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Aliases for USP18 Gene

Aliases for USP18 Gene

  • Ubiquitin Specific Peptidase 18 2 3
  • ISG43 3 4 6
  • ISG15-Specific-Processing Protease 3 4
  • Ubiquitin Specific Protease 18 2 3
  • 43 KDa ISG15-Specific Protease 3 4
  • Ubl Thioesterase 18 3 4
  • HUBP43 3 4
  • UBP43 3 6
  • Ubl Carboxyl-Terminal Hydrolase 18 3
  • Ubl Thiolesterase 18 3
  • EC 63
  • EC 3.4.19.- 4

External Ids for USP18 Gene

Previous GeneCards Identifiers for USP18 Gene

  • GC22P015573
  • GC22P017007
  • GC22P018632
  • GC22P002445

Summaries for USP18 Gene

Entrez Gene Summary for USP18 Gene

  • The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

GeneCards Summary for USP18 Gene

USP18 (Ubiquitin Specific Peptidase 18) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP18 Gene

  • Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms

  • Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).

Gene Wiki entry for USP18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP18 Gene

Genomics for USP18 Gene

Regulatory Elements for USP18 Gene

Genomic Location for USP18 Gene

18,149,899 bp from pter
18,177,397 bp from pter
27,499 bases
Plus strand

Genomic View for USP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP18 Gene

Proteins for USP18 Gene

  • Protein details for USP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubl carboxyl-terminal hydrolase 18
    Protein Accession:
    Secondary Accessions:
    • Q53Y90
    • Q6IAD9
    • Q9NY71

    Protein attributes for USP18 Gene

    372 amino acids
    Molecular mass:
    43011 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP18 Gene


neXtProt entry for USP18 Gene

Proteomics data for USP18 Gene at MOPED

Selected DME Specific Peptides for USP18 Gene

Post-translational modifications for USP18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for USP18 Gene

Gene Families for USP18 Gene

  • USP :Ubiquitin-specific peptidases

Protein Domains for USP18 Gene

Suggested Antigen Peptide Sequences for USP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UMW8
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP18: view

Function for USP18 Gene

Molecular function for USP18 Gene

GENATLAS Biochemistry: ubiquitin specific protease 18,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms
UniProtKB/Swiss-Prot Function: Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).

Enzyme Numbers (IUBMB) for USP18 Gene

Gene Ontology (GO) - Molecular Function for USP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity TAS 10777664
GO:0005515 protein binding IPI 16189514
GO:0019785 ISG15-specific protease activity IBA --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP18: view
genes like me logo Genes that share phenotypes with USP18: view

miRNA for USP18 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP18 Gene

Localization for USP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP18 Gene

Isoform 1: Cytoplasm.
Isoform 2: Nucleus.

Subcellular locations from

Jensen Localization Image for USP18 Gene COMPARTMENTS Subcellular localization image for USP18 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for USP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP18: view

Pathways for USP18 Gene

genes like me logo Genes that share pathways with USP18: view

Pathways by source for USP18 Gene

1 Qiagen pathway for USP18 Gene
1 Cell Signaling Technology pathway for USP18 Gene

Gene Ontology (GO) - Biological Process for USP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IBA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with USP18: view

Transcripts for USP18 Gene

mRNA/cDNA for USP18 Gene

Unigene Clusters for USP18 Gene

Ubiquitin specific peptidase 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -

Relevant External Links for USP18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP18 Gene

mRNA expression in normal human tissues for USP18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP18 Gene

SOURCE GeneReport for Unigene cluster for USP18 Gene Hs.38260

genes like me logo Genes that share expressions with USP18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP18 Gene

Orthologs for USP18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP18 35
  • 99.01 (n)
  • 98.92 (a)
USP18 36
  • 99 (a)
(Bos Taurus)
Mammalia USP18 35
  • 81.3 (n)
  • 76.18 (a)
USP18 36
  • 76 (a)
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
USP18 35
  • 84.68 (n)
  • 81.19 (a)
(Mus musculus)
Mammalia Usp18 35
  • 77.69 (n)
  • 72.18 (a)
Usp18 16
Usp18 36
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Usp18 35
  • 78.8 (n)
  • 73.39 (a)
(Gallus gallus)
Aves USP18 35
  • 60.84 (n)
  • 53.94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp18 35
  • 50.49 (n)
  • 41.81 (a)
(Danio rerio)
Actinopterygii LOC100334535 35
  • 46.03 (n)
  • 33.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ubp64E 36
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T05H10.1 36
  • 7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
Species with no ortholog for USP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP18 Gene

Gene Tree for USP18 (if available)
Gene Tree for USP18 (if available)

Paralogs for USP18 Gene

Paralogs for USP18 Gene

Selected SIMAP similar genes for USP18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP18: view

Variants for USP18 Gene

Sequence variations from dbSNP and Humsavar for USP18 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8293 -- 18,177,228(+) CTGGC(C/T)GAATA utr-variant-3-prime
rs78946 -- 18,175,729(-) ccaaa(G/T)tgccg intron-variant
rs361553 -- 18,155,845(+) tccca(C/T)cgacc intron-variant
rs361604 -- 18,152,009(+) AGATC(C/G)GGCCA intron-variant
rs361711 -- 18,154,623(+) gtatt(-/TTTTTGT)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP18 Gene

Variant ID Type Subtype PubMed ID
nsv428385 CNV Gain+Loss 18775914
dgv1380e1 CNV Complex 17122850
nsv469560 CNV Gain 16826518
nsv471594 CNV Gain+Loss 15918152
nsv914161 CNV Gain 21882294
nsv914162 CNV Loss 21882294
nsv516997 CNV Gain+Loss 19592680
esv2751935 CNV Loss 17911159
dgv173e55 CNV Gain 17911159
esv32687 CNV Gain+Loss 17666407
dgv4820n71 CNV Gain 21882294
nsv471339 CNV Duplication 19718026
nsv914164 CNV Gain 21882294
esv22247 CNV Gain+Loss 19812545
nsv514961 CNV Complex 21397061

Relevant External Links for USP18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP18 Gene

Disorders for USP18 Gene

No disorders were found for USP18 Gene.

No data available for UniProtKB/Swiss-Prot for USP18 Gene

Publications for USP18 Gene

  1. Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). (PMID: 10777664) Schwer H. … Hetherington C.J. (Genomics 2000) 3 4 23
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus. (PMID: 22170061) Burkart C. … Zhang D.E. (J. Biol. Chem. 2012) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for USP18 Gene

  • Addgene plasmids for USP18

Sources for USP18 Gene

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