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Aliases for USP17L2 Gene

Aliases for USP17L2 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 2 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 2 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 2 3 4
  • Deubiquitinating Enzyme 17-Like Protein 2 3 4
  • Ubiquitin Thioesterase 17-Like Protein 2 3 4
  • Ubiquitin Specific Peptidase 17-Like 2 2 3
  • Deubiquitinating Protein 3 3 4
  • Deubiquitinating Enzyme 3 2 3
  • DUB-3 3 4
  • USP17 3 4
  • DUB3 3 4
  • Ubiquitin Thiolesterase 17-Like Protein 2 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 17 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • USP17L 4
  • USP17H 4
  • USP17I 4
  • USP17J 4
  • USP17K 4
  • USP17M 4

External Ids for USP17L2 Gene

Previous GeneCards Identifiers for USP17L2 Gene

  • GC08M012034
  • GC08M011994

Summaries for USP17L2 Gene

Entrez Gene Summary for USP17L2 Gene

  • DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

GeneCards Summary for USP17L2 Gene

USP17L2 (Ubiquitin Specific Peptidase 17-Like Family Member 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Remodeling of Adherens Junctions. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L4.

UniProtKB/Swiss-Prot for USP17L2 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of Lys-48- and Lys-63-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L2 Gene

Genomics for USP17L2 Gene

Regulatory Elements for USP17L2 Gene

Enhancers for USP17L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F012149 0.6 Ensembl 0.4 -10.7 -10724 0.4 POLR2H GC08M012151 USP17L2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USP17L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP17L2 Gene

Chromosome:
8
Start:
12,137,168 bp from pter
End:
12,139,077 bp from pter
Size:
1,910 bases
Orientation:
Minus strand

Genomic View for USP17L2 Gene

Genes around USP17L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L2 Gene

Proteins for USP17L2 Gene

  • Protein details for USP17L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6R6M4-U17L2_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17
    Protein Accession:
    Q6R6M4

    Protein attributes for USP17L2 Gene

    Size:
    530 amino acids
    Molecular mass:
    59619 Da
    Quaternary structure:
    • Interacts with SUDS3; the interaction is direct.
    Miscellaneous:
    • Overexpressed in a subset of human breast cancers, overexpression leading to an abnormally high level of CDC25A, which arrests cells through replication stress or premature mitosis, the latter occurring when CDK1 is activated inappropriately.

neXtProt entry for USP17L2 Gene

Selected DME Specific Peptides for USP17L2 Gene

Q6R6M4:
  • AQSVKQAL
  • SDTFDPYLDI
  • WRSQIKCL
  • VYVLYAVLVH
  • QALEQLVKPEELNGENAYHCG
  • HEFLMFTVDAMKKACLPGHKQVDHH
  • QCLTYTPPLANY
  • SVLSQQAYVLFYI
  • TLTLHTSAKVLILVLKRFSDV
  • LVERATQESTLDHWKF
  • CTMQAHIT
  • RVDLCDDLAPVARQLAPR
  • GFHRGKQED

Post-translational modifications for USP17L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L2 Gene

Gene Families for USP17L2 Gene

Protein Domains for USP17L2 Gene

Suggested Antigen Peptide Sequences for USP17L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6R6M4

UniProtKB/Swiss-Prot:

U17L2_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L2: view

Function for USP17L2 Gene

Molecular function for USP17L2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of Lys-48- and Lys-63-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4, IL6/interleukin-6 and chemokines including CXCL8 and CXCL12 (at protein level). Up-regulated during the G1/S transition of the cell cycle.

Enzyme Numbers (IUBMB) for USP17L2 Gene

Gene Ontology (GO) - Molecular Function for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IMP 19188362
GO:0005515 protein binding IPI 21239494
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L2: view
genes like me logo Genes that share phenotypes with USP17L2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L2 Gene

Localization for USP17L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L2 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP17L2 Gene COMPARTMENTS Subcellular localization image for USP17L2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21239494
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 19188362
genes like me logo Genes that share ontologies with USP17L2: view

Pathways & Interactions for USP17L2 Gene

genes like me logo Genes that share pathways with USP17L2: view

Pathways by source for USP17L2 Gene

Gene Ontology (GO) - Biological Process for USP17L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint IMP 20228808
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with USP17L2: view

No data available for SIGNOR curated interactions for USP17L2 Gene

Transcripts for USP17L2 Gene

mRNA/cDNA for USP17L2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L2 Gene

No ASD Table

Relevant External Links for USP17L2 Gene

GeneLoc Exon Structure for
USP17L2
ECgene alternative splicing isoforms for
USP17L2

Expression for USP17L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP17L2 Gene

Protein differential expression in normal tissues from HIPED for USP17L2 Gene

This gene is overexpressed in Breast (50.9) and Fetal gut (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP17L2 Gene



Protein tissue co-expression partners for USP17L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L2 Gene:

USP17L2

SOURCE GeneReport for Unigene cluster for USP17L2 Gene:

Hs.531448

mRNA Expression by UniProt/SwissProt for USP17L2 Gene:

Q6R6M4-U17L2_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with USP17L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP17L2 Gene

Orthologs for USP17L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17lb 35
  • 47 (a)
ManyToMany
Usp17la 35
  • 46 (a)
ManyToMany
Usp17lc 35
  • 45 (a)
ManyToMany
Usp17ld 35
  • 45 (a)
ManyToMany
Usp17le 35
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 35
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 20 (a)
OneToMany
Species where no ortholog for USP17L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L2 Gene

ENSEMBL:
Gene Tree for USP17L2 (if available)
TreeFam:
Gene Tree for USP17L2 (if available)

Paralogs for USP17L2 Gene

Variants for USP17L2 Gene

Sequence variations from dbSNP and Humsavar for USP17L2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090565 -- 12,140,019(+) ACAGA(A/G)GGTAG intron-variant, upstream-variant-2KB
rs10090570 -- 12,140,021(+) AGAGG(A/G)TAGCA intron-variant, upstream-variant-2KB
rs111428074 -- 12,140,316(+) TAGAC(A/G)GTAAG intron-variant, upstream-variant-2KB
rs111978476 -- 12,139,665(+) TGTGT(A/G)CCAGA intron-variant, upstream-variant-2KB
rs112165118 -- 12,140,020(+) CAGAG(A/G)GTAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L2 Gene

Variant ID Type Subtype PubMed ID
dgv11960n54 CNV gain 21841781
dgv11961n54 CNV loss 21841781
dgv11964n54 CNV loss 21841781
dgv1270e199 CNV deletion 23128226
dgv1375e214 CNV gain 21293372
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv27n31 CNV gain 19718026
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
dgv7025n100 CNV gain 25217958
dgv7026n100 CNV gain+loss 25217958
esv1009029 CNV gain 20482838
esv22986 CNV gain+loss 19812545
esv2550155 CNV deletion 19546169
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
esv3447577 CNV duplication 20981092
esv3584578 CNV gain 24956385
esv3616267 CNV loss 21293372
nsv1034132 CNV gain 25217958
nsv1077517 CNV duplication 25765185
nsv1110510 CNV duplication 24896259
nsv1139930 CNV duplication 24896259
nsv1161718 OTHER complex 26073780
nsv428195 CNV gain 18775914
nsv442420 CNV gain+loss 18776908
nsv471462 CNV gain 19718026
nsv516685 CNV gain+loss 19592680
nsv610297 CNV gain 21841781
nsv610309 CNV loss 21841781
nsv610313 CNV loss 21841781
nsv8288 CNV gain+loss 18304495
nsv951104 CNV deletion 24416366
nsv967564 CNV duplication 23825009

Variation tolerance for USP17L2 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP17L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP17L2 Gene

Disorders for USP17L2 Gene

Relevant External Links for USP17L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L2

No disorders were found for USP17L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L2 Gene

Publications for USP17L2 Gene

  1. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. (PMID: 14699124) Burrows J.F. … Johnston J.A. (J. Biol. Chem. 2004) 3 4 22 64
  2. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 4 64
  3. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 4 64
  4. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3 4 64
  5. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y. … Dixit V.M. (Nat. Cell Biol. 2010) 3 4 64

Products for USP17L2 Gene

Sources for USP17L2 Gene

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