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Aliases for USP2 Gene

Aliases for USP2 Gene

  • Ubiquitin Specific Peptidase 2 2 3 5
  • Ubiquitin-Specific-Processing Protease 2 3 4
  • 41 KDa Ubiquitin-Specific Protease 3 4
  • Deubiquitinating Enzyme 2 3 4
  • Ubiquitin Thioesterase 2 3 4
  • UBP41 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 2 3
  • Ubiquitin Specific Protease 12 3
  • Ubiquitin Specific Protease 2 2
  • Ubiquitin Specific Protease 9 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56
  • USP9 3

External Ids for USP2 Gene

Previous GeneCards Identifiers for USP2 Gene

  • GC11M121226
  • GC11M120738
  • GC11M119259
  • GC11M118764
  • GC11M118763
  • GC11M118731
  • GC11M115167
  • GC11M119225

Summaries for USP2 Gene

Entrez Gene Summary for USP2 Gene

  • This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for USP2 Gene

USP2 (Ubiquitin Specific Peptidase 2) is a Protein Coding gene. Diseases associated with USP2 include Ovarian Serous Cystadenocarcinoma and Serous Cystadenocarcinoma. Among its related pathways are Metabolism of proteins and Gene Expression. Gene Ontology (GO) annotations related to this gene include identical protein binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP21.

UniProtKB/Swiss-Prot for USP2 Gene

  • Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity).

  • Isoform 4: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine.

Gene Wiki entry for USP2 Gene

Additional gene information for USP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP2 Gene

Genomics for USP2 Gene

GeneHancer (GH) Regulatory Elements for USP2 Gene

Promoters and enhancers for USP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I119380 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559.7 +0.4 368 2.4 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 USP2 USP2-AS1 THY1 ENSG00000254740
GH11I119360 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 559 +18.7 18736 5.8 PKNOX1 FOXA2 SIN3A FEZF1 YY1 GLIS2 FOS RXRA JUNB REST USP2 RNF26 ENSG00000245385 THY1 ABCG4 NLRX1 LOC101929089 GC11M119369 C1QTNF5 MFRP
GH11I119374 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 561.6 +4.7 4712 5.5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF143 SP5 NFYC USP2 THY1 C1QTNF5 MFRP ENSG00000254740
GH11I119352 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.2 +28.7 28658 1.2 PKNOX1 FOXA2 ARID4B BMI1 RARA SCRT2 THAP11 SP5 MXD4 KAT8 USP2 IFT46 KMT2A VPS11 RPL5P30 USP2-AS1 ENSG00000255121 THY1 NLRX1 C1QTNF5
GH11I119356 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.3 +24.8 24818 1.4 HDGF ATF1 NFIB RB1 SIN3A ZBTB40 RAD21 ARID2 ZNF207 ZNF143 USP2 USP2-AS1 THY1 NLRX1 GC11M119369 C1QTNF5 MFRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP2 gene promoter:

Genomic Locations for USP2 Gene

Genomic Locations for USP2 Gene
chr11:119,355,215-119,381,726
(GRCh38/hg38)
Size:
26,512 bases
Orientation:
Minus strand
chr11:119,225,925-119,252,436
(GRCh37/hg19)

Genomic View for USP2 Gene

Genes around USP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP2 Gene

Proteins for USP2 Gene

  • Protein details for USP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75604-UBP2_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 2
    Protein Accession:
    O75604
    Secondary Accessions:
    • B0YJB8
    • E9PPM2
    • Q8IUM2
    • Q8IW04
    • Q96MB9
    • Q9BQ21

    Protein attributes for USP2 Gene

    Size:
    605 amino acids
    Molecular mass:
    68072 Da
    Quaternary structure:
    • Homooligomer (By similarity). Found in trimeric complex with MDM2 and MDM4 and USP2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C-terminus) with MDM2. Interacts with MDM4. Interacts with PER1 (By similarity). Interacts with KCNQ1; counteracts the NEDD4L-specific down-regulation of I(Ks) and restore plasma membrane localization of KCNQ1 (PubMed:22024150). Isoform 4: Interacts with PDZD3 and CLTC (By similarity).

    Three dimensional structures from OCA and Proteopedia for USP2 Gene

    Alternative splice isoforms for USP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP2 Gene

Selected DME Specific Peptides for USP2 Gene

O75604:
  • LSNTRELRD
  • DLFVGQLKS
  • QQDAQEFL
  • FLLDGLH
  • YLEREDS
  • AYLLFYE
  • NLGNTCF
  • GNTCFMN

Post-translational modifications for USP2 Gene

No Post-translational modifications

Domains & Families for USP2 Gene

Gene Families for USP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP2 Gene

Suggested Antigen Peptide Sequences for USP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75604

UniProtKB/Swiss-Prot:

UBP2_HUMAN :
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • Belongs to the peptidase C19 family. USP2 subfamily.
Domain:
  • The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
Family:
  • Belongs to the peptidase C19 family. USP2 subfamily.
genes like me logo Genes that share domains with USP2: view

Function for USP2 Gene

Molecular function for USP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Cleavage is inhibited by ubiquitin in a dosage-dependent manner. Cleavage is blocked by ubiquitin aldehyde.
UniProtKB/Swiss-Prot Function:
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 4: Circadian clock output effector that regulates Ca(2+) absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca(2+) membrane permeability mediated by the Ca(2+) channel TRPV6 in the intestine.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cisplatin (at protein level).

Enzyme Numbers (IUBMB) for USP2 Gene

Phenotypes From GWAS Catalog for USP2 Gene

Gene Ontology (GO) - Molecular Function for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP,IDA 19917254
GO:0005515 protein binding IPI 16189514
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP2: view
genes like me logo Genes that share phenotypes with USP2: view

Animal Models for USP2 Gene

MGI Knock Outs for USP2:

Clone Products

  • Addgene plasmids for USP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP2 Gene

Localization for USP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250 UniProtKB:Q5U349}.
Isoform 4: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly expressed at membranes. {ECO:0000250 UniProtKB:O88623}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with USP2: view

Pathways & Interactions for USP2 Gene

genes like me logo Genes that share pathways with USP2: view

Pathways by source for USP2 Gene

1 Cell Signaling Technology pathway for USP2 Gene
1 BioSystems pathway for USP2 Gene

Gene Ontology (GO) - Biological Process for USP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 17290220
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0007517 muscle organ development IEA --
genes like me logo Genes that share ontologies with USP2: view

No data available for SIGNOR curated interactions for USP2 Gene

Drugs & Compounds for USP2 Gene

(3) Drugs for USP2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor 0
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor 0

(2) ApexBio Compounds for USP2 Gene

Compound Action Cas Number
NSC 632839 hydrochloride Isopeptidases inhibitor 157654-67-6
PR-619 Deubiquitylating enzymes (DBUs) inhibitor 2645-32-1
genes like me logo Genes that share compounds with USP2: view

Drug Products

Transcripts for USP2 Gene

Unigene Clusters for USP2 Gene

Ubiquitin specific peptidase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for USP2

Alternative Splicing Database (ASD) splice patterns (SP) for USP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for USP2 Gene

GeneLoc Exon Structure for
USP2
ECgene alternative splicing isoforms for
USP2

Expression for USP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP2 Gene

mRNA differential expression in normal tissues according to GTEx for USP2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7), Testis (x6.5), and Heart - Left Ventricle (x4.6).

Protein differential expression in normal tissues from HIPED for USP2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP2 Gene



Protein tissue co-expression partners for USP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP2 Gene:

USP2

SOURCE GeneReport for Unigene cluster for USP2 Gene:

Hs.524085

mRNA Expression by UniProt/SwissProt for USP2 Gene:

O75604-UBP2_HUMAN
Tissue specificity: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).

Evidence on tissue expression from TISSUES for USP2 Gene

  • Muscle(2.8)
  • Kidney(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with USP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP2 Gene

Orthologs for USP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP2 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia USP2 33 34
  • 88.93 (n)
rat
(Rattus norvegicus)
Mammalia Usp2 33
  • 88.48 (n)
dog
(Canis familiaris)
Mammalia USP2 33 34
  • 87.74 (n)
mouse
(Mus musculus)
Mammalia Usp2 33 16 34
  • 87.71 (n)
oppossum
(Monodelphis domestica)
Mammalia USP2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP2 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP2 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP2 34
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9150 33
zebrafish
(Danio rerio)
Actinopterygii usp2a 34
  • 73 (a)
OneToMany
USP2 (2 of 3) 34
  • 68 (a)
OneToMany
USP2 (3 of 3) 34
  • 68 (a)
OneToMany
Dr.14438 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8726 33
fruit fly
(Drosophila melanogaster)
Insecta CG14619 35 34
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71A12B.9 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for USP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP2 Gene

ENSEMBL:
Gene Tree for USP2 (if available)
TreeFam:
Gene Tree for USP2 (if available)

Paralogs for USP2 Gene

Paralogs for USP2 Gene

(10) SIMAP similar genes for USP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP2: view

Variants for USP2 Gene

Sequence variations from dbSNP and Humsavar for USP2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000137380 -- 119,363,584(-) G/A intron_variant
rs1000188796 -- 119,363,732(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000393885 -- 119,382,618(-) T/C upstream_transcript_variant
rs1000475276 -- 119,382,888(-) G/A/C upstream_transcript_variant
rs1000600849 -- 119,376,840(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for USP2 Gene

Variant ID Type Subtype PubMed ID
esv2662290 CNV deletion 23128226
esv33796 CNV gain 17666407
nsv1118222 CNV deletion 24896259
nsv556470 CNV loss 21841781
nsv826103 CNV gain 20364138
nsv832284 CNV gain 17160897

Variation tolerance for USP2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP2 Gene

Human Gene Mutation Database (HGMD)
USP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP2 Gene

Disorders for USP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for USP2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian serous cystadenocarcinoma
  • serous cystadenoma
serous cystadenocarcinoma
  • serous adenocarcinoma
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search USP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with USP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP2 Gene

Publications for USP2 Gene

  1. Expression of USP2-69 in mesangial cells in vivo and in vitro. (PMID: 20403044) Wang S … Zhang Z (Pathology international 2010) 3 4 22 58
  2. Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. (PMID: 16905103) Renatus M … Kroemer M (Structure (London, England : 1993) 2006) 3 4 22 58
  3. Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. (PMID: 22024150) Krzystanek K … Jespersen T (Heart rhythm 2012) 3 4 58
  4. MdmX is a substrate for the deubiquitinating enzyme USP2a. (PMID: 19838211) Allende-Vega N … Saville MK (Oncogene 2010) 3 4 58
  5. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PMID: 19917254) Shan J … Gu W (Molecular cell 2009) 3 4 58

Products for USP2 Gene

  • Addgene plasmids for USP2

Sources for USP2 Gene

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