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Aliases for USP17L24 Gene

Aliases for USP17L24 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 24 2 3 5
  • USP17L24 USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L30 4
  • Ubiquitin-Specific-Processing Protease 17 4
  • Deubiquitinating Enzyme 17 4
  • Ubiquitin Thioesterase 17 4
  • EC 3.4.19.12 4
  • USP17L 4
  • USP17H 4
  • USP17I 4
  • USP17J 4
  • USP17K 4
  • USP17M 4
  • USP17 4

External Ids for USP17L24 Gene

Summaries for USP17L24 Gene

GeneCards Summary for USP17L24 Gene

USP17L24 (Ubiquitin Specific Peptidase 17-Like Family Member 24) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP17L24 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L24 Gene

Genomics for USP17L24 Gene

Genomic Location for USP17L24 Gene

Chromosome:
4
Start:
9,325,165 bp from pter
End:
9,327,116 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L24 Gene

Genes around USP17L24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L24 Gene

No data available for Regulatory Elements for USP17L24 Gene

Proteins for USP17L24 Gene

  • Protein details for USP17L24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0WX57-U17LO_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 24
    Protein Accession:
    Q0WX57
    Secondary Accessions:
    • A8MRA9
    • Q0WX56
    • Q3BEM1

    Protein attributes for USP17L24 Gene

    Size:
    530 amino acids
    Molecular mass:
    59711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L24 Gene

Proteomics data for USP17L24 Gene at MOPED

Post-translational modifications for USP17L24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L24 Gene

Domains & Families for USP17L24 Gene

Protein Domains for USP17L24 Gene

Graphical View of Domain Structure for InterPro Entry

Q0WX57

UniProtKB/Swiss-Prot:

U17LO_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L24: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L24 Gene

Function for USP17L24 Gene

Molecular function for USP17L24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L24 Gene

Gene Ontology (GO) - Molecular Function for USP17L24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP17L24: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L24 Gene

Localization for USP17L24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP17L24 Gene COMPARTMENTS Subcellular localization image for USP17L24 gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for USP17L24 Gene

Pathways & Interactions for USP17L24 Gene

genes like me logo Genes that share pathways with USP17L24: view

Pathways by source for USP17L24 Gene

1 Qiagen pathway for USP17L24 Gene

Gene Ontology (GO) - Biological Process for USP17L24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with USP17L24: view

No data available for SIGNOR curated interactions for USP17L24 Gene

Drugs & Compounds for USP17L24 Gene

No Compound Related Data Available

Transcripts for USP17L24 Gene

mRNA/cDNA for USP17L24 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L24 Gene

No ASD Table

Relevant External Links for USP17L24 Gene

GeneLoc Exon Structure for
USP17L24
ECgene alternative splicing isoforms for
USP17L24

Expression for USP17L24 Gene

mRNA expression in normal human tissues for USP17L24 Gene

mRNA Expression by UniProt/SwissProt for USP17L24 Gene

Q0WX57-U17LO_HUMAN
Tissue specificity: Expressed in heart, brain, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with USP17L24: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for USP17L24 Gene

Orthologs for USP17L24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L24 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17la 36
  • 45 (a)
ManyToMany
Usp17lb 36
  • 47 (a)
ManyToMany
Usp17lc 36
  • 45 (a)
ManyToMany
Usp17ld 36
  • 44 (a)
ManyToMany
Usp17le 36
  • 44 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
ManyToMany
-- 36
  • 97 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 36
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 20 (a)
OneToMany
Species with no ortholog for USP17L24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L24 Gene

ENSEMBL:
Gene Tree for USP17L24 (if available)
TreeFam:
Gene Tree for USP17L24 (if available)

Paralogs for USP17L24 Gene

genes like me logo Genes that share paralogs with USP17L24: view

Variants for USP17L24 Gene

Sequence variations from dbSNP and Humsavar for USP17L24 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4131 -- 9,324,139(+) ACAAA(A/C)GGTTA upstream-variant-2KB
rs4151 -- 9,323,528(-) CCATG(A/G)AATTA upstream-variant-2KB
rs2291201 -- 9,324,037(+) TTTCA(C/T)CTCTA upstream-variant-2KB
rs1962997 -- 9,323,654(+) ATTCC(C/T)GCTAA upstream-variant-2KB
rs1963535 -- 9,323,780(+) AATGC(C/G)TAACT upstream-variant-2KB

Relevant External Links for USP17L24 Gene

HapMap Linkage Disequilibrium report
USP17L24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for USP17L24 Gene

Disorders for USP17L24 Gene

Relevant External Links for USP17L24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L24

No disorders were found for USP17L24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L24 Gene

Publications for USP17L24 Gene

  1. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PMID: 20403174) Burrows J.F. … Johnston J.A. (BMC Genomics 2010) 3 4 67
  2. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3
  3. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3
  4. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3
  5. Cdc25A and Dub3 in a high-stakes balancing act. (PMID: 20228807) Hayes S.D. … Harper J.W. (Nat. Cell Biol. 2010) 3

Products for USP17L24 Gene

Sources for USP17L24 Gene

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