n)
  • 98.08 (a)
USP22 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp22 35
  • 89.21 (n)
  • 97.9 (a)
Usp22 16
Usp22 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP22 35
  • 97.6 (n)
  • 96.71 (a)
USP22 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp22 35
  • 89.46 (n)
  • 98.1 (a)
chicken
(Gallus gallus)
Aves USP22 35
  • 83.44 (n)
  • 96.38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp22 35
  • 78.5 (n)
  • 93.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25481 35
zebrafish
(Danio rerio)
Actinopterygii usp22 35
  • 80.02 (n)
  • 91.07 (a)
usp22 36
  • 94 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta not 37
  • 54 (a)
not 35
  • 60.69 (n)
  • 57.17 (a)
not 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012119 35
  • 60.92 (n)
  • 57.35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR551W 35
  • 48.21 (n)
  • 37.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06974g 35
  • 43.19 (n)
  • 35.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 45.68 (n)
  • 37.56 (a)
UBP8 36
  • 31 (a)
OneToMany
UBP8 38
rice
(Oryza sativa)
Liliopsida Os04g0647300 35
  • 50 (n)
  • 43.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02375 35
  • 46.67 (n)
  • 34.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp8 35
  • 44.63 (n)
  • 37.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1941 36
  • 56 (a)
OneToMany
Species with no ortholog for USP22:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP22 Gene

ENSEMBL:
Gene Tree for USP22 (if available)
TreeFam:
Gene Tree for USP22 (if available)

Paralogs for USP22 Gene

Paralogs for USP22 Gene

(6) SIMAP similar genes for USP22 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for USP22 Gene

genes like me logo Genes that share paralogs with USP22: view

Variants for USP22 Gene

Sequence variations from dbSNP and Humsavar for USP22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3612 -- 21,001,771(+) AGTTT(A/C)TAATT utr-variant-3-prime
rs984007 -- 21,018,955(+) GCTGA(A/G)CACAT intron-variant
rs996065 -- 21,033,090(+) GACCG(C/T)GGAGG intron-variant
rs716959 -- 21,013,277(-) TCAGC(C/T)GTCTC intron-variant
rs719093 -- 21,013,049(-) ATGGC(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP22 Gene

Variant ID Type Subtype PubMed ID
esv2751619 CNV Gain 17911159
nsv827917 CNV Gain 20364138
esv2715749 CNV Deletion 23290073
esv2103773 CNV Deletion 18987734
esv2715750 CNV Deletion 23290073
dgv515n67 CNV Gain 20364138
esv28319 CNV Loss 19812545

Variation tolerance for USP22 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP22 Gene

HapMap Linkage Disequilibrium report
USP22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP22 Gene

Disorders for USP22 Gene

Relevant External Links for USP22

Genetic Association Database (GAD)
USP22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP22

No disorders were found for USP22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP22 Gene

Publications for USP22 Gene

  1. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y. … Devys D. (Mol. Cell 2008) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor I^1. (PMID: 25369910) Ji M. … Li Y. (Oncol. Rep. 2015) 3
  4. Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma. (PMID: 25445209) He Y. … Jin X.M. (Transl Res 2015) 3
  5. ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma. (PMID: 25482932) Zhuang Y.J. … Zhou T.C. (Cancer Biol. Ther. 2015) 3

Products for USP22 Gene

Sources for USP22 Gene

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