Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP17L10 Gene

Aliases for USP17L10 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 10 2 3 5
  • EC 3.4.19.12 4

External Ids for USP17L10 Gene

Summaries for USP17L10 Gene

GeneCards Summary for USP17L10 Gene

USP17L10 (Ubiquitin Specific Peptidase 17-Like Family Member 10) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L28.

UniProtKB/Swiss-Prot for USP17L10 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L10 Gene

Genomics for USP17L10 Gene

Regulatory Elements for USP17L10 Gene

Enhancers for USP17L10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G009170 0.2 Ensembl 0.3 -40.0 -39956 0.2 FAM86KP FAM90A26 USP17L10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP17L10 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP17L10 Gene

Chromosome:
4
Start:
9,210,657 bp from pter
End:
9,212,608 bp from pter
Size:
1,952 bases
Orientation:
Plus strand

Genomic View for USP17L10 Gene

Genes around USP17L10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L10 Gene

Proteins for USP17L10 Gene

  • Protein details for USP17L10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JJH3-U17LA_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 10
    Protein Accession:
    C9JJH3

    Protein attributes for USP17L10 Gene

    Size:
    530 amino acids
    Molecular mass:
    59886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L10 Gene

Post-translational modifications for USP17L10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USP17L10 Gene

Domains & Families for USP17L10 Gene

Protein Domains for USP17L10 Gene

Graphical View of Domain Structure for InterPro Entry

C9JJH3

UniProtKB/Swiss-Prot:

U17LA_HUMAN :
  • Belongs to the peptidase C19 family. USP17 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L10: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for USP17L10 Gene

Function for USP17L10 Gene

Molecular function for USP17L10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L10 Gene

Gene Ontology (GO) - Molecular Function for USP17L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L10: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L10 Gene

Localization for USP17L10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L10 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP17L10 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2

Gene Ontology (GO) - Cellular Components for USP17L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L10: view

Pathways & Interactions for USP17L10 Gene

genes like me logo Genes that share pathways with USP17L10: view

Pathways by source for USP17L10 Gene

Gene Ontology (GO) - Biological Process for USP17L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L10: view

No data available for SIGNOR curated interactions for USP17L10 Gene

Drugs & Compounds for USP17L10 Gene

No Compound Related Data Available

Transcripts for USP17L10 Gene

mRNA/cDNA for USP17L10 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L10 Gene

No ASD Table

Relevant External Links for USP17L10 Gene

GeneLoc Exon Structure for
USP17L10
ECgene alternative splicing isoforms for
USP17L10

Expression for USP17L10 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L10 Gene:

USP17L10

SOURCE GeneReport for Unigene cluster for USP17L10 Gene:

Hs.741130
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP17L10 Gene

Orthologs for USP17L10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP17L10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 94 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Usp17lb 35
  • 45 (a)
ManyToMany
Usp17la 35
  • 44 (a)
ManyToMany
Usp17lc 35
  • 44 (a)
ManyToMany
Usp17ld 35
  • 43 (a)
ManyToMany
Usp17le 35
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii usp42 35
  • 17 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta scny 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 20 (a)
OneToMany
Species where no ortholog for USP17L10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP17L10 Gene

ENSEMBL:
Gene Tree for USP17L10 (if available)
TreeFam:
Gene Tree for USP17L10 (if available)

Paralogs for USP17L10 Gene

genes like me logo Genes that share paralogs with USP17L10: view

Variants for USP17L10 Gene

Sequence variations from dbSNP and Humsavar for USP17L10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1051690168 -- 9,209,893(+) TGGCA(A/G)TCTAG intron-variant, upstream-variant-2KB
rs137952652 -- 9,210,398(+) TCATG(A/C)TGTGG intron-variant, upstream-variant-2KB
rs139813323 -- 9,210,939(+) CTTCC(C/T)TGCAG intron-variant, reference, synonymous-codon
rs142481985 -- 9,210,496(+) GCGCA(C/T)CTGAT intron-variant, upstream-variant-2KB
rs143756616 -- 9,210,259(+) TTTCC(A/T)AGGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP17L10 Gene

Variant ID Type Subtype PubMed ID
dgv2732n106 CNV deletion 24896259
dgv922e199 CNV deletion 23128226
dgv923e199 CNV deletion 23128226
esv2678198 CNV deletion 23128226
esv2759222 CNV gain+loss 17122850
esv2763860 CNV gain+loss 21179565
esv34196 OTHER inversion 12058347
esv3599566 CNV loss 21293372
nsv1005698 CNV gain 25217958
nsv1074150 CNV deletion 25765185
nsv428437 CNV gain 18775914
nsv949789 CNV deletion 24416366

Variation tolerance for USP17L10 Gene

Gene Damage Index Score: 3.20; 52.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP17L10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP17L10 Gene

Disorders for USP17L10 Gene

Relevant External Links for USP17L10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L10

No disorders were found for USP17L10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L10 Gene

Publications for USP17L10 Gene

  1. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 3 64
  2. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 3 64
  3. The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. (PMID: 20147298) de la Vega M. … Johnston J.A. (J. Biol. Chem. 2010) 3 64
  4. Cdc25A and Dub3 in a high-stakes balancing act. (PMID: 20228807) Hayes S.D. … Harper J.W. (Nat. Cell Biol. 2010) 3 64
  5. Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. (PMID: 20228808) Pereg Y. … Dixit V.M. (Nat. Cell Biol. 2010) 3 64

Products for USP17L10 Gene

Sources for USP17L10 Gene

Content
Loading form....