USP20 Gene
protein-coding GIFtS: 55
GCID: GC09P132596
|
|
ubiquitin specific peptidase 20(Previous name: ubiquitin specific protease 20 )
| |
Aliases
for USP20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 201 2 | | HVDU21 | | KIAA10031 3 | | Ubiquitin Specific Protease 201 | | Deubiquitinating Enzyme 202 3 | | PVHL-Interacting Deubiquitinating Enzyme 22 | | Ubiquitin Thioesterase 202 3 | | Ubiquitin Carboxyl-Terminal Hydrolase 202 | | Ubiquitin-Specific-Processing Protease 202 3 | | Ubiquitin Thiolesterase 202 | | LSFR3A2 3 | | EC 3.4.19.123 | | VDU22 3 | | VHL-Interacting Deubiquitinating Enzyme 23 |
Export aliases for USP20 gene to outside databasesPrevious GC identifers: GC09P123726 GC09P124244 GC09P126051 GC09P127973 GC09P129677 GC09P131637 GC09P102196 |
Summaries
for USP20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP20:
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (vonHippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligasecomplex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression ofHIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis.The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitinationof beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternativesplicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator ofG-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutivelybinding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation,it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination anddisengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins.Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1Aand enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains
Gene Wiki entry for USP20
|
Genomic Views
for USP20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP20 gene promoter:
p53 Lmo2 CUTL1 AP-2gamma Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.2USP20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P132596: view genomic region
(about GC identifiers)
Start:
|
132,596,977 bp from pter |
End:
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132,644,107 bp from pter |
Size:
|
47,131 bases |
Orientation:
|
plus strand |
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Proteins
for USP20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 20 Size: 914 amino acids; 102003 Da
Subunit: Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with DIO2 and HIF1A
Subcellular location: Cytoplasm, perinuclear region (By similarity). Note=According to PubMed:12865408, it localizes inthe endoplasmic reticulum; however the relevance of such result is unclear
Sequence caution: Sequence=BAA76847.2; Type=Erroneous initiation;
Secondary accessions: Q541F1 Q8IXQ1 Q96LG5 Q9UQN8 Q9UQP0Explore the universe of human proteins at neXtProt for USP20: NX_Q9Y2K6
Post-translational modifications:
Ubiquitinated via a VHL-dependent pathway for proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2K6
USP20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001008563.2 NP_001103773.2 NP_006667.3
ENSEMBL proteins: ENSP00000361506 ENSP00000313811 ENSP00000351122
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0048471 | perinuclear region of cytoplasm |
IEA | -- |
USP20 for ontologies About GeneDecksing
USP20 Antibody Products:
Assay Products for USP20: |
Protein
Domains /
Families
for USP20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP20 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2K6ProtoNet protein and cluster: Q9Y2K6 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase IPB006615 Ubiquitin-specific protease DUSP
UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6Domain: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conservedArg in position 55 is replaced by a Glu residue (By similarity)Similarity: Belongs to the peptidase C19 family. USP20/USP33 subfamilySimilarity: Contains 2 DUSP domainsSimilarity: Contains 1 UBP-type zinc finger |
Function
for USP20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator ofG-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutivelybinding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation,it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination anddisengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins.Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1Aand enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitinchainsCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): USP20 (NM_001008563) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP20 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
USP20 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Usp20 (no phenotypes)
USP20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP20
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP20
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/59 Interacting proteins for USP20 (Q9Y2K63 ENSP000003138114) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
USP20 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP20
1 HMDB Compound for USP20 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP20 / UBP20
|
Transcripts
for USP20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP20 gene (3 alternative transcripts): NM_001008563.4 NM_001110303.3 NM_006676.7 Unigene Cluster for USP20: Ubiquitin specific peptidase 20 Hs.5452 [show with all ESTs]Unigene Representative Sequence: NM_0066769 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491053 ENST00000372429(uc004bys.2) ENST00000494971 ENST00000315480(uc004byr.2)
ENST00000358355(uc004byt.1) ENST00000474895 ENST00000491731 ENST00000496927
ENST00000472108
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): USP20 (NM_001008563) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP20 |
Additional cDNA sequence: AB023220.1 AY074877.1 BC033669.1 BC039593.1 10 DOTS entries: DT.95240534 DT.112115 DT.97815890 DT.112116 DT.100808043 DT.92410229 DT.100036632 DT.91941257 DT.95350976 DT.100708013 24/139 AceView cDNA sequences (see all 139): BG281837 AI123893 BM788785 AI365119 BQ948911 BQ225334 AI559289 BQ636666 BM723899 BE929079 BF727179 BE396904 T11455 CR589994 AI784621 BI490545 BQ882312 BI754579 AB023220 BU528927 CD656333 BQ709550 BM720399 AL701773
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP20 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b | · | 25c | · | 25d | · | 25e |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP20
|
Expression
for USP20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTGCTGT
About this image
See USP20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP20
SOURCE GeneReport for Unigene cluster: Hs.5452
SABiosciences Custom PCR Arrays for USP20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP20 |
Orthologs
for USP20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP20 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP201 |
ubiquitin specific peptidase 20 |
78.62(n)
87.44(a) |
|
417188 XM_415470.3 XP_415470.3 |
lizard
(Anolis carolinensis) |
Reptilia |
USP206 |
-- |
78(a) |
1 ↔ 1 |
GL344641.1(1033-20423) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ030728.12 |
-- |
78.36(n) |
|
BJ030728.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636612 |
similar to ubiquitin specific protease 20 |
77.34(n) |
|
393962 BC055192.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG84941 , 3 |
protein deubiquitination ubiquitin-specific
protease3
CG84941 |
40(a)3
52.81(n)1
46.6(a)1 |
|
365801 NM_137099.21 NP_610943.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
T22F3.26 |
Protein T22F3.2, isoform b |
17(a) |
possible ortholog |
V(3586637-3589004) |
ENSEMBL Gene Tree for USP20 (if available)
TreeFam Gene Tree for USP20 (if available) |
Paralogs
for USP20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP20 gene
- USP332 USP32 USP442 USP452 USP222 USP512 USP162 USP492
2 SIMAP similar genes for USP20 using alignment to 1 protein entry: UBP20_HUMAN:DKFZp586N041 USP33
USP20 for paralogs About GeneDecksing
|
Genomic Variants
for USP20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP20 (132596977 - 132644107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for USP20
3 CNVs: 2838 52732 31529
1 Indel: 70805 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP20 |
|
Disorders
/ Diseases
for USP20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP20 for disorders About GeneDecksing
4  diseases for USP20: About MalaCardst-cell leukemia leukemia thyroiditis malaria
Human Genome Epidemiology (HuGE) Navigator: USP20 (2 documents)
Export disorders for USP20 gene to outside databases
|
Publications
for USP20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP20 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with USP20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. (PubMed id 15776016)1, 2, 9 Li Z.... Wu G. (2005)
- The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. (PubMed id 19424180)1, 2 Berthouze M.... Shenoy S.K. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Deubiquitination of type 2 iodothyronine deiodinase by von Hippel- Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. (PubMed id 12865408)1, 2 Curcio-Morelli C.... Bianco A.C. (2003)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. (PubMed id 12056827)1, 2 Li Z.... Wu G. (2002)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PubMed id 10369878)1, 2 Gilley J. and Fried M. (1999)
- A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
- Analysis of indel variations in the human disease-asso ciated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PubMed id 22552337)1 Kim R.N....Park H.S. (2012)
|
External Searches for USP20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP20 gene
(According to HUGE)
About This Section
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Specialized Databases showing USP20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for USP20 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for USP20 gene:
Search GeneIP for patents involving USP20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for USP20 | | OriGene shRNA RFP for USP20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP20 | | | OriGene Protein Over-expression Lysate for USP20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP20 | | OriGene 3'-UTR Clone for USP20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP20 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP20 | | OriGene Custom Protein Services for USP20 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP20 |
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| | | | Search Tocris compounds for USP20 |
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 | | | USP20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP20 |
|  |  |  | | | | ThermoFisher Antibodies for USP20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP20 |
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