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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP15 Gene

protein-coding   GIFtS: 64
GCID: GC12P062706

Ubiquitin Specific Peptidase 15

(Previous name: ubiquitin specific protease 15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 151 2     Ubiquitin Carboxyl-Terminal Hydrolase 152
Deubiquitinating Enzyme 152 3     Ubiquitin Thiolesterase 152
Ubiquitin Thioesterase 152 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 152 3     KIAA05293
Ubiquitin Specific Protease 151     Unph-23
UNPH-22     Unph43
UNPH42     EC 3.1.2.158

External Ids:    HGNC: 126131   Entrez Gene: 99582   Ensembl: ENSG000001356557   OMIM: 6047315   UniProtKB: Q9Y4E83   

Export aliases for USP15 gene to outside databases

Previous GC identifers: GC12P062434 GC12P060940 GC12P059705


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP15 Gene:
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP
enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and
hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays
a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD
transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. (provided by RefSeq, Nov
2011)

GeneCards Summary for USP15 Gene: 
USP15 (ubiquitin specific peptidase 15) is a protein-coding gene. Diseases associated with USP15 include spinocerebellar ataxia type 3, and spinocerebellar ataxia, and among its related super-pathways are Downregulation of TGF-beta receptor signaling and Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as
the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling
pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of
monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting
activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta
receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced
TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as
'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated
component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates
NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and
human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway

Gene Wiki entry for USP15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP15 gene promoter:
         Nkx3-1   Brachyury   HSF1 (long)   AP-4   AP-2gamma   AP-2beta   HSF1short   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP15 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14

USP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP15 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P062706:  view genomic region     (about GC identifiers)

Start:
62,654,119 bp from pter      End:
62,811,211 bp from pter
Size:
157,093 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 15  
Size: 981 amino acids; 112419 Da
Subunit: A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in
vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1,
SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1.
Interacts with human papillomavirus type 16 protein E6
Subcellular location: Cytoplasm. Nucleus
6/7 PDB 3D structures from and Proteopedia for USP15 (see all 7):
1W6V (3D)        3LMN (3D)        3PPA (3D)        3PV1 (3D)        3T9L (3D)        4A3O (3D)    
Secondary accessions: Q08AL5 Q9H8G9 Q9HCA6 Q9UNP0 Q9Y5B5
Alternative splicing: 4 isoforms:  Q9Y4E8-1   Q9Y4E8-2   Q9Y4E8-3   Q9Y4E8-4   

Explore the universe of human proteins at neXtProt for USP15: NX_Q9Y4E8

Explore proteomics data for USP15 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome
  • UniProtKB: Ubiquitinated, leading to degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4E8

  • 4/18 DME Specific Peptides for USP15 (Q9Y4E8) (see all 18)
     FLLDGLH  KWYYFDD  AAYVLFY  HQQATKK 

    USP15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP15 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001239007.1  NP_001239008.1  NP_006304.1  

    ENSEMBL proteins: 
     ENSP00000258123   ENSP00000447603   ENSP00000280377   ENSP00000309240   ENSP00000448393  
     ENSP00000446843   ENSP00000449563   ENSP00000447367   ENSP00000448372   ENSP00000446559  
     ENSP00000377264  
    Reactome Protein details: Q9Y4E8
    Human Recombinant Protein Products for USP15: 
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    OriGene MassSpec for USP15 
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    GenScript Custom Purified and Recombinant Proteins Services for USP15
    Novus Biologicals USP15 Proteins
    Novus Biologicals USP15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    USP15 for ontologies           About GeneDecksing



    USP15 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for USP15 
    Cloud-Clone Corp. CLIAs for USP15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR006615 Pept_C19_DUSP
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b

    Graphical View of Domain Structure for InterPro Entry Q9Y4E8

    ProtoNet protein and cluster: Q9Y4E8

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP
    IPB010460 Ubiquitin carboxyl-terminal hydrolase


    UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 DUSP domain


    USP15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP15_HUMAN, Q9Y4E8
    Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as
    the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling
    pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of
    monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting
    activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta
    receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced
    TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as
    'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated
    component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates
    NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and
    human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP15:
    ubiquitin specific protease 15,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA16005295
    GO:0005160transforming growth factor beta receptor binding IPI--
         
    USP15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP15 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP15
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate USP15 (see all 78):
    hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidUSP15 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.90
    TGF-beta receptor signaling activates SMADs0.90
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signaling by TGF-beta Receptor Complex0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP15
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP15
        Integrated Breast Cancer Pathway

    4        Reactome Pathways for USP15
        Signaling by TGF-beta Receptor Complex
    TGF-beta receptor signaling activates SMADs
    Signal Transduction
    Downregulation of TGF-beta receptor signaling



    USP15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for USP15 (Q9Y4E82, 3 ENSP000002581234) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=2 STRING: ENSP00000414006
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=2 STRING: ENSP00000414634
    ENSG00000172850Q9Y3333I2D: score=2 
    ENSG00000225998Q9Y3333I2D: score=2 
    ENSG00000231502Q9Y3333I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0016579protein deubiquitination IDA16005295
    GO:0030509BMP signaling pathway IDA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway TAS--

    USP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP15 (UBP15)

    1 HMDB Compound for USP15    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP15 / UBP15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP15 gene (3 alternative transcripts): 
    NM_001252078.1  NM_001252079.1  NM_006313.2  

    Unigene Cluster for USP15:

    Ubiquitin specific peptidase 15
    Hs.434951  [show with all ESTs]
    Unigene Representative Sequence: NM_001252078
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000353364(uc001srb.2) ENST00000549523 ENST00000280377(uc001src.2)
    ENST00000550632 ENST00000312635(uc001sra.3) ENST00000548524 ENST00000546718
    ENST00000551206(uc010ssj.2) ENST00000537297(uc010ssk.2) ENST00000549237
    ENST00000548836 ENST00000546694 ENST00000552997 ENST00000547317 ENST00000549268
    ENST00000549415 ENST00000548620 ENST00000552346
    miRNA
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    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate USP15 (see all 78):
    hsa-miR-100* hsa-miR-607 hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidUSP15 3' UTR sequence
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    Additional mRNA sequence: 

    AB011101.2 AF013990.1 AF106069.1 AF153604.1 AK023703.1 AK292337.1 AK295947.1 AK297759.1 
    BC020688.1 BC063454.1 BC110908.1 BC125123.1 

    24/28 DOTS entries (see all 28):

    DT.95195315  DT.453898  DT.91731441  DT.100820262  DT.121173373  DT.408422  DT.100820263  DT.91731451 
    DT.121173335  DT.100054864  DT.101957413  DT.121173307  DT.95195319  DT.121173455  DT.40132381  DT.86838160 
    DT.100820260  DT.121173368  DT.40113073  DT.75134651  DT.91731438  DT.95195316  DT.99935998  DT.121173428 

    24/237 AceView cDNA sequences (see all 237):

    AW272495 H88890 AB011101 BP870450 BP348704 BQ187610 H88889 CB143967 
    AA765405 BX405611 AF153604 AA969928 AU120962 BP341557 CF593338 BF476162 
    BQ217308 BU620616 CA424258 BM677806 AI188018 CB163626 BQ029416 BX105021 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP15 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                          -           -           -                 -                       -                 -                                             
    SP2:                          -           -           -                 -     -                 -                 -                                             
    SP3:                          -           -           -                                                                                                         
    SP4:                                                                                                              -                                             
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for USP15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP15 Expression
    About this image


    See USP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP15

    SOURCE GeneReport for Unigene cluster: Hs.434951

    UniProtKB/Swiss-Prot: UBP15_HUMAN, Q9Y4E8
    Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with
    little or no expression in other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP15 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp151 , 5 ubiquitin specific peptidase 151, 5 90.23(n)1
    97.69(a)1
      10 (72.31 cM)5
    144791  NM_027604.31  NP_081880.21 
     1231132445 
    chicken
    (Gallus gallus)
    Aves USP151 ubiquitin specific peptidase 15 87.17(n)
    95.58(a)
      395644  NM_204840.3  NP_990171.2 
    lizard
    (Anolis carolinensis)
    Reptilia USP156
    Ubiquitin carboxyl-terminal hydrolase
    89(a)
    1 ↔ 1
    5(51166417-51233838)
    zebrafish
    (Danio rerio)
    Actinopterygii USP156
    ubiquitin specific peptidase 15
    50(a)
    1 ↔ 1
    Zv9_NA683(15449-28844)
    worm
    (Caenorhabditis elegans)
    Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 58(a)
    (best of 2)
      IV(6757531-6761964)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP12(YJL197W)4
    UBP121
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific more4
    Ubp12p1
    50.02(n)1
    38.9(a)1
      10(63805-67569)4
    8532421, 4  NP_012338.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP101 ubiquitin carboxyl-terminal hydrolase 9 53.21(n)
    45.08(a)
      826651  NM_117127.2  NP_567363.1 
    rice
    (Oryza sativa)
    Liliopsida Os.149092 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.55(n)    AK111889.1 


    ENSEMBL Gene Tree for USP15 (if available)
    TreeFam Gene Tree for USP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP15 gene
    USP452  USP192  USP62  USP162  USP112  USP312  USP432  USP322  
    USP42  
    18/34 SIMAP similar genes for USP15 using alignment to 10 protein entries:     UBP15_HUMAN (see all proteins) (see all similar genes):
    USP4    USP8    USP3    USP11    USP2    USP32
    USP6    tre    USP19    USP33    USP31    USP21
    DKFZp434K1822    USP50    USP17L12    USP17L13    USP17L15    USP17L17

    USP15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USP15
    PGOHUM00000240227


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2769 SNPs in USP15 are shown (see all 2769)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs612588171,2
    C--62505420(+) AAAAAA/-CGGTG 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1918249651,2
    --62652194(+) AAAAAC/TGCATT 3 -- us2k10--------
    rs1454453621,2
    --62652227(+) TTAGGA/GTATAA 3 -- us2k10--------
    rs1832492841,2
    --62652324(+) ATAGCA/TTTATT 3 -- us2k10--------
    rs1488278891,2
    --62652348(+) CATACG/TGTACA 3 -- us2k10--------
    rs1879484001,2
    --62652940(+) GCAAAC/TGAGAA 3 -- us2k10--------
    rs751221741,2
    C,F--62653014(+) ACCCCT/CGGACA 3 -- us2k11Minor allele frequency- C:0.14WA 118
    rs1920222781,2
    --62653078(+) ATTTAA/GGTAAT 3 -- us2k10--------
    rs1434886231,2
    C--62653085(+) TAATTG/TTTACA 3 -- us2k10--------
    rs1829785151,2
    --62653202(+) GAGAGA/GCAGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP15 (62654119 - 62811211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for USP15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv738CNV Insertion18451855
    dgv1432n71CNV Loss21882294
    dgv1433n71CNV Loss21882294
    nsv899153CNV Loss21882294
    nsv821671CNV Loss15273396
    dgv1431n71CNV Loss21882294
    nsv469417CNV Gain19166990


    Human Gene Mutation Database (HGMD): USP15
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604731    OMIM disorders: --

    5 diseases for USP15:    About MalaCards
    spinocerebellar ataxia type 3    spinocerebellar ataxia    ataxia    glioblastoma
    breast cancer


    USP15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP15
    Human Genome Epidemiology (HuGE) Navigator: USP15 (1 document)

    Export disorders for USP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP15 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with USP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PubMed id 10444327)1, 2, 9 Baker R.T.... Sutherland G.R. (1999)
    2. The COP9 signalosome mediates beta-catenin degradatio n by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PubMed id 19576224)1, 2, 9 Huang X....Dubiel W. (2009)
    3. The ubiquitin-specific peptidase USP15 regulates huma n papillomavirus type 16 E6 protein stability. (PubMed id 19553310)1, 2, 9 Vos R.M....Howley P.M. (2009)
    4. USP15 stabilizes TGF-b receptor I and promotes oncogen esis through the activation of TGF-b signaling in glioblastoma. (PubMed id 22344298)1, 2 Eichhorn P.J....Seoane J. (2012)
    5. Structure of the USP15 N-terminal domains: a I^-hairpi n mediates close association between the DUSP and UBL domains. (PubMed id 21848306)1, 2 Harper S....Dreveny I. (2011)
    6. Structural variability of the ubiquitin specific prot ease DUSP-UBL double domains. (PubMed id 22001210)1, 2 Elliott P.R....Barsukov I.L. (2011)
    7. USP15 is a deubiquitylating enzyme for receptor-activ ated SMADs. (PubMed id 21947082)1, 2 Inui M....Piccolo S. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    10. Solution structure of the human ubiquitin-specific protease 15 DUSP domain. (PubMed id 16298993)1, 2 de Jong R.N....Folkers G.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9958 HGNC: 12613 AceView: USP15 Ensembl:ENSG00000135655 euGenes: HUgn9958
    ECgene: USP15 H-InvDB: USP15

    (According to HUGE)
    About This Section
    HUGE: KIAA0529

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP15 gene:
    Search GeneIP for patents involving USP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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