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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP19 Gene

protein-coding   GIFtS: 56
GCID: GC03M049120

ubiquitin specific peptidase 19

(Previous name: ubiquitin specific protease 19 )
 Explore 2 diseases affiliated with
USP19 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP19    

Aliases
for USP19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 191 2     Ubiquitin-Specific-Processing Protease 192 3
ZMYND91 2 3     Zinc Finger MYND Domain-Containing Protein 92 3
Ubiquitin Specific Protease 191 2     Ubiquitin Carboxyl-Terminal Hydrolase 192
KIAA08911 3     Ubiquitin Thiolesterase 192
Deubiquitinating Enzyme 192 3     EC 3.4.19.123
Ubiquitin Thioesterase 192 3     EC 3.1.2.158

External Ids:    HGNC: 126171   Entrez Gene: 108692   Ensembl: ENSG000001720467   OMIM: 6144715   UniProtKB: O949663   

Export aliases for USP19 gene to outside databases

Previous GC identifers: GC03P046927 GC03P048487 GC03M048999 GC03M049104


Summaries
for USP19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966
Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents
proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a
role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates
transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated
degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their
ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a
non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of
ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards
'Lys-63'-linked Ubiquitin chains




Genomic Views
for USP19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP19 gene promoter:
         E2F-4   E2F-3a   Max   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP19 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

USP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049120:  view genomic region     (about GC identifiers)

Start:
 49,145,479 bp from pter      End:
 49,158,371 bp from pter
Size:
 12,893 bases      Orientation:
 minus strand

Proteins
for USP19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 19  
Size: 1318 amino acids; 145651 Da
Subunit: Interacts with RNF123 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts
with HIF1A (via N-terminus)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence caution: Sequence=AAI06030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI06030.1; Type=Frameshift; Positions=572; Sequence=AAI42661.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=BAA74914.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for USP19:
1WH0 (3D)    
Secondary accessions: A5PKX8 A6H8U2 B4DGT3 E7ETS0 E9PEG8 Q3KQW4 Q641Q9 Q6NZY8 Q86XV9
Alternative splicing: 6 isoforms:  O94966-1   O94966-2   O94966-3   O94966-4   O94966-5   O94966-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP19: NX_O94966

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94966

    • 4/11 DME Specific Peptides for USP19 (O94966) (see all 11)
     GLVNLGN  FLLDGLH  IVDLFQG  NSVIQSL 

    USP19 Protein expression data from MOPED and PaxDb:    About this image 
    USP19 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001186089.1  NP_001186090.1  NP_001186091.1  NP_006668.1  

    ENSEMBL proteins: 
     ENSP00000381870   ENSP00000381872   ENSP00000395260   ENSP00000400090   ENSP00000381867  
     ENSP00000381863   ENSP00000401197   ENSP00000303503   ENSP00000428539  

    Human Recombinant Protein Products for USP19: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: USP19
    OriGene Custom Protein Services for USP19 
    GenScript Custom Purified and Recombinant Proteins Services for USP19
    Novus Biologicals USP19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP19

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA19465887
    GO:0005829cytosol ----
    GO:0016021integral to membrane IEA--

    USP19 for ontologies           About GeneDecksing



    USP19 Antibody Products: 
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    Novus Biologicals USP19 Antibodies
    Abcam antibodies for USP19 
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    ThermoFisher Antibodies for USP19

    Assay Products for USP19: 
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    Uscn ELISAs and CLIAs for USP19

    Protein Domains /
    Families
    for USP19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP19 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR002893 Znf_MYND
     IPR015054 DUF1872
     IPR001394 Peptidase_C19
     IPR008978 HSP20-like_chaperone
     IPR017447 CS_domain

    Graphical View of Domain Structure for InterPro Entry O94966

    ProtoNet protein and cluster: O94966

    2 Blocks protein families:
    IPB001394 Ubiquitin thiolesterase
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: UBP19_HUMAN, O94966
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 2 CS domains
    Similarity: Contains 1 MYND-type zinc finger


    Function
    for USP19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP19_HUMAN, O94966
    Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents
    proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a
    role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates
    transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated
    degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their
    ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a
    non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of
    ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards
    'Lys-63'-linked Ubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP19:
    putative ubiquitin specific protease 19,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0004843ubiquitin-specific protease activity IDA19465887
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    USP19 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP19:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP19 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: USP19
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP19
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate USP19 (see all 12):
    hsa-miR-3163 hsa-miR-492 hsa-miR-15a hsa-miR-497 hsa-miR-4282 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmid: USP19 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP19 (see all 7)
    OriGene shRNA RFP: USP19
    OriGene siRNA: USP19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP19
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP19 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USP19
    Sirion Biotech Customized adenovirus for overexpression of USP19 
    Sirion Biotech Customized adenovirus for potent knockdown of USP19

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP19 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): USP19 (NM_001199162)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP19 

    Cell Line
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    Search LifeMap BioReagents cell lines for USP19
    Sirion Biotech Customized stable knockdown cell line services for USP19 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP19


    Pathways & Interactions
    for USP19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP19
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for USP19 (O949662, 3 ENSP000003818634) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFTRP135692, 3, ENSP000000030844MINT-7218998 I2D: score=1 STRING: ENSP00000003084
    CANXP278242, 3, ENSP000002474614MINT-7218984 I2D: score=1 STRING: ENSP00000247461
    PTCRAQ6ISU12, 3, ENSP000003044474MINT-7219035 I2D: score=1 STRING: ENSP00000304447
    ACADSBP459543, ENSP000003578734I2D: score=2 STRING: ENSP00000357873
    ATAD1Q8NBU53, ENSP000003390164I2D: score=2 STRING: ENSP00000339016
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0014732skeletal muscle atrophy ISS--
    GO:0016579protein deubiquitination ISS--
    GO:0030433ER-associated protein catabolic process IDA19465887
    GO:0031647regulation of protein stability ISS--

    USP19 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP19
    Search CenterWatch for drugs/clinical trials and news about USP19 / UBP19 

    Transcripts
    for USP19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP19 gene (4 alternative transcripts): 
    NM_001199160.1  NM_001199161.1  NM_001199162.1  NM_006677.2  

    Unigene Cluster for USP19:

    Ubiquitin specific peptidase 19
    Hs.255596  [show with all ESTs]
    Unigene Representative Sequence: NM_001199161
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398896 ENST00000398898 ENST00000417901(uc003cwa.3) ENST00000453664(uc003cvz.4 uc011bcg.2 uc003cwb.3 uc011bci.2)
    ENST00000398892(uc003cwc.2) ENST00000398888(uc003cwd.2) ENST00000434032(uc011bch.2)
    ENST00000483667 ENST00000306026 ENST00000464931 ENST00000479073 ENST00000488993
    ENST00000480163 ENST00000491859 ENST00000465902

    miRNA
    Products:             		 OriGene 3'-UTR Clone: USP19
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP19
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate USP19 (see all 12):
    hsa-miR-3163 hsa-miR-492 hsa-miR-15a hsa-miR-497 hsa-miR-4282 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmid: USP19 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP19 (see all 7)
    OriGene shRNA RFP: USP19
    OriGene siRNA: USP19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP19
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP19 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP19 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP19 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): USP19 (NM_001199162)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP19 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP19

    Additional cDNA sequence: 

    AB020698.1 AK294756.1 AK296447.1 AK300425.1 BC014934.1 BC048269.1 BC065909.1 BC082241.1 
    BC127009.1 BC142660.1 BC142727.1 BC146752.1 EF036501.1 

    6 DOTS entries:

    DT.100751628  DT.212382  DT.443067  DT.95085278  DT.75172514  DT.92026854 

    24/190 AceView cDNA sequences (see all 190):

    CD516950 BM828107 BM477264 BM129503 AL045144 AI200125 BG029242 BQ440780 
    BM682395 CK821109 CD108178 BM967194 AW297009 AW451502 BF941731 CA390387 
    BG826973 AA256351 BM802653 CA430202 BX475291 BC082241 AI124644 AB020698 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for USP19 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                -         
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for USP19

    Expression
    for USP19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    USP19 Expression
    About this image

    USP19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See USP19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP19

    SOURCE GeneReport for Unigene cluster: Hs.255596
        SABiosciences Custom PCR Arrays for USP19
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    Orthologs
    for USP19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USP19 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008587271 ubiquitin carboxyl-terminal hydrolase 19-like 71.22(n)
    72.19(a)    		   100858727  XM_003642004.1  XP_003642052.1 
    lizard
    (Anolis carolinensis)    		 Reptilia USP196
    		 --
    		 62(a)
    		 1 ↔ 1
    		 2(188336063-188378003)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1377213252   -- 74.76(n)    137721325 
    zebrafish
    (Danio rerio)    		 Actinopterygii BG729270.12   -- 78.84(n)    BG729270.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 51(a)
    (best of 2)    		   IV(6757531-6761964)   --


    ENSEMBL Gene Tree for USP19 (if available)
    TreeFam Gene Tree for USP19 (if available) 

    Paralogs
    for USP19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP19 gene
    USP152  USP112  USP312  USP322  USP432  USP42  USP62  
    4 SIMAP similar genes for USP19 using alignment to 8 protein entries:     UBP19_HUMAN (see all proteins):
    USP15    DKFZp761E10121    USP11    USP3

    USP19 for paralogs           About GeneDecksing



    Genomic Variants
    for USP19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in USP19 are shown (see all 176)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs49554111,2
    		C,F,H--49145304(-) CAGCTC/TTTTGG 2 -- int121Minor allele frequency- T:0.22NS EA NA WA CSA 2021
    rs1462310531,2
    		--49145322(+) TGGGGA/GCTTCA 2 -- int10--------
    rs1400795071,2
    		--49145393(+) GTCTCC/TCATAT 2 -- int10--------
    rs2006895791,2
    		--49145544(+) AATGC-/AAAAAA 2 -- ut310--------
    rs146441,2
    		A,H--49145614(+) GTACAA/TCAGAA 4 -- int1 ut317Minor allele frequency- T:0.00MN NS EA NA 489
    rs32121,2
    		C,F,O,A,H--49145741(+) TCCCAC/TTGACA 4 -- int1 ut31 ese329Minor allele frequency- T:0.31MN NA NS EA WA CSA 2866
    rs729368201,2
    		C--49146258(+) GGGGCG/CACAAC 4 -- ut31 int11Minor allele frequency- C:0.50WA 2
    rs2018345591,2
    		C--49146401(+) TCCAGC/TGACTC 6 H R int1 mis11Minor allele frequency- T:0.00EU 653
    rs1420373821,2
    		C--49146469(+) CCCAGC/GACAAA 6 V syn1 int10--------
    rs799655141,2
    		C--49146612(+) AATCCG/AGGAAG 6 /R /W int1 mis11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for USP19 (49145479 - 49158371 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for USP19: --

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    Disorders / Diseases
    for USP19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP19 for disorders           About GeneDecksing

    OMIM gene information: 614471    OMIM disorders: --

    2 diseases for USP19:    About MalaCards
    hypoxia    malaria


    Export disorders for USP19 gene to outside databases

    Publications
    for USP19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP19 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with USP19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia. (PubMed id 22128162)1, 2 Altun M.... Lindsten K. (2012)
    2. The USP19 deubiquitinase regulates the stability of c -IAP1 and c-IAP2. (PubMed id 21849505)1, 2 Mei Y....Yang X. (2011)
    3. The ER-resident ubiquitin-specific protease 19 partic ipates in the UPR and rescues ERAD substrates. (PubMed id 19465887)1, 2 Hassink G.C....Lindsten K. (2009)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. (PubMed id 22689415)2 Iphofer A.... Franke R. (2012)
    8. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-b type I receptor. (PubMed id 22706160)1 Zhang L....ten Dijke P. (2012)

    External Searches for USP19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10869 HGNC: 12617 AceView: USP19 Ensembl:ENSG00000172046 euGenes: HUgn10869
    ECgene: USP19 H-InvDB: USP19

    Other Databases showing USP19 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0891

    Specialized Databases showing USP19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP19 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP19 gene:
    Search GeneIP for patents involving USP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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