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USP18 Gene

protein-coding   GIFtS: 59
GCID: GC22P018632

Ubiquitin Specific Peptidase 18

(Previous name: ubiquitin specific protease 18)
  See USP18-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 181 2     ISG15-Specific-Processing Protease2 3
ISG432 3 5     UBP432 5
Ubiquitin Specific Protease 181 2     Ubl Carboxyl-Terminal Hydrolase 182
Ubl Thioesterase 182 3     Ubl Thiolesterase 182
43 KDa ISG15-Specific Protease2 3     EC 3.4.19.-3
hUBP432 3     EC 3.1.2.158

External Ids:    HGNC: 126161   Entrez Gene: 112742   Ensembl: ENSG000001849797   OMIM: 6070575   UniProtKB: Q9UMW83   

Export aliases for USP18 gene to outside databases

Previous GC identifers: GC22P015573 GC22P017007 GC22P002445


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP18 Gene:
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave
ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to
the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this
gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a
major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a
function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards
ISG15. (provided by RefSeq, Sep 2011)

GeneCards Summary for USP18 Gene:
USP18 (ubiquitin specific peptidase 18) is a protein-coding gene. Diseases associated with USP18 include acute promyelocytic leukemia. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8
Function: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds.
Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed
organisms

Gene Wiki entry for USP18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_187355.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP18 gene promoter:
         STAT1   HTF   Pax-2   STAT1beta   Pax-2a   STAT1alpha   Pax-2b   POU2F1   HOXA5   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP18 promoter sequence
   Search Chromatin IP Primers for USP18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

USP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP18 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P018632:  view genomic region     (about GC identifiers)

Start:
18,632,666 bp from pter      End:
18,660,164 bp from pter
Size:
27,499 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8 (See protein sequence)
Recommended Name: Ubl carboxyl-terminal hydrolase 18  
Size: 372 amino acids; 43011 Da
Secondary accessions: Q6IAD9 Q9NY71

Explore the universe of human proteins at neXtProt for USP18: NX_Q9UMW8

Explore proteomics data for USP18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for USP18 (Q9UMW8)
     ILKRITVPR  VDGKWFCFNDS  LLLLEKMQDSRQKA 


    See USP18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059110.2  
    ENSEMBL proteins: 
     ENSP00000215794  
    Reactome Protein details: Q9UMW8

    USP18 Human Recombinant Protein Products:

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    Novus Biologicals USP18 Proteins
    Novus Biologicals USP18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP18

     
    Search eBioscience for Proteins for USP18 

     
    antibodies-online proteins for USP18 (5 products) 

     
    antibodies-online peptides for USP18

    USP18 Antibody Products:

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    antibodies-online kits for USP18 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q9UMW8

    ProtoNet protein and cluster: Q9UMW8

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP18_HUMAN, Q9UMW8
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP18_HUMAN, Q9UMW8
    Function: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds.
    Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed
    organisms
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP18:
    ubiquitin specific protease 18,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity TAS10777664
    GO:0005515protein binding IPI16710296
         
    Find genes that share ontologies with USP18           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp18):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system 

    Find genes that share phenotypes with USP18           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP18

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP18:
    hsa-mir-215-5p (MIRT024799), hsa-mir-192-5p (MIRT026176), hsa-mir-221-3p (MIRT003365), hsa-mir-26b-5p (MIRT028905)

    Block miRNA regulation of human, mouse, rat USP18 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate USP18:
    hsa-miR-146a* hsa-miR-4279 hsa-miR-216b hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidUSP18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP18

    Gene Editing
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    Sino Biological Human cDNA Clone for USP18
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP18
    Addgene plasmids for USP18 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with USP18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP18 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    Regulation of IFNA signaling0.69
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4Protein Stability
    Protein Stability


    Find genes that share SuperPaths with USP18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP18
        Ubiquitin-Proteasome Dependent Proteolysis

    1 Cell Signaling Technology (CST) Pathway for USP18
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for USP18
        Immune response IFN alpha/beta signaling pathway


    2 Reactome Pathways for USP18
        Regulation of IFNA signaling
    ISG15 antiviral mechanism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP18
    Interactions:

        Search GeneGlobe Interaction Network for USP18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for USP18 (Q9UMW81, 2, 3 ENSP000002157944) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48210 I2D: score=2 
    IFNAR2P485511, 2, 3, ENSP000003439574EBI-356206,EBI-958408 MINT-2729669 MINT-2729733 MINT-2729692 MINT-2729631 I2D: score=2 STRING: ENSP00000343957
    ISG15P051612, 3, ENSP000003686994MINT-66847 I2D: score=5 STRING: ENSP00000368699
    KDM3BQ7LBC63, ENSP000003265634I2D: score=2 STRING: ENSP00000326563
    MYL6P606603, ENSP000002934224I2D: score=2 STRING: ENSP00000293422
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0060337type I interferon signaling pathway TAS--
    GO:0060338regulation of type I interferon-mediated signaling pathway TAS--

    Find genes that share ontologies with USP18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP18 (UBP18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP18 gene: 
    NM_017414.3  

    Unigene Cluster for USP18:

    Ubiquitin specific peptidase 18
    Hs.38260  [show with all ESTs]
    Unigene Representative Sequence: NM_017414
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000215794(uc002zny.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate USP18:
    hsa-miR-146a* hsa-miR-4279 hsa-miR-216b hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidUSP18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP18
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF176642.2 AJ243526.1 AJ583822.1 AJ586979.1 AK303463.1 AK313385.1 AL136690.1 BC014896.1 
    BT006835.1 CR457216.1 CT841507.1 

    13 DOTS entries:

    DT.100699062  DT.100775966  DT.120667954  DT.451675  DT.120642020  DT.120646499  DT.120668581  DT.100641117 
    DT.91725649  DT.92422619  DT.102825674  DT.87046339  DT.95287161 

    Selected AceView cDNA sequences (see all 63):

    AA136383 CD364378 AL136690 BQ213074 AA976038 NM_017414 CR604420 AW136867 
    BC014896 AI055870 AI222587 BQ018510 BU616063 BT006835 AW172474 BF089771 
    BX280356 AI352180 AF176642 BU944614 BG206330 BE542857 CF265188 BV177304 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for USP18    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -                                                         
    SP2:                                                                              
    SP3:                                                                              


    ECgene alternative splicing isoforms for USP18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP18 Expression
    About this image

    USP18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38260
        Custom PCR Arrays for USP18
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP18 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp181 , 5 ubiquitin specific peptidase 181, 5 77.69(n)1
    72.18(a)1
      6 (57.17 cM)5
    241101  NM_011909.21  NP_036039.21 
     1212459065 
    chicken
    (Gallus gallus)
    Aves USP181 ubiquitin specific peptidase 18 60.84(n)
    53.94(a)
      418167  XM_004937959.1  XP_004938016.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp181 ubiquitin specific peptidase 18 50.49(n)
    41.81(a)
      100486062  XM_004912493.1  XP_004912550.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003345351 ubl carboxyl-terminal hydrolase 18-like 46.03(n)
    33.44(a)
      100334535  XM_002661352.2  XP_002661398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubp64E6
    Ubiquitin-specific protease 64E
    6(a)
    1 → many
    3L(5746073-5754668)
    worm
    (Caenorhabditis elegans)
    Secernentea T05H10.16
    Protein T05H10.1 (T05H10.1) mRNA, complete cds
    7(a)
    1 → many
    II(8042589-8047446) WBGene00011507
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP156
    Ubiquitin-specific protease involved in protein de...
    6(a)
    1 → many
    XIII(874987-878679) YMR304W


    ENSEMBL Gene Tree for USP18 (if available)
    TreeFam Gene Tree for USP18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP18 gene
    USP242  USP482  USP412  USP402  USP72  USP472  USP342  USP9Y2  
    USP9X2  
    2 SIMAP similar genes for USP18 using alignment to 1 protein entry:     UBP18_HUMAN:
    USP41    Em

    Find genes that share paralogs with USP18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP18 (see all 677)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150840661,2
    C,F--18630760(+) TGGGCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.14WA 118
    rs1392963341,2
    --18630762(+) GGCCGA/GGCTGC 1 -- us2k10--------
    rs1848757691,2
    --18630766(+) GGGCTA/GCACCA 1 -- us2k10--------
    rs1880041011,2
    --18630781(+) CCATTC/TGTGTC 1 -- us2k10--------
    rs622295031,2
    C,F--18630802(+) CTGGGC/AAGCCC 1 -- us2k14Minor allele frequency- A:0.06NA CSA WA 241
    rs1168468771,2
    F--18630924(+) CGGAAT/GTGTTC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1443330511,2
    --18630949(+) AAGGAC/TGGAAG 1 -- us2k10--------
    rs1925742311,2
    --18630965(+) GCCCCA/GTAGAA 1 -- us2k10--------
    rs1510576691,2
    --18630977(+) TGTAAC/TGGATC 1 -- us2k10--------
    rs1409471681,2
    --18631004(+) CAGCCA/TCCAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP18 (18632666 - 18660164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP18 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471339CNV Duplication19718026
    nsv914162CNV Loss21882294
    esv2751935CNV Loss17911159
    nsv914164CNV Gain21882294
    nsv469560CNV Gain16826518
    dgv173e55CNV Gain17911159
    dgv4820n71CNV Gain21882294
    nsv914161CNV Gain21882294
    esv22247CNV Gain+Loss19812545
    nsv471594CNV Gain+Loss15918152

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607057    OMIM disorders: --

    1 disease for USP18:    
    About MalaCards
    acute promyelocytic leukemia


    Find genes that share disorders with USP18           About GenesLikeMe


    Export disorders for USP18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP18 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with USP18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). (PubMed id 10777664)1, 2, 9 Schwer H.... Hetherington C.J. (Genomics 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    4. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. (PubMed id 11788588)1, 2 Malakhov M.P.... Zhang D.-E. (J. Biol. Chem. 2002)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. (PubMed id 10722734)1, 9 Li X.L....Hassel B.A. (J. Biol. Chem. 2000)
    7. Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target. (PubMed id 23291318)1 Shahidul Makki M....Huff V. (Exp. Cell Res. 2013)
    8. A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (Biochim. Biophys. Acta 2012)
    9. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. (PubMed id 23152055)1 Santin I....Eizirik D.L. (amp 2012)
    10. Interferon-I^-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C. (PubMed id 22677194)1 Dill M.T....Heim M.H. (Gastroenterology 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11274 HGNC: 12616 AceView: USP18 Ensembl:ENSG00000184979 euGenes: HUgn11274
    ECgene: USP18 H-InvDB: USP18

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for USP18 gene:
    Search GeneIP for patents involving USP18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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