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Aliases for USP17L6P Gene

Aliases for USP17L6P Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 6, Pseudogene 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 6 4
  • Ubiquitin Specific Peptidase 17-Like 6 (Pseudogene) 3
  • Ubiquitin Specific Peptidase 17-Like 6, Pseudogene 2
  • Deubiquitinating Enzyme 17-Like Protein 6 4
  • Ubiquitin Thioesterase 17-Like Protein 6 4
  • Chorionic Villi Deubiquitinating Enzyme 3
  • Deubiquitinating Enzyme DUB4 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 58
  • USP17L6 3
  • USP17C 4
  • USP17D 4
  • USP17N 4
  • VDUB4 3
  • DUB4 3

External Ids for USP17L6P Gene

Previous GeneCards Identifiers for USP17L6P Gene

  • GC04P008979
  • GC04P008724

Summaries for USP17L6P Gene

GeneCards Summary for USP17L6P Gene

USP17L6P (Ubiquitin Specific Peptidase 17-Like Family Member 6, Pseudogene) is a Pseudogene. GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity.

UniProtKB/Swiss-Prot for USP17L6P Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.

Additional gene information for USP17L6P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L6P Gene

Genomics for USP17L6P Gene

Regulatory Elements for USP17L6P Gene

Enhancers for USP17L6P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H009380 0.6 Ensembl 0.4 +13.3 13344 0 CTCF ZNF654 ZNF680 ZBTB2 NRF1 REST RAD21 GLIS2 ZNF423 FAM86KP ENSG00000205959 ENSG00000219492 USP17L6P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP17L6P on UCSC Golden Path with GeneCards custom track

Genomic Location for USP17L6P Gene

Chromosome:
4
Start:
9,367,874 bp from pter
End:
9,369,070 bp from pter
Size:
1,197 bases
Orientation:
Plus strand

Genomic View for USP17L6P Gene

Genes around USP17L6P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L6P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L6P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L6P Gene

Proteins for USP17L6P Gene

  • Protein details for USP17L6P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QN14-U17L6_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 6
    Protein Accession:
    Q6QN14

    Protein attributes for USP17L6P Gene

    Size:
    398 amino acids
    Molecular mass:
    44690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L6P Gene

Selected DME Specific Peptides for USP17L6P Gene

Q6QN14:
  • SDTFDPYLDI
  • WRSQIKCL
  • VYVLYAVLVH
  • QALEQLVKPEELNGENAYHCG
  • HEFLMFTVDAMKKACLPGHKQVDHH
  • QCLTYTPPLANY
  • SVLSQQAYVLFYI
  • TLTLHTSAKVLILVLKRFSDV
  • CTMQAHIT
  • RVDLCDDLAPVARQLAPR
  • GFHRGKQED

Post-translational modifications for USP17L6P Gene

No Post-translational modifications

Domains & Families for USP17L6P Gene

Protein Domains for USP17L6P Gene

Suggested Antigen Peptide Sequences for USP17L6P Gene

Graphical View of Domain Structure for InterPro Entry

Q6QN14

UniProtKB/Swiss-Prot:

U17L6_HUMAN :
  • Belongs to the peptidase C19 family. USP17 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L6P: view

No data available for Gene Families for USP17L6P Gene

Function for USP17L6P Gene

Molecular function for USP17L6P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, cell migration, and the cellular response to viral infection. Seems to be non-functional in the regulation of apoptosis.

Enzyme Numbers (IUBMB) for USP17L6P Gene

Gene Ontology (GO) - Molecular Function for USP17L6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 NOT RNA binding IDA 17109758
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 17109758
GO:0005540 NOT hyaluronic acid binding IDA 17109758
genes like me logo Genes that share ontologies with USP17L6P: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for USP17L6P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L6P Gene

Localization for USP17L6P Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L6P Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for USP17L6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17109758
GO:0005737 cytoplasm IDA 17109758
genes like me logo Genes that share ontologies with USP17L6P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for USP17L6P Gene

Pathways & Interactions for USP17L6P Gene

SuperPathways for USP17L6P Gene

No Data Available

Interacting Proteins for USP17L6P Gene

Gene Ontology (GO) - Biological Process for USP17L6P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IDA 17109758
GO:1904035 NOT regulation of epithelial cell apoptotic process IDA 17109758
genes like me logo Genes that share ontologies with USP17L6P: view

No data available for Pathways by source and SIGNOR curated interactions for USP17L6P Gene

Drugs & Compounds for USP17L6P Gene

No Compound Related Data Available

Transcripts for USP17L6P Gene

mRNA/cDNA for USP17L6P Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for USP17L6P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L6P Gene

No ASD Table

Relevant External Links for USP17L6P Gene

GeneLoc Exon Structure for
USP17L6P
ECgene alternative splicing isoforms for
USP17L6P

Expression for USP17L6P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP17L6P Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L6P Gene:

USP17L6P

SOURCE GeneReport for Unigene cluster for USP17L6P Gene:

Hs.722658
genes like me logo Genes that share expression patterns with USP17L6P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L6P Gene

Orthologs for USP17L6P Gene

Evolution for USP17L6P Gene

ENSEMBL:
Gene Tree for USP17L6P (if available)
TreeFam:
Gene Tree for USP17L6P (if available)

No data available for Orthologs for USP17L6P Gene

Paralogs for USP17L6P Gene

No data available for Paralogs for USP17L6P Gene

Variants for USP17L6P Gene

Sequence variations from dbSNP and Humsavar for USP17L6P Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1002068772 -- 9,369,184(+) CTACC(C/G/T)CCCAA downstream-variant-500B
rs1002099863 -- 9,369,260(+) ATTCT(C/G/T)CTGAC downstream-variant-500B
rs10022360 -- 9,368,877(+) ACATT(A/G/T)CTTCT nc-transcript-variant
rs10032245 -- 9,368,964(+) CCTGA(A/C/G)TCAAC nc-transcript-variant
rs10032443 -- 9,369,191(+) ccaaa(A/G/T)atAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for USP17L6P Gene

Variant ID Type Subtype PubMed ID
dgv2934e59 CNV duplication 20981092
dgv5096n100 CNV gain 25217958
dgv5097n100 CNV gain 25217958
dgv5098n100 CNV gain+loss 25217958
dgv5099n100 CNV gain 25217958
dgv5100n100 CNV gain 25217958
dgv5101n100 CNV gain+loss 25217958
dgv5102n100 CNV gain 25217958
dgv5103n100 CNV gain 25217958
dgv5104n100 CNV gain 25217958
dgv8958n54 CNV gain 21841781
dgv922e199 CNV deletion 23128226
esv1010945 CNV gain 20482838
esv22777 CNV gain+loss 19812545
esv2678198 CNV deletion 23128226
esv2727131 CNV deletion 23290073
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
esv3584797 CNV loss 24956385
nsv1001942 CNV loss 25217958
nsv1002765 CNV loss 25217958
nsv1004543 CNV gain 25217958
nsv1005698 CNV gain 25217958
nsv1008919 CNV gain 25217958
nsv1014242 CNV loss 25217958
nsv4227 CNV deletion 18451855
nsv428437 CNV gain 18775914
nsv469637 CNV loss 16826518
nsv471623 CNV gain+loss 15918152
nsv593646 CNV gain 21841781
nsv829856 CNV gain+loss 17160897
nsv980182 CNV duplication 23825009

Relevant External Links for USP17L6P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L6P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L6P Gene

Disorders for USP17L6P Gene

Relevant External Links for USP17L6P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L6P

No disorders were found for USP17L6P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L6P Gene

Publications for USP17L6P Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin JM … Baek KH (BMC genomics 2006) 2 3 4 60
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows JF … Johnston JA (Genomics 2005) 2 3 4 60
  3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3 60
  4. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M … Johnston JA (Nature communications 2011) 3 60
  5. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M … Johnston JA (The Journal of biological chemistry 2010) 3 60

Products for USP17L6P Gene

Sources for USP17L6P Gene

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