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Aliases for USP17L21 Gene

Aliases for USP17L21 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 21 2 3 5
  • EC 3.4.19.12 4

External Ids for USP17L21 Gene

Summaries for USP17L21 Gene

GeneCards Summary for USP17L21 Gene

USP17L21 (Ubiquitin Specific Peptidase 17-Like Family Member 21) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L25.

UniProtKB/Swiss-Prot for USP17L21 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L21 Gene

Genomics for USP17L21 Gene

Genomic Location for USP17L21 Gene

Chromosome:
4
Start:
9,262,872 bp from pter
End:
9,264,823 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L21 Gene

Genes around USP17L21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L21 Gene

No data available for Regulatory Elements for USP17L21 Gene

Proteins for USP17L21 Gene

  • Protein details for USP17L21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D6R901-U17LL_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 21
    Protein Accession:
    D6R901

    Protein attributes for USP17L21 Gene

    Size:
    530 amino acids
    Molecular mass:
    59659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L21 Gene

Post-translational modifications for USP17L21 Gene

No Post-translational modifications

Other Protein References for USP17L21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L21 Gene

Domains & Families for USP17L21 Gene

Protein Domains for USP17L21 Gene

Graphical View of Domain Structure for InterPro Entry

D6R901

UniProtKB/Swiss-Prot:

U17LL_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L21: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L21 Gene

Function for USP17L21 Gene

Molecular function for USP17L21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L21 Gene

Gene Ontology (GO) - Molecular Function for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L21: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L21 Gene

Localization for USP17L21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L21 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L21 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L21: view

Pathways & Interactions for USP17L21 Gene

genes like me logo Genes that share pathways with USP17L21: view

Pathways by source for USP17L21 Gene

Interacting Proteins for USP17L21 Gene

Gene Ontology (GO) - Biological Process for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L21: view

No data available for SIGNOR curated interactions for USP17L21 Gene

Transcripts for USP17L21 Gene

mRNA/cDNA for USP17L21 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L21 Gene

No ASD Table

Relevant External Links for USP17L21 Gene

GeneLoc Exon Structure for
USP17L21
ECgene alternative splicing isoforms for
USP17L21

Expression for USP17L21 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L21 Gene:

USP17L21

SOURCE GeneReport for Unigene cluster for USP17L21 Gene:

Hs.741136
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USP17L21 Gene

Orthologs for USP17L21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 94 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17lb 35
  • 47 (a)
ManyToMany
Usp17la 35
  • 45 (a)
ManyToMany
Usp17lc 35
  • 45 (a)
ManyToMany
Usp17ld 35
  • 44 (a)
ManyToMany
Usp17le 35
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 35
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 20 (a)
OneToMany
Species where no ortholog for USP17L21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L21 Gene

ENSEMBL:
Gene Tree for USP17L21 (if available)
TreeFam:
Gene Tree for USP17L21 (if available)

Paralogs for USP17L21 Gene

genes like me logo Genes that share paralogs with USP17L21: view

Variants for USP17L21 Gene

Sequence variations from dbSNP and Humsavar for USP17L21 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs149983253 -- 9,262,477(+) TCCTA(C/G)GTAAA upstream-variant-2KB
rs367580016 -- 9,262,174(+) CACTC(A/G)GATAG upstream-variant-2KB
rs368486843 -- 9,262,253(+) TCTCA(C/T)TAGGG upstream-variant-2KB
rs368806102 -- 9,262,532(+) TGGCC(A/G)CTGTC upstream-variant-2KB
rs370153499 -- 9,262,474(+) GTTTC(C/G)TACGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L21 Gene

Variant ID Type Subtype PubMed ID
dgv922e199 CNV deletion 23128226
dgv923e199 CNV deletion 23128226
esv2678198 CNV deletion 23128226
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1077433 CNV duplication 25765185
nsv1077434 CNV duplication 25765185
nsv1118712 CNV duplication 24896259
nsv1118713 CNV duplication 24896259
nsv1141453 CNV duplication 24896259
nsv1147485 CNV duplication 26484159
nsv428437 CNV gain 18775914
nsv949793 CNV duplication 24416366

Relevant External Links for USP17L21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L21 Gene

Disorders for USP17L21 Gene

Relevant External Links for USP17L21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L21

No disorders were found for USP17L21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L21 Gene

Publications for USP17L21 Gene

  1. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 64
  2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 64
  3. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. (PMID: 20388806) McFarlane C. … Johnston J.A. (Cancer Res. 2010) 3 64
  4. Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. (PMID: 20715989) Ramakrishna S. … Baek K.H. (Hybridoma (Larchmt) 2010) 3 64
  5. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PMID: 20403174) Burrows J.F. … Johnston J.A. (BMC Genomics 2010) 3 64

Products for USP17L21 Gene

Sources for USP17L21 Gene

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