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Aliases for USP17L13 Gene

Aliases for USP17L13 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 13 2 3 5
  • EC 3.4.19.12 4

External Ids for USP17L13 Gene

Previous GeneCards Identifiers for USP17L13 Gene

  • GC04P009216

Summaries for USP17L13 Gene

GeneCards Summary for USP17L13 Gene

USP17L13 (Ubiquitin Specific Peptidase 17-Like Family Member 13) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L19.

UniProtKB/Swiss-Prot for USP17L13 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Additional gene information for USP17L13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L13 Gene

Genomics for USP17L13 Gene

Genomic Location for USP17L13 Gene

Chromosome:
4
Start:
9,224,896 bp from pter
End:
9,226,847 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L13 Gene

Genes around USP17L13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L13 Gene

No data available for Regulatory Elements for USP17L13 Gene

Proteins for USP17L13 Gene

  • Protein details for USP17L13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLJ4-U17LD_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 13
    Protein Accession:
    C9JLJ4

    Protein attributes for USP17L13 Gene

    Size:
    530 amino acids
    Molecular mass:
    59694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L13 Gene

Post-translational modifications for USP17L13 Gene

No Post-translational modifications

Other Protein References for USP17L13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L13 Gene

Domains & Families for USP17L13 Gene

Gene Families for USP17L13 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP17L13 Gene

Graphical View of Domain Structure for InterPro Entry

C9JLJ4

UniProtKB/Swiss-Prot:

U17LD_HUMAN :
  • Belongs to the peptidase C19 family. USP17 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L13: view

No data available for Suggested Antigen Peptide Sequences for USP17L13 Gene

Function for USP17L13 Gene

Molecular function for USP17L13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L13 Gene

Gene Ontology (GO) - Molecular Function for USP17L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L13: view

Animal Model Products

No data available for Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L13 Gene

Localization for USP17L13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L13 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L13 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP17L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USP17L13 Gene

Pathways & Interactions for USP17L13 Gene

genes like me logo Genes that share pathways with USP17L13: view

Pathways by source for USP17L13 Gene

Interacting Proteins for USP17L13 Gene

Gene Ontology (GO) - Biological Process for USP17L13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L13: view

No data available for SIGNOR curated interactions for USP17L13 Gene

Drugs & Compounds for USP17L13 Gene

No Compound Related Data Available

Transcripts for USP17L13 Gene

mRNA/cDNA for USP17L13 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L13 Gene

No ASD Table

Relevant External Links for USP17L13 Gene

GeneLoc Exon Structure for
USP17L13
ECgene alternative splicing isoforms for
USP17L13

Expression for USP17L13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP17L13 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L13 Gene:

USP17L13

SOURCE GeneReport for Unigene cluster for USP17L13 Gene:

Hs.741127
genes like me logo Genes that share expression patterns with USP17L13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L13 Gene

Orthologs for USP17L13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 94 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 61 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17lb 34
  • 46 (a)
ManyToMany
Usp17la 34
  • 45 (a)
ManyToMany
Usp17lc 34
  • 44 (a)
ManyToMany
Usp17ld 34
  • 44 (a)
ManyToMany
Usp17le 34
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 34
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 34
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 20 (a)
OneToMany
Species where no ortholog for USP17L13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L13 Gene

ENSEMBL:
Gene Tree for USP17L13 (if available)
TreeFam:
Gene Tree for USP17L13 (if available)

Paralogs for USP17L13 Gene

Pseudogenes.org Pseudogenes for USP17L13 Gene

genes like me logo Genes that share paralogs with USP17L13: view

Variants for USP17L13 Gene

Sequence variations from dbSNP and Humsavar for USP17L13 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1030915230 -- 9,223,625(+) AAAAT(C/G)GCACG upstream-variant-2KB
rs150476103 -- 9,223,674(+) ATGTT(G/T)CTCCC upstream-variant-2KB
rs187119808 -- 9,223,661(+) TTAAA(A/C)GTCTC upstream-variant-2KB
rs368726356 -- 9,225,986(+) CCTGA(C/G)TCAAC reference, missense
rs370538587 -- 9,223,693(+) GGCCT(C/G)ACTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L13 Gene

Variant ID Type Subtype PubMed ID
dgv922e199 CNV deletion 23128226
dgv923e199 CNV deletion 23128226
esv2678198 CNV deletion 23128226
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1077433 CNV duplication 25765185
nsv1128884 CNV duplication 24896259
nsv1147485 CNV duplication 26484159
nsv428437 CNV gain 18775914

Relevant External Links for USP17L13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L13 Gene

Disorders for USP17L13 Gene

Relevant External Links for USP17L13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L13

No disorders were found for USP17L13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L13 Gene

Publications for USP17L13 Gene

  1. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S … Baek KH (The Journal of biological chemistry 2011) 3 60
  2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M … Johnston JA (Nature communications 2011) 3 60
  3. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M … Johnston JA (The Journal of biological chemistry 2010) 3 60
  4. Cdc25A and Dub3 in a high-stakes balancing act. (PMID: 20228807) Hayes SD … Harper JW (Nature cell biology 2010) 3 60
  5. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y … Dixit VM (Nature cell biology 2010) 3 60

Products for USP17L13 Gene

Sources for USP17L13 Gene

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