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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP17L1P Gene

pseudogene   GIFtS: 24
GCID: GC08P007190

Ubiquitin Specific Peptidase 17-Like Family Member 1, Pseudogene

(Previous names: ubiquitin specific peptidase 17-like 1, pseudogene)
Microbiology & Infectious Diseases Congress
  Search for USP17L1P
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 17-Like Family Member 1, Pseudogene1 2     Putative Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 12
Ubiquitin Specific Peptidase 17-Like 1, Pseudogene1 2     Ubiquitin Specific Peptidase 17-Like 1 (Pseudogene)2
Deubiquitinating Enzyme 17-Like Protein 12 3     EC 3.4.19.123
Ubiquitin Thioesterase 17-Like Protein 12 3     USP17L3
Ubiquitin-Specific-Processing Protease 17-Like Protein 12 3     EC 3.1.2.158
USP17L12 3     

External Ids:    HGNC: 371821   Entrez Gene: 4014472   Ensembl: ENSG000002305497   UniProtKB: Q7RTZ23   

Export aliases for USP17L1P gene to outside databases

Previous GC identifers: GC08P007188 GC08P006884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP17L1P Gene: 
USP17L1P (ubiquitin specific peptidase 17-like family member 1, pseudogene) is a pseudogene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity.

UniProtKB/Swiss-Prot: U17L1_HUMAN, Q7RTZ2
Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell
migration, and the cellular response to viral infection (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_023736.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for USP17L1P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP17L1P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

USP17L1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP17L1P gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P007190:  view genomic region     (about GC identifiers)

Start:
7,189,909 bp from pter      End:
7,191,501 bp from pter
Size:
1,593 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: U17L1_HUMAN, Q7RTZ2 (See protein sequence)
Recommended Name: Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 1  
Size: 530 amino acids; 59590 Da
Subcellular location: Nucleus (By similarity). Endoplasmic reticulum (By similarity)
Caution: Could be the product of a pseudogene
Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a
copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103,
and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like
genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in
RNAi experiments are for instance not specific of a given UPS17-like gene

Explore the universe of human proteins at neXtProt for USP17L1P: NX_Q7RTZ2

Explore proteomics data for USP17L1P at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7RTZ2

  • 4/12 DME Specific Peptides for USP17L1P (Q7RTZ2) (see all 12)
     AQSVKQAL  CTMQAHIT  WRSQIKCL  GFHRGKQED 

    USP17L1P Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP17L1P Protein Expression
    REFSEQ proteins: NP_001243802.1  
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--

    USP17L1P for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR006861 HABP4_PAIRBP1-bd

    Graphical View of Domain Structure for InterPro Entry Q7RTZ2

    ProtoNet protein and cluster: Q7RTZ2

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: U17L1_HUMAN, Q7RTZ2
    Similarity: Belongs to the peptidase C19 family. USP17 subfamily


    USP17L1P for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: U17L1_HUMAN, Q7RTZ2
    Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different
    cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell
    migration, and the cellular response to viral infection (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP17L1P for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP17L1P

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006915apoptotic process IEA--

    USP17L1P for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP17L1P (U17L1)

    Search CenterWatch for drugs/clinical trials and news about USP17L1P

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP17L1P gene: 
    NM_001256873.1  

    Unigene Cluster for USP17L1P:

    Ubiquitin specific peptidase 17-like family member 1, pseudogene
    Hs.653091
    Unigene Representative Sequence: NM_001256873
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000529559
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    1 AceView cDNA sequence:

    NM_001001324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP17L1P expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP17L1P Expression
    About this image


    See USP17L1P Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.653091
        SABiosciences Custom PCR Arrays for USP17L1P
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP17L1P

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for USP17L1P (if available)
    TreeFam Gene Tree for USP17L1P (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP17L1P gene
    18/29 SIMAP similar genes for USP17L1P using alignment to 1 protein entry:     U17L1_HUMAN(see all similar genes):
    USP17L2    USP17L3    USP17L4    USP17L11    USP17L17    USP17L18
    USP17L19    USP17L20    USP17L22    USP17L24    USP17L25    USP17L26
    USP17L27    USP17L28    USP17L29    USP17L30    USP17L5    USP17L6

    USP17L1P for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP17L1P gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with USP17L1P)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PubMed id 17109758)1, 2, 3 Shin J.-M.... Baek K.-H. (2006)
    2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PubMed id 15780755)1, 2, 3 Burrows J.F.... Johnston J.A. (2005)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2 Puente X.S.... Lopez-Otin C. (2003)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. The deubiquitinating enzyme USP17 is essential for GT Pase subcellular localization and cell motility. (PubMed id 21448158)1 de la Vega M....Johnston J.A. (2011)
    7. Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494)1 Ramakrishna S....Baek K.H. (2011)
    8. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progressi on. (PubMed id 20388806)1 McFarlane C....Johnston J.A. (2010)
    9. The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number var iable beta-defensin cluster. (PubMed id 20403174)1 Burrows J.F....Johnston J.A. (2010)
    10. Polyclonal and monoclonal antibodies specific for USP1 7, a proapoptotic deubiquitinating enzyme. (PubMed id 20715989)1 Ramakrishna S....Baek K.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401447 HGNC: 37182 AceView: LOC401447 Ensembl:ENSG00000230549 euGenes: HUgn401447
    ECgene: USP17L1P H-InvDB: USP17L1P

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP17L1P gene:
    Search GeneIP for patents involving USP17L1P

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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