Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



USP16 Gene

protein-coding   GIFtS: 59
GCID: GC21P030396

Ubiquitin Specific Peptidase 16

(Previous name: ubiquitin specific protease 16)
  Search for USP16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin Specific Peptidase 161 2     Human Ubiquitin Processing Protease, EC 3.1.2.1511
Ubiquitin Specific Protease 161 2     UBP-M2
Deubiquitinating Enzyme 162 3     Ubiquitin Carboxyl-Terminal Hydrolase 162
Ubiquitin Thioesterase 162 3     Ubiquitin Thiolesterase 162
Ubiquitin-Processing Protease UBP-M2 3     Ubiquitin-Specific Processing Protease 162
Ubiquitin-Specific-Processing Protease 162 3     EC 3.4.19.123
UBPM2 5     EC 3.1.2.158

External Ids:    HGNC: 126141   Entrez Gene: 106002   Ensembl: ENSG000001562567   OMIM: 6047355   UniProtKB: Q9Y5T53   

Export aliases for USP16 gene to outside databases

Previous GC identifers: GC21P026975 GC21P029318 GC21P015803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for USP16 Gene:
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then
dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated
proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul
2008)

GeneCards Summary for USP16 Gene:
USP16 (ubiquitin specific peptidase 16) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and histone binding. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
Function: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic
transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite
for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation
when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its
activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A
deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B

Gene Wiki entry for USP16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP16 gene promoter:
         c-Fos   ISGF-3   AML1a   AP-1   p53   RREB-1   GATA-1   FOXJ2 (long isoform)   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): USP16 promoter sequence

   Search Chromatin IP Primers for USP16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21
Nature(405: 311-319) cytogenetic band:   21q22.11
USP16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP16 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P030396:   GeneLoc Nature:405,311-319
Start:
30,396,938 bp from pter       15,974,947 bp from centromere
End:
30,426,809 bp from pter 16,004,744 bp from centromere
Size:
29,872 bases 29,798 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF126736
genomic clones: P100J12 P79E4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 16  
Size: 823 amino acids; 93570 Da
Subunit: Homotetramer
Miscellaneous: USP16 may contribute to somatic stem cell defects observed in Down syndrome. USP16 is triplicated
in Down syndrome and its overexpression may contribute to proliferation defects in stem cells. Reduction of USP16
levels results in increased proliferation capacity of Down syndrome fibroblasts (PubMed:24025767)
Sequence caution: Sequence=AAG39290.1; Type=Erroneous initiation; Sequence=BAG51175.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for USP16:
2I50 (3D)    
Secondary accessions: A8MU43 B3KN13 B4DFV8 B4DY37 D3DSD9 Q53GP7 Q53HA0 Q5VKN8 Q8NEL3 Q9H3E6
Alternative splicing: 5 isoforms:  Q9Y5T5-1   Q9Y5T5-2   Q9Y5T5-3   Q9Y5T5-4   Q9Y5T5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP16: NX_Q9Y5T5

Explore proteomics data for USP16 at MOPED

Post-translational modifications: 

  • Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition.
    Phosphorylation by AURKB enhances the deubiquitinase activity1
  • Ubiquitination2 at Lys293
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP16 (Q9Y5T5) (see all 23)
     ALVNVEW  WLCLKCG  AYLLFYE  NLGNTCF 


    See USP16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001992.1  NP_001027582.1  NP_006438.1  

    ENSEMBL proteins: 
     ENSP00000382857   ENSP00000382858   ENSP00000334808   ENSP00000382855   ENSP00000442855  

    USP16 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP16
    OriGene Protein Over-expression Lysate for USP16
    OriGene MassSpec for USP16
    OriGene Custom Protein Services for USP16
    GenScript Custom Purified and Recombinant Proteins Services for USP16
    Novus Biologicals USP16 Protein
    Novus Biologicals USP16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for USP16
    Cloud-Clone Corp. Proteins for USP16

     
    Search eBioscience for Proteins for USP16 

    USP16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP16
    OriGene Custom Antibody Services for USP16
    Novus Biologicals USP16 Antibodies
    Abcam antibodies for USP16
    Cloud-Clone Corp. Antibodies for USP16
    ThermoFisher Antibodies for USP16
    LSBio Antibodies in human, mouse, rat for USP16

    USP16 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP16
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP16
    Cloud-Clone Corp. CLIAs for USP16
    Search eBioscience for ELISAs for USP16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q9Y5T5

    ProtoNet protein and cluster: Q9Y5T5

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
    Domain: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated
    within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin
    Similarity: Belongs to the peptidase C19 family. USP16 subfamily
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP16_HUMAN, Q9Y5T5
    Function: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic
    transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite
    for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation
    when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its
    activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A
    deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP16:
    ubiquitin specific protease 16,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA17914355
    GO:0004197cysteine-type endopeptidase activity IMP17914355
    GO:0004221ubiquitin thiolesterase activity IDA17914355
    GO:0004843ubiquitin-specific protease activity IDA17914355
    GO:0008270zinc ion binding IDA17512543
         
    Find genes that share ontologies with USP16           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP16

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP16:
    hsa-mir-30a-5p (MIRT049954), hsa-mir-320a (MIRT044492), hsa-mir-182-5p (MIRT047199), hsa-mir-324-5p (MIRT043256)

    Block miRNA regulation of human, mouse, rat USP16 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate USP16:
    hsa-miR-223 hsa-miR-548d-3p hsa-miR-4328 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidUSP16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP16
    Predesigned siRNA for gene silencing in human, mouse, rat USP16

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP16

    Clone
    Products:
         
    OriGene clones in human, mouse for USP16 (see all 16)
    OriGene ORF clones in mouse, rat for USP16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP16 (NM_006447)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP16
    Addgene plasmids for USP16 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP16
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBP16_HUMAN, Q9Y5T5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17914355
    GO:0005737cytoplasm TAS10077596

    Find genes that share ontologies with USP16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for USP16 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP16
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP16
        Integrated Breast Cancer Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including USP16: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP16 (Q9Y5T53 ENSP000003348084) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    DBTP111823, ENSP000003591514I2D: score=2 STRING: ENSP00000359151
    HERC2O957143, ENSP000002616094I2D: score=2 STRING: ENSP00000261609
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0007049cell cycle TAS10077596

    Find genes that share ontologies with USP16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP16 (UBP16)

    1 HMDB Compound for USP16    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for USP16 gene (3 alternative transcripts): 
    NM_001001992.1  NM_001032410.1  NM_006447.2  

    Unigene Cluster for USP16:

    Ubiquitin specific peptidase 16
    Hs.99819  [show with all ESTs]
    Unigene Representative Sequence: NM_001032410
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399975(uc002ymx.3 uc011acm.2 uc011acn.2 uc011aco.2)
    ENST00000399976(uc002ymy.3) ENST00000334352(uc002ymw.3) ENST00000474835
    ENST00000399973 ENST00000485067 ENST00000535828
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP16 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate USP16:
    hsa-miR-223 hsa-miR-548d-3p hsa-miR-4328 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidUSP16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP16
    Predesigned siRNA for gene silencing in human, mouse, rat USP16
    Clone
    Products:
         
    OriGene clones in human, mouse for USP16 (see all 16)
    OriGene ORF clones in mouse, rat for USP16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP16 (NM_006447)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP16
    Addgene plasmids for USP16 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP16
    OriGene qSTAR qPCR primer pairs in human, mouse for USP16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP16
      QuantiTect SYBR Green Assays in human, mouse, rat USP16
      QuantiFast Probe-based Assays in human, mouse, rat USP16

    Additional mRNA sequence: 

    AF113219.1 AF126736.1 AK023247.1 AK025104.1 AK025989.1 AK222681.1 AK222884.1 AK294284.1 
    AK300771.1 AK302247.1 BC010375.1 BC030777.2 

    15 DOTS entries:

    DT.414600  DT.100675324  DT.121138269  DT.40230171  DT.434769  DT.95333463  DT.108188  DT.121138191 
    DT.121138257  DT.121138279  DT.40273751  DT.95170557  DT.97845207  DT.100654308  DT.91828809 

    Selected AceView cDNA sequences (see all 223):

    AA730261 BM724651 BQ009564 AI244027 BM968158 AA489720 BM853094 BP337738 
    BM982490 AI248115 BP336080 AA740715 AA743843 BM822119 CD679400 BG940884 
    AA489619 BP335168 AW002690 NM_006447 AI565454 CR618560 BG541581 AI435036 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP16 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
    SP1:                          -     -                                                                       -                                               -   
    SP2:                          -     -                                                                       -                                                   
    SP3:                                -                                                                                                                           
    SP4:                          -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for USP16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    USP16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTAAA
    USP16 Expression
    About this image


    USP16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    USP16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99819

    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
    Tissue specificity: Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult
    heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including USP16: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USP16
    OriGene qSTAR qPCR primer pairs in human, mouse for USP16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP16
    QuantiTect SYBR Green Assays in human, mouse, rat USP16
    QuantiFast Probe-based Assays in human, mouse, rat USP16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for USP16 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp161 , 5 ubiquitin specific peptidase 161, 5 84.94(n)1
    82.78(a)1
      16 (49.54 cM)5
    741121  NM_024258.21  NP_077220.21 
     874547035 
    chicken
    (Gallus gallus)
    Aves USP161 ubiquitin specific peptidase 16 70.2(n)
    66.75(a)
      418485  XM_004938372.1  XP_004938429.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP166
    ubiquitin specific peptidase 16
    61(a)
    1 ↔ 1
    3(146579479-146596315)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687012 hypothetical protein MGC68701 75.64(n)    BC060022.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049336.12   -- 74.4(n)    BC049336.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG41656
    --
    23(a)
    1 → many
    X(5315563-5320941)
    worm
    (Caenorhabditis elegans)
    Secernentea cyk-36
    Protein CYK-3, isoform b (cyk-3) mRNA, complete cd...
    14(a)
    1 → many
    III(6020165-6024653) WBGene00000874


    ENSEMBL Gene Tree for USP16 (if available)
    TreeFam Gene Tree for USP16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for USP16 gene
    USP452  USP192  USP62  USP152  USP112  USP312  USP432  USP322  
    USP42  
    3 SIMAP similar genes for USP16 using alignment to 3 protein entries:     UBP16_HUMAN (see all proteins):
    DKFZp313B2010    USP45    USP30

    Find genes that share paralogs with USP16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for USP16 (see all 699)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494990011,2
    C--30394938(+) AGAGG-/CTTT  
            
    CTGAC
    3 -- us2k10--------
    rs1849278161,2
    C--30394969(+) ATGACC/TCTAAG 3 -- us2k10--------
    rs797838201,2
    --30394992(+) AATGCA/GTGGGG 3 -- us2k10--------
    rs1462316171,2
    --30395020(+) CTGGAA/GCTTGG 3 -- us2k10--------
    rs800436681,2
    C,F--30395321(+) CTTATG/CCCTGT 3 -- us2k11Minor allele frequency- C:0.05NA 120
    rs1134793001,2
    C,F--30395347(+) GAGGCC/TGAGGC 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1512550181,2
    --30395488(+) AGGGTA/GAGGTG 3 -- us2k10--------
    rs1893418421,2
    --30395501(+) AGAATC/TGGGAG 3 -- us2k10--------
    rs786602791,2
    C,F--30395612(+) AAATTA/GTCTCA 3 -- us2k12Minor allele frequency- G:0.11CSA WA 120
    rs1823289651,2
    --30395708(+) TTTATA/CTGATT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP16 (30396938 - 30426809 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP16: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP16
    DNA2.0 Custom Variant and Variant Library Synthesis for USP16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604735    OMIM disorders: --

    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
  • Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion
    inv(21) (q21;q22) with RUNX1/AML1


  • Find genes that share disorders with USP16           About GenesLikeMe


    Export disorders for USP16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for USP16 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with USP16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. (PubMed id 10077596)1, 2, 9 Cai S.-Y.... Marchesi V.T. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. (PubMed id 17512543)1, 2, 9 Pai M.-T.... Zhou P. (J. Mol. Biol. 2007)
    3. Usp16 contributes to somatic stem-cell defects in Down's syndrome. (PubMed id 24025767)1, 2 Adorno M.... Clarke M.F. (Nature 2013)
    4. Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. (PubMed id 18925961)1, 2 Gelsi-Boyer V.... Chaffanet M. (BMC Cancer 2008)
    5. Regulation of cell cycle progression and gene expression by H2A deubiquitination. (PubMed id 17914355)1, 2 Joo H.-Y.... Wang H. (Nature 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    10. Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli. (PubMed id 11753566)2, 9 Mimnaugh E.G.... Neckers L. (Cell Death Differ. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10600 HGNC: 12614 AceView: USP16 Ensembl:ENSG00000156256 euGenes: HUgn10600
    ECgene: USP16 H-InvDB: USP16

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for USP16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for USP16 gene:
    Search GeneIP for patents involving USP16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for USP16   OriGene RNAi products in human, mouse, rat for USP16  
     OriGene qPCR primer pairs and template standards for USP16   OriGene Protein Over-expression Lysate for USP16  
     OriGene MassSpec something-or-other for USP16   OriGene clones in human, mouse for USP16  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP16   OriGene Purified Protein for USP16  
     OriGene ORF clones in mouse, rat for USP16   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP16   OriGene Custom Protein Services for USP16  

     
     
     Block miRNA regulation of human, mouse, rat USP16 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing USP16
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP16 Predesigned siRNA for gene silencing in human, mouse, rat USP16
     QuantiFast Probe-based Assays in human, mouse, rat USP16 QuantiTect SYBR Green Assays in human, mouse, rat USP16
     PCR Arrays including human, mouse, rat USP16 Search Chromatin IP Primers for USP16
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP16  Search GeneGlobe Interaction Network for USP16
     Regulatory tfbs in USP16 promoter
     GenScript Custom Purified and Recombinant Proteins Services for USP16 GenScript cDNA clones with any tag delivered in your preferred vector for USP16
     GenScript Custom Assay Services for USP16 GenScript Custom overexpressing Cell Line Services for USP16
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for USP16 (UBP16)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     USP16 antibodies
     USP16 proteins
     USP16 lysates
     Antibodies for USP16
     See all of Abcam's Antibodies, Kits and Proteins for USP16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for USP16
     Proteins for USP16
     Antibodies for USP16
     ELISAs for USP16
     CLIAs for USP16



     Browse ESI BIO Cell Lines and PureStem Progenitors for USP16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP16
     SwitchGear 3'UTR luciferase reporter plasmids for USP16
     SwitchGear Promoter luciferase reporter plasmids for USP16
     ThermoFisher Antibodies for USP16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP16
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP16
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP16
     LSBio Antibodies in human, mouse, rat for USP16
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for USP16
      Search eBioscience for proteins for USP16
      Search eBioscience for elisas for USP16
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP16 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4