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Aliases for USP2 Gene

Aliases for USP2 Gene

  • Ubiquitin Specific Peptidase 2 2 3 5
  • Ubiquitin-Specific-Processing Protease 2 3 4
  • 41 KDa Ubiquitin-Specific Protease 3 4
  • Deubiquitinating Enzyme 2 3 4
  • Ubiquitin Thioesterase 2 3 4
  • UBP41 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 2 3
  • Ubiquitin Specific Protease 12 3
  • Ubiquitin Specific Protease 2 2
  • Ubiquitin Specific Protease 9 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • USP9 3

External Ids for USP2 Gene

Previous GeneCards Identifiers for USP2 Gene

  • GC11M121226
  • GC11M120738
  • GC11M119259
  • GC11M118764
  • GC11M118763
  • GC11M118731
  • GC11M115167
  • GC11M119225

Summaries for USP2 Gene

Entrez Gene Summary for USP2 Gene

  • This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for USP2 Gene

USP2 (Ubiquitin Specific Peptidase 2) is a Protein Coding gene. Diseases associated with USP2 include Ovarian Serous Cystadenocarcinoma and Serous Cystadenocarcinoma. Among its related pathways are Circadian rythm related genes and Regulation of TP53 Activity. GO annotations related to this gene include identical protein binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP21.

UniProtKB/Swiss-Prot for USP2 Gene

  • Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Gene Wiki entry for USP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP2 Gene

Genomics for USP2 Gene

Regulatory Elements for USP2 Gene

Enhancers for USP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G119469 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -89.0 -89039 2.0 CTCF SUZ12 SIN3A DPF2 NR2F2 JUND GABPB1 ZBTB33 FOS HNRNPL THY1 USP2 USP2-AS1 ENSG00000254740 MFRP C1QTNF5 LOC105369520 GC11P119452 GC11P119503
GH11G119352 1.3 Ensembl ENCODE dbSUPER 20.1 +28.7 28659 1.2 PKNOX1 FOXA2 ARID4B BMI1 RARA SCRT2 THAP11 SP5 MXD4 KAT8 USP2 USP2-AS1 THY1 NLRX1 MFRP C1QTNF5 GC11M119369
GH11G119356 1.4 Ensembl ENCODE dbSUPER 18.3 +24.8 24818 1.4 HDGF ATF1 CBX3 RB1 NFIB CREB3L1 ZBTB40 RAD21 ZNF143 ZNF207 USP2 USP2-AS1 THY1 NLRX1 GC11M119369 C1QTNF5 MFRP
GH11G119459 1.1 Ensembl ENCODE dbSUPER 18.9 -79.0 -79007 2.9 GATAD2A ZNF366 IKZF1 ZKSCAN8 ZNF512 HNF4G HNF4A HNRNPL THY1 USP2 USP2-AS1 ENSG00000254740 C1QTNF5 MFRP GC11P119452 GC11P119503
GH11G119366 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +12.2 12157 6.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS SP5 MXD4 THY1 C1QTNF5 ABCG4 MFRP USP2 NLRX1 H2AFX GC11M119369
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP2 Gene

Chromosome:
11
Start:
119,355,215 bp from pter
End:
119,381,726 bp from pter
Size:
26,512 bases
Orientation:
Minus strand

Genomic View for USP2 Gene

Genes around USP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP2 Gene

Proteins for USP2 Gene

  • Protein details for USP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75604-UBP2_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 2
    Protein Accession:
    O75604
    Secondary Accessions:
    • B0YJB8
    • E9PPM2
    • Q8IUM2
    • Q8IW04
    • Q96MB9
    • Q9BQ21

    Protein attributes for USP2 Gene

    Size:
    605 amino acids
    Molecular mass:
    68072 Da
    Quaternary structure:
    • Homooligomer (By similarity). Found in trimeric complex with MDM2 and MDM4 and USP2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C-terminus) with MDM2. Interacts with MDM4. Interacts with PER1 (By similarity). Interacts with KCNQ1; counteracts the NEDD4L-specific down-regulation of I(Ks) and restore plasma membrane localization of KCNQ1 (PubMed:22024150).

    Three dimensional structures from OCA and Proteopedia for USP2 Gene

    Alternative splice isoforms for USP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP2 Gene

Selected DME Specific Peptides for USP2 Gene

O75604:
  • LSNTRELRD
  • DLFVGQLKS
  • QQDAQEFL
  • FLLDGLH
  • YLEREDS
  • AYLLFYE
  • NLGNTCF
  • GNTCFMN

Post-translational modifications for USP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for USP2 Gene

Gene Families for USP2 Gene

Protein Domains for USP2 Gene

Suggested Antigen Peptide Sequences for USP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75604

UniProtKB/Swiss-Prot:

UBP2_HUMAN :
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • Belongs to the peptidase C19 family. USP2 subfamily.
Domain:
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
Family:
  • Belongs to the peptidase C19 family. USP2 subfamily.
genes like me logo Genes that share domains with USP2: view

Function for USP2 Gene

Molecular function for USP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin aldehyde.
UniProtKB/Swiss-Prot Function:
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by cisplatin (at protein level).

Enzyme Numbers (IUBMB) for USP2 Gene

Gene Ontology (GO) - Molecular Function for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 17290220
GO:0005515 protein binding IPI 16189514
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP2: view
genes like me logo Genes that share phenotypes with USP2: view

Animal Models for USP2 Gene

MGI Knock Outs for USP2:

Animal Model Products

CRISPR Products

miRNA for USP2 Gene

miRTarBase miRNAs that target USP2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP2
  • Applied Biological Materials Clones for USP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP2 Gene

Localization for USP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250 UniProtKB:Q5U349}.
Isoform 4: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with USP2: view

Pathways & Interactions for USP2 Gene

genes like me logo Genes that share pathways with USP2: view

Pathways by source for USP2 Gene

1 Cell Signaling Technology pathway for USP2 Gene
1 BioSystems pathway for USP2 Gene
1 R&D Systems pathway for USP2 Gene
1 Qiagen pathway for USP2 Gene

Gene Ontology (GO) - Biological Process for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 17290220
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with USP2: view

No data available for SIGNOR curated interactions for USP2 Gene

Drugs & Compounds for USP2 Gene

(3) Drugs for USP2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor 0
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor, Broad spectrum DUB inhibitor 0

(2) ApexBio Compounds for USP2 Gene

Compound Action Cas Number
NSC 632839 hydrochloride Isopeptidases inhibitor 157654-67-6
PR-619 Deubiquitylating enzymes (DBUs) inhibitor 2645-32-1
genes like me logo Genes that share compounds with USP2: view

Drug Products

Transcripts for USP2 Gene

Unigene Clusters for USP2 Gene

Ubiquitin specific peptidase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP2
  • Applied Biological Materials Clones for USP2

Alternative Splicing Database (ASD) splice patterns (SP) for USP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for USP2 Gene

GeneLoc Exon Structure for
USP2
ECgene alternative splicing isoforms for
USP2

Expression for USP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP2 Gene

mRNA differential expression in normal tissues according to GTEx for USP2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Testis (x6.5), and Heart - Left Ventricle (x4.6).

Protein differential expression in normal tissues from HIPED for USP2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP2 Gene



Protein tissue co-expression partners for USP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP2 Gene:

USP2

SOURCE GeneReport for Unigene cluster for USP2 Gene:

Hs.524085

mRNA Expression by UniProt/SwissProt for USP2 Gene:

O75604-UBP2_HUMAN
Tissue specificity: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).

Evidence on tissue expression from TISSUES for USP2 Gene

  • Muscle(2.8)
  • Kidney(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with USP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP2 Gene

Orthologs for USP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP2 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia USP2 34 35
  • 88.93 (n)
rat
(Rattus norvegicus)
Mammalia Usp2 34
  • 88.48 (n)
dog
(Canis familiaris)
Mammalia USP2 34 35
  • 87.74 (n)
mouse
(Mus musculus)
Mammalia Usp2 34 16 35
  • 87.71 (n)
oppossum
(Monodelphis domestica)
Mammalia USP2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP2 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP2 35
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9150 34
zebrafish
(Danio rerio)
Actinopterygii usp2a 35
  • 73 (a)
OneToMany
USP2 (2 of 3) 35
  • 68 (a)
OneToMany
USP2 (3 of 3) 35
  • 68 (a)
OneToMany
Dr.14438 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8726 34
fruit fly
(Drosophila melanogaster)
Insecta CG14619 36 35
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71A12B.9 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for USP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP2 Gene

ENSEMBL:
Gene Tree for USP2 (if available)
TreeFam:
Gene Tree for USP2 (if available)

Paralogs for USP2 Gene

Paralogs for USP2 Gene

(10) SIMAP similar genes for USP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP2: view

Variants for USP2 Gene

Sequence variations from dbSNP and Humsavar for USP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000137380 -- 119,363,584(+) GAGAG(A/G)CCAAG intron-variant
rs1000188796 -- 119,363,732(+) AGGAG(C/G)GGTGG intron-variant, upstream-variant-2KB
rs1000393885 -- 119,382,618(+) GCTCT(C/T)GTTGC intron-variant, upstream-variant-2KB
rs1000475276 -- 119,382,888(+) ACCAC(C/G)CCTGG intron-variant, upstream-variant-2KB
rs1000600849 -- 119,376,840(+) GCTCT(C/T)ATCGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP2 Gene

Variant ID Type Subtype PubMed ID
esv2662290 CNV deletion 23128226
esv33796 CNV gain 17666407
nsv1118222 CNV deletion 24896259
nsv556470 CNV loss 21841781
nsv826103 CNV gain 20364138
nsv832284 CNV gain 17160897

Variation tolerance for USP2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP2 Gene

Human Gene Mutation Database (HGMD)
USP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP2 Gene

Disorders for USP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for USP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian serous cystadenocarcinoma
  • serous cystadenoma
serous cystadenocarcinoma
  • serous adenocarcinoma
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search USP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP2

Genetic Association Database (GAD)
USP2
Human Genome Epidemiology (HuGE) Navigator
USP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP2
genes like me logo Genes that share disorders with USP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP2 Gene

Publications for USP2 Gene

  1. Expression of USP2-69 in mesangial cells in vivo and in vitro. (PMID: 20403044) Wang S. … Zhang Z. (Pathol. Int. 2010) 3 4 22 64
  2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. (PMID: 16905103) Renatus M. … Kroemer M. (Structure 2006) 3 4 22 64
  3. Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. (PMID: 22024150) Krzystanek K. … Jespersen T. (Heart Rhythm 2012) 3 4 64
  4. MdmX is a substrate for the deubiquitinating enzyme USP2a. (PMID: 19838211) Allende-Vega N. … Saville M.K. (Oncogene 2010) 3 4 64
  5. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PMID: 19917254) Shan J. … Gu W. (Mol. Cell 2009) 3 4 64

Products for USP2 Gene

  • Addgene plasmids for USP2

Sources for USP2 Gene

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