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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP18 Gene

protein-coding   GIFtS: 60
GCID: GC22P018632

Ubiquitin Specific Peptidase 18

(Previous name: ubiquitin specific protease 18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 181 2     ISG15-Specific-Processing Protease2 3
ISG432 3 5     UBP432 5
Ubiquitin Specific Protease 181 2     Ubl Carboxyl-Terminal Hydrolase 182
Ubl Thioesterase 182 3     Ubl Thiolesterase 182
43 KDa ISG15-Specific Protease2 3     EC 3.4.19.-3
hUBP432 3     EC 3.1.2.158

External Ids:    HGNC: 126161   Entrez Gene: 112742   Ensembl: ENSG000001849797   OMIM: 6070575   UniProtKB: Q9UMW83   

Export aliases for USP18 gene to outside databases

Previous GC identifers: GC22P015573 GC22P017007 GC22P002445


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP18 Gene:
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave
ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to
the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this
gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a
major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a
function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards
ISG15. (provided by RefSeq, Sep 2011)

GeneCards Summary for USP18 Gene: 
USP18 (ubiquitin specific peptidase 18) is a protein-coding gene. Diseases associated with USP18 include lymphocytic choriomeningitis, and digeorge syndrome, and among its related super-pathways are Immune response IFN alpha/beta signaling pathway and Interferon Signaling. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8
Function: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds.
Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed
organisms

Gene Wiki entry for USP18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP18 gene promoter:
         STAT1   HTF   Pax-2   STAT1beta   Pax-2a   STAT1alpha   Pax-2b   POU2F1   HOXA5   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP18 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

USP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP18 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P018632:  view genomic region     (about GC identifiers)

Start:
18,632,666 bp from pter      End:
18,660,164 bp from pter
Size:
27,499 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8 (See protein sequence)
Recommended Name: Ubl carboxyl-terminal hydrolase 18  
Size: 372 amino acids; 43011 Da
Secondary accessions: Q6IAD9 Q9NY71

Explore the universe of human proteins at neXtProt for USP18: NX_Q9UMW8

Explore proteomics data for USP18 at MOPED 

3 DME Specific Peptides for USP18 (Q9UMW8)
 ILKRITVPR  VDGKWFCFNDS  LLLLEKMQDSRQKA 

USP18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

USP18 Protein Expression
REFSEQ proteins: NP_059110.2  
ENSEMBL proteins: 
 ENSP00000215794  
Reactome Protein details: Q9UMW8
Human Recombinant Protein Products for USP18: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for USP18 (UBP43/USP18)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for USP18
OriGene Custom MassSpec 
OriGene Custom Protein Services for USP18
GenScript Custom Purified and Recombinant Proteins Services for USP18
Novus Biologicals USP18 Proteins
Novus Biologicals USP18 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for USP18 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005829cytosol TAS--

USP18 for ontologies           About GeneDecksing



USP18 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of USP18
Browse R&D Systems for Antibodies
Cell Signaling Technology (CST) Antibodies for USP18 
Browse OriGene Antibodies
OriGene Custom Antibody Services for USP18
GenScript Custom Superior Antibodies Services for USP18
Novus Biologicals USP18 Antibodies
Abcam antibodies for USP18
Cloud-Clone Corp. Antibodies for USP18 
ThermoFisher Antibodies for USP18
LSBio Antibodies in human, mouse, rat for USP18 

Assay Products for USP18: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for USP18
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for USP18
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for USP18 
Cloud-Clone Corp. CLIAs for USP18


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
USP: Ubiquitin-specific peptidases

2 InterPro protein domains:
 IPR001394 Peptidase_C19
 IPR018200 Pept_C19ubi-hydrolase_C_CS

Graphical View of Domain Structure for InterPro Entry Q9UMW8

ProtoNet protein and cluster: Q9UMW8

1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8
Similarity: Belongs to the peptidase C19 family


USP18 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UBP18_HUMAN, Q9UMW8
Function: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds.
Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed
organisms
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

     Genatlas biochemistry entry for USP18:
ubiquitin specific protease 18,deubiquitin enzyme family

     Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004221ubiquitin thiolesterase activity IEA--
GO:0004843ubiquitin-specific protease activity TAS10777664
GO:0005515protein binding IPI16710296
     
USP18 for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp18):
 behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
 immune system  mortality/aging  nervous system 

USP18 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for USP18 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP18

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP18 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP18 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP18
4 QIAGEN miScript miRNA Assays for microRNAs that regulate USP18:
hsa-miR-146a* hsa-miR-4279 hsa-miR-216b hsa-miR-340
SwitchGear 3'UTR luciferase reporter plasmidUSP18 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for USP18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP18

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for USP18
Sirion Biotech Customized adenovirus for overexpression of USP18

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for USP18 (see all 7)
OriGene ORF clones in mouse, rat for USP18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: USP18 (NM_017414)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP18
Sirion Biotech Customized lentivirus for stable overexpression of USP18 
                     Customized lentivirus expression plasmids for stable overexpression of USP18 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for USP18
Search LifeMap BioReagents cell lines for USP18
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP18


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for USP18 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response IFN alpha/beta signaling pathway
Immune response IFN alpha/beta signaling pathway0.71
Interferon alpha/beta signaling0.45
Regulation of IFNA signaling0.71
2Interferon Signaling
Interferon Signaling0.61
Antiviral mechanism by IFN-stimulated genes0.42
Cytokine Signaling in Immune system0.61
ISG15 antiviral mechanism0.42
3Immune System
Immune System0.56
4Ubiquitin-Proteasome Dependent Proteolysis
Ubiquitin-Proteasome Dependent Proteolysis
5Protein Stability
Protein Stability

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for USP18
    Immune response IFN alpha/beta signaling pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP18
    Ubiquitin-Proteasome Dependent Proteolysis

1 Cell Signaling Technology (CST) Pathway for USP18
    Protein Stability

1 GeneGo (Thomson Reuters) Pathway for USP18
    Immune response IFN alpha/beta signaling pathway

5/7        Reactome Pathways for USP18 (see all 7)
    Regulation of IFNA signaling
Antiviral mechanism by IFN-stimulated genes
Interferon alpha/beta signaling
Cytokine Signaling in Immune system
Interferon Signaling



USP18 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP18

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for USP18 (Q9UMW82, 3 ENSP000002157944) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
IKBKGQ9Y6K92, 3MINT-48210 I2D: score=2 
IFNAR2P485512, 3, ENSP000003439574MINT-2729669 MINT-2729733 MINT-2729692 MINT-2729631 I2D: score=2 STRING: ENSP00000343957
ISG15P051612, 3, ENSP000003686994MINT-66847 I2D: score=5 STRING: ENSP00000368699
KDM3BQ7LBC63, ENSP000003265634I2D: score=2 STRING: ENSP00000326563
MYL6P606603, ENSP000002934224I2D: score=2 STRING: ENSP00000293422
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006511ubiquitin-dependent protein catabolic process IEA--
GO:0019221cytokine-mediated signaling pathway TAS--
GO:0060337type I interferon-mediated signaling pathway TAS--
GO:0060338regulation of type I interferon-mediated signaling pathway TAS--

USP18 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for USP18 (UBP18)

Search CenterWatch for drugs/clinical trials and news about USP18 / UBP18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for USP18 gene: 
NM_017414.3  

Unigene Cluster for USP18:

Ubiquitin specific peptidase 18
Hs.38260  [show with all ESTs]
Unigene Representative Sequence: NM_017414
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000215794(uc002zny.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP18
4 QIAGEN miScript miRNA Assays for microRNAs that regulate USP18:
hsa-miR-146a* hsa-miR-4279 hsa-miR-216b hsa-miR-340
SwitchGear 3'UTR luciferase reporter plasmidUSP18 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for USP18
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP18
Clone
Products:
     
OriGene clones in human, mouse for USP18 (see all 7)
OriGene ORF clones in mouse, rat for USP18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: USP18 (NM_017414)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP18
Sirion Biotech Customized lentivirus for stable overexpression of USP18 
                     Customized lentivirus expression plasmids for stable overexpression of USP18 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for USP18
OriGene qSTAR qPCR primer pairs in human, mouse for USP18
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP18
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP18
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP18

Additional mRNA sequence: 

AF176642.2 AJ243526.1 AJ583822.1 AJ586979.1 AK303463.1 AK313385.1 AL136690.1 BC014896.1 
BT006835.1 CR457216.1 CT841507.1 

13 DOTS entries:

DT.100699062  DT.100775966  DT.120667954  DT.451675  DT.120642020  DT.120646499  DT.120668581  DT.100641117 
DT.91725649  DT.92422619  DT.102825674  DT.87046339  DT.95287161 

24/63 AceView cDNA sequences (see all 63):

AW172474 BF089771 AI055870 AW136867 AI352180 BU616063 BC014896 BT006835 
AI222587 BQ018510 BX280356 CR604420 AL136690 NM_017414 CD364378 AA136383 
BQ213074 AA976038 BE542857 BU944614 BM924468 AA758414 BG206330 CR457216 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for USP18    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:                    -                                                         
SP2:                                                                              
SP3:                                                                              


ECgene alternative splicing isoforms for USP18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

USP18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
USP18 Expression
About this image


See USP18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP18

SOURCE GeneReport for Unigene cluster: Hs.38260
    SABiosciences Custom PCR Arrays for USP18
Primer
Products:
OriGene qPCR primer pairs and template standards for USP18
OriGene qSTAR qPCR primer pairs in human, mouse for USP18
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP18
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP18
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP18
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP18

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP18 gene from 7/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Usp181 , 5 ubiquitin specific peptidase 181, 5 77.69(n)1
72.18(a)1
  6 (57.17 cM)5
241101  NM_011909.21  NP_036039.21 
 1212459065 
chicken
(Gallus gallus)
Aves USP181 ubiquitin specific peptidase 18 60.87(n)
53.62(a)
  418167  XM_416398.2  XP_416398.2 
lizard
(Anolis carolinensis)
Reptilia --
--
49(a)
1 → many
5(14357512-14377121)
zebrafish
(Danio rerio)
Actinopterygii LOC1003345351 ubl carboxyl-terminal hydrolase 18-like 46.43(n)
33.87(a)
  100334535  XM_002661352.1  XP_002661398.1 
fruit fly
(Drosophila melanogaster)
Insecta Ubp64E6
Ubiquitin-specific protease 64E
6(a)
1 → many
3L(5746073-5754668)
worm
(Caenorhabditis elegans)
Secernentea T05H10.16
Protein T05H10.1
7(a)
1 → many
II(8042589-8047446)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP156
Ubiquitin-specific protease involved in protein de...
6(a)
1 → many
XIII(874987-878679)


ENSEMBL Gene Tree for USP18 (if available)
TreeFam Gene Tree for USP18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for USP18 gene
USP242  USP482  USP412  USP402  USP72  USP472  USP342  USP9Y2  
USP9X2  
2 SIMAP similar genes for USP18 using alignment to 1 protein entry:     UBP18_HUMAN:
USP41    Em

USP18 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/677 SNPs in USP18 are shown (see all 677)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1150840661,2
C,F--18630760(+) TGGGCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.14WA 118
rs1392963341,2
--18630762(+) GGCCGA/GGCTGC 1 -- us2k10--------
rs1848757691,2
--18630766(+) GGGCTA/GCACCA 1 -- us2k10--------
rs1880041011,2
--18630781(+) CCATTC/TGTGTC 1 -- us2k10--------
rs622295031,2
C,F--18630802(+) CTGGGC/AAGCCC 1 -- us2k14Minor allele frequency- A:0.06NA CSA WA 241
rs1168468771,2
F--18630924(+) CGGAAT/GTGTTC 1 -- us2k11Minor allele frequency- G:0.01NA 120
rs1443330511,2
--18630949(+) AAGGAC/TGGAAG 1 -- us2k10--------
rs1925742311,2
--18630965(+) GCCCCA/GTAGAA 1 -- us2k10--------
rs1510576691,2
--18630977(+) TGTAAC/TGGATC 1 -- us2k10--------
rs1409471681,2
--18631004(+) CAGCCA/TCCAAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for USP18 (18632666 - 18660164 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/15 variations for USP18 (see all 15):    About this table     
Variant IDTypeSubtypePubMed ID
nsv471339CNV Duplication19718026
nsv914162CNV Loss21882294
esv2751935CNV Loss17911159
nsv914164CNV Gain21882294
nsv469560CNV Gain16826518
dgv173e55CNV Gain17911159
dgv4820n71CNV Gain21882294
nsv914161CNV Gain21882294
esv22247CNV Gain+Loss19812545
nsv471594CNV Gain+Loss15918152

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607057    OMIM disorders: --

9 diseases for USP18:    About MalaCards
lymphocytic choriomeningitis    digeorge syndrome    burkitt's lymphoma    hepatitis c
hepatitis    hepatitis b    lung cancer    melanoma
endotheliitis


USP18 for disorders           About GeneDecksing


Export disorders for USP18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for USP18 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with USP18)
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world of online information

  1. Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). (PubMed id 10777664)1, 2, 9 Schwer H.... Hetherington C.J. (2000)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
  4. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. (PubMed id 11788588)1, 2 Malakhov M.P.... Zhang D.-E. (2002)
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
  6. RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. (PubMed id 10722734)1, 9 Li X.L....Hassel B.A. (2000)
  7. Ubiquitin specific protease 18 (Usp18) is a WT1 transc riptional target. (PubMed id 23291318)1 Shahidul Makki M....Huff V. (2013)
  8. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
  9. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. (PubMed id 23152055)1 Santin I....Eizirik D.L. (2012)
  10. Interferon-g-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C. (PubMed id 22677194)1 Dill M.T....Heim M.H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 11274 HGNC: 12616 AceView: USP18 Ensembl:ENSG00000184979 euGenes: HUgn11274
ECgene: USP18 H-InvDB: USP18

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for USP18 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for USP18 gene:
Search GeneIP for patents involving USP18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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