Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



USP21 Gene

protein-coding   GIFtS: 58
GCID: GC01P161129

Ubiquitin Specific Peptidase 21

(Previous name: ubiquitin specific protease 21)
(Previous symbol: USP23)
  Search for USP21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin Specific Peptidase 211 2     NEDD8-Specific Protease2
USP231 2 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 212
Ubiquitin Specific Protease 211 2     Ubiquitin Thiolesterase 212
Deubiquitinating Enzyme 212 3     Ubiquitin-Specific Processing Protease 212
Ubiquitin Thioesterase 212 3     Ubiquitin-Specific Protease 162
Ubiquitin-Specific-Processing Protease 212 3     EC 3.4.19.123
USP162     EC 3.1.2.158

External Ids:    HGNC: 126201   Entrez Gene: 270052   Ensembl: ENSG000001432587   OMIM: 6047295   UniProtKB: Q9UK803   

Export aliases for USP21 gene to outside databases

Previous GC identifers: GC01P158840 GC01P156861 GC01P157907 GC01P158346 GC01P157942 GC01P159395 GC01P132486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for USP21 Gene:
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal
hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular
protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from
NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for USP21 Gene:
USP21 (ubiquitin specific peptidase 21) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and transcription coactivator activity. An important paralog of this gene is USP3.

UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as
a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at
'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A
deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on
Sentrin-1 conjugates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP21 gene promoter:
         p53   ATF-2   HNF-4alpha2   HNF-4alpha1   GATA-1   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP21 promoter sequence
   Search Chromatin IP Primers for USP21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22

USP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161129:  view genomic region     (about GC identifiers)

Start:
161,129,240 bp from pter      End:
161,135,516 bp from pter
Size:
6,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 21  
Size: 565 amino acids; 62656 Da
Sequence caution: Sequence=AAF61308.1; Type=Frameshift; Positions=90, 132; Sequence=AAG17222.1; Type=Frameshift;
Positions=188, 214, 228; Sequence=BAD92136.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for USP21:
2Y5B (3D)        3I3T (3D)        3MTN (3D)    
Secondary accessions: Q59H60 Q5BKT5 Q5VTW9 Q5VTX0 Q9BTV1 Q9HBS2 Q9NYN4
Alternative splicing: 3 isoforms:  Q9UK80-1   Q9UK80-2   Q9UK80-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP21: NX_Q9UK80

Explore proteomics data for USP21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP21 (Q9UK80) (see all 5)
     NLGNTCF  YLEREDS  EEELESEN  QQDAQEFL 


    See USP21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014443.1  NP_036607.3  

    ENSEMBL proteins: 
     ENSP00000476344   ENSP00000289865   ENSP00000476830   ENSP00000356980   ENSP00000356981  

    USP21 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP21
    OriGene Protein Over-expression Lysate for USP21
    OriGene MassSpec for USP21
    OriGene Custom Protein Services for USP21
    GenScript Custom Purified and Recombinant Proteins Services for USP21
    Novus Biologicals USP21 Proteins
    Novus Biologicals USP21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP21

     
    Search eBioscience for Proteins for USP21 

    USP21 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP21
    Novus Biologicals USP21 Antibodies
    Abcam antibodies for USP21
    Cloud-Clone Corp. Antibodies for USP21
    ThermoFisher Antibodies for USP21
    LSBio Antibodies in human, mouse, rat for USP21

    USP21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP21
    Cloud-Clone Corp. CLIAs for USP21
    Search eBioscience for ELISAs for USP21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q9UK80

    ProtoNet protein and cluster: Q9UK80

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
    Similarity: Belongs to the peptidase C19 family. USP21 subfamily
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP21_HUMAN, Q9UK80
    Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as
    a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at
    'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A
    deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on
    Sentrin-1 conjugates
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP21:
    ubiquitin specific protease 21,acting as an efficient deubiquitinating enzyme,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0004221ubiquitin thiolesterase activity TAS10786635
    GO:0004843ubiquitin-specific protease activity IDA10799498
    GO:0008234cysteine-type peptidase activity ISS--
    GO:0019784NEDD8-specific protease activity IDA10799498
         
    Find genes that share ontologies with USP21           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP21:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI phenotypic allele for Usp21 (no phenotypes)

    Find genes that share phenotypes with USP21           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP21

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP21:
    hsa-mir-32-5p (MIRT028308), hsa-mir-744-5p (MIRT037440), hsa-mir-331-3p (MIRT043379), hsa-mir-93-5p (MIRT028020), hsa-mir-671-5p (MIRT039291)

    Block miRNA regulation of human, mouse, rat USP21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP21 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-let-7c hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidUSP21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP21
    Predesigned siRNA for gene silencing in human, mouse, rat USP21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP21

    Clone
    Products:
         
    OriGene clones in human, mouse for USP21 (see all 12)
    OriGene ORF clones in mouse, rat for USP21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP21 (NM_001014443)
    Sino Biological Human cDNA Clone for USP21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP21
    Addgene plasmids for USP21 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP21
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBP21_HUMAN, Q9UK80: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with USP21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for USP21 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP21
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP21
        Integrated Breast Cancer Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including USP21: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP21 (Q9UK802, 3 ENSP000002898654) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274483, ENSP000004113974I2D: score=2 STRING: ENSP00000411397
    PPIBP232843, ENSP000003000264I2D: score=2 STRING: ENSP00000300026
    RBM8AQ9Y5S93, ENSP000003330014I2D: score=2 STRING: ENSP00000333001
    UCHL1P099363, ENSP000002844404I2D: score=2 STRING: ENSP00000284440
    UPF3BQ9BZI73, ENSP000002762014I2D: score=2 STRING: ENSP00000276201
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006464cellular protein modification process ----
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016578histone deubiquitination ISS--
    GO:0045893positive regulation of transcription, DNA-templated ISS--

    Find genes that share ontologies with USP21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP21 (UBP21)

    1 HMDB Compound for USP21    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for USP21 gene (2 alternative transcripts): 
    NM_001014443.2  NM_012475.4  

    Unigene Cluster for USP21:

    Ubiquitin specific peptidase 21
    Hs.8015  [show with all ESTs]
    Unigene Representative Sequence: BC090946
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492950 ENST00000289865 ENST00000479344 ENST00000368001(uc021pbv.1)
    ENST00000486299 ENST00000487163 ENST00000482385 ENST00000493054 ENST00000485277
    ENST00000368002(uc010pkc.2 uc010pkd.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP21 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-let-7c hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidUSP21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP21
    Predesigned siRNA for gene silencing in human, mouse, rat USP21
    Clone
    Products:
         
    OriGene clones in human, mouse for USP21 (see all 12)
    OriGene ORF clones in mouse, rat for USP21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP21 (NM_001014443)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP21
    Addgene plasmids for USP21 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP21
    OriGene qSTAR qPCR primer pairs in human, mouse for USP21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP21
      QuantiTect SYBR Green Assays in human, mouse, rat USP21
      QuantiFast Probe-based Assays in human, mouse, rat USP21

    Additional mRNA sequence: 

    AF177758.1 AF217979.1 AF233442.1 AK292319.1 AK310326.1 BC003130.1 BC090946.1 BC136291.1 

    15 DOTS entries:

    DT.87010969  DT.91755019  DT.416654  DT.101963412  DT.95274882  DT.95274881  DT.100708293  DT.75103388 
    DT.97859548  DT.100708283  DT.102827979  DT.121390956  DT.121391038  DT.121391040  DT.121391155 

    Selected AceView cDNA sequences (see all 216):

    BG236155 AA339968 BM744869 AI151170 AF177758 BM695856 BQ068015 CD109620 
    CB961068 BM826945 AL520138 BM917983 AA528171 BG679378 BM757189 AI540170 
    CA444969 AA689335 BM854949 CB241918 BM742944 AI249927 BC003130 Z39310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP21 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^
    SP1:                          -     -                                         -                                                                       -         
    SP2:                          -     -     -                                   -                                                                       -         
    SP3:                          -     -     -                                   -                                                                       -         
    SP4:                          -     -     -                                   -                                                                                 
    SP5:                                                                                                                                                  -         

    ExUns: 15a · 15b ^ 16a · 16b
    SP1:                        
    SP2:  -                     
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for USP21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    USP21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCCCCC
    USP21 Expression
    About this image

    USP21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8015

    UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
    Tissue specificity: Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta,
    liver and kidney, and at very low level in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including USP21: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USP21
    OriGene qSTAR qPCR primer pairs in human, mouse for USP21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP21
    QuantiTect SYBR Green Assays in human, mouse, rat USP21
    QuantiFast Probe-based Assays in human, mouse, rat USP21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for USP21 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp211 , 5 ubiquitin specific peptidase 211, 5 92.27(n)1
    96.46(a)1
      1 (79.30 cM)5
    309411  NM_013919.41  NP_038947.21 
     1712819455 
    lizard
    (Anolis carolinensis)
    Reptilia USP216
    ubiquitin specific peptidase 21
    61(a)
    1 ↔ 1
    GL343781.1(27083-45646)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp211 ubiquitin specific peptidase 21 60.13(n)
    61.19(a)
      100487480  XM_002942436.2  XP_002942482.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185852 Transcribed sequence with weak similarity to protein more 75.27(n)    CF348649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146196
    --
    19(a)
    1 → many
    X(21857641-21870311)


    ENSEMBL Gene Tree for USP21 (if available)
    TreeFam Gene Tree for USP21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for USP21 gene
    USP32  USP442  USP82  USP492  USP22  USP502  
    3 SIMAP similar genes for USP21 using alignment to 4 protein entries:     UBP21_HUMAN (see all proteins):
    DKFZp761E10121    USP2    USP15

    Find genes that share paralogs with USP21           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for USP21
    PGOHUM00000240105 PGOHUM00000241123


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for USP21 (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38136141,2
    C,F--161129159(+) ACCCTA/GAACTT 2 -- us2k14Minor allele frequency- G:0.02NA EA 260
    rs38136151,2
    C,F,H--161129240(+) GAGGAG/TTTCGG 2 -- us2k112Minor allele frequency- T:0.07NA NS EA 1178
    rs730217601,2
    C,F--161129602(+) GGGACG/AGCATC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs778161851,2
    C--161129752(+) TCCTCC/TATCCC 2 -- int14Minor allele frequency- T:0.09CSA WA NA EA 360
    rs67037411,2
    C,F,H--161129786(+) ACACCA/GTGTCG 2 -- int111Minor allele frequency- G:0.04NS EA NA WA 1306
    rs1379814521,2
    --161129817(+) GAATGA/GATCGT 2 -- int10--------
    rs801187921,2
    F--161129855(+) GCAGCC/TCAGAG 2 -- int11Minor allele frequency- T:0.01NA 120
    rs342223371,2
    C,F--161130021(+) ACTGGC/GTTTTC 2 -- int13Minor allele frequency- G:0.13NA EA 128
    rs1997373441,2
    C--161130453(+) GCACCG/ACCTGG 4 /H /R mis11Minor allele frequency- A:0.00EU 1323
    rs1499857891,2
    F--161130461(+) TGGGCC/TGTACC 4 R C mis11Minor allele frequency- T:0.00NA 4542

    HapMap Linkage Disequilibrium report for USP21 (161129240 - 161135516 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP21: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP21
    DNA2.0 Custom Variant and Variant Library Synthesis for USP21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604729    OMIM disorders: --


    Find genes that share disorders with USP21           About GenesLikeMe


    Export disorders for USP21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for USP21 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with USP21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. (PubMed id 10799498)1, 2, 3, 9 Gong L.... Yeh E.T.H. (J. Biol. Chem. 2000)
    2. Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23. (PubMed id 10786635)1, 2, 9 Smith T.S. and Southan C. (Biochim. Biophys. Acta 2000)
    3. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PubMed id 21888622)1, 2 Garcia-Santisteban I.... Rodriguez J.A. (Biochem. J. 2012)
    4. Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. (PubMed id 21399617)1, 2 Ye Y....Komander D. (EMBO Rep. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. (PubMed id 19910467)1, 9 Xu G....Yang J. (J. Biol. Chem. 2010)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. (PubMed id 23395819)1 Zhang J....Li B. (J. Biol. Chem. 2013)
    10. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (Science 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27005 HGNC: 12620 AceView: USP21 Ensembl:ENSG00000143258 euGenes: HUgn27005
    ECgene: USP21 H-InvDB: USP21

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for USP21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for USP21 gene:
    Search GeneIP for patents involving USP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for USP21  
     OriGene qPCR primer pairs and template standards for USP21   OriGene Protein Over-expression Lysate for USP21  
     OriGene MassSpec something-or-other for USP21   OriGene clones in human, mouse for USP21  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP21   OriGene Purified Protein for USP21  
     OriGene ORF clones in mouse, rat for USP21   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP21   OriGene Custom Protein Services for USP21  

     
     
     Block miRNA regulation of human, mouse, rat USP21 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing USP21
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP21 Predesigned siRNA for gene silencing in human, mouse, rat USP21
     QuantiFast Probe-based Assays in human, mouse, rat USP21 QuantiTect SYBR Green Assays in human, mouse, rat USP21
     PCR Arrays including human, mouse, rat USP21 Search Chromatin IP Primers for USP21
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP21  Search GeneGlobe Interaction Network for USP21
     Regulatory tfbs in USP21 promoter
     GenScript Custom Purified and Recombinant Proteins Services for USP21 GenScript cDNA clones with any tag delivered in your preferred vector for USP21
     GenScript Custom Assay Services for USP21 GenScript Custom overexpressing Cell Line Services for USP21
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for USP21 (UBP21)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for USP21
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     USP21 antibodies
     USP21 proteins
     USP21 lysates
     Antibodies for USP21
     See all of Abcam's Antibodies, Kits and Proteins for USP21
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for USP21
     Antibodies for USP21
     ELISAs for USP21
     CLIAs for USP21



     Browse ESI BIO Cell Lines and PureStem Progenitors for USP21
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP21
     SwitchGear 3'UTR luciferase reporter plasmids for USP21
     SwitchGear Promoter luciferase reporter plasmids for USP21
     ThermoFisher Antibodies for USP21
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP21
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP21
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP21
     LSBio Antibodies in human, mouse, rat for USP21
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for USP21
      Search eBioscience for proteins for USP21
      Search eBioscience for elisas for USP21
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP21 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4