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Aliases for USP19 Gene

Aliases for USP19 Gene

  • Ubiquitin Specific Peptidase 19 2 3 5
  • Zinc Finger MYND Domain-Containing Protein 9 3 4
  • Ubiquitin-Specific-Processing Protease 19 3 4
  • Ubiquitin Specific Protease 19 2 3
  • Deubiquitinating Enzyme 19 3 4
  • Ubiquitin Thioesterase 19 3 4
  • ZMYND9 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 19 3
  • Ubiquitin Thiolesterase 19 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • KIAA0891 4

External Ids for USP19 Gene

Previous GeneCards Identifiers for USP19 Gene

  • GC03P046927
  • GC03P048487
  • GC03M048999
  • GC03M049104
  • GC03M049120
  • GC03M049145

Summaries for USP19 Gene

GeneCards Summary for USP19 Gene

USP19 (Ubiquitin Specific Peptidase 19) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is MIR6125.

UniProtKB/Swiss-Prot for USP19 Gene

  • Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards Lys-63-linked Ubiquitin chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP19 Gene

Genomics for USP19 Gene

Regulatory Elements for USP19 Gene

Enhancers for USP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049068 1 FANTOM5 11.4 +52.4 52357 0.1 ARIH2 QRICH1 MIR6890 QARS USP19 LAMB2 ENSG00000223343 P4HTM LOC105377080 RN7SL182P
GH03F048551 1.3 FANTOM5 ENCODE 6.5 +561.7 561668 15.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 TMA7 WDR6 NICN1 FCF1P2 COL7A1 MIR711 ATRIP ENSG00000244380 CCDC51 FBXW12
GH03F049320 0.5 FANTOM5 1.6 -200.2 -200217 0.6 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GLIS2 WDR6 C3orf62 NICN1 AMT LAMB2 CCDC71 KLHDC8B MIR6890 QARS USP4
GH03F049118 0.6 ENCODE 0.8 +0.4 424 3.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP3 SP5 WDR6 USP19 MIR6890 QARS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USP19 on UCSC Golden Path with GeneCards custom track

Promoters for USP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001363579 338 1201 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP3 SP5

Genomic Location for USP19 Gene

Chromosome:
3
Start:
49,108,046 bp from pter
End:
49,120,938 bp from pter
Size:
12,893 bases
Orientation:
Minus strand

Genomic View for USP19 Gene

Genes around USP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP19 Gene

Proteins for USP19 Gene

  • Protein details for USP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94966-UBP19_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 19
    Protein Accession:
    O94966
    Secondary Accessions:
    • A5PKX8
    • A6H8U2
    • B4DGT3
    • B4DTZ0
    • E7EN22
    • E7ETS0
    • E9PEG8
    • Q3KQW4
    • Q641Q9
    • Q6NZY8
    • Q86XV9

    Protein attributes for USP19 Gene

    Size:
    1318 amino acids
    Molecular mass:
    145651 Da
    Quaternary structure:
    • Interacts with RNF123 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with HIF1A (via N-terminus).
    SequenceCaution:
    • Sequence=AAI06030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI06030.1; Type=Frameshift; Positions=572; Evidence={ECO:0000305}; Sequence=AAI42661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74914.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP19 Gene

    Alternative splice isoforms for USP19 Gene

neXtProt entry for USP19 Gene

Selected DME Specific Peptides for USP19 Gene

O94966:
  • LSNTRELRD
  • FLLDGLH
  • INYNNPLG
  • IVDLFQG
  • DGLHEDLN
  • LFYRRRN
  • NSVIQSL
  • TRELRDFF
  • GLVNLGN
  • NLGNTCF
  • GNTCFMN

Post-translational modifications for USP19 Gene

  • Ubiquitination at Lys 610 and Lys 1120
  • Modification sites at PhosphoSitePlus

Domains & Families for USP19 Gene

Graphical View of Domain Structure for InterPro Entry

O94966

UniProtKB/Swiss-Prot:

UBP19_HUMAN :
  • Contains 2 CS domains.
  • Belongs to the peptidase C19 family.
  • Contains 1 MYND-type zinc finger.
Domain:
  • Contains 2 CS domains.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with USP19: view

Function for USP19 Gene

Molecular function for USP19 Gene

GENATLAS Biochemistry:
putative ubiquitin specific protease 19,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards Lys-63-linked Ubiquitin chains.

Enzyme Numbers (IUBMB) for USP19 Gene

Gene Ontology (GO) - Molecular Function for USP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP 24356957
GO:0005515 protein binding IPI 21849505
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP19: view
genes like me logo Genes that share phenotypes with USP19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP19

miRNA for USP19 Gene

Clone Products

  • Addgene plasmids for USP19

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP19 Gene

Localization for USP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP19 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP19 Gene COMPARTMENTS Subcellular localization image for USP19 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 19465887
GO:0005829 cytosol IEA,IDA 24356957
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with USP19: view

Pathways & Interactions for USP19 Gene

genes like me logo Genes that share pathways with USP19: view

Pathways by source for USP19 Gene

Gene Ontology (GO) - Biological Process for USP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,ISS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 19465887
GO:0031647 regulation of protein stability ISS --
genes like me logo Genes that share ontologies with USP19: view

No data available for SIGNOR curated interactions for USP19 Gene

Transcripts for USP19 Gene

Unigene Clusters for USP19 Gene

Ubiquitin specific peptidase 19:
Representative Sequences:

Clone Products

  • Addgene plasmids for USP19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP19 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - -
SP13:
SP14: -
SP15:

ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for USP19 Gene

GeneLoc Exon Structure for
USP19
ECgene alternative splicing isoforms for
USP19

Expression for USP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP19 Gene

Protein differential expression in normal tissues from HIPED for USP19 Gene

This gene is overexpressed in Fetal Liver (23.3) and Adrenal (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP19 Gene



Protein tissue co-expression partners for USP19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP19 Gene:

USP19

SOURCE GeneReport for Unigene cluster for USP19 Gene:

Hs.255596
genes like me logo Genes that share expression patterns with USP19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP19 Gene

Orthologs for USP19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP19 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia USP19 34 35
  • 91.07 (n)
cow
(Bos Taurus)
Mammalia USP19 34 35
  • 89.72 (n)
mouse
(Mus musculus)
Mammalia Usp19 34 16 35
  • 88.03 (n)
rat
(Rattus norvegicus)
Mammalia Usp19 34
  • 87.74 (n)
oppossum
(Monodelphis domestica)
Mammalia USP19 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP19 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP19 34 35
  • 70.93 (n)
lizard
(Anolis carolinensis)
Reptilia USP19 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp19 34
  • 67.76 (n)
zebrafish
(Danio rerio)
Actinopterygii usp19 34 35
  • 65.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea H34C03.2 36
  • 51 (a)
F07A11.4 36 34 35
  • 47.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7794 34
Species where no ortholog for USP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP19 Gene

ENSEMBL:
Gene Tree for USP19 (if available)
TreeFam:
Gene Tree for USP19 (if available)

Paralogs for USP19 Gene

Paralogs for USP19 Gene

(5) SIMAP similar genes for USP19 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with USP19: view

Variants for USP19 Gene

Sequence variations from dbSNP and Humsavar for USP19 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs769399002 Pathogenic 49,122,063(+) CTTCT(-/G)TTTCT upstream-variant-2KB, reference, frameshift-variant
rs786205562 Likely pathogenic 49,121,728(-) CAGAA(G/T)AAACG upstream-variant-2KB, reference, stop-gained
rs148648480 Likely benign 49,121,989(+) GCCCC(C/T)CGGAT upstream-variant-2KB, reference, synonymous-codon
rs796052187 Likely benign 49,116,600(-) CCCGA(G/T)TCGAT upstream-variant-2KB, reference, missense
rs116836607 Benign 49,121,927(+) TGATG(C/T)CCTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP19 Gene

Variant ID Type Subtype PubMed ID
nsv834686 CNV loss 17160897

Variation tolerance for USP19 Gene

Residual Variation Intolerance Score: 7.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP19 Gene

Disorders for USP19 Gene

Relevant External Links for USP19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP19

No disorders were found for USP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP19 Gene

Publications for USP19 Gene

  1. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia. (PMID: 22128162) Altun M. … Lindsten K. (J. Biol. Chem. 2012) 3 4 64
  2. The USP19 deubiquitinase regulates the stability of c-IAP1 and c- IAP2. (PMID: 21849505) Mei Y. … Yang X. (J. Biol. Chem. 2011) 3 4 64
  3. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. (PMID: 19465887) Hassink G.C. … Lindsten K. (EMBO Rep. 2009) 3 4 64
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64

Products for USP19 Gene

Sources for USP19 Gene

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