Aliases for USP17L18 Gene
Aliases for USP17L18 Gene
External Ids for USP17L18 Gene
- HGNC: 44446
- Entrez Gene: 100287364
- Ensembl: ENSG00000250844
- UniProtKB: D6R9N7
Summaries for USP17L18 Gene
GeneCards Summary for USP17L18 Gene
USP17L18 (Ubiquitin Specific Peptidase 17-Like Family Member 18) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L27.
UniProtKB/Swiss-Prot for USP17L18 Gene
-
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L18 Gene
Genomics for USP17L18 Gene
Regulatory Element Products
Genomic Location for USP17L18 Gene
- Chromosome:
- 4
- Start:
- 9,248,630 bp from pter
- End:
- 9,250,581 bp from pter
- Size:
- 1,952 bases
- Orientation:
- Plus strand
Genomic View for USP17L18 Gene
Genes around USP17L18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by Ensembl
- 4p16.1 by Entrez Gene
- 4p16.1 by HGNC
USP17L18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for USP17L18 Gene
No data available for Regulatory Elements for USP17L18 Gene
Proteins for USP17L18 Gene
-
Protein details for USP17L18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- D6R9N7-U17LI_HUMAN
- Recommended name:
- Ubiquitin carboxyl-terminal hydrolase 17-like protein 18
- Protein Accession:
- D6R9N7
Protein attributes for USP17L18 Gene
- Size:
- 530 amino acids
- Molecular mass:
- 59657 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for USP17L18 Gene
No Post-translational modifications
Other Protein References for USP17L18 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for USP17L18
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for USP17L18
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- Search GeneTex for Proteins for USP17L18
No data available for DME Specific Peptides for USP17L18 Gene
Domains & Families for USP17L18 Gene
Protein Domains for USP17L18 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
D6R9N7- Family:
-
- Belongs to the peptidase C19 family. USP17 subfamily.
No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L18 Gene
Function for USP17L18 Gene
Molecular function for USP17L18 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
- UniProtKB/Swiss-Prot Function:
- Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Enzyme Numbers (IUBMB) for USP17L18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008234 | cysteine-type peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for USP17L18
-
- Search ViGene Biosciences for USP17L18
CRISPR Products
-
OriGene CRISPR knockouts for USP17L18
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for USP17L18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for USP17L18
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L18 Gene
Localization for USP17L18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for USP17L18 Gene
- Nucleus. Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for USP17L18 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Deubiquitination |
.74
|
|
| 2 | Metabolism of proteins | ||
Pathways by source for USP17L18 Gene
4 Reactome pathways for USP17L18 Gene
Interacting Proteins for USP17L18 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0016579 | protein deubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for USP17L18 Gene
Transcripts for USP17L18 Gene
mRNA/cDNA for USP17L18 Gene
- (1) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for USP17L18
- GenScript: Design CRISPR guide RNA sequences for USP17L18
miRNA Products
- Search ViGene Biosciences for USP17L18
Inhibitory RNA Products
- Search ViGene Biosciences for USP17L18
Clone Products
- VectorBuilder custom plasmid, inducible vectors for USP17L18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for USP17L18
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for USP17L18 Gene
NURSA nuclear receptor signaling pathways regulating expression of USP17L18 Gene:
USP17L18SOURCE GeneReport for Unigene cluster for USP17L18 Gene:
Hs.741138Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L18 Gene
Orthologs for USP17L18 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Usp17lb 35 |
|
ManyToMany | |
| Usp17la 35 |
|
ManyToMany | |||
| Usp17lc 35 |
|
ManyToMany | |||
| Usp17ld 35 |
|
ManyToMany | |||
| Usp17le 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | usp42 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | scny 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBP8 35 |
|
OneToMany |
- Species where no ortholog for USP17L18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for USP17L18 Gene
Paralogs for USP17L18 Gene
- USP17L27 5
- USP17L19 5
- USP17L11 5
- USP17L22 5
- USP17L26 5
- USP17L29 5
- USP17L17 5
- USP17L20 5
- USP17L25 5
- USP17L5 5
- USP17L24 5
- USP17L15 5
- USP17L30 5
- USP17L28 5
- USP17L12 5
- USP17L21 5
- USP17L13 5
- USP17L10 5
- USP17L2 5
- USP17L1 5
- USP17L8 5
- USP42 5
- USP36 5
- USP17L23 5
- USP1 5
- USP46 5
- USP12 5
- USP17L11 34
- USP17L20 34
- USP17L19 34
- USP17L22 34
- USP17L27 34
- USP17L30 34
- USP17L26 34
- USP17L29 34
- USP17L24 34
- USP17L28 34
- USP17L25 34
- USP17L17 34
- USP17L15 34
- USP17L5 34
- USP17L12 34
- USP17L21 34
- USP17L13 34
- USP17L10 34
(30) SIMAP similar genes for USP17L18 Gene using alignment to 1 proteins:
Variants for USP17L18 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1968851 | -- | 9,248,181(-) | gtgtg(A/G/T)ggggg | upstream-variant-2KB | |
| rs1968852 | -- | 9,248,147(-) | TTCTG(C/G)GATGA | upstream-variant-2KB | |
| rs367596200 | -- | 9,248,271(+) | TAAAA(G/T)AAGGC | upstream-variant-2KB | |
| rs367690250 | -- | 9,247,601(+) | AAAGG(G/T)TATAG | upstream-variant-2KB | |
| rs367753069 | -- | 9,248,484(+) | GGGTG(G/T)GGTGT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv922e199 | CNV | deletion | 23128226 |
| dgv923e199 | CNV | deletion | 23128226 |
| esv2678198 | CNV | deletion | 23128226 |
| esv2759222 | CNV | gain+loss | 17122850 |
| esv2763860 | CNV | gain+loss | 21179565 |
| esv34196 | OTHER | inversion | 12058347 |
| nsv1005698 | CNV | gain | 25217958 |
| nsv1077433 | CNV | duplication | 25765185 |
| nsv1118712 | CNV | duplication | 24896259 |
| nsv1118713 | CNV | duplication | 24896259 |
| nsv1139810 | CNV | duplication | 24896259 |
| nsv1141451 | CNV | duplication | 24896259 |
| nsv1147485 | CNV | duplication | 26484159 |
| nsv428437 | CNV | gain | 18775914 |
| nsv949791 | CNV | duplication | 24416366 |
Gene Damage Index Score:
0.10;
2.20% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for USP17L18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- USP17L18
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP17L18 Gene
Disorders for USP17L18 Gene
Relevant External Links for USP17L18
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- USP17L18
No disorders were found for USP17L18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L18 Gene
Publications for USP17L18 Gene
- Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 64
- The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 64
- The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3 64
- Cdc25A and Dub3 in a high-stakes balancing act. (PMID: 20228807) Hayes S.D. … Harper J.W. (Nat. Cell Biol. 2010) 3 64
- Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y. … Dixit V.M. (Nat. Cell Biol. 2010) 3 64
Products for USP17L18 Gene
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- VectorBuilder custom plasmid, inducible vectors for USP17L18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for USP17L18
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for USP17L18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (55) HORDE
- (56) HUGE
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- (60) miRBase
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
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- (100) COMPARTMENTS
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