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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP16 Gene

protein-coding   GIFtS: 56
GCID: GC21P030396

ubiquitin specific peptidase 16

(Previous name: ubiquitin specific protease 16 )
 Explore 5 diseases affiliated with
USP16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP16    

Aliases
for USP16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Ubiquitin Specific Peptidase 161 2     Human Ubiquitin Processing Protease, EC 3.1.2.1511
Ubiquitin Specific Protease 161 2     UBP-M2
Deubiquitinating Enzyme 162 3     Ubiquitin Carboxyl-Terminal Hydrolase 162
Ubiquitin Thioesterase 162 3     Ubiquitin Thiolesterase 162
Ubiquitin-Processing Protease UBP-M2 3     Ubiquitin-Specific Processing Protease 162
Ubiquitin-Specific-Processing Protease 162 3     EC 3.4.19.123
Ubp-M1     EC 3.1.2.158

External Ids:    HGNC: 126141   Entrez Gene: 106002   Ensembl: ENSG000001562567   OMIM: 6047355   UniProtKB: Q9Y5T53   

Export aliases for USP16 gene to outside databases

Previous GC identifers: GC21P026975 GC21P029318 GC21P015803


Summaries
for USP16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USP16:
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at
the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in
vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
Function: Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby
acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10'
of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression
via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B

Gene Wiki entry for USP16


Genomic Views
for USP16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP16 gene promoter:
         c-Fos   ISGF-3   AML1a   AP-1   p53   RREB-1   GATA-1   FOXJ2 (long isoform)   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): USP16 promoter sequence

   Search SABiosciences Chromatin IP Primers for USP16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21
Nature(405: 311-319) cytogenetic band:   21q22.11
USP16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP16 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P030396:   GeneLoc Nature:405,311-319
Start:
 30,396,938 bp from pter       15,974,947 bp from centromere
End:
 30,426,809 bp from pter 16,004,744 bp from centromere
Size:
 29,872 bases 29,798 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AF126736
genomic clones: P100J12 P79E4


Proteins
for USP16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 16  
Size: 823 amino acids; 93570 Da
Subunit: Homotetramer
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAG39290.1; Type=Erroneous initiation; Sequence=BAG51175.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for USP16:
2I50 (3D)    
Secondary accessions: A8MU43 B3KN13 B4DFV8 B4DY37 D3DSD9 Q53GP7 Q53HA0 Q5VKN8 Q8NEL3 Q9H3E6
Alternative splicing: 5 isoforms:  Q9Y5T5-1   Q9Y5T5-2   Q9Y5T5-3   Q9Y5T5-4   Q9Y5T5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP16: NX_Q9Y5T5

Post-translational modifications:

  • Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The
    • phosphorylated form of the protein is also enzymatically active1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5T5

    • 4/23 DME Specific Peptides for USP16 (Q9Y5T5) (see all 23)
     ALVNVEW  WLCLKCG  AYLLFYE  NLGNTCF 

    USP16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001992.1  NP_001027582.1  NP_006438.1  

    ENSEMBL proteins: 
     ENSP00000382857   ENSP00000382858   ENSP00000334808   ENSP00000382855   ENSP00000442855  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: USP16
    OriGene Protein Over-expression Lysate (see all 5): USP16
    OriGene Custom Protein Services for USP16 
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    Novus Biologicals USP16 Protein
    Novus Biologicals USP16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17914355
    GO:0005737cytoplasm TAS10077596


    USP16 for ontologies           About GeneDecksing



    USP16 Antibody Products: 
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    ThermoFisher Antibodies for USP16

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    Uscn ELISAs and CLIAs for USP16

    Protein Domains /
    Families
    for USP16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP16 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR001607 Znf_UBP
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y5T5

    ProtoNet protein and cluster: Q9Y5T5

    2 Blocks protein families:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
    Domain: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a
    third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin
    Similarity: Belongs to the peptidase C19 family. USP16 subfamily
    Similarity: Contains 1 UBP-type zinc finger


    Function
    for USP16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
    Function: Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby
    acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10'
    of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression
    via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP16:
    ubiquitin specific protease 16,deubiquitin enzyme family

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate USP16:
    hsa-miR-223 hsa-miR-548d-3p hsa-miR-4328 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: USP16 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP16 (see all 7)
    OriGene shRNA RFP: USP16
    OriGene siRNA: USP16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP16

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP16 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 3): USP16 (NM_006447)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP16 

    Cell Line
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    Search LifeMap BioReagents cell lines for USP16

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP16

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA17914355
    GO:0004197cysteine-type endopeptidase activity IMP17914355
    GO:0004221ubiquitin thiolesterase activity IDA17914355
    GO:0004843ubiquitin-specific protease activity IDA17914355
    GO:0008270zinc ion binding IDA17512543


    USP16 for ontologies           About GeneDecksing



    Pathways & Interactions
    for USP16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    2Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP16
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP16 
        Integrated Breast Cancer Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for USP16 (Q9Y5T53 ENSP000003348084) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    DBTP111823, ENSP000003591514I2D: score=2 STRING: ENSP00000359151
    HERC2O957143, ENSP000002616094I2D: score=2 STRING: ENSP00000261609
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006974response to DNA damage stimulus IDA--
    GO:0007049cell cycle TAS10077596
    GO:0007067mitosis IDA17914355


    USP16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP16

    1 HMDB Compound for USP16    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about USP16 / UBP16 

    Transcripts
    for USP16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP16 gene (3 alternative transcripts): 
    NM_001001992.1  NM_001032410.1  NM_006447.2  

    Unigene Cluster for USP16:

    Ubiquitin specific peptidase 16
    Hs.99819  [show with all ESTs]
    Unigene Representative Sequence: NM_001032410
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399975(uc002ymx.3 uc011acm.2 uc011acn.2 uc011aco.2)
    ENST00000399976(uc002ymy.3) ENST00000334352(uc002ymw.3) ENST00000474835
    ENST00000399973 ENST00000485067 ENST00000535828

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP16
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate USP16:
    hsa-miR-223 hsa-miR-548d-3p hsa-miR-4328 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: USP16 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP16 (see all 7)
    OriGene shRNA RFP: USP16
    OriGene siRNA: USP16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP16
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): USP16 (NM_006447)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP16 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP16

    Additional cDNA sequence: 

    AF113219.1 AF126736.1 AK023247.1 AK025104.1 AK025989.1 AK222681.1 AK222884.1 AK294284.1 
    AK300771.1 AK302247.1 BC010375.1 BC030777.2 

    15 DOTS entries:

    DT.414600  DT.100675324  DT.121138269  DT.40230171  DT.434769  DT.95333463  DT.108188  DT.121138191 
    DT.121138257  DT.121138279  DT.40273751  DT.95170557  DT.97845207  DT.100654308  DT.91828809 

    24/223 AceView cDNA sequences (see all 223):

    AW002690 CB108488 BQ009564 AA730261 AI370723 BQ938256 CD679400 AI341803 
    AI244027 BP336080 BG940884 BU688072 BG541581 BM853094 BM822119 AA489619 
    AI076959 BP335168 AA679617 AA743843 AA740715 AI248115 BE542867 BG621060 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USP16 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
    SP1:                          -     -                                                                       -                                               -   
    SP2:                          -     -                                                                       -                                                   
    SP3:                                -                                                                                                                           
    SP4:                          -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for USP16

    Expression
    for USP16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATTTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See USP16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP16

    SOURCE GeneReport for Unigene cluster: Hs.99819

    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
    Tissue specificity: Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart,
    brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including USP16: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP16
    In Situ
    Assay Products:     
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    Orthologs
    for USP16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP16 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves USP161 ubiquitin specific peptidase 16 69.87(n)
    66.46(a)    		   418485  XM_416693.3  XP_416693.2 
    lizard
    (Anolis carolinensis)    		 Reptilia USP166
    		 --
    		 61(a)
    		 1 ↔ 1
    		 3(146579479-146596315)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687012 hypothetical protein MGC68701 75.64(n)    BC060022.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049336.12   -- 74.4(n)    BC049336.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 ubiquitin carboxyl-terminal hydrolase domain conta...
    ubiquitin carboxyl-terminal hydrolase family prote...
    (see all 5)    		 18(a)
    17(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 8(26272590-26276621)
    8(26279316-26283229)


    ENSEMBL Gene Tree for USP16 (if available)
    TreeFam Gene Tree for USP16 (if available) 

    Paralogs
    for USP16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP16 gene
    USP332  USP32  USP442  USP452  USP222  USP512  USP492  USP202  
    3 SIMAP similar genes for USP16 using alignment to 3 protein entries:     UBP16_HUMAN (see all proteins):
    DKFZp313B2010    USP45    BRAP

    USP16 for paralogs           About GeneDecksing



    Genomic Variants
    for USP16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/570 NCBI SNPs in USP16 are shown (see all 570)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1494990011,2
    		--30394938(+) AGAGG-/CTTT  
                CTGAC     		3 -- us2k10--------
    rs1849278161,2
    		--30394969(+) ATGACC/TCTAAG 3 -- us2k10--------
    rs797838201,2
    		--30394992(+) AATGCA/GTGGGG 3 -- us2k10--------
    rs1462316171,2
    		--30395020(+) CTGGAA/GCTTGG 3 -- us2k10--------
    rs800436681,2
    		F,--30395321(+) CTTATG/CCCTGT 3 -- us2k11Minor allele frequency- C:0.05NA 120
    rs1134793001,2
    		--30395347(+) GAGGCC/TGAGGC 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1512550181,2
    		--30395488(+) AGGGTA/GAGGTG 3 -- us2k10--------
    rs1893418421,2
    		--30395501(+) AGAATC/TGGGAG 3 -- us2k10--------
    rs786602791,2
    		--30395612(+) AAATTA/GTCTCA 3 -- us2k12Minor allele frequency- G:0.11CSA WA 120
    rs1823289651,2
    		--30395708(+) TTTATA/CTGATT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP16 (30396938 - 30426809 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for USP16: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP16
    DNA2.0 Custom Variant and Variant Library Synthesis for USP16

    Disorders / Diseases
    for USP16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP16 for disorders           About GeneDecksing

    OMIM gene information: 604735    OMIM disorders: --

    UniProtKB/Swiss-Prot: UBP16_HUMAN, Q9Y5T5
  • Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21)
    • (q21;q22) with RUNX1/AML1

    5 diseases for USP16:    About MalaCards
    peutz-jeghers syndrome    myelomonocytic leukemia    chronic myelomonocytic leukemia    leukemia
    retinitis


    Export disorders for USP16 gene to outside databases

    Publications
    for USP16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP16 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with USP16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. (PubMed id 10077596)1, 2, 9 Cai S.-Y.... Marchesi V.T. (1999)
    2. Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. (PubMed id 17512543)1, 2, 9 Pai M.-T.... Zhou P. (2007)
    3. Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. (PubMed id 18925961)1, 2 Gelsi-Boyer V.... Chaffanet M. (2008)
    4. Regulation of cell cycle progression and gene expression by H2A deubiquitination. (PubMed id 17914355)1, 2 Joo H.-Y.... Wang H. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    9. Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli. (PubMed id 11753566)2, 9 Mimnaugh E.G.... Neckers L. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for USP16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10600 HGNC: 12614 AceView: USP16 Ensembl:ENSG00000156256 euGenes: HUgn10600
    ECgene: USP16 H-InvDB: USP16

    Other Databases showing USP16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP16 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP16 gene:
    Search GeneIP for patents involving USP16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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