Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP17L6P Gene

Aliases for USP17L6P Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 6, Pseudogene 2 3 5
  • Ubiquitin Specific Peptidase 17-Like 6, Pseudogene 2 3
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 6 4
  • Ubiquitin Specific Peptidase 17-Like 6 (Pseudogene) 3
  • Deubiquitinating Enzyme 17-Like Protein 6 4
  • Ubiquitin Thioesterase 17-Like Protein 6 4
  • Chorionic Villi Deubiquitinating Enzyme 3
  • Deubiquitinating Enzyme DUB4 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • USP17L6 3
  • USP17C 4
  • USP17D 4
  • USP17N 4
  • VDUB4 3
  • DUB4 3

External Ids for USP17L6P Gene

Previous GeneCards Identifiers for USP17L6P Gene

  • GC04P008979
  • GC04P008724

Summaries for USP17L6P Gene

GeneCards Summary for USP17L6P Gene

USP17L6P (Ubiquitin Specific Peptidase 17-Like Family Member 6, Pseudogene) is a Pseudogene. GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity.

UniProtKB/Swiss-Prot for USP17L6P Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L6P Gene

Genomics for USP17L6P Gene

Genomic Location for USP17L6P Gene

Chromosome:
4
Start:
9,367,874 bp from pter
End:
9,369,070 bp from pter
Size:
1,197 bases
Orientation:
Plus strand

Genomic View for USP17L6P Gene

Genes around USP17L6P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L6P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L6P Gene

No data available for Regulatory Elements for USP17L6P Gene

Proteins for USP17L6P Gene

  • Protein details for USP17L6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QN14-U17L6_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 6
    Protein Accession:
    Q6QN14

    Protein attributes for USP17L6P Gene

    Size:
    398 amino acids
    Molecular mass:
    44690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L6P Gene

Proteomics data for USP17L6P Gene at MOPED

Post-translational modifications for USP17L6P Gene

No Post-translational modifications

Domains & Families for USP17L6P Gene

Protein Domains for USP17L6P Gene

Suggested Antigen Peptide Sequences for USP17L6P Gene

Graphical View of Domain Structure for InterPro Entry

Q6QN14

UniProtKB/Swiss-Prot:

U17L6_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L6P: view

No data available for Gene Families for USP17L6P Gene

Function for USP17L6P Gene

Molecular function for USP17L6P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.

Enzyme Numbers (IUBMB) for USP17L6P Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L6P Gene

Localization for USP17L6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L6P Gene

Nucleus. Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for USP17L6P Gene

Pathways & Interactions for USP17L6P Gene

SuperPathways for USP17L6P Gene

No Data Available

Interacting Proteins for USP17L6P Gene

Gene Ontology (GO) - Biological Process for USP17L6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP17L6P: view

No data available for Pathways by source and SIGNOR curated interactions for USP17L6P Gene

Drugs & Compounds for USP17L6P Gene

No Compound Related Data Available

Transcripts for USP17L6P Gene

mRNA/cDNA for USP17L6P Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L6P Gene

No ASD Table

Relevant External Links for USP17L6P Gene

GeneLoc Exon Structure for
USP17L6P
ECgene alternative splicing isoforms for
USP17L6P

Expression for USP17L6P Gene

mRNA expression in normal human tissues for USP17L6P Gene

SOURCE GeneReport for Unigene cluster for USP17L6P Gene Hs.722658

genes like me logo Genes that share expression patterns with USP17L6P: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP17L6P Gene

Orthologs for USP17L6P Gene

Evolution for USP17L6P Gene

ENSEMBL:
Gene Tree for USP17L6P (if available)
TreeFam:
Gene Tree for USP17L6P (if available)

No data available for Orthologs for USP17L6P Gene

Paralogs for USP17L6P Gene

genes like me logo Genes that share paralogs with USP17L6P: view

No data available for Paralogs for USP17L6P Gene

Variants for USP17L6P Gene

Sequence variations from dbSNP and Humsavar for USP17L6P Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6835865 -- 9,369,088(+) GAAAC(A/C/T)AAATA downstream-variant-500B
rs6857414 -- 9,368,938(+) GTCAC(C/T)GCCTC nc-transcript-variant
rs6853122 -- 9,369,236(+) GGGTT(C/G)CTCTT downstream-variant-500B
rs6857841 -- 9,369,171(+) CAGTG(C/T)CTAGT downstream-variant-500B
rs6858036 -- 9,369,222(+) TAACC(C/G)TGGTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for USP17L6P Gene

Variant ID Type Subtype PubMed ID
dgv1569e1 CNV Complex 17122850
nsv428437 CNV Gain 18775914
dgv1570e1 CNV Complex 17122850
dgv922e199 CNV Deletion 23128226
esv2678198 CNV Deletion 23128226
nsv469637 CNV Loss 16826518
nsv471623 CNV Gain+Loss 15918152
dgv1572e1 CNV Complex 17122850
dgv1573e1 CNV Complex 17122850
dgv1574e1 CNV Complex 17122850
esv1010945 CNV Gain 20482838
esv22777 CNV Gain+Loss 19812545
nsv4227 CNV Loss 18451855
nsv878640 CNV Loss 21882294
dgv5467n71 CNV Gain 21882294
nsv878643 CNV Gain+Loss 21882294
esv2727131 CNV Deletion 23290073
nsv829856 CNV Gain+Loss 17160897

Relevant External Links for USP17L6P Gene

HapMap Linkage Disequilibrium report
USP17L6P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L6P Gene

Disorders for USP17L6P Gene

Relevant External Links for USP17L6P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L6P

No disorders were found for USP17L6P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L6P Gene

Publications for USP17L6P Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 2 3 4 67
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 2 3
  3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3
  4. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3
  5. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3

Products for USP17L6P Gene

Sources for USP17L6P Gene

Back to Top

Content