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Aliases for USP21 Gene

Aliases for USP21 Gene

  • Ubiquitin Specific Peptidase 21 2 3
  • Ubiquitin-Specific-Processing Protease 21 3 4
  • Ubiquitin Specific Protease 21 2 3
  • Deubiquitinating Enzyme 21 3 4
  • Ubiquitin Thioesterase 21 3 4
  • USP23 3 4
  • Ubiquitin-Specific Processing Protease 21 3
  • Ubiquitin-Specific Protease 16 3
  • Ubiquitin Thiolesterase 21 3
  • NEDD8-Specific Protease 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • USP16 3

External Ids for USP21 Gene

Previous HGNC Symbols for USP21 Gene

  • USP23

Previous GeneCards Identifiers for USP21 Gene

  • GC01P158840
  • GC01P156861
  • GC01P157907
  • GC01P158346
  • GC01P157942
  • GC01P159395
  • GC01P161129
  • GC01P132486

Summaries for USP21 Gene

Entrez Gene Summary for USP21 Gene

  • This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP21 Gene

USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Integrated Breast Cancer Pathway. GO annotations related to this gene include transcription coactivator activity and cysteine-type peptidase activity. An important paralog of this gene is USP49.

UniProtKB/Swiss-Prot for USP21 Gene

  • Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at Lys-4, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP21 Gene

Genomics for USP21 Gene

Regulatory Elements for USP21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP21 Gene

Chromosome:
1
Start:
161,159,450 bp from pter
End:
161,165,726 bp from pter
Size:
6,277 bases
Orientation:
Plus strand

Genomic View for USP21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP21 Gene

Proteins for USP21 Gene

  • Protein details for USP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK80-UBP21_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 21
    Protein Accession:
    Q9UK80
    Secondary Accessions:
    • Q59H60
    • Q5BKT5
    • Q5VTW9
    • Q5VTX0
    • Q9BTV1
    • Q9HBS2
    • Q9NYN4

    Protein attributes for USP21 Gene

    Size:
    565 amino acids
    Molecular mass:
    62656 Da
    Quaternary structure:
    • Interacts with BEND3 and BAZ2A/TIP5.
    SequenceCaution:
    • Sequence=AAF61308.1; Type=Frameshift; Positions=90, 132; Evidence={ECO:0000305}; Sequence=AAG17222.1; Type=Frameshift; Positions=188, 214, 228; Evidence={ECO:0000305}; Sequence=BAD92136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP21 Gene

    Alternative splice isoforms for USP21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP21 Gene

Proteomics data for USP21 Gene at MOPED

Selected DME Specific Peptides for USP21 Gene

Post-translational modifications for USP21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP21 Gene

Antibody Products

Domains & Families for USP21 Gene

Gene Families for USP21 Gene

Protein Domains for USP21 Gene

Suggested Antigen Peptide Sequences for USP21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK80

UniProtKB/Swiss-Prot:

UBP21_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP21 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP21 subfamily.
genes like me logo Genes that share domains with USP21: view

Function for USP21 Gene

Molecular function for USP21 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 21,acting as an efficient deubiquitinating enzyme,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function:
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at Lys-4, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

Enzyme Numbers (IUBMB) for USP21 Gene

Gene Ontology (GO) - Molecular Function for USP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS --
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IMP 26100909
GO:0005515 protein binding IPI 25416956
GO:0008234 cysteine-type peptidase activity ISS --
genes like me logo Genes that share ontologies with USP21: view
genes like me logo Genes that share phenotypes with USP21: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for USP21 Gene

Localization for USP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP21 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP21 Gene COMPARTMENTS Subcellular localization image for USP21 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for USP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with USP21: view

Pathways & Interactions for USP21 Gene

genes like me logo Genes that share pathways with USP21: view

Pathways by source for USP21 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat

Gene Ontology (GO) - Biological Process for USP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016578 histone deubiquitination ISS --
GO:0031175 neuron projection development IEA --
genes like me logo Genes that share ontologies with USP21: view

No data available for SIGNOR curated interactions for USP21 Gene

Drugs & Compounds for USP21 Gene

(1) Additional Compounds for USP21 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP21: view

Transcripts for USP21 Gene

Unigene Clusters for USP21 Gene

Ubiquitin specific peptidase 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP21 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: -
SP8: - -
SP9: -
SP10: -
SP11: - -

ExUns: 15a · 15b ^ 16a · 16b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for USP21 Gene

GeneLoc Exon Structure for
USP21
ECgene alternative splicing isoforms for
USP21

Expression for USP21 Gene

mRNA expression in normal human tissues for USP21 Gene

Protein differential expression in normal tissues from HIPED for USP21 Gene

This gene is overexpressed in Fetal Brain (60.7) and Tlymphocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP21 Gene



SOURCE GeneReport for Unigene cluster for USP21 Gene Hs.8015

mRNA Expression by UniProt/SwissProt for USP21 Gene

Q9UK80-UBP21_HUMAN
Tissue specificity: Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
genes like me logo Genes that share expression patterns with USP21: view

Protein tissue co-expression partners for USP21 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP21 Gene

Orthologs for USP21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP21 35
  • 93.75 (n)
  • 97.17 (a)
USP21 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP21 35
  • 92.09 (n)
  • 96.99 (a)
USP21 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp21 35
  • 92.27 (n)
  • 96.46 (a)
Usp21 16
Usp21 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP21 35
  • 99.35 (n)
  • 99.47 (a)
USP21 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp21 35
  • 92.15 (n)
  • 96.64 (a)
oppossum
(Monodelphis domestica)
Mammalia USP21 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP21 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp21 35
  • 60.13 (n)
  • 61.19 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18585 35
LOC563546 35
  • 57.38 (n)
  • 55.72 (a)
USP21 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14619 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP11 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for USP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP21 Gene

ENSEMBL:
Gene Tree for USP21 (if available)
TreeFam:
Gene Tree for USP21 (if available)

Paralogs for USP21 Gene

Paralogs for USP21 Gene

(3) SIMAP similar genes for USP21 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for USP21 Gene

genes like me logo Genes that share paralogs with USP21: view

Variants for USP21 Gene

Sequence variations from dbSNP and Humsavar for USP21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1127525 - 161,163,031(+) CCTCT(A/C)CACCC missense, reference
rs3813614 -- 161,159,369(+) ACCCT(A/G)AACTT upstream-variant-2KB
rs3813615 -- 161,159,450(+) GAGGA(G/T)TTCGG upstream-variant-2KB
rs3813616 -- 161,161,029(+) GCACC(A/G)TGGCA missense, reference, intron-variant
rs3813617 -- 161,161,784(+) CGTCA(A/G)CTAGC intron-variant

Variation tolerance for USP21 Gene

Residual Variation Intolerance Score: 22.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP21 Gene

HapMap Linkage Disequilibrium report
USP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP21 Gene

Disorders for USP21 Gene

Relevant External Links for USP21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP21
genes like me logo Genes that share disorders with USP21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP21 Gene

Publications for USP21 Gene

  1. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. (PMID: 10799498) Gong L. … Yeh E.T.H. (J. Biol. Chem. 2000) 2 23 67
  2. Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. (PMID: 19910467) Xu G. … Yang J. (J. Biol. Chem. 2010) 23 67
  3. Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. (PMID: 15567417) Reverter D. … Lima C.D. (J. Mol. Biol. 2005) 23 67
  4. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PMID: 12730221) Mendoza H.M. … Hay R.T. (J. Biol. Chem. 2003) 23 67
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 67

Products for USP21 Gene

Sources for USP21 Gene

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