Aliases for USP21 Gene
External Ids for USP21 Gene
Previous HGNC Symbols for USP21 Gene
Previous GeneCards Identifiers for USP21 Gene
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for USP21 Gene
USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription coactivator activity and cysteine-type peptidase activity. An important paralog of this gene is USP49.
UniProtKB/Swiss-Prot for USP21 Gene
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at Lys-4, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).