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Aliases for USP17L4 Gene

Aliases for USP17L4 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 4 2 3 5
  • Ubiquitin Specific Peptidase 17-Like 4 2
  • EC 3.1.2.15 61

External Ids for USP17L4 Gene

Previous GeneCards Identifiers for USP17L4 Gene

  • GC08P007187
  • GC08P007181
  • GC08P007194

Summaries for USP17L4 Gene

GeneCards Summary for USP17L4 Gene

USP17L4 (Ubiquitin Specific Peptidase 17-Like Family Member 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L4 Gene

Genomics for USP17L4 Gene

Regulatory Elements for USP17L4 Gene


Genomic Location for USP17L4 Gene

Chromosome:
8
Start:
7,337,115 bp from pter
End:
7,338,707 bp from pter
Size:
1,593 bases
Orientation:
Plus strand

Genomic View for USP17L4 Gene

Genes around USP17L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L4 Gene

Proteins for USP17L4 Gene

  • Protein details for USP17L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCW7-U17L4_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4
    Protein Accession:
    A6NCW7

    Protein attributes for USP17L4 Gene

    Size:
    530 amino acids
    Molecular mass:
    59636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L4 Gene

Post-translational modifications for USP17L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L4 Gene

Protein Domains for USP17L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for USP17L4 Gene

Graphical View of Domain Structure for InterPro Entry

A6NCW7

UniProtKB/Swiss-Prot:

U17L4_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L4: view

No data available for Gene Families for USP17L4 Gene

Function for USP17L4 Gene

Enzyme Numbers (IUBMB) for USP17L4 Gene

Gene Ontology (GO) - Molecular Function for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L4: view

Phenotypes for USP17L4 Gene

genes like me logo Genes that share phenotypes with USP17L4: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L4 Gene

Localization for USP17L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L4 Gene

Nucleus. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L4: view

No data available for Subcellular locations from COMPARTMENTS for USP17L4 Gene

Pathways & Interactions for USP17L4 Gene

genes like me logo Genes that share pathways with USP17L4: view

Pathways by source for USP17L4 Gene

Interacting Proteins for USP17L4 Gene

Gene Ontology (GO) - Biological Process for USP17L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L4: view

No data available for SIGNOR curated interactions for USP17L4 Gene

Transcripts for USP17L4 Gene

mRNA/cDNA for USP17L4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L4 Gene

No ASD Table

Relevant External Links for USP17L4 Gene

GeneLoc Exon Structure for
USP17L4
ECgene alternative splicing isoforms for
USP17L4

Expression for USP17L4 Gene

mRNA expression in normal human tissues for USP17L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L4 Gene:

USP17L4

SOURCE GeneReport for Unigene cluster for USP17L4 Gene:

Hs.741134
genes like me logo Genes that share expression patterns with USP17L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USP17L4 Gene

Orthologs for USP17L4 Gene

Evolution for USP17L4 Gene

ENSEMBL:
Gene Tree for USP17L4 (if available)
TreeFam:
Gene Tree for USP17L4 (if available)

No data available for Orthologs for USP17L4 Gene

Paralogs for USP17L4 Gene

Variants for USP17L4 Gene

Sequence variations from dbSNP and Humsavar for USP17L4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs112397662 -- 7,336,821(+) CCCTG(A/G)GGAGT intron-variant, upstream-variant-2KB
rs112988941 -- 7,335,710(+) CACCA(A/T)ATGTG intron-variant, upstream-variant-2KB
rs113847916 -- 7,336,074(+) GTTTT(G/T)ATTTT intron-variant, upstream-variant-2KB
rs143414176 -- 7,338,108(+) GTCAC(A/G)ACGGA intron-variant, reference, missense
rs149214644 -- 7,336,969(+) GGGTG(C/G)GGTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L4 Gene

Variant ID Type Subtype PubMed ID
dgv11911n54 CNV loss 21841781
dgv11912n54 CNV loss 21841781
dgv2035e212 CNV gain 25503493
dgv6878n100 CNV gain 25217958
dgv6879n100 CNV gain 25217958
dgv6882n100 CNV gain 25217958
dgv6884n100 CNV gain 25217958
dgv6885n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6888n100 CNV gain+loss 25217958
dgv6889n100 CNV loss 25217958
dgv6890n100 CNV gain 25217958
dgv6891n100 CNV gain+loss 25217958
dgv6892n100 CNV loss 25217958
dgv6893n100 CNV gain 25217958
dgv6894n100 CNV gain+loss 25217958
dgv6895n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6897n100 CNV gain 25217958
dgv6898n100 CNV loss 25217958
dgv6899n100 CNV gain 25217958
dgv6900n100 CNV gain+loss 25217958
dgv6901n100 CNV gain+loss 25217958
dgv6902n100 CNV gain 25217958
dgv6903n100 CNV loss 25217958
dgv6904n100 CNV gain 25217958
dgv6905n100 CNV gain 25217958
dgv6906n100 CNV gain 25217958
dgv6907n100 CNV loss 25217958
dgv6908n100 CNV gain 25217958
dgv6909n100 CNV gain 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6911n100 CNV loss 25217958
dgv6912n100 CNV loss 25217958
dgv6913n100 CNV gain 25217958
dgv6914n100 CNV gain+loss 25217958
dgv6915n100 CNV gain 25217958
esv1000362 CNV gain 20482838
esv21583 CNV gain+loss 19812545
esv2759589 CNV gain+loss 17122850
esv2761169 CNV gain+loss 21179565
esv2764098 CNV gain+loss 21179565
esv33606 CNV gain+loss 17666407
esv3616114 CNV loss 21293372
esv3891318 CNV gain 25118596
esv3891324 CNV gain 25118596
nsv1023986 CNV loss 25217958
nsv1026778 CNV gain 25217958
nsv1027709 CNV gain+loss 25217958
nsv1028208 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv1075101 CNV deletion 25765185
nsv1161709 CNV duplication 26073780
nsv1161710 CNV deletion 26073780
nsv1161711 OTHER complex 26073780
nsv428194 CNV gain+loss 18775914
nsv471650 CNV gain+loss 15918152
nsv510977 OTHER complex 20534489
nsv515968 CNV gain+loss 19592680
nsv610036 CNV loss 21841781
nsv821142 CNV deletion 20802225
nsv821656 CNV gain 15273396
nsv8281 CNV gain+loss 18304495
nsv831223 CNV loss 17160897
nsv831224 CNV gain+loss 17160897
nsv831225 CNV loss 17160897
nsv951091 CNV deletion 24416366
nsv971277 CNV duplication 23825009

Relevant External Links for USP17L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L4 Gene

Disorders for USP17L4 Gene

Relevant External Links for USP17L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L4

No disorders were found for USP17L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L4 Gene

Publications for USP17L4 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 2 3 4 64
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 2 3 4 64
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  4. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 64
  5. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 64

Products for USP17L4 Gene

Sources for USP17L4 Gene

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