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USP19 Gene

protein-coding   GIFtS: 59
GCID: GC03M049145

Ubiquitin Specific Peptidase 19

(Previous name: ubiquitin specific protease 19)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 191 2     ZMYND92 3
Ubiquitin Specific Protease 191 2     KIAA08913 5
Deubiquitinating Enzyme 192 3     Ubiquitin Carboxyl-Terminal Hydrolase 192
Ubiquitin Thioesterase 192 3     Ubiquitin Thiolesterase 192
Ubiquitin-Specific-Processing Protease 192 3     EC 3.4.19.123
Zinc Finger MYND Domain-Containing Protein 92 3     EC 3.1.2.158

External Ids:    HGNC: 126171   Entrez Gene: 108692   Ensembl: ENSG000001720467   OMIM: 6144715   UniProtKB: O949663   

Export aliases for USP19 gene to outside databases

Previous GC identifers: GC03P046927 GC03P048487 GC03M048999 GC03M049104 GC03M049120


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP19 Gene:
USP19 (ubiquitin specific peptidase 19) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966
Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents
proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing
a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates
transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated
degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their
ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation
in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the
levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a
preference towards 'Lys-63'-linked Ubiquitin chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP19 gene promoter:
         E2F-4   E2F-3a   Max   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP19 promoter sequence
   Search Chromatin IP Primers for USP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

USP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049145:  view genomic region     (about GC identifiers)

Start:
49,145,479 bp from pter      End:
49,158,371 bp from pter
Size:
12,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 19  
Size: 1318 amino acids; 145651 Da
Subunit: Interacts with RNF123 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.
Interacts with HIF1A (via N-terminus)
Sequence caution: Sequence=AAI06030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI06030.1; Type=Frameshift; Positions=572; Sequence=AAI42661.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=BAA74914.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
1 PDB 3D structure from and Proteopedia for USP19:
1WH0 (3D)    
Secondary accessions: A5PKX8 A6H8U2 B4DGT3 B4DTZ0 E7EN22 E7ETS0 E9PEG8 Q3KQW4 Q641Q9 Q6NZY8
Q86XV9
Alternative splicing: 7 isoforms:  O94966-1   O94966-2   O94966-3   O94966-4   O94966-5   O94966-6   O94966-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP19: NX_O94966

Explore proteomics data for USP19 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys610, Lys1120
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP19 (O94966) (see all 11)
     GLVNLGN  FLLDGLH  IVDLFQG  NSVIQSL 


    See USP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001186089.1  NP_001186090.1  NP_001186091.1  NP_006668.1  

    ENSEMBL proteins: 
     ENSP00000381870   ENSP00000381872   ENSP00000395260   ENSP00000400090   ENSP00000381867  
     ENSP00000381863   ENSP00000401197   ENSP00000303503   ENSP00000428539  

    USP19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP19
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP19
    GenScript Custom Purified and Recombinant Proteins Services for USP19
    Novus Biologicals USP19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP19

     
    Search eBioscience for Proteins for USP19 

     
    Search antibodies-online for proteins for USP19 

     
    antibodies-online peptides for USP19

    USP19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals USP19 Antibodies
    Abcam antibodies for USP19
    Cloud-Clone Corp. Antibodies for USP19
    ThermoFisher Antibodies for USP19
    antibodies-online antibodies for USP19 (25 products) 

    USP19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP19
    Cloud-Clone Corp. CLIAs for USP19
    Search eBioscience for ELISAs for USP19 
    antibodies-online kits for USP19 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR002893 Znf_MYND
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR008978 HSP20-like_chaperone

    Graphical View of Domain Structure for InterPro Entry O94966

    ProtoNet protein and cluster: O94966

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 2 CS domains
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP19_HUMAN, O94966
    Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents
    proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing
    a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates
    transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated
    degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their
    ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation
    in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the
    levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a
    preference towards 'Lys-63'-linked Ubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP19:
    putative ubiquitin specific protease 19,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA19465887
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with USP19           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for USP19:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP19

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP19:
    hsa-mir-615-3p (MIRT040472), hsa-mir-183-5p (MIRT047096), hsa-mir-186-5p (MIRT045286), hsa-mir-196a-5p (MIRT048191)

    Block miRNA regulation of human, mouse, rat USP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP19 (see all 12):
    hsa-miR-3163 hsa-miR-492 hsa-miR-15a hsa-miR-497 hsa-miR-4282 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidUSP19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP19
    Predesigned siRNA for gene silencing in human, mouse, rat USP19

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for USP19

    Clone
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    OriGene clones in human, mouse for USP19 (see all 11)
    OriGene ORF clones in mouse, rat for USP19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): USP19 (NM_001199162)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP19
    Addgene plasmids for USP19 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP19
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP19 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP19_HUMAN, O94966: Endoplasmic reticulum membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA19465887
    GO:0005829cytosol IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with USP19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP19 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP19
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP19
    Interactions:

        Search GeneGlobe Interaction Network for USP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP19 (O949662, 3 ENSP000003818634) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFTRP135692, 3, ENSP000000030844MINT-7218998 I2D: score=1 STRING: ENSP00000003084
    CANXP278242, 3, ENSP000002474614MINT-7218984 I2D: score=1 STRING: ENSP00000247461
    PTCRAQ6ISU12, 3, ENSP000003044474MINT-7219035 I2D: score=1 STRING: ENSP00000304447
    ACADSBP459543, ENSP000003578734I2D: score=2 STRING: ENSP00000357873
    ATAD1Q8NBU53, ENSP000003390164I2D: score=2 STRING: ENSP00000339016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0014732skeletal muscle atrophy ISS--
    GO:0016579protein deubiquitination ISS--
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IDA19465887
    GO:0031647regulation of protein stability ISS--

    Find genes that share ontologies with USP19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP19 (UBP19)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP19 gene (4 alternative transcripts): 
    NM_001199160.1  NM_001199161.1  NM_001199162.1  NM_006677.2  

    Unigene Cluster for USP19:

    Ubiquitin specific peptidase 19
    Hs.255596  [show with all ESTs]
    Unigene Representative Sequence: NM_001199161
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398896 ENST00000398898 ENST00000417901(uc003cwa.3) ENST00000453664(uc003cvz.4 uc011bcg.2 uc003cwb.3 uc011bci.2)
    ENST00000398892(uc003cwc.2) ENST00000398888(uc003cwd.2) ENST00000434032(uc011bch.2)
    ENST00000483667 ENST00000306026 ENST00000464931 ENST00000479073 ENST00000488993
    ENST00000480163 ENST00000491859 ENST00000465902
    miRNA
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    Block miRNA regulation of human, mouse, rat USP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP19 (see all 12):
    hsa-miR-3163 hsa-miR-492 hsa-miR-15a hsa-miR-497 hsa-miR-4282 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidUSP19 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP19
    Predesigned siRNA for gene silencing in human, mouse, rat USP19
    Clone
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    OriGene clones in human, mouse for USP19 (see all 11)
    OriGene ORF clones in mouse, rat for USP19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): USP19 (NM_001199162)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP19
    Addgene plasmids for USP19 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP19
      QuantiTect SYBR Green Assays in human, mouse, rat USP19
      QuantiFast Probe-based Assays in human, mouse, rat USP19

    Additional mRNA sequence: 

    AB020698.1 AK294756.1 AK296447.1 AK300425.1 BC014934.1 BC048269.1 BC065909.1 BC082241.1 
    BC127009.1 BC142660.1 BC142727.1 BC146752.1 EF036501.1 

    5 DOTS entries:

    DT.100751628  DT.212382  DT.443067  DT.95085278  DT.92026854 

    Selected AceView cDNA sequences (see all 190):

    BX956761 BG025097 BM682395 CK821110 BI792975 BG029242 AI200125 BC082241 
    BM967194 BI793268 AB020698 BG826973 BG222865 BM477264 AA806467 BM129503 
    BF941731 BM828107 BM802653 BX475291 CD108178 BM717864 BC014934 CA390387 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP19 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                -         
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for USP19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP19 Expression
    About this image

    USP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.255596
        Custom PCR Arrays for USP19
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP19
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    QuantiFast Probe-based Assays in human, mouse, rat USP19
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP19 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp191 , 5 ubiquitin specific peptidase 191, 5 88.03(n)1
    90.93(a)1
      9 (59.42 cM)5
    714721  NM_027804.41  NP_082080.31 
     1084906765 
    chicken
    (Gallus gallus)
    Aves USP191 ubiquitin specific peptidase 19 70.93(n)
    71.5(a)
      100858727  XM_004944628.1  XP_004944685.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP196
    ubiquitin specific peptidase 19
    65(a)
    1 ↔ 1
    2(188334604-188378034)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377213252   -- 74.76(n)    137721325 
    zebrafish
    (Danio rerio)
    Actinopterygii BG729270.12   -- 78.84(n)    BG729270.1 
    worm
    (Caenorhabditis elegans)
    Secernentea H34C03.23
    F07A11.41
    ubiquitin carboxy-terminal hydrolase3
    F07A11.41
    51(a)
    (best of 2)3
    47.33(n)1
    41.69(a)1
      IV(6757531-6761964)3
    1747801  NM_001267376.11  NP_001254305.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP126
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    21(a)
    1 → many
    X(63805-67569) YJL197W


    ENSEMBL Gene Tree for USP19 (if available)
    TreeFam Gene Tree for USP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP19 gene
    USP452  USP62  USP152  USP112  USP162  USP312  USP432  USP322  
    USP42  
    5 SIMAP similar genes for USP19 using alignment to 7 protein entries:     UBP19_HUMAN (see all proteins):
    USP15    USP30    DKFZp761E10121    USP11    USP3

    Find genes that share paralogs with USP19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP19 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49554111,2
    C,F,H--49145304(-) CAGCTC/TTTTGG 2 -- int121Minor allele frequency- T:0.22NS EA NA WA CSA 2021
    rs1462310531,2
    --49145322(+) TGGGGA/GCTTCA 2 -- int10--------
    rs1400795071,2
    --49145393(+) GTCTCC/TCATAT 2 -- int10--------
    rs2006895791,2
    --49145544(+) AATGC-/AAAAAA 2 -- ut310--------
    rs146441,2
    A,H--49145614(+) GTACAA/TCAGAA 4 -- int1 ut317Minor allele frequency- T:0.00MN NS EA NA 489
    rs32121,2
    C,F,O,A,H--49145741(+) TCCCAC/TTGACA 4 -- int1 ut31 ese329Minor allele frequency- T:0.31MN NA NS EA WA CSA 2866
    rs729368201,2
    C--49146258(+) GGGGCG/CACAAC 4 -- ut31 int11Minor allele frequency- C:0.50WA 2
    rs2018345591,2
    C--49146401(+) TCCAGC/TGACTC 6 H R mis1 int11Minor allele frequency- T:0.00EU 653
    rs1420373821,2
    C--49146469(+) CCCAGC/GACAAA 6 V syn1 int10--------
    rs799655141,2
    C--49146612(+) AATCCG/AGGAAG 6 /R /W mis1 int11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for USP19 (49145479 - 49158371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for USP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834686CNV Loss17160897
    nsv876764CNV Loss21882294
    nsv876765CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP19
    DNA2.0 Custom Variant and Variant Library Synthesis for USP19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614471    OMIM disorders: --


    Find genes that share disorders with USP19           About GenesLikeMe


    Export disorders for USP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP19 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with USP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia. (PubMed id 22128162)1, 2 Altun M.... Lindsten K. (J. Biol. Chem. 2012)
    2. The USP19 deubiquitinase regulates the stability of c-IAP1 and c- IAP2. (PubMed id 21849505)1, 2 Mei Y.... Yang X. (J. Biol. Chem. 2011)
    3. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. (PubMed id 19465887)1, 2 Hassink G.C.... Lindsten K. (EMBO Rep. 2009)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19. (PubMed id 23500468)1 Velasco K....Lindsten K. (Biochem. Biophys. Res. Commun. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. (PubMed id 22689415)2 Iphofer A.... Franke R. (ChemBioChem 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10869 HGNC: 12617 AceView: USP19 Ensembl:ENSG00000172046 euGenes: HUgn10869
    ECgene: USP19 H-InvDB: USP19

    (According to HUGE)
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    HUGE: KIAA0891

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP19 gene:
    Search GeneIP for patents involving USP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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