Aliases for USP22 Gene
External Ids for USP22 Gene
Previous HGNC Symbols for USP22 Gene
Previous GeneCards Identifiers for USP22 Gene
GeneCards Summary for USP22 Gene
USP22 (Ubiquitin Specific Peptidase 22) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription coactivator activity and ubiquitin-specific protease activity. An important paralog of this gene is USP36.
UniProtKB/Swiss-Prot for USP22 Gene
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.