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USP17L18 Gene

protein-coding GIFtS: 20
GCID: GC04P009254 (predicted)

Ubiquitin Specific Peptidase 17-Like Family Member 18

Microbiology & Infectious Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ubiquitin Specific Peptidase 17-Like Family Member 18¹ ²
Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 18²
EC 3.4.19.12³

External Ids:	HGNC: 44446¹	Entrez Gene: 100287364²	Ensembl: ENSG00000250844⁷	UniProtKB: D6R9N7³

Export aliases for USP17L18 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP17L18 Gene:

USP17L18 (ubiquitin specific peptidase 17-like family member 18) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP17L13.

UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7

Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different

cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell

migration, and the cellular response to viral infection (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for USP17L18
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for USP17L18

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP17L18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1

USP17L18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP17L18 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P009254: view genomic region (about GC identifiers)

Start:	9,250,356 bp from pter	End:	9,251,948 bp from pter
Size:	1,593 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7 (See protein sequence)

Recommended Name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 18

Size: 530 amino acids; 59657 Da

Caution: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a

copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103,

and can be found in the genome on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes

makes it impossible to specifically assign data to a particular gene of the family. Oligonucleotides designed in

RNAi experiments are for instance not specific for a given UPS17-like gene

Explore the universe of human proteins at neXtProt for USP17L18: NX_D6R9N7

REFSEQ proteins: NP_001243788.1

ENSEMBL proteins:

ENSP00000423503

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR001394 Peptidase_C19_UCH

IPR018200 Pept_C19ubi-hydrolase_C_CS

IPR028889 UCH/PAN2

IPR006861 HABP4_PAIRBP1-bd

Graphical View of Domain Structure for InterPro Entry D6R9N7

ProtoNet protein and cluster: D6R9N7

UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7

Similarity: Belongs to the peptidase C19 family. USP17 subfamily

Similarity: Contains 1 USP domain

USP17L18 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: U17LI_HUMAN, D6R9N7

Function: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different

cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell

migration, and the cellular response to viral infection (By similarity)

Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by

the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

Enzyme Number (IUBMB): EC 3.4.19.12¹

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004221	ubiquitin thiolesterase activity	--	--
GO:0008234	cysteine-type peptidase activity	IEA	--

USP17L18 for ontologies About GeneDecksing

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

U17LI_HUMAN, D6R9N7: Nucleus (By similarity). Endoplasmic reticulum (By similarity)

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--

USP17L18 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

Search GeneGlobe Interaction Network for USP17L18

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	--

USP17L18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for USP17L18 (U17LI)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for USP17L18 gene:

NM_001256859.1

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000504209(uc011bwp.2)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

USP17L18 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

Custom PCR Arrays for USP17L18

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L18 gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	usp42⁶	ubiquitin specific peptidase 42	17(a)	1 → many	12(18638224-18659764) ENSDARG00000077300
fruit fly (Drosophila melanogaster)	Insecta	scny⁶	scrawny	13(a)	1 → many	3L(5762223-5769371)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	UBP8⁶	Ubiquitin-specific protease that is a component of...	20(a)	1 → many	XIII(716715-718130) YMR223W

Species with no ortholog for USP17L18

ENSEMBL Gene Tree for USP17L18 (if available)
TreeFam Gene Tree for USP17L18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for USP17L18 gene

USP17L11¹ ² USP17L20¹ ² USP17L19¹ ² USP17L22¹ ² USP17L25¹ ² USP17L28¹ ² USP17L29¹ ² USP17L26¹ ²

USP17L27¹ ² USP17L24¹ ² USP17L30¹ ² USP17L17¹ ² USP17L15¹ ² USP17L5¹ ² USP17L21¹ ² USP17L12¹ ²

USP17L13¹ ² USP17L10¹ ² USP22² USP17L23² USP51² USP42² USP36² USP27X²

USP17L2²

Selected SIMAP similar genes for USP17L18 using alignment to 1 protein entry: U17LI_HUMAN(see all similar genes):

USP17L11 USP17L17 USP17L19 USP17L20 USP17L22 USP17L23

USP17L6P USP17L12 USP17L13 USP17L15 USP17L21 USP17L24

USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L30

USP17L18 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs377485396^1,2	C	--	9249568(+)	`CATTTC/GTGCTT`	1	--	us2k¹		0	--	--	--	--
rs371238812^1,2	C	--	9249628(+)	`GTCTTC/GTCTCC`	1	--	us2k¹		0	--	--	--	--
rs374400150^1,2	C	--	9249655(+)	`CACTCA/GATAGA`	1	--	us2k¹		0	--	--	--	--
rs368465451^1,2	C	--	9249781(+)	`ACTATC/TTCAGG`	1	--	us2k¹		0	--	--	--	--
rs71264118^1,2	C	--	9250053(+)	`TGCCTG/ATCATC`	1	--	us2k¹		1		NA	2
rs367753069^1,2	C	--	9250210(+)	`GGGTGG/TGTGTT`	1	--	us2k¹		0	--	--	--	--
rs371231911^1,2	C	--	9250226(+)	`GTTGGA/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs372475970^1,2	--	--	9249690(+)	`AGGTTA/TCGCTG`	1	--	us2k¹		0	--	--	--	--
rs374502687^1,2	--	--	9249906(+)	`CCCCCA/CACACA`	1	--	us2k¹		0	--	--	--	--
rs376110430^1,2	--	--	9250422(+)	`CATCTC/TTCGGC`	2	P S	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for USP17L18 (9250356 - 9251948 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for USP17L18: --

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for USP17L18 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with USP17L18)

Utopia: connect your pdf to the dynamic
world of online information

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PubMed id 21448158)¹ de la Vega M.... Johnston J.A. (Nat. Commun. 2011)
Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PubMed id 21239494)¹ Ramakrishna S.... Baek K.H. (J. Biol. Chem. 2011)
The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. (PubMed id 20388806)¹ McFarlane C.... Johnston J.A. (Cancer Res. 2010)
The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. (PubMed id 20403174)¹ Burrows J.F.... Johnston J.A. (BMC Genomics 2010)
Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. (PubMed id 20715989)¹ Ramakrishna S....Baek K.H. (Hybridoma (Larchmt) 2010)
Cdc25A and Dub3 in a high-stakes balancing act. (PubMed id 20228807)¹ Hayes S.D. and Harper J.W. (Nat. Cell Biol. 2010)
The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. (PubMed id 20368735)¹ Chen R.... Shu H.B. (Cell Res. 2010)
The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PubMed id 20147298)¹ de la Vega M....Johnston J.A. (J. Biol. Chem. 2010)
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PubMed id 20228808)¹ Pereg Y.... Dixit V.M. (Nat. Cell Biol. 2010)
USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PubMed id 19188362)¹ Burrows J.F....Johnston J.A. (J. Biol. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100287364	HGNC: 44446	Ensembl:ENSG00000250844	euGenes: HUgn100287364	ECgene: USP17L18
H-InvDB: USP17L18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for USP17L18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for USP17L18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for USP17L18 gene:
Search GeneIP for patents involving USP17L18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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USP17L18 Gene

Ubiquitin Specific Peptidase 17-Like Family Member 18

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USP17L18 Gene

Ubiquitin Specific Peptidase 17-Like Family Member 18

Aliasesfor USP17L18 gene

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USP17L18 Human Recombinant Protein Products:

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

Expression
for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene

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for USP17L18 gene