USP17L18 Gene protein-coding GIFtS : 22 GCID: GC04 P009254 (predicted)
Ubiquitin Specific Peptidase 17-Like Family Member 18
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Aliasesfor USP17L18 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Ubiquitin Specific Peptidase 17-Like Family Member 18 1 2 Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 182 EC 3.4.19.123
Export aliases for USP17L18 gene to outside databases
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Summariesfor USP17L18 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Summary for USP17L18 Gene: USP17L18 (ubiquitin specific peptidase 17-like family member 18) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity . An important paralog of this gene is USP17L13 . UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7 Function : Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate differentcellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cellmigration, and the cellular response to viral infection (By similarity)
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Genomic Viewsfor USP17L18 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.2 NT_006316.16 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for USP17L18 Other transcription factors Search SABiosciences Chromatin IP Primers for USP17L18 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L18
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1 USP17L18 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P009254: view genomic region
(about GC identifiers )
Start: 9,250,356 bp from pter End:
9,251,948 bp from pter
Size: 1,593 bases Orientation:
plus strand
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Proteinsfor USP17L18 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7 See
protein sequence )Recommended Name: Size : 530 amino acids; 59657 DaSubcellular location : Nucleus (By similarity). Endoplasmic reticulum (By similarity)Caution : The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains acopy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103,and can be found in the genome on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genesmakes it impossible to specifically assign data to a particular gene of the family. Oligonucleotides designed inRNAi experiments are for instance not specific for a given UPS17-like gene Explore the universe of human proteins at neXtProt for USP17L18: NX_D6R9N7 USP17L18 Protein expression data from MOPED1 2 3 : --
REFSEQ proteins: NP_001243788.1 ENSEMBL proteins: ENSP00000423503 Human Recombinant Protein Products for USP17L18: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA -- GO:0005783 endoplasmic reticulum
IEA --
About GeneDecksing USP17L18 Antibody Products: Assay Products for USP17L18:
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Protein
Domains /for USP17L18 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 3 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry D6R9N7 ProtoNet protein and cluster: D6R9N7
UniProtKB/Swiss-Prot: U17LI_HUMAN, D6R9N7 Similarity : Belongs to the peptidase C19 family. USP17 subfamilyAbout GeneDecksing
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Functionfor USP17L18 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: U17LI_HUMAN, D6R9N7 Function : Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate differentcellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cellmigration, and the cellular response to viral infection (By similarity) Catalytic activity : Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed bythe C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme Number (IUBMB): EC 3.4.19.12 1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004221 ubiquitin thiolesterase activity
IEA -- GO:0008234 cysteine-type peptidase activity
IEA --
About GeneDecksing Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for USP17L18 Search LifeMap BioReagents cell lines for USP17L18
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Pathways & Interactionsfor USP17L18 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP17L18 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006511 ubiquitin-dependent protein catabolic process
IEA --
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Drugs & Compoundsfor USP17L18 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for USP17L18 (U17LI) USP17L18 / U17LI
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Transcriptsfor USP17L18 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for USP17L18 gene: NM_001256859.1 Unigene Cluster for USP17L18:
Ubiquitin specific peptidase 17-like family member 18 Hs.741138 Unigene Representative Sequence: NM_001256859 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000504209 (uc011bwp.2 ) Congresses - knowledge worth sharing: European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014 GeneLoc Exon Structure
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Expression for USP17L18 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- SOURCE GeneReport for Unigene cluster: Hs.741138 SABiosciences Custom PCR Arrays for USP17L18 Primer Browse OriGene qPCR Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat USP17L18 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP17L18 QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor USP17L18 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for USP17L18 gene from 4/6 species (see all 6 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves USP426
Ubiquitin carboxyl-terminal hydrolase
3(a)
possible ortholog
14(943568-954595)
fruit fly Insecta scny6
scrawny
12(a)
1 → many
3L(5762223-5769371)
worm Secernentea E01B7.16
Protein E01B7.1
11(a)
1 → many
V(17924916-17934227)
baker's yeast Saccharomycetes DOA46 6
Ubiquitin isopeptidase, required for recycling ubi... Putative ubiquitin-specific protease, closest para... 9(a) 11(a)
many ↔ manymany ↔ many
IV(584939-587719) V(457806-460223)
Species with no ortholog for USP17L18 ENSEMBL Gene Tree for USP17L18 (if available)TreeFam Gene Tree for USP17L18 (if available)
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Paralogsfor USP17L18 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for USP17L18 gene USP17L13 2 USP17L28 2 USP17L24 2 USP17L30 2 USP17L12 2 USP17L17 2 USP17L23 2 USP17L26 2 USP42 2 USP17L25 2 USP17L15 2 USP17L20 2 USP17L19 2 USP17L21 2 USP17L10 2 USP36 2 USP17L27 2 USP17L22 2 USP17L29 2 USP17L5 2 USP17L2 2 USP17L11 2 18/30 SIMAP similar genes for USP17L18 using alignment to 1 protein entry: U17LI_HUMAN (see all similar genes ):USP17L11 USP17L17 USP17L19 USP17L20 USP17L22 USP17L23 USP17L6 USP17L12 USP17L13 USP17L15 USP17L21 USP17L24 USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L30 About GeneDecksing
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Genomic Variantsfor USP17L18 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 4 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for USP17L18 (9250356 - 9251948 bp)
Structural Variations Database of Genomic Variants (DGV) variations for USP17L18: -- SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor USP17L18 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
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Publicationsfor USP17L18 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for USP17L18 gene, integrated from 9 sources (see all 18 ):(articles sorted by number of sources associating them with USP17L18) Utopia : connect your pdf to the dynamic
The deubiquitinating enzyme USP17 is essential for GT Pase subcellular localization and cell motility. (PubMed id 21448158) 1 (2011) Lys-63-specific deubiquitination of SDS3 by USP17 reg ulates HDAC activity. (PubMed id 21239494) 1 (2011) The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progressi on. (PubMed id 20388806) 1 (2010) The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number var iable beta-defensin cluster. (PubMed id 20403174) 1 (2010) Polyclonal and monoclonal antibodies specific for USP1 7, a proapoptotic deubiquitinating enzyme. (PubMed id 20715989) 1 (2010) Cdc25A and Dub3 in a high-stakes balancing act. (PubMed id 20228807) 1 (2010) The ubiquitin-specific protease 17 is involved in vir us-triggered type I IFN signaling. (PubMed id 20368735) 1 (2010) The deubiquitinating enzyme USP17 blocks N-Ras membra ne trafficking and activation but leaves K-Ras unaffected. (PubMed id 20147298) 1 (2010) Ubiquitin hydrolase Dub3 promotes oncogenic transform ation by stabilizing Cdc25A. (PubMed id 20228808) 1 (2010) USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. (PubMed id 19188362) 1 (2009)
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External Searches for USP17L18 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing USP17L18 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing USP17L18 gene
(According to HUGE )
About This Section --
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Specialized Databases showing USP17L18 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for USP17L18 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for USP17L18 gene: USP17L18 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor USP17L18 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP17L18 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP17L18 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP17L18 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP17L18
Search ThermoFisher Antibodies for USP17L18
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP17L18
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