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Aliases for USP17L1 Gene

Aliases for USP17L1 Gene

  • Ubiquitin Specific Peptidase 17-Like Family Member 1 2 3
  • Ubiquitin-Specific-Processing Protease 17-Like Protein 1 3 4
  • Deubiquitinating Enzyme 17-Like Protein 1 3 4
  • Ubiquitin Thioesterase 17-Like Protein 1 3 4
  • USP17L1P 3 4
  • Ubiquitin Specific Peptidase 17-Like Family Member 1, Pseudogene 2
  • Putative Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 1 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • USP17L 4

External Ids for USP17L1 Gene

Previous HGNC Symbols for USP17L1 Gene

  • USP17L1P

Summaries for USP17L1 Gene

GeneCards Summary for USP17L1 Gene

USP17L1 (Ubiquitin Specific Peptidase 17-Like Family Member 1) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitinyl hydrolase activity. An important paralog of this gene is USP17L3.

UniProtKB/Swiss-Prot for USP17L1 Gene

  • Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP17L1 Gene

Genomics for USP17L1 Gene

Genomic Location for USP17L1 Gene

Chromosome:
8
Start:
7,332,387 bp from pter
End:
7,333,979 bp from pter
Size:
1,593 bases
Orientation:
Plus strand

Genomic View for USP17L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP17L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP17L1 Gene

No data available for Regulatory Elements for USP17L1 Gene

Proteins for USP17L1 Gene

  • Protein details for USP17L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTZ2-U17L1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 1
    Protein Accession:
    Q7RTZ2

    Protein attributes for USP17L1 Gene

    Size:
    530 amino acids
    Molecular mass:
    59590 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP17L1 Gene

Proteomics data for USP17L1 Gene at MOPED

Post-translational modifications for USP17L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP17L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP17L1 Gene

Protein Domains for USP17L1 Gene

Suggested Antigen Peptide Sequences for USP17L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTZ2

UniProtKB/Swiss-Prot:

U17L1_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP17 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP17 subfamily.
genes like me logo Genes that share domains with USP17L1: view

No data available for Gene Families for USP17L1 Gene

Function for USP17L1 Gene

Molecular function for USP17L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Enzyme Numbers (IUBMB) for USP17L1 Gene

Gene Ontology (GO) - Molecular Function for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
GO:0036459 ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP17L1: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP17L1 Gene

Localization for USP17L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP17L1 Gene

Nucleus. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with USP17L1: view

No data available for Subcellular locations from COMPARTMENTS for USP17L1 Gene

Pathways & Interactions for USP17L1 Gene

SuperPathways for USP17L1 Gene

No Data Available

Interacting Proteins for USP17L1 Gene

Gene Ontology (GO) - Biological Process for USP17L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP17L1: view

No data available for Pathways by source and SIGNOR curated interactions for USP17L1 Gene

Drugs & Compounds for USP17L1 Gene

No Compound Related Data Available

Transcripts for USP17L1 Gene

mRNA/cDNA for USP17L1 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP17L1 Gene

No ASD Table

Relevant External Links for USP17L1 Gene

GeneLoc Exon Structure for
USP17L1
ECgene alternative splicing isoforms for
USP17L1

Expression for USP17L1 Gene

mRNA expression in normal human tissues for USP17L1 Gene

genes like me logo Genes that share expression patterns with USP17L1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP17L1 Gene

Orthologs for USP17L1 Gene

Evolution for USP17L1 Gene

ENSEMBL:
Gene Tree for USP17L1 (if available)
TreeFam:
Gene Tree for USP17L1 (if available)

No data available for Orthologs for USP17L1 Gene

Paralogs for USP17L1 Gene

Paralogs for USP17L1 Gene

genes like me logo Genes that share paralogs with USP17L1: view

Variants for USP17L1 Gene

Relevant External Links for USP17L1 Gene

HapMap Linkage Disequilibrium report
USP17L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for USP17L1 Gene

Disorders for USP17L1 Gene

Relevant External Links for USP17L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP17L1
genes like me logo Genes that share disorders with USP17L1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP17L1 Gene

Publications for USP17L1 Gene

  1. Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. (PMID: 17109758) Shin J.-M. … Baek K.-H. (BMC Genomics 2006) 2 67
  2. The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. (PMID: 15780755) Burrows J.F. … Johnston J.A. (Genomics 2005) 2 67
  3. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. (PMID: 21448158) de la Vega M. … Johnston J.A. (Nat. Commun. 2011) 67
  4. Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. (PMID: 21239494) Ramakrishna S. … Baek K.H. (J. Biol. Chem. 2011) 67
  5. The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. (PMID: 20388806) McFarlane C. … Johnston J.A. (Cancer Res. 2010) 67

Products for USP17L1 Gene

Sources for USP17L1 Gene

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