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Aliases for USP20 Gene

Aliases for USP20 Gene

  • Ubiquitin Specific Peptidase 20 2 3
  • Ubiquitin-Specific-Processing Protease 20 3 4
  • Deubiquitinating Enzyme 20 3 4
  • Ubiquitin Thioesterase 20 3 4
  • LSFR3A 3 4
  • HVDU2 3 4
  • VDU2 3 4
  • PVHL-Interacting Deubiquitinating Enzyme 2 3
  • VHL-Interacting Deubiquitinating Enzyme 2 4
  • Ubiquitin Specific Protease 20 2
  • Ubiquitin Thiolesterase 20 3
  • EC 3.4.19.12 4
  • KIAA1003 4

External Ids for USP20 Gene

Previous GeneCards Identifiers for USP20 Gene

  • GC09P123726
  • GC09P124244
  • GC09P126051
  • GC09P127973
  • GC09P129677
  • GC09P131637
  • GC09P132596
  • GC09P102196

Summaries for USP20 Gene

Entrez Gene Summary for USP20 Gene

  • This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

GeneCards Summary for USP20 Gene

USP20 (Ubiquitin Specific Peptidase 20) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitinyl hydrolase activity. An important paralog of this gene is USP33.

UniProtKB/Swiss-Prot for USP20 Gene

  • Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for USP20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP20 Gene

Genomics for USP20 Gene

Regulatory Elements for USP20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP20 Gene

Chromosome:
9
Start:
129,834,698 bp from pter
End:
129,881,838 bp from pter
Size:
47,141 bases
Orientation:
Plus strand

Genomic View for USP20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP20 Gene

Proteins for USP20 Gene

  • Protein details for USP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K6-UBP20_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 20
    Protein Accession:
    Q9Y2K6
    Secondary Accessions:
    • Q541F1
    • Q8IXQ1
    • Q96LG5
    • Q9UQN8
    • Q9UQP0

    Protein attributes for USP20 Gene

    Size:
    914 amino acids
    Molecular mass:
    102003 Da
    Quaternary structure:
    • Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with CCP110, DIO2 and HIF1A.
    SequenceCaution:
    • Sequence=BAA76847.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP20 Gene

Proteomics data for USP20 Gene at MOPED

Post-translational modifications for USP20 Gene

  • Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
  • Ubiquitination at Lys 906
  • Modification sites at PhosphoSitePlus

Other Protein References for USP20 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for USP20

No data available for DME Specific Peptides for USP20 Gene

Domains & Families for USP20 Gene

Gene Families for USP20 Gene

Suggested Antigen Peptide Sequences for USP20 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2K6

UniProtKB/Swiss-Prot:

UBP20_HUMAN :
  • The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
  • Belongs to the peptidase C19 family. USP20/USP33 subfamily.
  • Contains 1 UBP-type zinc finger.
Domain:
  • The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
  • Contains 2 DUSP domains.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP20/USP33 subfamily.
Similarity:
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP20: view

Function for USP20 Gene

Molecular function for USP20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both Lys-48- and Lys-63-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for USP20 Gene

Gene Ontology (GO) - Molecular Function for USP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 19424180
GO:0004197 cysteine-type endopeptidase activity IMP 19424180
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0005515 protein binding IPI 23486064
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with USP20: view
genes like me logo Genes that share phenotypes with USP20: view

Animal Model Products

miRNA for USP20 Gene

miRTarBase miRNAs that target USP20

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for USP20 Gene

Localization for USP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP20 Gene

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP20 Gene COMPARTMENTS Subcellular localization image for USP20 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for USP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 23486064
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with USP20: view

Pathways & Interactions for USP20 Gene

genes like me logo Genes that share pathways with USP20: view

Pathways by source for USP20 Gene

1 Qiagen pathway for USP20 Gene

Gene Ontology (GO) - Biological Process for USP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0006897 endocytosis IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP 19424180
GO:0016579 protein deubiquitination IDA 19424180
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP20: view

No data available for SIGNOR curated interactions for USP20 Gene

Drugs & Compounds for USP20 Gene

(1) Additional Compounds for USP20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP20: view

Transcripts for USP20 Gene

Unigene Clusters for USP20 Gene

Ubiquitin specific peptidase 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e
SP1: - - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: - -
SP8:
SP9:

Relevant External Links for USP20 Gene

GeneLoc Exon Structure for
USP20
ECgene alternative splicing isoforms for
USP20

Expression for USP20 Gene

mRNA expression in normal human tissues for USP20 Gene

Protein differential expression in normal tissues from HIPED for USP20 Gene

This gene is overexpressed in Retina (39.2), Placenta (12.2), and Frontal cortex (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP20 Gene



SOURCE GeneReport for Unigene cluster for USP20 Gene Hs.5452

genes like me logo Genes that share expression patterns with USP20: view

Protein tissue co-expression partners for USP20 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP20 Gene

Orthologs for USP20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP20 35
  • 89.5 (n)
  • 94.29 (a)
USP20 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP20 35
  • 88.77 (n)
  • 94.09 (a)
USP20 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp20 35
  • 87.49 (n)
  • 92.78 (a)
Usp20 16
Usp20 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP20 35
  • 99.31 (n)
  • 99.56 (a)
USP20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp20 35
  • 87.64 (n)
  • 92.34 (a)
oppossum
(Monodelphis domestica)
Mammalia USP20 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves USP20 35
  • 78.51 (n)
  • 87.31 (a)
USP20 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP20 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp20 35
  • 74.49 (n)
  • 80.05 (a)
zebrafish
(Danio rerio)
Actinopterygii usp20 35
  • 70.28 (n)
  • 78.01 (a)
zgc63661 35
usp20 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8494 37
  • 40 (a)
CG8494 35
  • 54.9 (n)
  • 48.8 (a)
CG8494 36
  • 32 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003821 35
  • 53.83 (n)
  • 49.7 (a)
worm
(Caenorhabditis elegans)
Secernentea usp-33 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP10 36
  • 15 (a)
OneToMany
UBP10 38
UBP10 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for USP20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP20 Gene

ENSEMBL:
Gene Tree for USP20 (if available)
TreeFam:
Gene Tree for USP20 (if available)

Paralogs for USP20 Gene

Paralogs for USP20 Gene

(2) SIMAP similar genes for USP20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP20: view

Variants for USP20 Gene

Sequence variations from dbSNP and Humsavar for USP20 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs733000 -- 129,881,316(+) AGCCC(A/G)CCTGG utr-variant-3-prime
rs735115 -- 129,875,433(+) TTCGC(A/G)GAGCC synonymous-codon, reference
rs736056 -- 129,863,438(+) agcaa(A/G)cctgc intron-variant
rs750466 -- 129,865,224(-) AGCCC(A/G)TCAGG intron-variant
rs762828 -- 129,874,579(+) AGATC(C/T)TGTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for USP20 Gene

Variant ID Type Subtype PubMed ID
dgv2422e1 CNV Complex 17122850
esv24598 CNV Loss 19812545
esv1000693 CNV Insertion 20482838
esv1323037 CNV Insertion 17803354
nsv893928 CNV Loss 21882294
nsv8571 CNV Gain 18304495
nsv469902 CNV Loss 18288195
nsv517374 CNV Loss 19592680
nsv893929 CNV Gain 21882294

Variation tolerance for USP20 Gene

Residual Variation Intolerance Score: 65.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP20 Gene

HapMap Linkage Disequilibrium report
USP20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP20 Gene

Disorders for USP20 Gene

Relevant External Links for USP20

Genetic Association Database (GAD)
USP20
Human Genome Epidemiology (HuGE) Navigator
USP20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP20
genes like me logo Genes that share disorders with USP20: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP20 Gene

Publications for USP20 Gene

  1. VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. (PMID: 15776016) Li Z. … Wu G. (EMBO Rep. 2005) 23 67
  2. Cellular and structural biology of the deiodinases. (PMID: 16131321) Bianco A.C. … Larsen P.R. (Thyroid 2005) 23 67
  3. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. (PMID: 15611815) Bianco A.C. (Arq Bras Endocrinol Metabol 2004) 23 67
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for USP20 Gene

Sources for USP20 Gene

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