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USP20 Gene

protein-coding   GIFtS: 60
GCID: GC09P132596

Ubiquitin Specific Peptidase 20

(Previous name: ubiquitin specific protease 20)
  See USP20-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin Specific Peptidase 201 2     Ubiquitin Specific Protease 201
VDU22 3 5     PVHL-Interacting Deubiquitinating Enzyme 22
Deubiquitinating Enzyme 202 3     Ubiquitin Carboxyl-Terminal Hydrolase 202
Ubiquitin Thioesterase 202 3     Ubiquitin Thiolesterase 202
Ubiquitin-Specific-Processing Protease 202 3     EC 3.4.19.123
LSFR3A2 3     KIAA10033
hVDU22 3     VHL-Interacting Deubiquitinating Enzyme 23

External Ids:    HGNC: 126191   Entrez Gene: 108682   Ensembl: ENSG000001368787   OMIM: 6151435   UniProtKB: Q9Y2K63   
ORGUL members:         

Export aliases for USP20 gene to outside databases

Previous GC identifers: GC09P123726 GC09P124244 GC09P126051 GC09P127973 GC09P129677 GC09P131637 GC09P102196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP20 Gene:
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL
(von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3
ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased
expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation
and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating
the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester
hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. (provided by
RefSeq, Jan 2013)

GeneCards Summary for USP20 Gene:
USP20 (ubiquitin specific peptidase 20) is a protein-coding gene. Diseases associated with USP20 include hypoxia. GO annotations related to this gene include ubiquitin thiolesterase activity and G-protein coupled receptor binding. An important paralog of this gene is USP33.

UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6
Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of
G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).
Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively
binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon
dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins
deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the
ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates
HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both
'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for USP20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP20 gene promoter:
         p53   Lmo2   CUTL1   AP-2gamma   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP20 promoter sequence
   Search Chromatin IP Primers for USP20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

USP20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP20 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132596:  view genomic region     (about GC identifiers)

Start:
132,596,977 bp from pter      End:
132,644,107 bp from pter
Size:
47,131 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 20  
Size: 914 amino acids; 102003 Da
Subunit: Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with CCP110, DIO2
and HIF1A
Sequence caution: Sequence=BAA76847.2; Type=Erroneous initiation;
Secondary accessions: Q541F1 Q8IXQ1 Q96LG5 Q9UQN8 Q9UQP0

Explore the universe of human proteins at neXtProt for USP20: NX_Q9Y2K6

Explore proteomics data for USP20 at MOPED

Post-translational modifications: 

  • Ubiquitinated via a VHL-dependent pathway for proteasomal degradation1
  • Ubiquitination2 at Lys906
  • Modification sites at PhosphoSitePlus

  • See USP20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008563.2  NP_001103773.2  NP_006667.3  

    ENSEMBL proteins: 
     ENSP00000361506   ENSP00000313811   ENSP00000351122  

    USP20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    GenScript Custom Purified and Recombinant Proteins Services for USP20
    Novus Biologicals USP20 Proteins
    Novus Biologicals USP20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP20

     
    Search eBioscience for Proteins for USP20 

    USP20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP20
    OriGene Custom Antibody Services for USP20
    Novus Biologicals USP20 Antibodies
    Abcam antibodies for USP20
    Cloud-Clone Corp. Antibodies for USP20
    ThermoFisher Antibodies for USP20
    LSBio Antibodies in human, mouse, rat for USP20

    USP20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP20
    Cloud-Clone Corp. CLIAs for USP20
    Search eBioscience for ELISAs for USP20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR006615 Pept_C19_DUSP

    Graphical View of Domain Structure for InterPro Entry Q9Y2K6

    ProtoNet protein and cluster: Q9Y2K6

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP


    UniProtKB/Swiss-Prot: UBP20_HUMAN, Q9Y2K6
    Domain: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the
    conserved Arg in position 55 is replaced by a Glu residue (By similarity)
    Similarity: Belongs to the peptidase C19 family. USP20/USP33 subfamily
    Similarity: Contains 2 DUSP domains
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP20_HUMAN, Q9Y2K6
    Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of
    G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).
    Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively
    binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon
    dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins
    deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the
    ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates
    HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both
    'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IPI19424180
    GO:0004197cysteine-type endopeptidase activity IMP19424180
    GO:0004221ubiquitin thiolesterase activity IDA19424180
    GO:0004843ubiquitin-specific protease activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with USP20           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Usp20 (no phenotypes)

    Find genes that share phenotypes with USP20           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP20

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP20:
    hsa-mir-26b-5p (MIRT030042)

    Block miRNA regulation of human, mouse, rat USP20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP20 (see all 14):
    hsa-miR-98 hsa-miR-4291 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP20
    Predesigned siRNA for gene silencing in human, mouse, rat USP20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP20

    Clone
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    OriGene clones in human, mouse for USP20 (see all 25)
    OriGene ORF clones in mouse, rat for USP20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP20 (NM_001008563)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP20
    Addgene plasmids for USP20 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP20
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP20_HUMAN, Q9Y2K6: Cytoplasm, perinuclear region (By similarity). Cytoplasm, cytoskeleton, microtubule
    organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum;
    however the relevance of such result is unclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with USP20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP20 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP20
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP20
    Interactions:

        Search GeneGlobe Interaction Network for USP20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP20 (Q9Y2K63 ENSP000003138114) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    RGPD5Q996663, ENSP000000169464I2D: score=2 STRING: ENSP00000016946
    RGPD6Q996663, ENSP000003308424I2D: score=2 STRING: ENSP00000330842
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006897endocytosis IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IMP19424180
    GO:0016579protein deubiquitination IDA19424180
    GO:0070536protein K63-linked deubiquitination IDA19424180

    Find genes that share ontologies with USP20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP20 (UBP20)

    1 HMDB Compound for USP20    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP20 gene (3 alternative transcripts): 
    NM_001008563.4  NM_001110303.3  NM_006676.7  

    Unigene Cluster for USP20:

    Ubiquitin specific peptidase 20
    Hs.5452  [show with all ESTs]
    Unigene Representative Sequence: NM_006676
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491053 ENST00000494971 ENST00000372429(uc004bys.2) ENST00000315480(uc004byr.2)
    ENST00000358355(uc004byt.1) ENST00000474895 ENST00000491731 ENST00000496927
    ENST00000472108
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP20 (see all 14):
    hsa-miR-98 hsa-miR-4291 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP20 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP20
    Predesigned siRNA for gene silencing in human, mouse, rat USP20
    Clone
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    OriGene clones in human, mouse for USP20 (see all 25)
    OriGene ORF clones in mouse, rat for USP20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP20 (NM_001008563)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP20
    Addgene plasmids for USP20 
    Primer
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    OriGene qPCR primer pairs and template standards for USP20
    OriGene qSTAR qPCR primer pairs in human, mouse for USP20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP20
      QuantiTect SYBR Green Assays in human, mouse, rat USP20
      QuantiFast Probe-based Assays in human, mouse, rat USP20

    Additional mRNA sequence: 

    AB023220.1 AY074877.1 BC033669.1 BC039593.1 

    8 DOTS entries:

    DT.95240534  DT.112115  DT.97815890  DT.100808043  DT.92410229  DT.112116  DT.91941257  DT.95350976 

    Selected AceView cDNA sequences (see all 139):

    BG281837 BE929079 BM788785 AI559289 BI754579 BM723899 BE396904 BQ636666 
    AI123893 BF727179 BQ882312 CR589994 AI784621 BI490545 T11455 AI365119 
    BQ225334 BQ948911 AI026652 CF454582 BQ709550 R36552 AW196903 BI757606 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP20 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                                                                                      -     -                 -                                             
    SP2:                                                                                      -     -                 -                                             
    SP3:                                                                                -     -                       -                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                      -     -                                                               

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b · 25c · 25d · 25e
    SP1:                          -           -                 -                           
    SP2:                          -           -                                             
    SP3:                                                                                    
    SP4:                          -           -                                             
    SP5:                                                                                    


    ECgene alternative splicing isoforms for USP20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTGCTGT
    USP20 Expression
    About this image

    USP20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5452
        Custom PCR Arrays for USP20
    Primer
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    OriGene qPCR primer pairs and template standards for USP20
    OriGene qSTAR qPCR primer pairs in human, mouse for USP20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP20
    QuantiTect SYBR Green Assays in human, mouse, rat USP20
    QuantiFast Probe-based Assays in human, mouse, rat USP20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP20 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp201 , 5 ubiquitin specific peptidase 201, 5 87.49(n)1
    92.78(a)1
      2 (21.77 cM)5
    742701  NM_028846.51  NP_083122.11 
     309822795 
    chicken
    (Gallus gallus)
    Aves USP201 ubiquitin specific peptidase 20 78.51(n)
    87.31(a)
      417188  XM_004945867.1  XP_004945924.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP206
    ubiquitin specific peptidase 20
    78(a)
    1 ↔ 1
    GL344641.1(1033-26588)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ030728.12   -- 78.36(n)    BJ030728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636612 similar to ubiquitin specific protease 20 77.34(n)   393962  BC055192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84941 , 3 protein deubiquitination
    ubiquitin-specific protease3
    CG84941
    40(a)3
    54.9(n)1
    48.8(a)1
      365801  NM_137099.21  NP_610943.21 
    worm
    (Caenorhabditis elegans)
    Secernentea usp-336
    Protein USP-33 (usp-33) mRNA, complete cds
    21(a)
    1 → many
    X(15591368-15595354) WBGene00010702
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP10(YNL186W)4 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein more   --   14(289498-291876) 855535  NP_014213.1 


    ENSEMBL Gene Tree for USP20 (if available)
    TreeFam Gene Tree for USP20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP20 gene
    USP332  
    2 SIMAP similar genes for USP20 using alignment to 1 protein entry:     UBP20_HUMAN:
    DKFZp586N041    USP33

    Find genes that share paralogs with USP20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP20 (see all 1482)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38414541,2
    C--102197983(-) ACCCCC/-TGGAC 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs38414531,2
    C--102198085(-) TTCTTG/-CCCTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs106067831,2
    C--102201227(+) CTGAC-/TTGTTGTA 3 -- int11Minor allele frequency- TTG:0.50NA 2
    rs1116569831,2
    C--102204226(+) AATAAT/-TTTTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs339395241,2
    C--102221539(+) AAAGA-/A/AA  
            
    AAAAA
    3 -- int10--------
    rs575958541,2
    C--102221549(+) AAAAA-/A/AA  
            
    CGTCT
    3 -- int11NA 2
    rs352462341,2
    C--102227436(+) CCTCT-/CTTACCCC 3 -- cds10--------
    rs2013790071,2
    C--102229593(+) TTGACC/GACCAG 6 H D mis10--------
    rs1838512541,2
    --102232174(+) TCTCTC/TTTTTT 3 -- int10--------
    rs597126621,2
    C--102234305(+) TTTTT-/TTTT  
      
    /TTTTT
    GAGAT
    3 -- int11NA 2

    HapMap Linkage Disequilibrium report for USP20 (132596977 - 132644107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for USP20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1323037CNV Insertion17803354
    esv1000693CNV Insertion20482838
    esv24598CNV Loss19812545
    nsv469902CNV Loss18288195
    nsv517374CNV Loss19592680
    nsv893928CNV Loss21882294
    nsv893929CNV Gain21882294
    nsv8571CNV Gain18304495
    dgv2422e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP20
    DNA2.0 Custom Variant and Variant Library Synthesis for USP20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615143    OMIM disorders: --

    1 disease for USP20:    
    About MalaCards
    hypoxia


    Find genes that share disorders with USP20           About GenesLikeMe

    Genetic Association Database (GAD): USP20
    Human Genome Epidemiology (HuGE) Navigator: USP20 (2 documents)

    Export disorders for USP20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP20 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with USP20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. (PubMed id 15776016)1, 2, 9 Li Z.... Wu G. (EMBO Rep. 2005)
    2. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1, 2 Li J.... Dynlacht B.D. (Nature 2013)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. (PubMed id 19424180)1, 2 Berthouze M.... Shenoy S.K. (EMBO J. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel- Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. (PubMed id 12865408)1, 2 Curcio-Morelli C.... Bianco A.C. (J. Clin. Invest. 2003)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. (PubMed id 12056827)1, 2 Li Z.... Wu G. (Biochem. Biophys. Res. Commun. 2002)
    10. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10868 HGNC: 12619 AceView: USP20 Ensembl:ENSG00000136878 euGenes: HUgn10868
    ECgene: USP20 H-InvDB: USP20

    (According to HUGE)
    About This Section

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    HUGE: KIAA1003

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for USP20 gene:
    Search GeneIP for patents involving USP20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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