USP15 Gene
protein-coding GIFtS: 63
GCID: GC12P062706
|
|
ubiquitin specific peptidase 15(Previous name: ubiquitin specific protease 15 )
| |
Aliases
for USP15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 151 2 | | UNPH-22 | | UNPH41 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 152 | | KIAA05291 3 | | Ubiquitin Thiolesterase 152 | | Deubiquitinating Enzyme 152 3 | | EC 3.4.19.123 | | Ubiquitin Thioesterase 152 3 | | Unph-23 | | Ubiquitin-Specific-Processing Protease 152 3 | | Unph43 | | Ubiquitin Specific Protease 151 | | EC 3.1.2.158 |
Export aliases for USP15 gene to outside databasesPrevious GC identifers: GC12P062434 GC12P060940 GC12P059705 |
Summaries
for USP15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP15:
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymesplay critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis ofubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role intransforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors.Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and apseudogene of this gene is located on the long arm of chromosome 2. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as theTGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway,but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination ofmonoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promotingactivation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptorsignaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linkedpolyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediatingdeubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16protein E6 against degradation via the ubiquitin proteasome pathway
Gene Wiki entry for USP15
|
Genomic Views
for USP15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP15 gene promoter:
Nkx3-1 Brachyury HSF1 (long) AP-4 AP-2gamma AP-2beta HSF1short AP-2alpha Pax-4a AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q14USP15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P062706: view genomic region
(about GC identifiers)
Start:
|
62,654,119 bp from pter |
End:
|
62,811,211 bp from pter |
Size:
|
157,093 bases |
Orientation:
|
plus strand |
|
Proteins
for USP15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 15 Size: 981 amino acids; 112419 Da
Subunit: A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo(PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 andSMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with humanpapillomavirus type 16 protein E6
Subcellular location: Cytoplasm. Nucleus
6/7 PDB 3D structures from  and Proteopedia  for USP15 (see all 7):1W6V (3D)
3LMN (3D)
3PPA (3D)
3PV1 (3D)
3T9L (3D)
4A3O (3D)
Secondary accessions: Q08AL5 Q9H8G9 Q9HCA6 Q9UNP0 Q9Y5B5Alternative splicing: 4 isoforms: Q9Y4E8-1 Q9Y4E8-2 Q9Y4E8-3 Q9Y4E8-4 Explore the universe of human proteins at neXtProt for USP15: NX_Q9Y4E8
Post-translational modifications:
Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome1
Ubiquitinated, leading to degradation by the proteasome1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4E8
4/18 DME Specific Peptides for USP15 (Q9Y4E8) (see all 18)
USP15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001239007.1 NP_001239008.1 NP_006304.1
ENSEMBL proteins: ENSP00000258123 ENSP00000447603 ENSP00000280377 ENSP00000309240 ENSP00000448393 ENSP00000446843 ENSP00000449563 ENSP00000447367 ENSP00000448372 ENSP00000446559 ENSP00000377264 Reactome Protein details: Q9Y4E8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
USP15 for ontologies About GeneDecksing
USP15 Antibody Products:
Assay Products for USP15: |
Protein
Domains /
Families
for USP15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP15 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4E8ProtoNet protein and cluster: Q9Y4E8 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB006615 Ubiquitin-specific protease DUSP IPB010460 Ubiquitin carboxyl-terminal hydrolase
UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 DUSP domain |
Function
for USP15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as theTGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway,but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination ofmonoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promotingactivation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptorsignaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linkedpolyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediatingdeubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16protein E6 against degradation via the ubiquitin proteasome pathwayCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Genatlas biochemistry entry for USP15:ubiquitin specific protease 15,deubiquitin enzyme family
Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP15 (NM_006313) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP15 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004197 | cysteine-type endopeptidase activity |
IMP | -- | | GO:0004221 | ubiquitin thiolesterase activity |
IDA | -- | | GO:0004843 | ubiquitin-specific protease activity |
IDA | -- | | GO:0005160 | transforming growth factor beta receptor binding |
IPI | -- | | GO:0008233 | peptidase activity |
-- | -- |
USP15 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TGF-beta receptor signaling activates SMADs | | | 2 | Ubiquitin-Proteasome Dependent Proteolysis | | | 3 | Integrated Breast Cancer Pathway | | | 4 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP15
1  BioSystems Pathway for USP15
4 
Reactome Pathways for USP15
USP15 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/80 Interacting proteins for USP15 (Q9Y4E82, 3 ENSP000002581234) via UniProtKB, MINT, STRING, and/or I2D (see all 80)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
-- | -- | | GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0007179 | transforming growth factor beta receptor signaling pathway |
TAS | -- | | GO:0016579 | protein deubiquitination |
IDA | -- | | GO:0030509 | BMP signaling pathway |
IDA | -- |
USP15 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP15
1 HMDB Compound for USP15 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP15 / UBP15
|
Transcripts
for USP15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP15 gene (3 alternative transcripts): NM_001252078.1 NM_001252079.1 NM_006313.2 Unigene Cluster for USP15: Ubiquitin specific peptidase 15 Hs.434951 [show with all ESTs]Unigene Representative Sequence: NM_00125207818/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000353364(uc001srb.2) ENST00000549523 ENST00000280377(uc001src.2)
ENST00000550632 ENST00000312635(uc001sra.3) ENST00000548524 ENST00000546718
ENST00000551206(uc010ssj.2) ENST00000537297(uc010ssk.2) ENST00000549237
ENST00000548836 ENST00000546694 ENST00000552997 ENST00000547317 ENST00000549268
ENST00000549415 ENST00000548620 ENST00000552346
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP15 (NM_006313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP15 |
Additional cDNA sequence: AB011101.2 AF013990.1 AF106069.1 AF153604.1 AK023703.1 AK292337.1 AK295947.1 AK297759.1 BC020688.1 BC063454.1 BC110908.1 BC125123.1 24/27 DOTS entries (see all 27): DT.95195315 DT.453898 DT.91731441 DT.100820262 DT.121173373 DT.408422 DT.100820263 DT.91731451 DT.121173335 DT.100054864 DT.101957413 DT.121173307 DT.95195319 DT.121173455 DT.40132381 DT.86838160 DT.100820260 DT.121173368 DT.40113073 DT.75134651 DT.91731438 DT.95195316 DT.99935998 DT.121173428 24/237 AceView cDNA sequences (see all 237): AF106069 BM677806 BQ029416 CB163626 BG319465 CR600092 AB011101 AA749454 CB854870 CK904849 H88890 BC020688 AW272495 BX105021 BC063454 BP348704 BP870450 H88889 CB143967 BQ187610 AA765405 BX405611 AF153604 AA969928
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP15 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | - | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP15
|
Expression
for USP15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See USP15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP15
SOURCE GeneReport for Unigene cluster: Hs.434951
UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with littleor no expression in other tissues
SABiosciences Custom PCR Arrays for USP15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP15 |
Orthologs
for USP15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP15 gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP151 |
ubiquitin specific peptidase 15 |
87.17(n)
95.58(a) |
|
395644 NM_204840.3 NP_990171.2 |
lizard
(Anolis carolinensis) |
Reptilia |
USP156 |
-- |
92(a) |
1 ↔ 1 |
5(51170778-51232985) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01074307.16 |
-- |
34(a) |
1 ↔ 1 |
Zv9_NA683(15449-28844) |
worm
(Caenorhabditis elegans) |
Secernentea |
H34C03.23 |
ubiquitin carboxy-terminal hydrolase |
58(a)
(best of 2) |
|
IV(6757531-6761964) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBP12(YJL197W)4
UBP121 |
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific more4
Ubp12p1 |
50.02(n)1
38.9(a)1 |
|
10(63805-67569)4
8532421, 4 NP_012338.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBP101 |
ubiquitin carboxyl-terminal hydrolase 9 |
53.21(n)
45.08(a) |
|
826651 NM_117127.2 NP_567363.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.149092 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
72.55(n) |
|
AK111889.1 |
ENSEMBL Gene Tree for USP15 (if available)
TreeFam Gene Tree for USP15 (if available) |
Paralogs
for USP15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP15 gene
- USP112 USP312 USP322 USP432 USP192 USP42 USP62
18/23 SIMAP similar genes for USP15 using alignment to 10 protein entries: UBP15_HUMAN (see all proteins)
(see all similar genes):USP4 USP8 USP3 USP11 USP2 USP32
USP6 tre USP19 USP33 USP31 USP21
USP43 DKFZp434K1822 USP50 USP17L13 USP17L5 USP51
USP15 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for USP15
PGOHUM00000240227
|
Genomic Variants
for USP15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP15 (62654119 - 62811211 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for USP15
1 CNV: 0311
Human Gene Mutation Database (HGMD): USP15
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP15 |
|
Disorders
/ Diseases
for USP15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP15 for disorders About GeneDecksing
OMIM gene information: 604731
OMIM disorders: --
6  diseases for USP15: About MalaCardsspinocerebellar ataxia type 3 adenomatous polyposis coli spinocerebellar ataxia polyposis
ataxia malaria
Human Genome Epidemiology (HuGE) Navigator: USP15 (1 document)
Export disorders for USP15 gene to outside databases
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Publications
for USP15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for USP15 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with USP15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PubMed id 10444327)1, 2, 9 Baker R.T.... Sutherland G.R. (1999)
- The COP9 signalosome mediates beta-catenin degradatio n by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PubMed id 19576224)1, 2, 9 Huang X....Dubiel W. (2009)
- The ubiquitin-specific peptidase USP15 regulates huma n papillomavirus type 16 E6 protein stability. (PubMed id 19553310)1, 2, 9 Vos R.M....Howley P.M. (2009)
- USP15 stabilizes TGF-b receptor I and promotes oncogen esis through the activation of TGF-b signaling in glioblastoma. (PubMed id 22344298)1, 2 Eichhorn P.J....Seoane J. (2012)
- Structure of the USP15 N-terminal domains: a I^-hairpi n mediates close association between the DUSP and UBL domains. (PubMed id 21848306)1, 2 Harper S....Dreveny I. (2011)
- Structural variability of the ubiquitin specific prot ease DUSP-UBL double domains. (PubMed id 22001210)1, 2 Elliott P.R....Barsukov I.L. (2011)
- USP15 is a deubiquitylating enzyme for receptor-activ ated SMADs. (PubMed id 21947082)1, 2 Inui M....Piccolo S. (2011)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Solution structure of the human ubiquitin-specific protease 15 DUSP domain. (PubMed id 16298993)1, 2 de Jong R.N....Folkers G.E. (2006)
- The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. (PubMed id 16005295)1, 2 Hetfeld B.K....Dubiel W. (2005)
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External Searches for USP15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing USP15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing USP15 gene
(According to HUGE)
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Specialized Databases showing USP15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for USP15 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for USP15 gene:
Search GeneIP for patents involving USP15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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