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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP17L2 Gene

protein-coding   GIFtS: 44
GCID: GC08M011994

ubiquitin specific peptidase 17-like family member 2

(Previous name: ubiquitin specific peptidase 17-like 2 )
 Explore 1 disease affiliated with
USP17L2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP17L2    

Aliases
for USP17L2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 17-Like Family Member 21 2     Ubiquitin Carboxyl-Terminal Hydrolase 172
DUB31 2 3     Ubiquitin Thiolesterase 17-Like Protein 22
Ubiquitin Specific Peptidase 17-Like 21 2     EC 3.4.19.123
Deubiquitinating Enzyme 17-Like Protein 22 3     USP17H3
Deubiquitinating Protein 32 3     USP17I3
Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 22 3     USP17J3
Ubiquitin Thioesterase 17-Like Protein 22 3     USP17K3
Ubiquitin-Specific-Processing Protease 17-Like Protein 22 3     USP17L3
DUB-32 3     USP17M3
USP172 3     EC 3.1.2.158
Deubiquitinating Enzyme 32     

External Ids:    HGNC: 344341   Entrez Gene: 3776302   Ensembl: ENSG000002234437   OMIM: 6101865   UniProtKB: Q6R6M43   

Export aliases for USP17L2 gene to outside databases

Previous GC identifer: GC08M012034


Summaries
for USP17L2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USP17L2:
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM
603478) for background information.(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small
GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A
degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell
proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation
of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and
'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the
cellular response to viral infection




Genomic Views
for USP17L2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_077531.4  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for USP17L2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP17L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP17L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

USP17L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP17L2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M011994:  view genomic region     (about GC identifiers)

Start:
 11,994,677 bp from pter      End:
 11,996,586 bp from pter
Size:
 1,910 bases      Orientation:
 minus strand

Proteins
for USP17L2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 17  
Size: 530 amino acids; 59619 Da
Subunit: Interacts with SUDS3; the interaction is direct
Subcellular location: Nucleus. Endoplasmic reticulum
Miscellaneous: Overexpressed in a subset of human breast cancers, overexpression leading to an abnormally high level of
CDC25A, which arrests cells through replication stress or premature mitosis, the latter occurring when CDK1 is
activated inappropriately (PubMed:20228808)
Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy
of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be
found in the genome both on chromosome 4 and chromosome 8. USP17 is also frequently named DUB3 in the literature. The
high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the
family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene

Explore the universe of human proteins at neXtProt for USP17L2: NX_Q6R6M4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6R6M4

    • 4/13 DME Specific Peptides for USP17L2 (Q6R6M4) (see all 13)
     AQSVKQAL  CTMQAHIT  WRSQIKCL  GFHRGKQED 

    USP17L2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_958804.2  
    ENSEMBL proteins: 
     ENSP00000333329  

    Human Recombinant Protein Products: 
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    Novus Biologicals USP17L2 Protein
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    Uscn Proteins for USP17L2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005789endoplasmic reticulum membrane IDA19188362


    USP17L2 for ontologies           About GeneDecksing



    USP17L2 Antibody Products: 
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    Uscn ELISAs and CLIAs for USP17L2

    Protein Domains /
    Families
    for USP17L2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP17L2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR006861 HABP4_PAIRBP1-bd

    Graphical View of Domain Structure for InterPro Entry Q6R6M4

    ProtoNet protein and cluster: Q6R6M4

    1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
    Similarity: Belongs to the peptidase C19 family. USP17 subfamily


    Function
    for USP17L2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
    Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
    cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small
    GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A
    degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell
    proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation
    of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and
    'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the
    cellular response to viral infection
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Up-regulated by IL4/interleukin-4, IL6/interleukin-6 and chemokines including CXCL8 and CXCL12 (at protein
    level). Up-regulated during the G1/S transition of the cell cycle

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

    miRNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP--
    GO:0004843ubiquitin-specific protease activity IMP--
    GO:0005515protein binding IPI--


    USP17L2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for USP17L2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP17L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/14 Interacting proteins for USP17L2 (Q6R6M43 ENSP000003333294) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0010955negative regulation of protein processing IMP19188362
    GO:0016579protein deubiquitination IDA--


    USP17L2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP17L2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP17L2
    Search CenterWatch for drugs/clinical trials and news about USP17L2 / U17L2 

    Transcripts
    for USP17L2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP17L2 gene: 
    NM_201402.2  

    Unigene Cluster for USP17L2:

    Ubiquitin specific peptidase 17-like family member 2
    Hs.531448
    Unigene Representative Sequence: NM_201402
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333796(uc003wvc.1)

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    OriGene shRNA RFP: USP17L2
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP17L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP17L2

    Additional cDNA sequence: AY509884.1 

    1 DOTS entry:

    DT.102827217 

    2 AceView cDNA sequences:

    NM_201402 AY509884 

    GeneLoc Exon Structure


    Expression
    for USP17L2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP17L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTCAGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See USP17L2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.531448

    UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
    Tissue specificity: Broadly expressed

        SABiosciences Custom PCR Arrays for USP17L2
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    In Situ
    Assay Products:     
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    Orthologs
    for USP17L2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP17L2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves E1C4I0_CHICK6
    		 Ubiquitin carboxyl-terminal hydrolase
    		 16(a)
    		 1 → many
    		 14(938420-953189)
    lizard
    (Anolis carolinensis)    		 Reptilia USP426
    		 --
    		 17(a)
    		 1 → many
    		 GL343507.1(184980-198082)
    zebrafish
    (Danio rerio)    		 Actinopterygii usp426
    		 ubiquitin specific peptidase 42
    		 18(a)
    		 1 → many
    		 12(18638224-18659764)
    fruit fly
    (Drosophila melanogaster)    		 Insecta scny6
    		 scrawny
    		 11(a)
    		 possible ortholog
    		 3L(5762223-5769371)
    worm
    (Caenorhabditis elegans)    		 Secernentea T22F3.26
    		 Protein T22F3.2, isoform b
    		 15(a)
    		 possible ortholog
    		 V(3586637-3589004)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UBP236
    UBP216
    (see all 3)    		 ubiquitin carboxyl-terminal hydrolase 21
    (see all 3)    		 15(a)
    15(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 5(23470014-23474104)
    5(18965271-18968742)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 ubiquitin carboxyl-terminal hydrolase domain conta...
    ubiquitin carboxyl-terminal hydrolase domain conta...
    (see all 4)    		 14(a)
    14(a)
    (see all 4)    		 possible ortholog
    many ↔ many
    (see all 4)    		 2(28466956-28472140)
    6(4212120-4217604)


    ENSEMBL Gene Tree for USP17L2 (if available)
    TreeFam Gene Tree for USP17L2 (if available) 

    Paralogs
    for USP17L2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP17L2 gene
    USP17L132  USP17L282  USP17L242  USP17L302  USP17L122  USP17L172  USP17L262  USP17L232  
    USP17L182  USP422  USP17L252  USP82  USP17L152  USP17L212  USP17L202  USP17L192  
    USP17L102  USP22  USP362  USP17L272  USP212  USP17L222  USP17L52  USP17L292  
    USP17L112  USP502  
    11 SIMAP similar genes for USP17L2 using alignment to 1 protein entry:     U17L2_HUMAN:
    USP17L1P    USP17L3    USP17L4    USP17L8    USP17L13    USP17L5
    USP17L6    USP17L7    DUB1    USP36    USP42

    USP17L2 for paralogs           About GeneDecksing



    Genomic Variants
    for USP17L2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 NCBI SNPs in USP17L2 are shown (see all 226)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs39888611,2
    		C,Fother11995987(-) CTTCCC/TTGCAG 3 L int1 syn11Minor allele frequency- T:0.18EU 612
    rs1433423291,2
    		--11994200(+) TCCAGC/TTTCCA 2 -- int1 ds50010--------
    rs1874031721,2
    		--11994227(+) GAATGA/TTCCAT 2 -- int1 ds50010--------
    rs563353151,2
    		C--11994271(+) GTGCCG/TCCCAA 2 -- int1 ds50010--------
    rs1919396691,2
    		--11994298(+) CACACC/GCCAAG 2 -- int1 ds50010--------
    rs117774251,2
    		C,F,A,H,--11994435(+) AGGTTC/TGGAAG 2 -- int1 ds50017Minor allele frequency- T:0.01NS EA NA 424
    rs789277061,2
    		C,--11994472(+) CCCATA/GTGTGG 2 -- ds5001 int10--------
    rs784251521,2
    		C,--11994475(+) ATGTGC/TGGGCT 2 -- int1 ds50010--------
    rs1884543211,2
    		--11994512(+) CAGTTG/TTCCCT 2 -- ds5001 int10--------
    rs1392781941,2
    		--11994522(+) TGTTGC/TAGAGA 2 -- int1 ds50010--------

    HapMap Linkage Disequilibrium report for USP17L2 (11994677 - 11996586 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 32 variations for USP17L2
         15/16 CNVs (see all 16): 82482 2736 31428 8596 70286 70283 70281 95259 100272 38848 52352 95260 70282 70285 3720
         15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306

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    Disorders / Diseases
    for USP17L2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP17L2 for disorders           About GeneDecksing

    OMIM gene information: 610186    OMIM disorders: --

    1 disease for USP17L2:    About MalaCards
    breast cancer


    Export disorders for USP17L2 gene to outside databases

    Publications
    for USP17L2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP17L2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with USP17L2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. (PubMed id 14699124)1, 2, 9 Burrows J.F....Johnston J.A. (2004)
    2. The deubiquitinating enzyme USP17 is essential for GT Pase subcellular localization and cell motility. (PubMed id 21448158)1, 2 de la Vega M....Johnston J.A. (2011)
    3. Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494)1, 2 Ramakrishna S....Baek K.H. (2011)
    4. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progressi on. (PubMed id 20388806)1, 2 McFarlane C....Johnston J.A. (2010)
    5. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number var iable beta-defensin cluster. (PubMed id 20403174)1, 2 Burrows J.F....Johnston J.A. (2010)
    6. The ubiquitin-specific protease 17 is involved in vir us-triggered type I IFN signaling. (PubMed id 20368735)1, 2 Chen R....Shu H.B. (2010)
    7. The deubiquitinating enzyme USP17 blocks N-Ras membra ne trafficking and activation but leaves K-Ras unaffected. (PubMed id 20147298)1, 2 de la Vega M....Johnston J.A. (2010)
    8. Ubiquitin hydrolase Dub3 promotes oncogenic transform ation by stabilizing Cdc25A. (PubMed id 20228808)1, 2 Pereg Y....Dixit V.M. (2010)
    9. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PubMed id 19188362)1, 2 Burrows J.F....Johnston J.A. (2009)
    10. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PubMed id 17109758)1, 2 Shin J.-M.... Baek K.-H. (2006)

    External Searches for USP17L2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing USP17L2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 377630 HGNC: 34434 AceView: DUB3 Ensembl:ENSG00000223443 euGenes: HUgn377630
    ECgene: USP17L2 H-InvDB: USP17L2

    Other Databases showing USP17L2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP17L2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP17L2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP17L2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP17L2 gene:
    Search GeneIP for patents involving USP17L2

    GeneCards and IP:
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