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Aliases for USP17L29 Gene

Aliases for USP17L29 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 29 2 3
  • USP17L24 USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L30 4
  • Ubiquitin-Specific-Processing Protease 17 4
  • Deubiquitinating Enzyme 17 4
  • Ubiquitin Thioesterase 17 4
  • EC 3.4.19.12 4
  • USP17H 4
  • USP17I 4
  • USP17J 4
  • USP17K 4
  • USP17L 4
  • USP17M 4
  • USP17 4

External Ids for USP17L29 Gene

Summaries for USP17L29 Gene

GeneCards Summary for USP17L29 Gene

USP17L29 (Ubiquitin Specific Peptidase 17-Like Family Member 29) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP17L29 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L29 Gene

Genomics for USP17L29 Gene

Genomic Location for USP17L29 Gene

Start:
9,353,638 bp from pter
End:
9,355,230 bp from pter
Size:
1,593 bases
Orientation:
Plus strand

Genomic View for USP17L29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP17L29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L29 Gene

No data available for Regulatory Elements for USP17L29 Gene

Proteins for USP17L29 Gene

  • Protein details for USP17L29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0WX57-U17LO_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 24
    Protein Accession:
    Q0WX57
    Secondary Accessions:
    • A8MRA9
    • Q0WX56
    • Q3BEM1

    Protein attributes for USP17L29 Gene

    Size:
    530 amino acids
    Molecular mass:
    59711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L29 Gene

Proteomics data for USP17L29 Gene at MOPED

Post-translational modifications for USP17L29 Gene

No Post-translational modifications

Other Protein References for USP17L29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L29 Gene

Domains for USP17L29 Gene

Protein Domains for USP17L29 Gene

UniProtKB/Swiss-Prot:

U17LO_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q0WX57
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.:
    • Q0WX57
genes like me logo Genes that share domains with USP17L29: view

No data available for Gene Families for USP17L29 Gene

Function for USP17L29 Gene

Molecular function for USP17L29 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L29 Gene

Gene Ontology (GO) - Molecular Function for USP17L29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP17L29: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP17L29 Gene

Localization for USP17L29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L29 Gene

Nucleus, nucleolus. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for USP17L29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with USP17L29: view

Pathways for USP17L29 Gene

genes like me logo Genes that share pathways with USP17L29: view

Pathways by source for USP17L29 Gene

1 Qiagen pathway for USP17L29 Gene

Interacting Proteins for USP17L29 Gene

Gene Ontology (GO) - Biological Process for USP17L29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0006915 apoptotic process --
genes like me logo Genes that share ontologies with USP17L29: view

Transcripts for USP17L29 Gene

mRNA/cDNA for USP17L29 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L29 Gene

No ASD Table

Relevant External Links for USP17L29 Gene

GeneLoc Exon Structure for
USP17L29
ECgene alternative splicing isoforms for
USP17L29

Expression for USP17L29 Gene

mRNA expression in normal human tissues for USP17L29 Gene

mRNA Expression by UniProt/SwissProt for USP17L29 Gene

Q0WX57-U17LO_HUMAN
Tissue specificity: Expressed in heart, brain, liver and skeletal muscle.
genes like me logo Genes that share expressions with USP17L29: view

Orthologs for USP17L29 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 94 (a)
ManyToMany
-- 37
  • 97 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 60 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17la 37
  • 45 (a)
ManyToMany
Usp17lb 37
  • 47 (a)
ManyToMany
Usp17lc 37
  • 45 (a)
ManyToMany
Usp17ld 37
  • 44 (a)
ManyToMany
Usp17le 37
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 37
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 37
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 37
  • 20 (a)
OneToMany
Species with no ortholog for USP17L29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L29 Gene

ENSEMBL:
Gene Tree for USP17L29 (if available)
TreeFam:
Gene Tree for USP17L29 (if available)

Paralogs for USP17L29 Gene

genes like me logo Genes that share paralogs with USP17L29: view

Variants for USP17L29 Gene

Sequence variations from dbSNP and Humsavar for USP17L29 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs62411731 -- 9,353,312(+) CCCGG(A/T)TACAC upstream-variant-2KB
rs199509357 -- 9,353,712(+) CGGCC(A/C)GATGC synonymous-codon, reference
rs199524560 -- 9,354,728(+) CCTGA(C/G)TCAAC missense, reference
rs199623778 -- 9,354,450(+) CACAC(C/T)TCTGC reference, synonymous-codon
rs199821388 -- 9,354,364(+) TGAAG(A/C)CCGAA missense, reference

Relevant External Links for USP17L29 Gene

HapMap Linkage Disequilibrium report
USP17L29

No data available for Structural Variations from Database of Genomic Variants (DGV) for USP17L29 Gene

Disorders for USP17L29 Gene

No disorders were found for USP17L29 Gene.

No data available for UniProtKB/Swiss-Prot for USP17L29 Gene

Publications for USP17L29 Gene

  1. The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. (PMID: 10936051) Saitoh Y. … Ikeda J.-E. (Genomics 2000) 3 4
  2. Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. (PMID: 11941478) Okada T. … Ikeda J.E. (Hum. Genet. 2002) 3 4
  3. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 3 4
  4. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 3 4
  5. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PMID: 20403174) Burrows J.F. … Johnston J.A. (BMC Genomics 2010) 3 4

Products for USP17L29 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate USP17L29
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for USP17L29
    • Block miRNA regulation of USP17L29 using miScript Target Protectors

    Sources for USP17L29 Gene

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