Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP17L21 Gene

Aliases for USP17L21 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 21 2 3
  • EC 3.4.19.12 4

External Ids for USP17L21 Gene

Summaries for USP17L21 Gene

GeneCards Summary for USP17L21 Gene

USP17L21 (Ubiquitin Specific Peptidase 17-Like Family Member 21) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP17L21 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L21 Gene

Genomics for USP17L21 Gene

Genomic Location for USP17L21 Gene

Start:
9,262,872 bp from pter
End:
9,264,823 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP17L21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L21 Gene

No data available for Regulatory Elements for USP17L21 Gene

Proteins for USP17L21 Gene

  • Protein details for USP17L21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    D6R901-U17LL_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 21
    Protein Accession:
    D6R901
    Secondary Accessions:

    Protein attributes for USP17L21 Gene

    Size:
    530 amino acids
    Molecular mass:
    59659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L21 Gene

Proteomics data for USP17L21 Gene at MOPED

Post-translational modifications for USP17L21 Gene

No Post-translational modifications

Other Protein References for USP17L21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L21 Gene

Domains for USP17L21 Gene

Protein Domains for USP17L21 Gene

Graphical View of Domain Structure for InterPro Entry

D6R901

UniProtKB/Swiss-Prot:

U17LL_HUMAN :
  • D6R901
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L21: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L21 Gene

Function for USP17L21 Gene

Molecular function for USP17L21 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L21 Gene

Gene Ontology (GO) - Molecular Function for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0008234 cysteine-type peptidase activity --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP17L21: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP17L21 Gene

Localization for USP17L21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L21 Gene

Nucleus. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L21: view

No data available for Subcellular locations from COMPARTMENTS for USP17L21 Gene

Pathways for USP17L21 Gene

SuperPathways for USP17L21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP17L21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP17L21: view

No data available for Pathways by source for USP17L21 Gene

Transcripts for USP17L21 Gene

mRNA/cDNA for USP17L21 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP17L21

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L21 Gene

No ASD Table

Relevant External Links for USP17L21 Gene

GeneLoc Exon Structure for
USP17L21
ECgene alternative splicing isoforms for
USP17L21

Expression for USP17L21 Gene

SOURCE GeneReport for Unigene cluster for USP17L21 Gene Hs.741136

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for USP17L21 Gene

Orthologs for USP17L21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17la 36
  • 45 (a)
ManyToMany
Usp17lb 36
  • 47 (a)
ManyToMany
Usp17lc 36
  • 45 (a)
ManyToMany
Usp17ld 36
  • 44 (a)
ManyToMany
Usp17le 36
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 36
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 20 (a)
OneToMany
Species with no ortholog for USP17L21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L21 Gene

ENSEMBL:
Gene Tree for USP17L21 (if available)
TreeFam:
Gene Tree for USP17L21 (if available)

Paralogs for USP17L21 Gene

genes like me logo Genes that share paralogs with USP17L21: view

Variants for USP17L21 Gene

Sequence variations from dbSNP and Humsavar for USP17L21 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs149983253 -- 9,262,477(+) TCCTA(C/G)GTAAA upstream-variant-2KB
rs367580016 -- 9,262,174(+) CACTC(A/G)GATAG upstream-variant-2KB
rs368486843 -- 9,262,253(+) TCTCA(C/T)TAGGG upstream-variant-2KB
rs368806102 -- 9,262,532(+) TGGCC(A/G)CTGTC upstream-variant-2KB
rs370153499 -- 9,262,474(+) GTTTC(C/G)TACGT upstream-variant-2KB

Relevant External Links for USP17L21 Gene

HapMap Linkage Disequilibrium report
USP17L21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP17L21 Gene

Disorders for USP17L21 Gene

No disorders were found for USP17L21 Gene.

No data available for UniProtKB/Swiss-Prot for USP17L21 Gene

Publications for USP17L21 Gene

  1. Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. (PMID: 9806828) Gondo Y. … Ikeda J.E. (Genomics 1998) 3
  2. The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. (PMID: 10936051) Saitoh Y. … Ikeda J.-E. (Genomics 2000) 3
  3. Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. (PMID: 11941478) Okada T. … Ikeda J.E. (Hum. Genet. 2002) 3
  4. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. (PMID: 14699124) Burrows J.F. … Johnston J.A. (J. Biol. Chem. 2004) 3
  5. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 3

Products for USP17L21 Gene

Sources for USP17L21 Gene

Back to Top

Content