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Aliases for USP2 Gene

Aliases for USP2 Gene

  • Ubiquitin Specific Peptidase 2 2 3 5
  • Ubiquitin-Specific-Processing Protease 2 3 4
  • 41 KDa Ubiquitin-Specific Protease 3 4
  • Deubiquitinating Enzyme 2 3 4
  • Ubiquitin Thioesterase 2 3 4
  • UBP41 3 4
  • Ubiquitin Specific Protease 12 3
  • Ubiquitin Specific Protease 2 2
  • Ubiquitin Specific Protease 9 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • USP9 3

External Ids for USP2 Gene

Previous GeneCards Identifiers for USP2 Gene

  • GC11M121226
  • GC11M120738
  • GC11M119259
  • GC11M118764
  • GC11M118763
  • GC11M118731
  • GC11M115167
  • GC11M119225

Summaries for USP2 Gene

Entrez Gene Summary for USP2 Gene

  • This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for USP2 Gene

USP2 (Ubiquitin Specific Peptidase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include identical protein binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP50.

UniProtKB/Swiss-Prot for USP2 Gene

  • Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Gene Wiki entry for USP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP2 Gene

Genomics for USP2 Gene

Regulatory Elements for USP2 Gene

Promoters for USP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP2 Gene

Chromosome:
11
Start:
119,355,215 bp from pter
End:
119,381,726 bp from pter
Size:
26,512 bases
Orientation:
Minus strand

Genomic View for USP2 Gene

Genes around USP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP2 Gene

Proteins for USP2 Gene

  • Protein details for USP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75604-UBP2_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 2
    Protein Accession:
    O75604
    Secondary Accessions:
    • B0YJB8
    • E9PPM2
    • Q8IUM2
    • Q8IW04
    • Q96MB9
    • Q9BQ21

    Protein attributes for USP2 Gene

    Size:
    605 amino acids
    Molecular mass:
    68072 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homooligomer (By similarity). Found in trimeric complex with MDM2 and MDM4 and USP2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C-terminus) with MDM2. Interacts with MDM4. Interacts with PER1 (By similarity). Interacts with KCNQ1; counteracts the NEDD4L-specific down-regulation of I(Ks) and restore plasma membrane localization of KCNQ1 (PubMed:22024150).

    Three dimensional structures from OCA and Proteopedia for USP2 Gene

    Alternative splice isoforms for USP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP2 Gene

Proteomics data for USP2 Gene at MOPED

Selected DME Specific Peptides for USP2 Gene

Post-translational modifications for USP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP2 (USP2)

Domains & Families for USP2 Gene

Gene Families for USP2 Gene

Protein Domains for USP2 Gene

Suggested Antigen Peptide Sequences for USP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75604

UniProtKB/Swiss-Prot:

UBP2_HUMAN :
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • Belongs to the peptidase C19 family. USP2 subfamily.
Domain:
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP2 subfamily.
genes like me logo Genes that share domains with USP2: view

Function for USP2 Gene

Molecular function for USP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin aldehyde.
UniProtKB/Swiss-Prot Function:
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by cisplatin (at protein level).

Enzyme Numbers (IUBMB) for USP2 Gene

Gene Ontology (GO) - Molecular Function for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with USP2: view
genes like me logo Genes that share phenotypes with USP2: view

Animal Models for USP2 Gene

MGI Knock Outs for USP2:

Animal Model Products

miRNA for USP2 Gene

miRTarBase miRNAs that target USP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP2 Gene

Localization for USP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250 UniProtKB:Q5U349}.
Isoform 4: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP2 Gene COMPARTMENTS Subcellular localization image for USP2 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with USP2: view

Pathways & Interactions for USP2 Gene

genes like me logo Genes that share pathways with USP2: view

Pathways by source for USP2 Gene

1 R&D Systems pathway for USP2 Gene
1 Qiagen pathway for USP2 Gene

Gene Ontology (GO) - Biological Process for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17290220
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007517 muscle organ development IEA --
GO:0016579 protein deubiquitination IEA,IDA 17290220
GO:0032922 circadian regulation of gene expression ISS --
genes like me logo Genes that share ontologies with USP2: view

No data available for SIGNOR curated interactions for USP2 Gene

Drugs & Compounds for USP2 Gene

(2) Drugs for USP2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor, Inhibitor of ubiquitin isopeptidase activity 0
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor, Broad spectrum DUB inhibitor 0

(1) Additional Compounds for USP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(2) ApexBio Compounds for USP2 Gene

Compound Action Cas Number
NSC 632839 hydrochloride Isopeptidases inhibitor 157654-67-6
PR-619 Deubiquitylating enzymes (DBUs) inhibitor 2645-32-1
genes like me logo Genes that share compounds with USP2: view

Transcripts for USP2 Gene

Unigene Clusters for USP2 Gene

Ubiquitin specific peptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for USP2 Gene

GeneLoc Exon Structure for
USP2
ECgene alternative splicing isoforms for
USP2

Expression for USP2 Gene

mRNA expression in normal human tissues for USP2 Gene

mRNA differential expression in normal tissues according to GTEx for USP2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Testis (x6.5), and Heart - Left Ventricle (x4.6).

Protein differential expression in normal tissues from HIPED for USP2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP2 Gene



SOURCE GeneReport for Unigene cluster for USP2 Gene Hs.524085

mRNA Expression by UniProt/SwissProt for USP2 Gene

O75604-UBP2_HUMAN
Tissue specificity: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
genes like me logo Genes that share expression patterns with USP2: view

Protein tissue co-expression partners for USP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP2 Gene

Orthologs for USP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP2 35
  • 88.93 (n)
  • 89.26 (a)
USP2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP2 35
  • 87.74 (n)
  • 88.58 (a)
USP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp2 35
  • 87.71 (n)
  • 90.08 (a)
Usp2 16
Usp2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP2 35
  • 99.45 (n)
  • 99.34 (a)
USP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp2 35
  • 88.48 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia USP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP2 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9150 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14438 35
USP2 (2 of 3) 36
  • 68 (a)
OneToMany
USP2 (3 of 3) 36
  • 68 (a)
OneToMany
usp2a 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8726 35
fruit fly
(Drosophila melanogaster)
Insecta CG14619 37
  • 45 (a)
CG14619 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71A12B.9 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for USP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP2 Gene

ENSEMBL:
Gene Tree for USP2 (if available)
TreeFam:
Gene Tree for USP2 (if available)

Paralogs for USP2 Gene

Paralogs for USP2 Gene

(10) SIMAP similar genes for USP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP2: view

Variants for USP2 Gene

Sequence variations from dbSNP and Humsavar for USP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs33929148 - 119,372,960(+) GCGTC(C/T)GGGCC intron-variant, reference, missense
rs45533837 - 119,359,048(-) CAGGG(A/C/G/T)TGGAC reference, missense
rs510272 -- 119,370,943(-) TCTGC(A/C)TCCTC intron-variant
rs511401 -- 119,379,350(+) AAGAG(C/G)ATTGA intron-variant, upstream-variant-2KB
rs513841 -- 119,370,539(-) GGACC(A/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP2 Gene

Variant ID Type Subtype PubMed ID
nsv898418 CNV Loss 21882294
nsv826103 CNV Gain 20364138
esv2662290 CNV Deletion 23128226
nsv832284 CNV Gain 17160897
esv33796 CNV Gain 17666407

Variation tolerance for USP2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP2 Gene

HapMap Linkage Disequilibrium report
USP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP2 Gene

Disorders for USP2 Gene

Relevant External Links for USP2

Genetic Association Database (GAD)
USP2
Human Genome Epidemiology (HuGE) Navigator
USP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP2

No disorders were found for USP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP2 Gene

Publications for USP2 Gene

  1. Expression of USP2-69 in mesangial cells in vivo and in vitro. (PMID: 20403044) Wang S. … Zhang Z. (Pathol. Int. 2010) 3 4 23 67
  2. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. (PMID: 17553343) Yang Y. … Yang H.J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007) 3 23
  3. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. (PMID: 16905103) Renatus M. … Kroemer M. (Structure 2006) 3 23
  4. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PMID: 16306228) Al-Hakim A.K. … Alessi D.R. (J. Cell Sci. 2005) 3 23
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3

Products for USP2 Gene

Sources for USP2 Gene

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