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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP2 Gene

protein-coding   GIFtS: 63
GCID: GC11M119259

ubiquitin specific peptidase 2

(Previous name: ubiquitin specific protease 2 )
 Explore 7 diseases affiliated with
USP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP2    

Aliases
for USP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 21 2     USP92
UBP411 2 3     Ubiquitin Carboxyl-Terminal Hydrolase 22
Deubiquitinating Enzyme 22 3     Ubiquitin Specific Protease 122
Ubiquitin Thioesterase 22 3     Ubiquitin Specific Protease 92
Ubiquitin-Specific-Processing Protease 22 3     EC 3.4.19.123
41 KDa Ubiquitin-Specific Protease2 3     EC 3.1.2.158
Ubiquitin Specific Protease 21     

External Ids:    HGNC: 126181   Entrez Gene: 90992   Ensembl: ENSG000000366727   OMIM: 6047255   UniProtKB: O756043   

Export aliases for USP2 gene to outside databases

Previous GC identifers: GC11M121226 GC11M120738 GC11M118764 GC11M118763 GC11M118731 GC11M115167


Summaries
for USP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USP2:
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily.
The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha)
-induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as
fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of
the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced
transcript variants encoding different isoforms have been identified. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: UBP2_HUMAN, O75604
Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and
isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without
reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53
activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in
the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation
of embryonic muscle cells

Gene Wiki entry for USP2


Genomic Views
for USP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP2 gene promoter:
         CREB   HTF   deltaCREB   MyoD   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): USP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

USP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119259:  view genomic region     (about GC identifiers)

Start:
 119,225,925 bp from pter      End:
 119,252,436 bp from pter
Size:
 26,512 bases      Orientation:
 minus strand

Proteins
for USP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBP2_HUMAN, O75604 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 2  
Size: 605 amino acids; 68072 Da
Cofactor: Binds 1 zinc ion
Subunit: Homooligomer (By similarity). Found in trimeric complex with MDM2 and MDM4 and UPB2. Interacts with CCND1; the
interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via
N-terminus and C-terminus) with MDM2. Interacts with MDM4
Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Localizes in the
spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma
membrane (By similarity)
Subcellular location: Isoform 4: Nucleus (By similarity)
5 PDB 3D structures from and Proteopedia for USP2:
2HD5 (3D)        2IBI (3D)        3NHE (3D)        3V6C (3D)        3V6E (3D)    
Secondary accessions: B0YJB8 Q8IUM2 Q8IW04 Q96MB9 Q9BQ21
Alternative splicing: 4 isoforms:  O75604-1   O75604-2   O75604-3   O75604-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP2: NX_O75604

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75604

    • 4/8 DME Specific Peptides for USP2 (O75604) (see all 8)
     NLGNTCF  FLLDGLH  GNTCFMN  AYLLFYE 

    USP2 Protein expression data from MOPED and PaxDb:    About this image 
    USP2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001230688.1  NP_004196.4  NP_741994.1  

    ENSEMBL proteins: 
     ENSP00000407842   ENSP00000260187   ENSP00000436952   ENSP00000433977   ENSP00000431857  

    Human Recombinant Protein Products for USP2: 
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    R&D Systems Recombinant & Natural Proteins for USP2
    Enzo Life Sciences proteins for USP2
    OriGene Purified Protein: USP2
    OriGene Protein Over-expression Lysate (see all 2): USP2
    OriGene Custom Protein Services for USP2 
    GenScript Custom Purified and Recombinant Proteins Services for USP2
    Novus Biologicals USP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome IEA--
    GO:0005938cell cortex IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    USP2 for ontologies           About GeneDecksing



    USP2 Antibody Products: 
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    Novus Biologicals USP2 Antibodies
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    ThermoFisher Antibody for USP2

    Assay Products for USP2: 
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    GenScript Custom Assay Services for USP2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for USP2

    Protein Domains /
    Families
    for USP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry O75604

    ProtoNet protein and cluster: O75604

    1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP2_HUMAN, O75604
    Domain: The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular
    localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different
    N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity (By similarity)
    Similarity: Belongs to the peptidase C19 family. USP2 subfamily


    Function
    for USP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP2_HUMAN, O75604
    Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and
    isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without
    reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53
    activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in
    the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation
    of embryonic muscle cells
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin
    aldehyde
    Induction: Down-regulated by cisplatin (at protein level)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IMP19917254
    GO:0005515protein binding IPI16189514
    GO:0008234cysteine-type peptidase activity ----
    GO:0030332cyclin binding IPI19917254
         
    USP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP2:
     Downregulation of TNF-I+/NF-I_ 

         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Usp2):
     behavior/neurological  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    USP2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for USP2: Usp2tm1.1Ssw Usp2tm1.1Bjc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP2 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate USP2 (see all 60):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-624 hsa-miR-30d hsa-miR-371-5p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmid: USP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP2 (see all 7)
    OriGene shRNA RFP: USP2
    OriGene siRNA: USP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USP2
    Sirion Biotech Customized adenovirus for overexpression of USP2 
    Sirion Biotech Customized adenovirus for potent knockdown of USP2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP2 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USP2 (NM_004418)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for USP2
    Sirion Biotech Customized stable knockdown cell line services for USP2 
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    Sirion Biotech Customized inducible overexpressing cell line services for USP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP2


    Pathways & Interactions
    for USP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein Stability
    		Protein Stability1.00
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    4TNF-alpha/NF-kB Signaling Pathway
    		TNF-alpha/NF-kB Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP2
        Ubiquitin-Proteasome Dependent Proteolysis

    2 Cell Signaling Technology (CST) Pathways for USP2
        Cell Cycle / Checkpoint Control
    Protein Stability

    1 BioSystems Pathway for USP2 
        TNF-alpha/NF-kB Signaling Pathway



    USP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for USP2 (O756041, 2, 3 ENSP000002601874) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-4509378 MINT-4509401 MINT-4508284 MINT-4304100 I2D: score=3 STRING: ENSP00000417281
    KRT15P190121, 3, ENSP000002540434EBI-743272,EBI-739566 I2D: score=6 STRING: ENSP00000254043
    UBCP0CG482, 3, ENSP000003448184MINT-7288863 I2D: score=2 STRING: ENSP00000344818
    CCDC85BQ158343, ENSP000003116954I2D: score=5 STRING: ENSP00000311695
    BEND5Q7L4P63, ENSP000003608994I2D: score=4 STRING: ENSP00000360899
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP17290220
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007049cell cycle IEA--
    GO:0007517muscle organ development IEA--
    GO:0016579protein deubiquitination IDA19917254

    USP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP2

    1 HMDB Compound for USP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about USP2 / UBP2 

    Transcripts
    for USP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP2 gene (3 alternative transcripts): 
    NM_001243759.1  NM_004205.4  NM_171997.2  

    Unigene Cluster for USP2:

    Ubiquitin specific peptidase 2
    Hs.524085  [show with all ESTs]
    Unigene Representative Sequence: NM_004205
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455332(uc001pwl.4) ENST00000260187(uc001pwm.4 uc001pwn.4)
    ENST00000525735 ENST00000525189 ENST00000532613 ENST00000530918 ENST00000531070
    ENST00000527843

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): USP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate USP2 (see all 60):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-624 hsa-miR-30d hsa-miR-371-5p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmid: USP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP2 (see all 7)
    OriGene shRNA RFP: USP2
    OriGene siRNA: USP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP2 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USP2 (NM_004418)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP2

    Additional cDNA sequence: 

    AF079564.1 AF440755.1 AK057225.1 AK292255.1 AK301805.1 BC002854.1 BC002955.1 BC041366.2 

    12 DOTS entries:

    DT.207490  DT.120730345  DT.120730322  DT.92422138  DT.120730154  DT.95138525  DT.102835887  DT.120730335 
    DT.409719  DT.95276841  DT.97797667  DT.40212670 

    24/121 AceView cDNA sequences (see all 121):

    AA909595 BU608016 AW274034 AI016812 CA434155 F27404 NM_171997 AW302257 
    CA433975 BM698358 BE222977 AI083751 CA311587 AF440755 CD671088 CA311839 
    BM726722 BM714044 AW771619 AA971425 BE513506 AL042374 BX385085 BI225110 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USP2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -                       -     -                                   -                                             
    SP2:                                                                                      -                                             
    SP3:              -     -     -     -     -     -     -                                   -                                             
    SP4:                                                                                                                                    
    SP5:                                                                                      -                                             


    ECgene alternative splicing isoforms for USP2

    Expression
    for USP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCAAGAGC
    USP2 Expression
    About this image

    USP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See USP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP2

    SOURCE GeneReport for Unigene cluster: Hs.524085

    UniProtKB/Swiss-Prot: UBP2_HUMAN, O75604
    Tissue specificity: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at
    protein level)

        SABiosciences Custom PCR Arrays for USP2
    Primer
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    Orthologs
    for USP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USP2 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves USP21 ubiquitin specific peptidase 2 74.24(n)
    75.52(a)    		   395766  NM_204926.1  NP_990257.1 
    lizard
    (Anolis carolinensis)    		 Reptilia USP26
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL344075.1(19772-71766)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.91502 Xenopus laevis transcribed sequence with moderate similarity more 77.5(n)    BJ061884.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.144382 Transcribed sequence with weak similarity to protein more 77.12(n)    CK030283.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG146193 protein deubiquitination ubiquitin-specific
    protease    		 45(a)   20B1   --


    ENSEMBL Gene Tree for USP2 (if available)
    TreeFam Gene Tree for USP2 (if available) 

    Paralogs
    for USP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP2 gene
    USP17L132  USP17L282  USP17L242  USP17L302  USP17L122  USP17L172  USP17L262  USP17L182  
    USP17L232  USP422  USP17L252  USP82  USP17L152  USP17L212  USP17L202  USP17L192  
    USP17L102  USP362  USP17L272  USP212  USP17L222  USP17L52  USP17L22  USP17L292  
    USP17L112  USP502  
    10 SIMAP similar genes for USP2 using alignment to 4 protein entries:     UBP2_HUMAN (see all proteins):
    USP11    USP21    USP15    DKFZp761E10121    USP8    USP32
    USP33    USP48    USP45    USP3

    USP2 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for USP2 (see all 7)
    PGOHUM00000263159 PGOHUM00000263328 PGOHUM00000263329 PGOHUM00000263330 PGOHUM00000263332


    Genomic Variants
    for USP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/490 NCBI SNPs in USP2 are shown (see all 490)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs455793341,2
    		C--119225429(+) GTTTCG/AGCAGA 3 -- ds50011Minor allele frequency- A:0.03NS 36
    rs1822319501,2
    		--119225467(+) CAATGA/CGGGCT 3 -- ds50010--------
    rs1501948511,2
    		C--119225488(+) GGGTC-/CACTTTC 3 -- ds50010--------
    rs1478500791,2
    		--119225545(+) TAAGAC/TGCAAA 3 -- ds50010--------
    rs1876896251,2
    		--119225561(+) CATATA/CTAGAA 3 -- ds50010--------
    rs1397198981,2
    		--119225584(+) TATACA/GCAGGT 3 -- ds50010--------
    rs1922810941,2
    		--119225637(+) GGTATA/GTGTGT 3 -- ds50010--------
    rs1380973061,2
    		C--119225763(+) TTTTT-/AAAAAA 3 -- ds50010--------
    rs25094011,2
    		C--119225932(+) ATTTCT/GCAAAG 3 -- ut312Minor allele frequency- G:0.09WA 120
    rs1453038251,2
    		--119225997(+) GCTTAC/GACAGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for USP2 (119225925 - 119252436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for USP2
         1 CNV: 6904

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    Disorders / Diseases
    for USP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP2 for disorders           About GeneDecksing

    OMIM gene information: 604725    OMIM disorders: --

    7 diseases for USP2:    About MalaCards
    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    cystadenocarcinoma    azoospermia
    prostate cancer    prostatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for USP2:
    Ovarian serous cystadenocarcinoma

    1 Novoseek disease relationship for USP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 53.7 2 14751364 (1), 16227348 (1)

    Human Genome Epidemiology (HuGE) Navigator: USP2 (1 document)

    Export disorders for USP2 gene to outside databases

    Publications
    for USP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP2 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with USP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of USP2-69 in mesangial cells in vivo and in vitro. (PubMed id 20403044)1, 2, 9 Wang S....Zhang Z. (2010)
    2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. (PubMed id 16905103)1, 2, 9 Renatus M....Kroemer M. (2006)
    3. MdmX is a substrate for the deubiquitinating enzyme U SP2a. (PubMed id 19838211)1, 2 Allende-Vega N....Saville M.K. (2010)
    4. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PubMed id 19917254)1, 2 Shan J....Gu W. (2009)
    5. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. (PubMed id 17290220)1, 2 Stevenson L.F....Saville M.K. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    9. UBP41 is a proapoptotic ubiquitin-specific protease. (PubMed id 12566314)1, 9 Gewies A. and Grimm S. (2003)
    10. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues] (PubMed id 17553343)1, 9 Yang Y....Yang H.J. (2007)

    External Searches for USP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9099 HGNC: 12618 AceView: USP2 Ensembl:ENSG00000036672 euGenes: HUgn9099
    ECgene: USP2 H-InvDB: USP2

    Other Databases showing USP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP2 gene:
    Search GeneIP for patents involving USP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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