Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP17L5 Gene

Aliases for USP17L5 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 5 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 5 4
  • Deubiquitinating Enzyme 17-Like Protein 5 4
  • Ubiquitin Thioesterase 17-Like Protein 5 4
  • Ubiquitin Specific Peptidase 17-Like 5 2
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63

External Ids for USP17L5 Gene

Previous GeneCards Identifiers for USP17L5 Gene

  • GC04P008952

Summaries for USP17L5 Gene

GeneCards Summary for USP17L5 Gene

USP17L5 (Ubiquitin Specific Peptidase 17-Like Family Member 5) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP17L5 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L5 Gene

Genomics for USP17L5 Gene

Regulatory Elements for USP17L5 Gene

Transcription factor binding sites by QIAGEN in the USP17L5 gene promoter:

Genomic Location for USP17L5 Gene

Chromosome:
4
Start:
9,339,403 bp from pter
End:
9,340,995 bp from pter
Size:
1,593 bases
Orientation:
Plus strand

Genomic View for USP17L5 Gene

Genes around USP17L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L5 Gene

Proteins for USP17L5 Gene

  • Protein details for USP17L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUK1-U17L5_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 5
    Protein Accession:
    A8MUK1

    Protein attributes for USP17L5 Gene

    Size:
    530 amino acids
    Molecular mass:
    59683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L5 Gene

Proteomics data for USP17L5 Gene at MOPED

Post-translational modifications for USP17L5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L5 Gene

Protein Domains for USP17L5 Gene

Suggested Antigen Peptide Sequences for USP17L5 Gene

Graphical View of Domain Structure for InterPro Entry

A8MUK1

UniProtKB/Swiss-Prot:

U17L5_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L5: view

No data available for Gene Families for USP17L5 Gene

Function for USP17L5 Gene

Molecular function for USP17L5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L5 Gene

Gene Ontology (GO) - Molecular Function for USP17L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP17L5: view

Phenotypes for USP17L5 Gene

genes like me logo Genes that share phenotypes with USP17L5: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L5 Gene

Localization for USP17L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L5 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP17L5 Gene COMPARTMENTS Subcellular localization image for USP17L5 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for USP17L5 Gene

Pathways & Interactions for USP17L5 Gene

SuperPathways for USP17L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP17L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with USP17L5: view

No data available for Pathways by source and SIGNOR curated interactions for USP17L5 Gene

Drugs & Compounds for USP17L5 Gene

No Compound Related Data Available

Transcripts for USP17L5 Gene

mRNA/cDNA for USP17L5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L5 Gene

No ASD Table

Relevant External Links for USP17L5 Gene

GeneLoc Exon Structure for
USP17L5
ECgene alternative splicing isoforms for
USP17L5

Expression for USP17L5 Gene

mRNA expression in normal human tissues for USP17L5 Gene

SOURCE GeneReport for Unigene cluster for USP17L5 Gene Hs.740243

genes like me logo Genes that share expression patterns with USP17L5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP17L5 Gene

Orthologs for USP17L5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17la 36
  • 45 (a)
ManyToMany
Usp17lb 36
  • 47 (a)
ManyToMany
Usp17lc 36
  • 45 (a)
ManyToMany
Usp17ld 36
  • 44 (a)
ManyToMany
Usp17le 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 36
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 20 (a)
OneToMany
Species with no ortholog for USP17L5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L5 Gene

ENSEMBL:
Gene Tree for USP17L5 (if available)
TreeFam:
Gene Tree for USP17L5 (if available)

Paralogs for USP17L5 Gene

genes like me logo Genes that share paralogs with USP17L5: view

Variants for USP17L5 Gene

Sequence variations from dbSNP and Humsavar for USP17L5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs142784386 -- 9,338,743(+) AGGTT(A/T)TCGCT upstream-variant-2KB
rs147432277 -- 9,338,787(+) TCTCA(C/T)TAGGG upstream-variant-2KB
rs201988425 -- 9,340,862(+) CCTGC(A/T)AAACC reference, missense
rs200006135 -- 9,340,692(+) ACTCA(C/G)GAAAG reference, missense
rs201042543 -- 9,340,636(+) GAGAC(C/T)ACCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for USP17L5 Gene

Variant ID Type Subtype PubMed ID
dgv1569e1 CNV Complex 17122850
nsv428437 CNV Gain 18775914
dgv1570e1 CNV Complex 17122850
dgv922e199 CNV Deletion 23128226
esv2678198 CNV Deletion 23128226
nsv469637 CNV Loss 16826518
nsv471623 CNV Gain+Loss 15918152
dgv1572e1 CNV Complex 17122850
dgv1573e1 CNV Complex 17122850
dgv1574e1 CNV Complex 17122850
esv1010945 CNV Gain 20482838
esv22777 CNV Gain+Loss 19812545
nsv4227 CNV Loss 18451855
nsv515014 CNV Complex 21397061
nsv515015 CNV Complex 21397061
nsv515016 CNV Complex 21397061
nsv878640 CNV Loss 21882294
dgv5467n71 CNV Gain 21882294
nsv878643 CNV Gain+Loss 21882294
esv2727131 CNV Deletion 23290073

Relevant External Links for USP17L5 Gene

HapMap Linkage Disequilibrium report
USP17L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L5 Gene

Disorders for USP17L5 Gene

Relevant External Links for USP17L5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L5

No disorders were found for USP17L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L5 Gene

Publications for USP17L5 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 2 3 4 67
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 2 3
  3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3
  4. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3
  5. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3

Products for USP17L5 Gene

Sources for USP17L5 Gene

Back to Top

Content