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Aliases for USP17L1 Gene

Aliases for USP17L1 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 1 2 3 5
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 1 3 4
  • Deubiquitinating Enzyme 17-Like Protein 1 3 4
  • Ubiquitin Thioesterase 17-Like Protein 1 3 4
  • USP17L1P 3 4
  • Ubiquitin Specific Peptidase 17-Like Family Member 1, Pseudogene 2
  • Putative Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 1 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 1 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • USP17L 4

External Ids for USP17L1 Gene

Previous HGNC Symbols for USP17L1 Gene

  • USP17L1P

Summaries for USP17L1 Gene

GeneCards Summary for USP17L1 Gene

USP17L1 (Ubiquitin Specific Peptidase 17-Like Family Member 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include cysteine-type peptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L4.

UniProtKB/Swiss-Prot for USP17L1 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L1 Gene

Genomics for USP17L1 Gene

Genomic Location for USP17L1 Gene

Chromosome:
8
Start:
7,332,387 bp from pter
End:
7,333,979 bp from pter
Size:
1,593 bases
Orientation:
Plus strand

Genomic View for USP17L1 Gene

Genes around USP17L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP17L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP17L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L1 Gene

No data available for Regulatory Elements for USP17L1 Gene

Proteins for USP17L1 Gene

  • Protein details for USP17L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTZ2-U17L1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 1
    Protein Accession:
    Q7RTZ2

    Protein attributes for USP17L1 Gene

    Size:
    530 amino acids
    Molecular mass:
    59590 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L1 Gene

Selected DME Specific Peptides for USP17L1 Gene

Q7RTZ2:
  • AQSVKQAL
  • SDTFDPYLDI
  • WRSQIKCL
  • VYVLYAVLVH
  • QALEQLVKPEELNGENAYHCG
  • HEFLMFTVDAMKKACLPGHKQVDHH
  • SVLSQQAYVLFYI
  • TLTLHTSAKVLILVLKRFSDV
  • LVERATQESTLDHWKF
  • CTMQAHIT
  • RVDLCDDLAPVARQLAPR
  • GFHRGKQED

Post-translational modifications for USP17L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L1 Gene

Protein Domains for USP17L1 Gene

Suggested Antigen Peptide Sequences for USP17L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTZ2

UniProtKB/Swiss-Prot:

U17L1_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L1: view

No data available for Gene Families for USP17L1 Gene

Function for USP17L1 Gene

Molecular function for USP17L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L1 Gene

Gene Ontology (GO) - Molecular Function for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L1: view

Phenotypes for USP17L1 Gene

genes like me logo Genes that share phenotypes with USP17L1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L1 Gene

Localization for USP17L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L1 Gene

Nucleus. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L1: view

No data available for Subcellular locations from COMPARTMENTS for USP17L1 Gene

Pathways & Interactions for USP17L1 Gene

genes like me logo Genes that share pathways with USP17L1: view

Pathways by source for USP17L1 Gene

Interacting Proteins for USP17L1 Gene

Gene Ontology (GO) - Biological Process for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L1: view

No data available for SIGNOR curated interactions for USP17L1 Gene

Transcripts for USP17L1 Gene

mRNA/cDNA for USP17L1 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L1 Gene

No ASD Table

Relevant External Links for USP17L1 Gene

GeneLoc Exon Structure for
USP17L1
ECgene alternative splicing isoforms for
USP17L1

Expression for USP17L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP17L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP17L1 Gene:

USP17L1
genes like me logo Genes that share expression patterns with USP17L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USP17L1 Gene

Orthologs for USP17L1 Gene

Evolution for USP17L1 Gene

ENSEMBL:
Gene Tree for USP17L1 (if available)
TreeFam:
Gene Tree for USP17L1 (if available)

No data available for Orthologs for USP17L1 Gene

Paralogs for USP17L1 Gene

Paralogs for USP17L1 Gene

genes like me logo Genes that share paralogs with USP17L1: view

Variants for USP17L1 Gene

Sequence variations from dbSNP and Humsavar for USP17L1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs117479685 -- 7,333,413(+) CTCAA(A/G)AAGTC intron-variant, reference, missense, utr-variant-3-prime
rs138910436 -- 7,330,419(+) TATCA(A/T)TTCGG intron-variant, upstream-variant-2KB
rs142234711 -- 7,333,994(+) AAGTG(C/T)CGACC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs143790050 -- 7,332,253(+) CGCGG(C/T)TGGTG intron-variant, upstream-variant-2KB
rs150285985 -- 7,341,561(+) TAGAA(G/T)TCATG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for USP17L1 Gene

Variant ID Type Subtype PubMed ID
dgv11911n54 CNV loss 21841781
dgv2035e212 CNV gain 25503493
dgv6878n100 CNV gain 25217958
dgv6879n100 CNV gain 25217958
dgv6882n100 CNV gain 25217958
dgv6884n100 CNV gain 25217958
dgv6885n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6888n100 CNV gain+loss 25217958
dgv6889n100 CNV loss 25217958
dgv6890n100 CNV gain 25217958
dgv6891n100 CNV gain+loss 25217958
dgv6892n100 CNV loss 25217958
dgv6893n100 CNV gain 25217958
dgv6894n100 CNV gain+loss 25217958
dgv6895n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6897n100 CNV gain 25217958
dgv6898n100 CNV loss 25217958
dgv6899n100 CNV gain 25217958
dgv6900n100 CNV gain+loss 25217958
dgv6901n100 CNV gain+loss 25217958
dgv6902n100 CNV gain 25217958
dgv6903n100 CNV loss 25217958
dgv6904n100 CNV gain 25217958
dgv6905n100 CNV gain 25217958
dgv6906n100 CNV gain 25217958
dgv6907n100 CNV loss 25217958
dgv6908n100 CNV gain 25217958
dgv6909n100 CNV gain 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6911n100 CNV loss 25217958
dgv6912n100 CNV loss 25217958
dgv6913n100 CNV gain 25217958
dgv6914n100 CNV gain+loss 25217958
dgv6915n100 CNV gain 25217958
esv1000362 CNV gain 20482838
esv21583 CNV gain+loss 19812545
esv2675221 CNV deletion 23128226
esv2759589 CNV gain+loss 17122850
esv2761169 CNV gain+loss 21179565
esv2764098 CNV gain+loss 21179565
esv33606 CNV gain+loss 17666407
esv3616114 CNV loss 21293372
esv3616115 CNV loss 21293372
esv3891318 CNV gain 25118596
esv3891324 CNV gain 25118596
nsv1023986 CNV loss 25217958
nsv1026778 CNV gain 25217958
nsv1027709 CNV gain+loss 25217958
nsv1028208 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv1161709 CNV duplication 26073780
nsv1161710 CNV deletion 26073780
nsv428194 CNV gain+loss 18775914
nsv471650 CNV gain+loss 15918152
nsv510977 OTHER complex 20534489
nsv515968 CNV gain+loss 19592680
nsv821142 CNV deletion 20802225
nsv821656 CNV gain 15273396
nsv8281 CNV gain+loss 18304495
nsv831223 CNV loss 17160897
nsv831224 CNV gain+loss 17160897
nsv831225 CNV loss 17160897
nsv951091 CNV deletion 24416366
nsv971277 CNV duplication 23825009

Relevant External Links for USP17L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP17L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for USP17L1 Gene

Disorders for USP17L1 Gene

Relevant External Links for USP17L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L1

No disorders were found for USP17L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L1 Gene

Publications for USP17L1 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 2 3 4 64
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 2 3 4 64
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for USP17L1 Gene

Sources for USP17L1 Gene

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