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Aliases for USP15 Gene

Aliases for USP15 Gene

  • Ubiquitin Specific Peptidase 15 2 3 5
  • Ubiquitin-Specific-Processing Protease 15 3 4
  • Deubiquitinating Enzyme 15 3 4
  • Ubiquitin Thioesterase 15 3 4
  • UNPH-2 3 4
  • UNPH4 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 15 3
  • Ubiquitin Specific Protease 15 2
  • Ubiquitin Thiolesterase 15 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56
  • KIAA0529 4

External Ids for USP15 Gene

Previous GeneCards Identifiers for USP15 Gene

  • GC12P062434
  • GC12P062706
  • GC12P060940
  • GC12P059705

Summaries for USP15 Gene

Entrez Gene Summary for USP15 Gene

  • This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

GeneCards Summary for USP15 Gene

USP15 (Ubiquitin Specific Peptidase 15) is a Protein Coding gene. Diseases associated with USP15 include Microphthalmia, Isolated 1 and Speech And Communication Disorders. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP15 Gene

  • Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of Lys-48- and Lys-63-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkins ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102).

  • (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Gene Wiki entry for USP15 Gene

Additional gene information for USP15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP15 Gene

Genomics for USP15 Gene

GeneHancer (GH) Regulatory Elements for USP15 Gene

Promoters and enhancers for USP15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I062256 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.9 -0.6 -608 6.7 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 USP15 MIR6125 MON2 ENSG00000257354 RPL14P1 FAM19A2 LINC01465 KLF17P1
GH12I062601 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +343.2 343198 4.5 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ENSG00000257354 ENSG00000275180 LINC01465 MIRLET7I GC12P062607 MON2 USP15 FAM19A2
GH12I062263 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 22.9 +4.3 4265 2.8 STAT1 PKNOX1 L3MBTL2 CHD1 ZMYM3 ELF1 ZNF217 CBX1 PRDM6 HDAC2 USP15 LINC01465 FAM19A2 MIR6125
GH12I062192 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 14.3 -67.3 -67333 0.8 CTCF ARNT SIN3A RAD21 CC2D1A CTBP1 ELK1 ZNF143 SMC3 ZNF444 GC12M062192 PIR40217 FAM19A2 USP15 ENSG00000257354 KLF17P1
GH12I062270 Enhancer 0.7 dbSUPER 20.8 +10.4 10385 1.1 SOX6 TEAD4 TAL1 CBFA2T3 DPF2 EP300 TCF12 PRDM6 ZNF316 SMARCA4 USP15 FAM19A2 MIR6125
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP15 gene promoter:

Genomic Locations for USP15 Gene

Genomic Locations for USP15 Gene
chr12:62,260,338-62,417,431
(GRCh38/hg38)
Size:
157,094 bases
Orientation:
Plus strand
chr12:62,654,119-62,811,211
(GRCh37/hg19)

Genomic View for USP15 Gene

Genes around USP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP15 Gene

Proteins for USP15 Gene

  • Protein details for USP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E8-UBP15_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 15
    Protein Accession:
    Q9Y4E8
    Secondary Accessions:
    • Q08AL5
    • Q9H8G9
    • Q9HCA6
    • Q9UNP0
    • Q9Y5B5

    Protein attributes for USP15 Gene

    Size:
    981 amino acids
    Molecular mass:
    112419 Da
    Quaternary structure:
    • A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN) (PubMed:16005295). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct (PubMed:21947082). Forms a complex with SMURF2 and SMAD7 (PubMed:22344298). Interacts with TGFBR1 (PubMed:22344298). Interacts with SART3; the interaction is direct (PubMed:24526689). May interact with RNF20 and RNF40 (PubMed:24526689). May interact with PRKN (PubMed:24852371).
    • (Microbial infection) Interacts with human papillomavirus type 16 protein E6.

    Three dimensional structures from OCA and Proteopedia for USP15 Gene

    Alternative splice isoforms for USP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP15 Gene

Selected DME Specific Peptides for USP15 Gene

Q9Y4E8:
  • DSRWFKQWKKYVGFDSWD
  • AAYVLFY
  • RLWNKYMSNT
  • HQQATKK
  • LKEHLIDELDY
  • CIELFTT
  • FLLDGLH
  • KWYYFDD
  • QPGLCGL
  • FHGLFKSTLVCPECAK
  • NEDGTWPR
  • GNTCFMN
  • RFAPQFSG
  • FVKHCKVEVYL
  • DGLHEDLN
  • DPWYCPNCK
  • NLGNTCF
  • YAELIKQMWSG

Post-translational modifications for USP15 Gene

  • Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
  • Ubiquitinated, leading to degradation by the proteasome.
  • Ubiquitination at isoforms=2, 3, 4154, posLast=353353, and isoforms=2, 3605

Domains & Families for USP15 Gene

Gene Families for USP15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9Y4E8

UniProtKB/Swiss-Prot:

UBP15_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP15: view

Function for USP15 Gene

Molecular function for USP15 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 15,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of Lys-48- and Lys-63-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkins ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Enzyme Numbers (IUBMB) for USP15 Gene

Phenotypes From GWAS Catalog for USP15 Gene

Gene Ontology (GO) - Molecular Function for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 21947082
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 16005295
GO:0005160 transforming growth factor beta receptor binding IPI 22344298
GO:0005515 protein binding IPI 21209336
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with USP15: view
genes like me logo Genes that share phenotypes with USP15: view

miRNA for USP15 Gene

miRTarBase miRNAs that target USP15

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP15 Gene

Localization for USP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP15 Gene

Cytoplasm. Nucleus. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP15 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21947082
GO:0005737 cytoplasm IDA,IEA 21947082
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP15: view

Pathways & Interactions for USP15 Gene

genes like me logo Genes that share pathways with USP15: view

Pathways by source for USP15 Gene

1 KEGG pathway for USP15 Gene
1 Qiagen pathway for USP15 Gene

Gene Ontology (GO) - Biological Process for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 22344298
GO:0016579 protein deubiquitination TAS,IEA --
GO:0030509 BMP signaling pathway IDA 21947082
genes like me logo Genes that share ontologies with USP15: view

No data available for SIGNOR curated interactions for USP15 Gene

Drugs & Compounds for USP15 Gene

(1) Drugs for USP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP15: view

Transcripts for USP15 Gene

Unigene Clusters for USP15 Gene

Ubiquitin specific peptidase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for USP15 Gene

GeneLoc Exon Structure for
USP15
ECgene alternative splicing isoforms for
USP15

Expression for USP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP15 Gene

This gene is overexpressed in Whole Blood (x9.2).

Protein differential expression in normal tissues from HIPED for USP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP15 Gene



Protein tissue co-expression partners for USP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP15 Gene:

USP15

SOURCE GeneReport for Unigene cluster for USP15 Gene:

Hs.434951

mRNA Expression by UniProt/SwissProt for USP15 Gene:

Q9Y4E8-UBP15_HUMAN
Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

Evidence on tissue expression from TISSUES for USP15 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Lung(4.3)
  • Skin(4.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with USP15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for USP15 Gene

Orthologs for USP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP15 33 34
  • 99.68 (n)
oppossum
(Monodelphis domestica)
Mammalia USP15 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP15 33 34
  • 96.64 (n)
cow
(Bos Taurus)
Mammalia USP15 33 34
  • 95.73 (n)
rat
(Rattus norvegicus)
Mammalia Usp15 33
  • 91.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia USP15 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp15 33 16 34
  • 90.23 (n)
chicken
(Gallus gallus)
Aves USP15 33 34
  • 87.17 (n)
lizard
(Anolis carolinensis)
Reptilia USP15 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp15 33
  • 81.47 (n)
zebrafish
(Danio rerio)
Actinopterygii USP15 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30421 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea H34C03.2 35 34
  • 58 (a)
F07A11.4 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 34 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP11 33
  • 52.69 (n)
rice
(Oryza sativa)
Liliopsida Os10g0160000 33
  • 51.88 (n)
Os.14909 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2770 34
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5425 33
Species where no ortholog for USP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP15 Gene

ENSEMBL:
Gene Tree for USP15 (if available)
TreeFam:
Gene Tree for USP15 (if available)

Paralogs for USP15 Gene

Variants for USP15 Gene

Sequence variations from dbSNP and Humsavar for USP15 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000008171 -- 62,310,891(+) TTGTCTTTTGTCTTTT/TTGTCTTTT genic_upstream_transcript_variant, intron_variant
rs1000029099 -- 62,260,261(+) C/G/T upstream_transcript_variant
rs1000030972 -- 62,344,653(+) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000050017 -- 62,270,602(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000057941 -- 62,266,439(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USP15 Gene

Variant ID Type Subtype PubMed ID
esv3394996 CNV insertion 20981092
esv3629732 CNV loss 21293372
nsv469417 CNV gain 19166990
nsv559155 CNV gain 21841781
nsv738 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952195 CNV duplication 24416366

Variation tolerance for USP15 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP15 Gene

Human Gene Mutation Database (HGMD)
USP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP15 Gene

Disorders for USP15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for USP15 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
microphthalmia, isolated 1
  • mcop1
speech and communication disorders
  • communication disorder
- elite association - COSMIC cancer census association via MalaCards
Search USP15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for USP15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with USP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP15 Gene

Publications for USP15 Gene

  1. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. (PMID: 19553310) Vos RM … Howley PM (Journal of virology 2009) 3 4 22 58
  2. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PMID: 19576224) Huang X … Dubiel W (Journal of molecular biology 2009) 3 4 22 58
  3. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PMID: 10444327) Baker RT … Sutherland GR (Genomics 1999) 3 4 22 58
  4. An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. (PMID: 27368102) Jongsma ML … Neefjes J (Cell 2016) 3 4 58
  5. The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. (PMID: 24852371) Cornelissen T … Vandenberghe W (Human molecular genetics 2014) 3 4 58

Products for USP15 Gene

  • Addgene plasmids for USP15

Sources for USP15 Gene

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