Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP15 Gene

Aliases for USP15 Gene

  • Ubiquitin Specific Peptidase 15 2 3 5
  • Ubiquitin-Specific-Processing Protease 15 3 4
  • Deubiquitinating Enzyme 15 3 4
  • Ubiquitin Thioesterase 15 3 4
  • Unph-2 3 4
  • Unph4 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 15 3
  • Ubiquitin Specific Protease 15 2
  • Ubiquitin Thiolesterase 15 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • KIAA0529 4

External Ids for USP15 Gene

Previous GeneCards Identifiers for USP15 Gene

  • GC12P062434
  • GC12P062706
  • GC12P060940
  • GC12P059705

Summaries for USP15 Gene

Entrez Gene Summary for USP15 Gene

  • This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

GeneCards Summary for USP15 Gene

USP15 (Ubiquitin Specific Peptidase 15) is a Protein Coding gene. Diseases associated with USP15 include Speech And Communication Disorders. Among its related pathways are Integrated Breast Cancer Pathway and TGF-beta receptor signaling activates SMADs. GO annotations related to this gene include identical protein binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP15 Gene

  • Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Gene Wiki entry for USP15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP15 Gene

Genomics for USP15 Gene

Regulatory Elements for USP15 Gene

Enhancers for USP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F062263 1 FANTOM5 ENCODE 22.9 +4.3 4265 2.8 PKNOX1 ZNF362 STAT1 ZMYM3 CHD1 POLR2H HDAC2 CBX5 STAT2 NBN USP15 LINC01465 FAM19A2 MIR6125
GH12F062256 1 FANTOM5 ENCODE 20.9 -0.6 -562 6.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000257354 USP15 AVPR1A RPL14P1 FAM19A2 LINC01465 MIR6125 KLF17P1
GH12F062271 0.6 Ensembl 20.8 +13.4 13363 4.6 HLF WRNIP1 BHLHE40 ZBTB40 OSR2 MEF2D ZNF121 ZNF580 HNF4G BCL6 USP15 FAM19A2 MIR6125
GH12F062379 0.5 FANTOM5 19.7 +119.0 118992 0.3 ZBTB33 USP15 MON2 ENSG00000275881 GC12M062335 RNU6-595P
GH12F062210 1.1 FANTOM5 Ensembl 14.5 -49.0 -49038 1.4 YBX3 CTCF PKNOX1 RAD21 GATA3 GATA2 ZNF143 SMC3 CBFB CHD1 USP15 FAM19A2 LINC01465 PIR40217 GC12M062192 KLF17P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USP15 on UCSC Golden Path with GeneCards custom track

Promoters for USP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244661 662 4001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for USP15 Gene

Chromosome:
12
Start:
62,260,338 bp from pter
End:
62,417,431 bp from pter
Size:
157,094 bases
Orientation:
Plus strand

Genomic View for USP15 Gene

Genes around USP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP15 Gene

Proteins for USP15 Gene

  • Protein details for USP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E8-UBP15_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 15
    Protein Accession:
    Q9Y4E8
    Secondary Accessions:
    • Q08AL5
    • Q9H8G9
    • Q9HCA6
    • Q9UNP0
    • Q9Y5B5

    Protein attributes for USP15 Gene

    Size:
    981 amino acids
    Molecular mass:
    112419 Da
    Quaternary structure:
    • A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. Interacts with human papillomavirus type 16 protein E6.
    • A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. Interacts with human papillomavirus type 16 protein E6.

    Three dimensional structures from OCA and Proteopedia for USP15 Gene

    Alternative splice isoforms for USP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP15 Gene

Selected DME Specific Peptides for USP15 Gene

Q9Y4E8:
  • DSRWFKQWKKYVGFDSWD
  • AAYVLFY
  • RLWNKYMSNT
  • HQQATKK
  • LKEHLIDELDY
  • CIELFTT
  • FLLDGLH
  • KWYYFDD
  • QPGLCGL
  • FHGLFKSTLVCPECAK
  • NEDGTWPR
  • GNTCFMN
  • RFAPQFSG
  • FVKHCKVEVYL
  • DGLHEDLN
  • DPWYCPNCK
  • NLGNTCF
  • YAELIKQMWSG

Post-translational modifications for USP15 Gene

  • Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
  • Ubiquitinated, leading to degradation by the proteasome.
  • Ubiquitination at Lys 154, Lys 353, and Lys 605
  • Modification sites at PhosphoSitePlus

Domains & Families for USP15 Gene

Gene Families for USP15 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4E8

UniProtKB/Swiss-Prot:

UBP15_HUMAN :
  • Contains 1 DUSP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 DUSP domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP15: view

Function for USP15 Gene

Molecular function for USP15 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 15,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Enzyme Numbers (IUBMB) for USP15 Gene

Gene Ontology (GO) - Molecular Function for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP,TAS 21947082
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IDA 16005295
GO:0005160 transforming growth factor beta receptor binding IPI 22344298
GO:0005515 protein binding IPI 24526689
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with USP15: view
genes like me logo Genes that share phenotypes with USP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP15

miRNA for USP15 Gene

miRTarBase miRNAs that target USP15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP15 Gene

Localization for USP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP15 Gene COMPARTMENTS Subcellular localization image for USP15 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21947082
GO:0005737 cytoplasm IEA,IDA 21947082
genes like me logo Genes that share ontologies with USP15: view

Pathways & Interactions for USP15 Gene

genes like me logo Genes that share pathways with USP15: view

Pathways by source for USP15 Gene

Gene Ontology (GO) - Biological Process for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 22344298
GO:0016579 protein deubiquitination IEA,IDA 16005295
GO:0030509 BMP signaling pathway IDA 21947082
genes like me logo Genes that share ontologies with USP15: view

No data available for SIGNOR curated interactions for USP15 Gene

Drugs & Compounds for USP15 Gene

(1) Drugs for USP15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP15: view

Transcripts for USP15 Gene

Unigene Clusters for USP15 Gene

Ubiquitin specific peptidase 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for USP15 Gene

GeneLoc Exon Structure for
USP15
ECgene alternative splicing isoforms for
USP15

Expression for USP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP15 Gene

This gene is overexpressed in Whole Blood (x9.2).

Protein differential expression in normal tissues from HIPED for USP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP15 Gene



Protein tissue co-expression partners for USP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP15 Gene:

USP15

SOURCE GeneReport for Unigene cluster for USP15 Gene:

Hs.434951

mRNA Expression by UniProt/SwissProt for USP15 Gene:

Q9Y4E8-UBP15_HUMAN
Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
genes like me logo Genes that share expression patterns with USP15: view

Primer Products

Orthologs for USP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP15 34 35
  • 99.68 (n)
oppossum
(Monodelphis domestica)
Mammalia USP15 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP15 34 35
  • 96.64 (n)
cow
(Bos Taurus)
Mammalia USP15 34 35
  • 95.73 (n)
rat
(Rattus norvegicus)
Mammalia Usp15 34
  • 91.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia USP15 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp15 34 16 35
  • 90.23 (n)
chicken
(Gallus gallus)
Aves USP15 34 35
  • 87.17 (n)
lizard
(Anolis carolinensis)
Reptilia USP15 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp15 34
  • 81.47 (n)
zebrafish
(Danio rerio)
Actinopterygii USP15 35
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30421 36
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea H34C03.2 36 35
  • 58 (a)
F07A11.4 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 35 37
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP11 34
  • 52.69 (n)
rice
(Oryza sativa)
Liliopsida Os10g0160000 34
  • 51.88 (n)
Os.14909 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2770 35
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5425 34
Species where no ortholog for USP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP15 Gene

ENSEMBL:
Gene Tree for USP15 (if available)
TreeFam:
Gene Tree for USP15 (if available)

Paralogs for USP15 Gene

Variants for USP15 Gene

Sequence variations from dbSNP and Humsavar for USP15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1008721 -- 62,346,274(-) ACatt(A/G)aaaaa intron-variant
rs10160868 -- 62,401,653(+) TACCT(G/T)TGATC intron-variant
rs10160955 -- 62,399,415(+) TTTGT(C/T)AGCCC intron-variant
rs10431509 -- 62,312,105(+) CTCAG(A/G)CTCCA intron-variant, upstream-variant-2KB
rs10431510 -- 62,312,399(+) AAAAT(A/G)CCCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USP15 Gene

Variant ID Type Subtype PubMed ID
esv3394996 CNV insertion 20981092
esv3629732 CNV loss 21293372
nsv469417 CNV gain 19166990
nsv559155 CNV gain 21841781
nsv738 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952195 CNV duplication 24416366

Variation tolerance for USP15 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP15 Gene

Human Gene Mutation Database (HGMD)
USP15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP15 Gene

Disorders for USP15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
- elite association - COSMIC cancer census association via MalaCards
Search USP15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP15

Genetic Association Database (GAD)
USP15
Human Genome Epidemiology (HuGE) Navigator
USP15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP15
genes like me logo Genes that share disorders with USP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP15 Gene

Publications for USP15 Gene

  1. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. (PMID: 19553310) Vos R.M. … Howley P.M. (J. Virol. 2009) 3 4 22 64
  2. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PMID: 19576224) Huang X. … Dubiel W. (J. Mol. Biol. 2009) 3 4 22 64
  3. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PMID: 10444327) Baker R.T. … Sutherland G.R. (Genomics 1999) 3 4 22 64
  4. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. (PMID: 24526689) Long L. … Yao T. (J. Biol. Chem. 2014) 3 4 64
  5. USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma. (PMID: 22344298) Eichhorn P.J. … Seoane J. (Nat. Med. 2012) 3 4 64

Products for USP15 Gene

Sources for USP15 Gene

Content
Loading form....