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USP17L2 Gene

protein-coding   GIFtS: 42
GCID: GC08M011994

Ubiquitin Specific Peptidase 17-Like Family Member 2

(Previous name: ubiquitin specific peptidase 17-like 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 17-Like Family Member 21 2     Ubiquitin Carboxyl-Terminal Hydrolase 172
DUB32 3 5     Ubiquitin Thiolesterase 17-Like Protein 22
Ubiquitin Specific Peptidase 17-Like 21 2     EC 3.4.19.123
Deubiquitinating Enzyme 31 2     USP17H3
Deubiquitinating Enzyme 17-Like Protein 22 3     USP17I3
Deubiquitinating Protein 32 3     USP17J3
Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 22 3     USP17K3
Ubiquitin Thioesterase 17-Like Protein 22 3     USP17L3
Ubiquitin-Specific-Processing Protease 17-Like Protein 22 3     USP17M3
DUB-32 3     EC 3.1.2.158
USP172 3     

External Ids:    HGNC: 344341   Entrez Gene: 3776302   Ensembl: ENSG000002234437   OMIM: 6101865   UniProtKB: Q6R6M43   

Export aliases for USP17L2 gene to outside databases

Previous GC identifer: GC08M012034


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP17L2 Gene:
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM
603478) for background information.(supplied by OMIM, Mar 2008)

GeneCards Summary for USP17L2 Gene:
USP17L2 (ubiquitin specific peptidase 17-like family member 2) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP17L13.

UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the
small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A,
preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression.
Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone
deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration.
Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune
receptors DDX58 and IFIH1 stimulates the cellular response to viral infection




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_077531.5  
Regulatory elements:
   Search for regulatory transcription factor binding sites for USP17L2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP17L2 promoter sequence
   Search Chromatin IP Primers for USP17L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP17L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

USP17L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP17L2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M011994:  view genomic region     (about GC identifiers)

Start:
11,994,677 bp from pter      End:
11,996,586 bp from pter
Size:
1,910 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 17  
Size: 530 amino acids; 59619 Da
Subunit: Interacts with SUDS3; the interaction is direct
Miscellaneous: Overexpressed in a subset of human breast cancers, overexpression leading to an abnormally high
level of CDC25A, which arrests cells through replication stress or premature mitosis, the latter occurring when
CDK1 is activated inappropriately (PubMed:20228808)
Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a
copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103,
and can be found in the genome both on chromosome 4 and chromosome 8. USP17 is also frequently named DUB3 in the
literature. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of
the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given
UPS17-like gene

Explore the universe of human proteins at neXtProt for USP17L2: NX_Q6R6M4

Explore proteomics data for USP17L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP17L2 (Q6R6M4) (see all 13)
     AQSVKQAL  CTMQAHIT  WRSQIKCL  GFHRGKQED 


    See USP17L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_958804.2  
    ENSEMBL proteins: 
     ENSP00000333329  

    USP17L2 Human Recombinant Protein Products:

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    antibodies-online proteins for USP17L2 (3 products) 

     
    antibodies-online peptides for USP17L2

    USP17L2 Antibody Products:

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    antibodies-online antibodies for USP17L2 (18 products) 

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    Search eBioscience for ELISAs for USP17L2 
    antibodies-online kits for USP17L2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR006861 HABP4_PAIRBP1-bd

    Graphical View of Domain Structure for InterPro Entry Q6R6M4

    ProtoNet protein and cluster: Q6R6M4

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
    Similarity: Belongs to the peptidase C19 family. USP17 subfamily
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP17L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: U17L2_HUMAN, Q6R6M4
    Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
    cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the
    small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A,
    preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression.
    Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone
    deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration.
    Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune
    receptors DDX58 and IFIH1 stimulates the cellular response to viral infection
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Up-regulated by IL4/interleukin-4, IL6/interleukin-6 and chemokines including CXCL8 and CXCL12 (at
    protein level). Up-regulated during the G1/S transition of the cell cycle

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP--
    GO:0004843ubiquitin-specific protease activity IMP19188362
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with USP17L2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP17L2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP17L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    U17L2_HUMAN, Q6R6M4: Nucleus. Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005789endoplasmic reticulum membrane IDA19188362

    Find genes that share ontologies with USP17L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP17L2
        Remodeling of Adherens Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP17L2
    Interactions:

        Search GeneGlobe Interaction Network for USP17L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for USP17L2 (Q6R6M43 ENSP000003333294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint IMP--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006915apoptotic process IEA--
    GO:0007093mitotic cell cycle checkpoint IMP--
    GO:0010955negative regulation of protein processing IMP19188362

    Find genes that share ontologies with USP17L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP17L2 (U17L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP17L2 gene: 
    NM_201402.2  

    Unigene Cluster for USP17L2:

    Ubiquitin specific peptidase 17-like family member 2
    Hs.531448
    Unigene Representative Sequence: NM_201402
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333796(uc003wvc.1)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP17L2
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat USP17L2
      QuantiFast Probe-based Assays in human, mouse, rat USP17L2

    Additional mRNA sequence: AY509884.1 

    1 DOTS entry:

    DT.102827217 

    2 AceView cDNA sequences:

    AY509884 NM_201402 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP17L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAGCAGA
    USP17L2 Expression
    About this image

    USP17L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP17L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531448

    UniProtKB/Swiss-Prot: U17L2_HUMAN, Q6R6M4
    Tissue specificity: Broadly expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP17L2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii usp426
    ubiquitin specific peptidase 42
    17(a)
    1 → many
    12(18638224-18659764) ENSDARG00000077300
    fruit fly
    (Drosophila melanogaster)
    Insecta scny6
    scrawny
    13(a)
    1 → many
    3L(5762223-5769371)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP86
    Ubiquitin-specific protease that is a component of...
    20(a)
    1 → many
    XIII(716715-718130) YMR223W
            Species with no ortholog for USP17L2

    ENSEMBL Gene Tree for USP17L2 (if available)
    TreeFam Gene Tree for USP17L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP17L2 gene
    USP17L3  USP17L1P  USP17L4  USP17L8  USP17L132  USP17L282  USP17L242  USP222  
    USP17L302  USP17L122  USP17L172  USP17L232  USP17L262  USP17L182  USP512  USP422  
    USP17L252  USP17L152  USP17L202  USP17L192  USP17L212  USP17L102  USP17L272  USP362  
    USP27X2  USP17L222  USP17L292  USP17L52  USP17L112  
    Selected SIMAP similar genes for USP17L2 using alignment to 1 protein entry:     U17L2_HUMAN(see all similar genes):
    USP17L1P    USP17L3    USP17L4    USP17L8    USP17L11    USP17L12
    USP17L13    USP17L15    USP17L17    USP17L18    USP17L19    USP17L20
    USP17L21    USP17L22    USP17L24    USP17L25    USP17L26    USP17L27

    Find genes that share paralogs with USP17L2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for USP17L2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125435781,2,4
    ----see VAR_0597502 mis40--------

    HapMap Linkage Disequilibrium report for USP17L2 (11994677 - 11996586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP17L2 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736622CNV Deletion23290073
    esv2550155CNV Deletion19546169
    dgv1270e199CNV Deletion23128226
    esv2736614CNV Deletion23290073
    dgv27n31CNV Duplication19718026
    nsv471462CNV Duplication19718026
    esv1009029CNV Gain20482838
    nsv890374CNV Gain21882294
    dgv244e55CNV Gain17911159
    nsv428195CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP17L2
    DNA2.0 Custom Variant and Variant Library Synthesis for USP17L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610186    OMIM disorders: --


    Find genes that share disorders with USP17L2           About GenesLikeMe


    Export disorders for USP17L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP17L2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with USP17L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. (PubMed id 14699124)1, 2, 9 Burrows J.F....Johnston J.A. (J. Biol. Chem. 2004)
    2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PubMed id 21448158)1, 2 de la Vega M.... Johnston J.A. (Nat. Commun. 2011)
    3. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PubMed id 21239494)1, 2 Ramakrishna S.... Baek K.H. (J. Biol. Chem. 2011)
    4. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. (PubMed id 20388806)1, 2 McFarlane C.... Johnston J.A. (Cancer Res. 2010)
    5. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PubMed id 20403174)1, 2 Burrows J.F.... Johnston J.A. (BMC Genomics 2010)
    6. The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. (PubMed id 20368735)1, 2 Chen R.... Shu H.B. (Cell Res. 2010)
    7. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PubMed id 20147298)1, 2 de la Vega M....Johnston J.A. (J. Biol. Chem. 2010)
    8. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PubMed id 20228808)1, 2 Pereg Y.... Dixit V.M. (Nat. Cell Biol. 2010)
    9. USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PubMed id 19188362)1, 2 Burrows J.F....Johnston J.A. (J. Biol. Chem. 2009)
    10. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PubMed id 17109758)1, 2 Shin J.-M.... Baek K.-H. (BMC Genomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 377630 HGNC: 34434 AceView: DUB3 Ensembl:ENSG00000223443 euGenes: HUgn377630
    ECgene: USP17L2 H-InvDB: USP17L2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP17L2 Pharmacogenomics, SNPs, Pathways

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