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Aliases for USP17L11 Gene

Aliases for USP17L11 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 11 2 3 5
  • EC 3.4.19.12 4

External Ids for USP17L11 Gene

Previous GeneCards Identifiers for USP17L11 Gene

  • GC04P009218

Summaries for USP17L11 Gene

GeneCards Summary for USP17L11 Gene

USP17L11 (Ubiquitin Specific Peptidase 17-Like Family Member 11) is a Protein Coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L17.

UniProtKB/Swiss-Prot for USP17L11 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L11 Gene

Genomics for USP17L11 Gene

Genomic Location for USP17L11 Gene

Chromosome:
4
Start:
9,215,405 bp from pter
End:
9,217,356 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L11 Gene

Genes around USP17L11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L11 Gene

No data available for Regulatory Elements for USP17L11 Gene

Proteins for USP17L11 Gene

  • Protein details for USP17L11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JVI0-U17LB_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 11
    Protein Accession:
    C9JVI0

    Protein attributes for USP17L11 Gene

    Size:
    530 amino acids
    Molecular mass:
    59630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L11 Gene

Post-translational modifications for USP17L11 Gene

No Post-translational modifications

Other Protein References for USP17L11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L11 Gene

Domains & Families for USP17L11 Gene

Protein Domains for USP17L11 Gene

Graphical View of Domain Structure for InterPro Entry

C9JVI0

UniProtKB/Swiss-Prot:

U17LB_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L11: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L11 Gene

Function for USP17L11 Gene

Molecular function for USP17L11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L11 Gene

Gene Ontology (GO) - Molecular Function for USP17L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L11: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L11 Gene

Localization for USP17L11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L11 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP17L11 Gene COMPARTMENTS Subcellular localization image for USP17L11 gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 3

Gene Ontology (GO) - Cellular Components for USP17L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L11: view

Pathways & Interactions for USP17L11 Gene

SuperPathways for USP17L11 Gene

No Data Available

Interacting Proteins for USP17L11 Gene

Gene Ontology (GO) - Biological Process for USP17L11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L11: view

No data available for Pathways by source and SIGNOR curated interactions for USP17L11 Gene

Drugs & Compounds for USP17L11 Gene

No Compound Related Data Available

Transcripts for USP17L11 Gene

mRNA/cDNA for USP17L11 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L11 Gene

No ASD Table

Relevant External Links for USP17L11 Gene

GeneLoc Exon Structure for
USP17L11
ECgene alternative splicing isoforms for
USP17L11

Expression for USP17L11 Gene

mRNA expression in normal human tissues for USP17L11 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L11 Gene:

USP17L11
genes like me logo Genes that share expression patterns with USP17L11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USP17L11 Gene

Orthologs for USP17L11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17la 35
  • 45 (a)
ManyToMany
Usp17lb 35
  • 47 (a)
ManyToMany
Usp17lc 35
  • 45 (a)
ManyToMany
Usp17ld 35
  • 44 (a)
ManyToMany
Usp17le 35
  • 44 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 4 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 35
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 20 (a)
OneToMany
Species where no ortholog for USP17L11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L11 Gene

ENSEMBL:
Gene Tree for USP17L11 (if available)
TreeFam:
Gene Tree for USP17L11 (if available)

Paralogs for USP17L11 Gene

genes like me logo Genes that share paralogs with USP17L11: view

Variants for USP17L11 Gene

Sequence variations from dbSNP and Humsavar for USP17L11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs183189805 -- 9,215,358(+) CTGCA(A/C)ACTGC upstream-variant-2KB
rs190541116 -- 9,215,352(+) GTCTT(G/T)CTGCA upstream-variant-2KB
rs186533639 -- 9,215,305(+) ATGCG(C/G)CAGAG upstream-variant-2KB
rs369750329 -- 9,215,413(+) GAGGA(A/C)GACTC reference, missense
rs373868026 -- 9,214,628(+) GCTTT(A/C)TTATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L11 Gene

Variant ID Type Subtype PubMed ID
dgv922e199 CNV deletion 23128226
dgv923e199 CNV deletion 23128226
esv2678198 CNV deletion 23128226
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1077433 CNV duplication 25765185
nsv1118712 CNV duplication 24896259
nsv1118713 CNV duplication 24896259
nsv1139810 CNV duplication 24896259
nsv1141451 CNV duplication 24896259
nsv1147485 CNV duplication 26484159
nsv428437 CNV gain 18775914
nsv949791 CNV duplication 24416366

Relevant External Links for USP17L11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L11 Gene

Disorders for USP17L11 Gene

Relevant External Links for USP17L11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L11

No disorders were found for USP17L11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L11 Gene

Publications for USP17L11 Gene

  1. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 65
  2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 65
  3. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3 65
  4. Cdc25A and Dub3 in a high-stakes balancing act. (PMID: 20228807) Hayes S.D. … Harper J.W. (Nat. Cell Biol. 2010) 3 65
  5. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y. … Dixit V.M. (Nat. Cell Biol. 2010) 3 65

Products for USP17L11 Gene

Sources for USP17L11 Gene

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