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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP21 Gene

protein-coding   GIFtS: 58
GCID: GC01P161129

Ubiquitin Specific Peptidase 21

(Previous name: ubiquitin specific protease 21)
(Previous symbol: USP23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 211 2     NEDD8-Specific Protease2
USP231 2 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 212
Ubiquitin Specific Protease 211 2     Ubiquitin Thiolesterase 212
Deubiquitinating Enzyme 212 3     Ubiquitin-Specific Processing Protease 212
Ubiquitin Thioesterase 212 3     Ubiquitin-Specific Protease 162
Ubiquitin-Specific-Processing Protease 212 3     EC 3.4.19.123
USP162     EC 3.1.2.158

External Ids:    HGNC: 126201   Entrez Gene: 270052   Ensembl: ENSG000001432587   OMIM: 6047295   UniProtKB: Q9UK803   

Export aliases for USP21 gene to outside databases

Previous GC identifers: GC01P158840 GC01P156861 GC01P157907 GC01P158346 GC01P157942 GC01P159395 GC01P132486


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP21 Gene:
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal
hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular
protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from
NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21.
Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for USP21 Gene: 
USP21 (ubiquitin specific peptidase 21) is a protein-coding gene. Diseases associated with USP21 include gastric cancer, and breast cancer. GO annotations related to this gene include cysteine-type peptidase activity and transcription coactivator activity. An important paralog of this gene is USP33.

UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as
a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at
'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A
deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on
Sentrin-1 conjugates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP21 gene promoter:
         p53   ATF-2   HNF-4alpha2   HNF-4alpha1   GATA-1   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP21 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22

USP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161129:  view genomic region     (about GC identifiers)

Start:
161,129,240 bp from pter      End:
161,135,516 bp from pter
Size:
6,277 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 21  
Size: 565 amino acids; 62656 Da
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAF61308.1; Type=Frameshift; Positions=90, 132; Sequence=AAG17222.1; Type=Frameshift;
Positions=188, 214, 228; Sequence=BAD92136.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for USP21:
2Y5B (3D)        3I3T (3D)        3MTN (3D)    
Secondary accessions: Q59H60 Q5BKT5 Q5VTW9 Q5VTX0 Q9BTV1 Q9HBS2 Q9NYN4
Alternative splicing: 3 isoforms:  Q9UK80-1   Q9UK80-2   Q9UK80-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP21: NX_Q9UK80

Explore proteomics data for USP21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK80

  • 4/5 DME Specific Peptides for USP21 (Q9UK80) (see all 5)
     NLGNTCF  YLEREDS  EEELESEN  QQDAQEFL 

    USP21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001014443.1  NP_036607.3  

    ENSEMBL proteins: 
     ENSP00000289865   ENSP00000356980   ENSP00000356981  

    Human Recombinant Protein Products for USP21: 
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    Novus Biologicals USP21 Proteins
    Novus Biologicals USP21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP21 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    USP21 for ontologies           About GeneDecksing



    USP21 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for USP21 
    Cloud-Clone Corp. CLIAs for USP21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q9UK80

    ProtoNet protein and cluster: Q9UK80

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
    Similarity: Belongs to the peptidase C19 family. USP21 subfamily


    USP21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP21_HUMAN, Q9UK80
    Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as
    a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at
    'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A
    deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on
    Sentrin-1 conjugates
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP21:
    ubiquitin specific protease 21,acting as an efficient deubiquitinating enzyme,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0004221ubiquitin thiolesterase activity TAS10786635
    GO:0004843ubiquitin-specific protease activity IDA10799498
    GO:0008234cysteine-type peptidase activity ISS--
    GO:0019784NEDD8-specific protease activity IDA10799498
         
    USP21 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP21:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI phenotypic allele for Usp21 (no phenotypes)

    USP21 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP21 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate USP21 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-let-7c hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidUSP21 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): USP21 (NM_001014443)
    Sino Biological Human cDNA Clone for USP21
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP21
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                         Customized lentivirus expression plasmids for stable overexpression of USP21 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP21
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP21
        Integrated Breast Cancer Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for USP21 (Q9UK802, 3 ENSP000002898654) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274483, ENSP000004113974I2D: score=2 STRING: ENSP00000411397
    PPIBP232843, ENSP000003000264I2D: score=2 STRING: ENSP00000300026
    RBM8AQ9Y5S93, ENSP000003330014I2D: score=2 STRING: ENSP00000333001
    UCHL1P099363, ENSP000002844404I2D: score=2 STRING: ENSP00000284440
    UPF3BQ9BZI73, ENSP000002762014I2D: score=2 STRING: ENSP00000276201
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006464cellular protein modification process NAS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016578histone deubiquitination ISS--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--

    USP21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP21 (UBP21)

    1 HMDB Compound for USP21    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP21 / UBP21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP21 gene (2 alternative transcripts): 
    NM_001014443.2  NM_012475.4  

    Unigene Cluster for USP21:

    Ubiquitin specific peptidase 21
    Hs.8015  [show with all ESTs]
    Unigene Representative Sequence: BC090946
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492950 ENST00000289865 ENST00000479344 ENST00000368001(uc021pbv.1)
    ENST00000486299 ENST00000487163 ENST00000482385 ENST00000493054 ENST00000485277
    ENST00000368002(uc010pkc.2 uc010pkd.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP21
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate USP21 (see all 17):
    hsa-let-7d hsa-miR-202 hsa-miR-513a-5p hsa-let-7c hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidUSP21 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for USP21 (see all 14)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP21 (NM_001014443)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP21
    Sirion Biotech Customized lentivirus for stable overexpression of USP21 
                         Customized lentivirus expression plasmids for stable overexpression of USP21 
    Primer
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    OriGene qPCR primer pairs and template standards for USP21
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP21

    Additional mRNA sequence: 

    AF177758.1 AF217979.1 AF233442.1 AK292319.1 AK310326.1 BC003130.1 BC090946.1 BC136291.1 

    15 DOTS entries:

    DT.87010969  DT.91755019  DT.416654  DT.101963412  DT.95274882  DT.95274881  DT.100708293  DT.75103388 
    DT.97859548  DT.100708283  DT.102827979  DT.121390956  DT.121391038  DT.121391040  DT.121391155 

    24/216 AceView cDNA sequences (see all 216):

    AI038040 NM_012475 BM742439 BI257595 BG679378 CB241918 AI151170 AA350270 
    NM_016572 AA279039 Z39310 AI249927 BX418793 BI831700 AL520138 BQ939665 
    BM854949 CA444969 AA339968 CB961068 BM742944 AA689335 BQ219674 BM826945 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for USP21 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^
    SP1:                          -     -                                         -                                                                       -         
    SP2:                          -     -     -                                   -                                                                       -         
    SP3:                          -     -     -                                   -                                                                       -         
    SP4:                          -     -     -                                   -                                                                                 
    SP5:                                                                                                                                                  -         

    ExUns: 15a · 15b ^ 16a · 16b
    SP1:                        
    SP2:  -                     
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for USP21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCCCCC
    USP21 Expression
    About this image


    See USP21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP21

    SOURCE GeneReport for Unigene cluster: Hs.8015

    UniProtKB/Swiss-Prot: UBP21_HUMAN, Q9UK80
    Tissue specificity: Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta,
    liver and kidney, and at very low level in lung

        SABiosciences Expression via Pathway-Focused PCR Array including USP21: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP21 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp211 , 5 ubiquitin specific peptidase 211, 5 92.27(n)1
    96.46(a)1
      1 (79.30 cM)5
    309411  NM_013919.41  NP_038947.21 
     1712819455 
    lizard
    (Anolis carolinensis)
    Reptilia USP216
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343781.1(27083-45646)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185852 Transcribed sequence with weak similarity to protein more 75.27(n)    CF348649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146196
    --
    17(a)
    1 → many
    X(21857641-21870311)


    ENSEMBL Gene Tree for USP21 (if available)
    TreeFam Gene Tree for USP21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP21 gene
    USP332  USP82  USP22  USP202  USP502  
    3 SIMAP similar genes for USP21 using alignment to 2 protein entries:     UBP21_HUMAN (see all proteins):
    DKFZp761E10121    USP2    USP15

    USP21 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for USP21
    PGOHUM00000240105 PGOHUM00000241123


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 SNPs in USP21 are shown (see all 142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38136141,2
    C,F--161129159(+) ACCCTA/GAACTT 2 -- us2k14Minor allele frequency- G:0.02NA EA 260
    rs38136151,2
    C,F,H--161129240(+) GAGGAG/TTTCGG 2 -- us2k112Minor allele frequency- T:0.07NA NS EA 1178
    rs730217601,2
    C,F--161129602(+) GGGACG/AGCATC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs778161851,2
    C--161129752(+) TCCTCC/TATCCC 2 -- int14Minor allele frequency- T:0.09CSA WA NA EA 360
    rs67037411,2
    C,F,H--161129786(+) ACACCA/GTGTCG 2 -- int111Minor allele frequency- G:0.04NS EA NA WA 1306
    rs1379814521,2
    --161129817(+) GAATGA/GATCGT 2 -- int10--------
    rs801187921,2
    F--161129855(+) GCAGCC/TCAGAG 2 -- int11Minor allele frequency- T:0.01NA 120
    rs342223371,2
    C,F--161130021(+) ACTGGC/GTTTTC 2 -- int13Minor allele frequency- G:0.13NA EA 128
    rs1997373441,2
    C--161130453(+) GCACCG/ACCTGG 4 /H /R mis11Minor allele frequency- A:0.00EU 1323
    rs1499857891,2
    F--161130461(+) TGGGCC/TGTACC 4 R C mis11Minor allele frequency- T:0.00NA 4542

    HapMap Linkage Disequilibrium report for USP21 (161129240 - 161135516 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP21: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP21
    DNA2.0 Custom Variant and Variant Library Synthesis for USP21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604729    OMIM disorders: --

    2 diseases for USP21:    About MalaCards
    gastric cancer    breast cancer


    USP21 for disorders           About GeneDecksing


    Export disorders for USP21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP21 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with USP21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. (PubMed id 10799498)1, 2, 3, 9 Gong L.... Yeh E.T.H. (2000)
    2. Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23. (PubMed id 10786635)1, 2, 9 Smith T.S. and Southan C. (2000)
    3. Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. (PubMed id 21399617)1, 2 Ye Y....Komander D. (2011)
    4. A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family. (PubMed id 21888622)1, 2 Garcia-Santisteban I.... Rodriguez J.A. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Ubiquitin-specific peptidase 21 inhibits tumor necros is factor alpha-induced nuclear factor kappaB activation via binding to and deu biquitinating receptor-interacting protein 1. (PubMed id 19910467)1, 9 Xu G....Yang J. (2010)
    7. Identification of the E3 deubiquitinase ubiquitin-spec ific peptidase 21 (USP21) as a positive regulator of the transcription factor GA TA3. (PubMed id 23395819)1 Zhang J....Li B. (2013)
    8. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (2013)
    9. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
    10. Systematic survey of deubiquitinase localization ident ifies USP21 as a regulator of centrosome- and microtubule-associated functions. (PubMed id 22298430)1 Urbe S....Clague M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27005 HGNC: 12620 AceView: USP21 Ensembl:ENSG00000143258 euGenes: HUgn27005
    ECgene: USP21 H-InvDB: USP21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP21 gene:
    Search GeneIP for patents involving USP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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