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USP15 Gene

protein-coding   GIFtS: 66
GCID: GC12P062706

Ubiquitin Specific Peptidase 15

(Previous name: ubiquitin specific protease 15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 151 2     Ubiquitin Carboxyl-Terminal Hydrolase 152
Deubiquitinating Enzyme 152 3     Ubiquitin Thiolesterase 152
Ubiquitin Thioesterase 152 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 152 3     KIAA05293
Ubiquitin Specific Protease 151     Unph-23
UNPH-22     Unph43
UNPH42     EC 3.1.2.158

External Ids:    HGNC: 126131   Entrez Gene: 99582   Ensembl: ENSG000001356557   OMIM: 6047315   UniProtKB: Q9Y4E83   

Export aliases for USP15 gene to outside databases

Previous GC identifers: GC12P062434 GC12P060940 GC12P059705


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP15 Gene:
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP
enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and
hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays
a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD
transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. (provided by RefSeq, Nov
2011)

GeneCards Summary for USP15 Gene:
USP15 (ubiquitin specific peptidase 15) is a protein-coding gene. Diseases associated with USP15 include spinocerebellar ataxia type 3, and spinocerebellar ataxia. GO annotations related to this gene include cysteine-type endopeptidase activity and identical protein binding. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as
the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling
pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of
monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting
activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta
receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced
TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as
'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated
component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates
NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and
human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway

Gene Wiki entry for USP15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP15 gene promoter:
         Nkx3-1   Brachyury   HSF1 (long)   AP-4   AP-2gamma   AP-2beta   HSF1short   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP15 promoter sequence
   Search Chromatin IP Primers for USP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14

USP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP15 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P062706:  view genomic region     (about GC identifiers)

Start:
62,654,119 bp from pter      End:
62,811,211 bp from pter
Size:
157,093 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 15  
Size: 981 amino acids; 112419 Da
Subunit: A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in
vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1,
SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1.
Interacts with human papillomavirus type 16 protein E6
Selected PDB 3D structures from and Proteopedia for USP15 (see all 7):
1W6V (3D)        3LMN (3D)        3PPA (3D)        3PV1 (3D)        3T9L (3D)        4A3O (3D)    
Secondary accessions: Q08AL5 Q9H8G9 Q9HCA6 Q9UNP0 Q9Y5B5
Alternative splicing: 4 isoforms:  Q9Y4E8-1   Q9Y4E8-2   Q9Y4E8-3   Q9Y4E8-4   

Explore the universe of human proteins at neXtProt for USP15: NX_Q9Y4E8

Explore proteomics data for USP15 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome1
  • Ubiquitinated, leading to degradation by the proteasome1
  • Ubiquitination2 at Lys154, Lys228, Lys353, Lys605
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP15 (Q9Y4E8) (see all 18)
     FLLDGLH  KWYYFDD  AAYVLFY  HQQATKK 


    See USP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001239007.1  NP_001239008.1  NP_006304.1  

    ENSEMBL proteins: 
     ENSP00000258123   ENSP00000447603   ENSP00000280377   ENSP00000309240   ENSP00000448393  
     ENSP00000446843   ENSP00000449563   ENSP00000447367   ENSP00000448372   ENSP00000446559  
     ENSP00000377264  
    Reactome Protein details: Q9Y4E8

    USP15 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for USP15
    OriGene MassSpec for USP15
    OriGene Custom Protein Services for USP15
    GenScript Custom Purified and Recombinant Proteins Services for USP15
    Novus Biologicals USP15 Proteins
    Novus Biologicals USP15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP15

    USP15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for USP15
    Cloud-Clone Corp. Antibodies for USP15
    ThermoFisher Antibody for USP15
    LSBio Antibodies in human, mouse, rat for USP15

    USP15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP15
    Cloud-Clone Corp. CLIAs for USP15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028135 Ub_USP-typ
     IPR028889 UCH/PAN2
     IPR006615 Pept_C19_DUSP

    Graphical View of Domain Structure for InterPro Entry Q9Y4E8

    ProtoNet protein and cluster: Q9Y4E8

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP
    IPB010460 Ubiquitin carboxyl-terminal hydrolase


    UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 DUSP domain
    Similarity: Contains 1 USP domain


    USP15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP15_HUMAN, Q9Y4E8
    Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as
    the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling
    pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of
    monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting
    activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta
    receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced
    TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as
    'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated
    component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates
    NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and
    human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP15:
    ubiquitin specific protease 15,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA16005295
    GO:0005160transforming growth factor beta receptor binding IPI--
         
    USP15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP15

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP15:
    hsa-mir-149-5p (MIRT045575), hsa-let-7b-5p (MIRT032405), hsa-mir-222-3p (MIRT046709), hsa-mir-103a-3p (MIRT027211), hsa-mir-16-5p (MIRT031860)

    Block miRNA regulation of human, mouse, rat USP15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP15 (see all 78):
    hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidUSP15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP15
    Predesigned siRNA for gene silencing in human, mouse, rat USP15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP15

    Clone
    Products:
         
    OriGene clones in human, mouse for USP15 (see all 7)
    OriGene ORF clones in mouse, rat for USP15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP15 (NM_006313)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP15

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP15
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP15 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP15_HUMAN, Q9Y4E8: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    USP15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP15 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.82
    TGF-beta receptor signaling activates SMADs0.82
    3Signaling by GPCR
    Signal Transduction0.58
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP15
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP15
        Integrated Breast Cancer Pathway

    1 Reactome Pathway for USP15
        Downregulation of TGF-beta receptor signaling



    USP15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP15
    Interactions:

        GeneGlobe Interaction Network for USP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP15 (Q9Y4E81, 2, 3 ENSP000002581234) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=2 STRING: ENSP00000414006
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=2 STRING: ENSP00000414634
    ENSG00000172850Q9Y3333I2D: score=2 
    ENSG00000225998Q9Y3333I2D: score=2 
    ENSG00000231502Q9Y3333I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0016579protein deubiquitination IDA16005295
    GO:0030509BMP signaling pathway IDA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway TAS--

    USP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP15 (UBP15)

    1 HMDB Compound for USP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP15 gene (3 alternative transcripts): 
    NM_001252078.1  NM_001252079.1  NM_006313.2  

    Unigene Cluster for USP15:

    Ubiquitin specific peptidase 15
    Hs.434951  [show with all ESTs]
    Unigene Representative Sequence: NM_001252078
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000353364(uc001srb.2) ENST00000549523 ENST00000280377(uc001src.2)
    ENST00000550632 ENST00000312635(uc001sra.3) ENST00000548524 ENST00000546718
    ENST00000551206(uc010ssj.2) ENST00000537297(uc010ssk.2) ENST00000549237
    ENST00000548836 ENST00000546694 ENST00000552997 ENST00000547317 ENST00000549268
    ENST00000549415 ENST00000548620 ENST00000552346
    miRNA
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    Block miRNA regulation of human, mouse, rat USP15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP15 (see all 78):
    hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidUSP15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP15
    Clone
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    OriGene ORF clones in mouse, rat for USP15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP15 (NM_006313)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP15
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP15
      QuantiTect SYBR Green Assays in human, mouse, rat USP15
      QuantiFast Probe-based Assays in human, mouse, rat USP15

    Additional mRNA sequence: 

    AB011101.2 AF013990.1 AF106069.1 AF153604.1 AK023703.1 AK292337.1 AK295947.1 AK297759.1 
    BC020688.1 BC063454.1 BC110908.1 BC125123.1 

    Selected DOTS entries (see all 28):

    DT.95195315  DT.453898  DT.91731441  DT.100820262  DT.121173373  DT.408422  DT.100820263  DT.91731451 
    DT.121173335  DT.100054864  DT.101957413  DT.121173307  DT.95195319  DT.121173455  DT.40132381  DT.86838160 
    DT.100820260  DT.121173368  DT.40113073  DT.75134651  DT.91731438  DT.95195316  DT.99935998  DT.121173428 

    Selected AceView cDNA sequences (see all 237):

    BP870725 C01419 AI188018 BQ224991 BI335006 BM677806 H88890 CB854870 
    AB011101 BC020688 AA749454 CR600092 CK904849 BG319465 CB163626 BU688932 
    AF106069 NM_006313 BQ029416 BE302353 BQ184515 AW272495 BC063454 BX105021 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP15 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                          -           -           -                 -                       -                 -                                             
    SP2:                          -           -           -                 -     -                 -                 -                                             
    SP3:                          -           -           -                                                                                                         
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for USP15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP15 Expression
    About this image


    USP15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    USP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434951

    UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
    Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with
    little or no expression in other tissues

        Custom PCR Arrays for USP15
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP15 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp151 , 5 ubiquitin specific peptidase 151, 5 90.23(n)1
    97.69(a)1
      10 (72.31 cM)5
    144791  NM_027604.31  NP_081880.21 
     1231132445 
    chicken
    (Gallus gallus)
    Aves USP151 ubiquitin specific peptidase 15 87.17(n)
    95.58(a)
      395644  NM_212537.2  NP_997702.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP156
    ubiquitin specific peptidase 15
    89(a)
    1 ↔ 1
    5(51166417-51233838)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp151 ubiquitin specific peptidase 15 81.47(n)
    89.87(a)
      100158604  NM_001128026.1  NP_001121498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii USP156
    ubiquitin specific peptidase 15
    51(a)
    1 ↔ 1
    Zv9_NA683(15449-28844) ENSDARG00000087217
    worm
    (Caenorhabditis elegans)
    Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 58(a)
    (best of 2)
      IV(6757531-6761964)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP12(YJL197W)4 Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific more   --   10(63805-67569) 853242  NP_012338.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP111 UBP11 52.69(n)
    46.22(a)
      840179  NM_103019.2  NP_174562.2 
    rice
    (Oryza sativa)
    Liliopsida Os.149092 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.55(n)    AK111889.1 


    ENSEMBL Gene Tree for USP15 (if available)
    TreeFam Gene Tree for USP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP15 gene
    USP452  USP192  USP62  USP112  USP162  USP312  USP432  USP322  
    USP42  
    Selected SIMAP similar genes for USP15 using alignment to 10 protein entries:     UBP15_HUMAN (see all proteins) (see all similar genes):
    USP4    USP8    USP3    USP11    USP2    USP32
    USP30    USP6    tre    USP19    USP33    USP31
    USP21    DKFZp434K1822    USP50    USP17L12    USP17L13    USP17L15

    USP15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USP15
    PGOHUM00000240227


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP15 (see all 2769)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612588171,2
    C--62505420(+) AAAAAA/-CGGTG 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1918249651,2
    --62652194(+) AAAAAC/TGCATT 3 -- us2k10--------
    rs1454453621,2
    --62652227(+) TTAGGA/GTATAA 3 -- us2k10--------
    rs1832492841,2
    --62652324(+) ATAGCA/TTTATT 3 -- us2k10--------
    rs1488278891,2
    --62652348(+) CATACG/TGTACA 3 -- us2k10--------
    rs1879484001,2
    --62652940(+) GCAAAC/TGAGAA 3 -- us2k10--------
    rs751221741,2
    C,F--62653014(+) ACCCCT/CGGACA 3 -- us2k11Minor allele frequency- C:0.14WA 118
    rs1920222781,2
    --62653078(+) ATTTAA/GGTAAT 3 -- us2k10--------
    rs1434886231,2
    C--62653085(+) TAATTG/TTTACA 3 -- us2k10--------
    rs1829785151,2
    --62653202(+) GAGAGA/GCAGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP15 (62654119 - 62811211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for USP15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv738CNV Insertion18451855
    dgv1432n71CNV Loss21882294
    dgv1433n71CNV Loss21882294
    nsv899153CNV Loss21882294
    nsv821671CNV Loss15273396
    dgv1431n71CNV Loss21882294
    nsv469417CNV Gain19166990

    Human Gene Mutation Database (HGMD): USP15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP15
    DNA2.0 Custom Variant and Variant Library Synthesis for USP15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604731    OMIM disorders: --

    6 diseases for USP15:    
    About MalaCards
    spinocerebellar ataxia type 3    spinocerebellar ataxia    ataxia    brain cancer
    asthma    breast cancer


    USP15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP15
    Human Genome Epidemiology (HuGE) Navigator: USP15 (1 document)

    Export disorders for USP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP15 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with USP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PubMed id 10444327)1, 2, 9 Baker R.T.... Sutherland G.R. (Genomics 1999)
    2. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PubMed id 19576224)1, 2, 9 Huang X.... Dubiel W. (J. Mol. Biol. 2009)
    3. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. (PubMed id 19553310)1, 2, 9 Vos R.M.... Howley P.M. (J. Virol. 2009)
    4. USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma. (PubMed id 22344298)1, 2 Eichhorn P.J....Seoane J. (Nat. Med. 2012)
    5. Structure of the USP15 N-terminal domains: a beta-hairpin mediates close association between the DUSP and UBL domains. (PubMed id 21848306)1, 2 Harper S.... Dreveny I. (Biochemistry 2011)
    6. Structural variability of the ubiquitin specific protease DUSP-UBL double domains. (PubMed id 22001210)1, 2 Elliott P.R.... Barsukov I.L. (FEBS Lett. 2011)
    7. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. (PubMed id 21947082)1, 2 Inui M.... Piccolo S. (Nat. Cell Biol. 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Solution structure of the human ubiquitin-specific protease 15 DUSP domain. (PubMed id 16298993)1, 2 de Jong R.N.... Folkers G.E. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9958 HGNC: 12613 AceView: USP15 Ensembl:ENSG00000135655 euGenes: HUgn9958
    ECgene: USP15 H-InvDB: USP15

    (According to HUGE)
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    HUGE: KIAA0529

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP15 gene:
    Search GeneIP for patents involving USP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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