USP17L3 Gene
pseudogene GIFtS: 22
GCID: GC08M007833
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ubiquitin specific peptidase 17-like family member 3(Previous name: ubiquitin specific peptidase 17-like 3 )
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Aliases
for USP17L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 17-Like Family Member 31 2 | | Ubiquitin Thioesterase 17-Like Protein 32 3 | | USP17B1 2 3 | | Ubiquitin-Specific-Processing Protease 17-Like Protein 32 3 | | USP17F1 2 3 | | Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 32 | | Ubiquitin Specific Peptidase 17-Like 31 2 | | EC 3.4.19.123 | | Deubiquitinating Enzyme 17-Like Protein 32 3 | | EC 3.1.2.158 |
Export aliases for USP17L3 gene to outside databasesPrevious GC identifers: GC08M007873 GC08M007875 GC08P006885 |
Summaries
for USP17L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: U17L3_HUMAN, A6NCW0Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate differentcellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration,and the cellular response to viral infection (By similarity)
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Genomic Views
for USP17L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP17L3 gene promoter:
COUP-TF1 COUP HNF-4alpha2 HNF-4alpha1 NF-AT NF-AT4 NF-AT2 COUP-TF NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP17L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1USP17L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M007833: view genomic region
(about GC identifiers)
Start:
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7,833,915 bp from pter |
End:
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7,835,507 bp from pter |
Size:
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1,593 bases |
Orientation:
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minus strand |
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Proteins
for USP17L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: U17L3_HUMAN, A6NCW0 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 Size: 530 amino acids; 59536 Da
Subcellular location: Nucleus (By similarity). Endoplasmic reticulum (By similarity)
Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copyof the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can befound in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makesimpossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments arefor instance not specific of a given UPS17-like geneExplore the universe of human proteins at neXtProt for USP17L3: NX_A6NCW0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NCW0
4/12 DME Specific Peptides for USP17L3 (A6NCW0) (see all 12)
USP17L3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001243800.1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- | | GO:0005783 | endoplasmic reticulum |
IEA | -- |
USP17L3 for ontologies About GeneDecksing
USP17L3 Antibody Products:
Assay Products for USP17L3: |
Protein
Domains /
Families
for USP17L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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USP17L3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NCW0ProtoNet protein and cluster: A6NCW0 UniProtKB/Swiss-Prot: U17L3_HUMAN, A6NCW0Similarity: Belongs to the peptidase C19 family. USP17 subfamily |
Function
for USP17L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: U17L3_HUMAN, A6NCW0Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate differentcellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration,and the cellular response to viral infection (By similarity)Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP17L3 for ontologies About GeneDecksing
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Pathways & Interactions
for USP17L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP17L3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0006915 | apoptotic process |
IEA | -- |
USP17L3 for ontologies About GeneDecksing
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Drugs & Compounds
for USP17L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for USP17L3
Search CenterWatch for drugs/clinical trials and news about USP17L3 
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Transcripts
for USP17L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for USP17L3 gene: NM_001256871.1 Unigene Cluster for USP17L3: Ubiquitin specific peptidase 17-like family member 3 Hs.741131 Unigene Representative Sequence: NM_0012568711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000530484
GeneLoc Exon Structure
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Expression
for USP17L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP17L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.741131
SABiosciences Custom PCR Arrays for USP17L3
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat USP17L3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP17L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP17L3 |
Orthologs
for USP17L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for USP17L3 (if available)
TreeFam Gene Tree for USP17L3 (if available) |
Paralogs
for USP17L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for USP17L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for USP17L3 (7833915 - 7835507 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP17L3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for USP17L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for USP17L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for USP17L3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with USP17L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PubMed id 17109758)1, 2, 3 Shin J.-M.... Baek K.-H. (2006)
- The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PubMed id 15780755)1, 2, 3 Burrows J.F.... Johnston J.A. (2005)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
- The deubiquitinating enzyme USP17 is essential for GT Pase subcellular localization and cell motility. (PubMed id 21448158)1 de la Vega M....Johnston J.A. (2011)
- Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494)1 Ramakrishna S....Baek K.H. (2011)
- The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progressi on. (PubMed id 20388806)1 McFarlane C....Johnston J.A. (2010)
- The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number var iable beta-defensin cluster. (PubMed id 20403174)1 Burrows J.F....Johnston J.A. (2010)
- Polyclonal and monoclonal antibodies specific for USP1 7, a proapoptotic deubiquitinating enzyme. (PubMed id 20715989)1 Ramakrishna S....Baek K.H. (2010)
- Cdc25A and Dub3 in a high-stakes balancing act. (PubMed id 20228807)1 Hayes S.D. and Harper J.W. (2010)
- The ubiquitin-specific protease 17 is involved in vir us-triggered type I IFN signaling. (PubMed id 20368735)1 Chen R....Shu H.B. (2010)
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External Searches for USP17L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing USP17L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing USP17L3 gene
(According to HUGE)
About This Section
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Specialized Databases showing USP17L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for USP17L3 gene:
Search GeneIP for patents involving USP17L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP17L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP17L3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP17L3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L3 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP17L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP17L3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP17L3 |
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| | | | Search Tocris compounds for USP17L3 |
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 | | | USP17L3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for USP17L3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP17L3 |
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