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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP17L7 Gene

protein-coding   GIFtS: 23
GCID: GC08M011990

Ubiquitin Specific Peptidase 17-Like Family Member 7

(Previous name: ubiquitin specific peptidase 17-like 7)
  Search for USP17L7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 17-Like Family Member 71 2
Ubiquitin Specific Peptidase 17-Like 71 2
Inactive Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 72
EC 3.1.2.158

External Ids:    HGNC: 371801   Entrez Gene: 3921972   Ensembl: ENSG000002264307   UniProtKB: P0C7H93   

Export aliases for USP17L7 gene to outside databases

Previous GC identifer: GC08M012030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP17L7 Gene: 
USP17L7 (ubiquitin specific peptidase 17-like family member 7) is a protein-coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_077531.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP17L7 gene promoter:
         COUP-TF1   C/EBPbeta   FOXF2   ATF-2   HTF   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP17L7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

USP17L7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP17L7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M011990:  view genomic region     (about GC identifiers)

Start:
11,989,926 bp from pter      End:
11,991,953 bp from pter
Size:
2,028 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: U17L7_HUMAN, P0C7H9 (See protein sequence)
Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7  
Size: 530 amino acids; 59751 Da
Subcellular location: Nucleus (By similarity). Endoplasmic reticulum (By similarity)
Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a
copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103,
and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like
genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in
RNAi experiments are for instance not specific of a given UPS17-like gene
Caution: Phe-89 is present instead of the conserved Cys which is expected to be an active site residue suggesting
that this protein has lost its catalytic activity

Explore the universe of human proteins at neXtProt for USP17L7: NX_P0C7H9

4/6 DME Specific Peptides for USP17L7 (P0C7H9) (see all 6)
 AQSVKQAL  CTMQAHIT  VYVLYAVLVH  SDTFDPYLDI 

USP17L7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
REFSEQ proteins: NP_001243798.1  
Human Recombinant Protein Products for USP17L7: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005783endoplasmic reticulum IEA--

USP17L7 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR001394 Peptidase_C19
 IPR018200 Pept_C19ubi-hydrolase_C_CS
 IPR006861 HABP4_PAIRBP1-bd

Graphical View of Domain Structure for InterPro Entry P0C7H9

ProtoNet protein and cluster: P0C7H9

UniProtKB/Swiss-Prot: U17L7_HUMAN, P0C7H9
Similarity: Belongs to the peptidase C19 family. USP17 subfamily


USP17L7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Enzyme Number (IUBMB): EC 3.1.2.152

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004221ubiquitin thiolesterase activity IEA--
     
USP17L7 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP17L7

5/9 Interacting proteins for USP17L7 (P0C7H93) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
USP17L24Q0WX573I2D: score=1 
USP17L25Q0WX573I2D: score=1 
USP17L26Q0WX573I2D: score=1 
USP17L27Q0WX573I2D: score=1 
USP17L28Q0WX573I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006511ubiquitin-dependent protein catabolic process IEA--

USP17L7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for USP17L7 (U17L7)

Search CenterWatch for drugs/clinical trials and news about USP17L7 / U17L7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for USP17L7 gene: 
NM_001256869.1  

Unigene Cluster for USP17L7:

Ubiquitin specific peptidase 17-like family member 7
Hs.741132
Unigene Representative Sequence: NM_001256869
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000530447 ENST00000416902
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

USP17L7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
USP17L7 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.741132
    SABiosciences Custom PCR Arrays for USP17L7
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for USP17L7 (if available)
TreeFam Gene Tree for USP17L7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for USP17L7 gene
18/29 SIMAP similar genes for USP17L7 using alignment to 1 protein entry:     U17L7_HUMAN(see all similar genes):
USP17L17    USP17L2    USP17L22    USP17L4    USP17L11    USP17L12
USP17L13    USP17L15    USP17L18    USP17L19    USP17L20    USP17L21
USP17L24    USP17L25    USP17L26    USP17L27    USP17L28    USP17L29

USP17L7 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in USP17L7 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0515274
----see VAR_0515272 P L mis40--------
VAR_0515264
----see VAR_0515262 A G mis40--------

HapMap Linkage Disequilibrium report for USP17L7 (11989926 - 11991953 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for USP17L7: --
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for USP17L7 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with USP17L7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PubMed id 17109758)1, 2, 3 Shin J.-M.... Baek K.-H. (2006)
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PubMed id 15780755)1, 2, 3 Burrows J.F.... Johnston J.A. (2005)
  3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
  4. The deubiquitinating enzyme USP17 is essential for GT Pase subcellular localization and cell motility. (PubMed id 21448158)1 de la Vega M....Johnston J.A. (2011)
  5. Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494)1 Ramakrishna S....Baek K.H. (2011)
  6. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progressi on. (PubMed id 20388806)1 McFarlane C....Johnston J.A. (2010)
  7. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number var iable beta-defensin cluster. (PubMed id 20403174)1 Burrows J.F....Johnston J.A. (2010)
  8. Polyclonal and monoclonal antibodies specific for USP1 7, a proapoptotic deubiquitinating enzyme. (PubMed id 20715989)1 Ramakrishna S....Baek K.H. (2010)
  9. Cdc25A and Dub3 in a high-stakes balancing act. (PubMed id 20228807)1 Hayes S.D. and Harper J.W. (2010)
  10. The ubiquitin-specific protease 17 is involved in vir us-triggered type I IFN signaling. (PubMed id 20368735)1 Chen R....Shu H.B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 392197 HGNC: 37180 Ensembl:ENSG00000226430 euGenes: HUgn392197 ECgene: USP17L7
H-InvDB: USP17L7

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for USP17L7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for USP17L7 gene:
Search GeneIP for patents involving USP17L7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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 Browse SwitchGear Promoter luciferase reporter plasmids for USP17L7
 Search ThermoFisher Antibodies for USP17L7
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP17L7
 inGenious Targeting Laboratory - Custom generated mouse model solutions for USP17L7
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP17L7
Customized:
 lentivirus for stable overexpression of USP17L7
 lentivirus expression plasmids for stable overexpression of USP17L7
 adenovirus for overexpression of USP17L7
 Search LSBio for Antibodies for USP17L7
Customized transgenic rodents for:
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 Biomarker expression
 Off-target effect monitoring
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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