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Aliases for USP15 Gene

Aliases for USP15 Gene

  • Ubiquitin Specific Peptidase 15 2 3
  • Ubiquitin-Specific-Processing Protease 15 3 4
  • Deubiquitinating Enzyme 15 3 4
  • Ubiquitin Thioesterase 15 3 4
  • UNPH-2 3 4
  • UNPH4 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 15 3
  • Ubiquitin Specific Protease 15 2
  • Ubiquitin Thiolesterase 15 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64
  • KIAA0529 4

External Ids for USP15 Gene

Summaries for USP15 Gene

Entrez Gene Summary for USP15 Gene

  • This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

GeneCards Summary for USP15 Gene

USP15 (Ubiquitin Specific Peptidase 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include identical protein binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP15 Gene

  • Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Gene Wiki entry for USP15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP15 Gene

Genomics for USP15 Gene

Genomic Location for USP15 Gene

Start:
62,260,338 bp from pter
End:
62,417,431 bp from pter
Size:
157,094 bases
Orientation:
Plus strand

Genomic View for USP15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP15 Gene

Proteins for USP15 Gene

  • Protein details for USP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E8-UBP15_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 15
    Protein Accession:
    Q9Y4E8
    Secondary Accessions:
    • Q08AL5
    • Q9H8G9
    • Q9HCA6
    • Q9UNP0
    • Q9Y5B5

    Protein attributes for USP15 Gene

    Size:
    981 amino acids
    Molecular mass:
    112419 Da
    Quaternary structure:
    • A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo (PubMed:22001210). Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. Interacts with human papillomavirus type 16 protein E6.

    Three dimensional structures from OCA and Proteopedia for USP15 Gene

    Alternative splice isoforms for USP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP15 Gene

Proteomics data for USP15 Gene at MOPED

Post-translational modifications for USP15 Gene

  • Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
  • Ubiquitinated, leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys154, Lys228, Lys353, and Lys605

Domains for USP15 Gene

Gene Families for USP15 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

UniProtKB/Swiss-Prot:

UBP15_HUMAN
Domain:
  • Contains 1 DUSP domain.:
    • Q9Y4E8
  • Contains 1 USP domain.:
    • Q9Y4E8
Family:
  • Belongs to the peptidase C19 family.:
    • Q9Y4E8
genes like me logo Genes that share domains with USP15: view

Function for USP15 Gene

Molecular function for USP15 Gene

GENATLAS Biochemistry: ubiquitin specific protease 15,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as Lys-48-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Enzyme Numbers (IUBMB) for USP15 Gene

Gene Ontology (GO) - Molecular Function for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004197 cysteine-type endopeptidase activity IMP 21947082
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 16005295
GO:0005160 transforming growth factor beta receptor binding IPI 22344298
genes like me logo Genes that share ontologies with USP15: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for USP15 Gene

Localization for USP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP15 Gene COMPARTMENTS Subcellular localization image for USP15 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21947082
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with USP15: view

Pathways for USP15 Gene

genes like me logo Genes that share pathways with USP15: view

Gene Ontology (GO) - Biological Process for USP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0008152 metabolic process --
GO:0016579 protein deubiquitination IDA 16005295
GO:0030509 BMP signaling pathway IDA 21947082
genes like me logo Genes that share ontologies with USP15: view

Compounds for USP15 Gene

(1) HMDB Compounds for USP15 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP15: view

Transcripts for USP15 Gene

Unigene Clusters for USP15 Gene

Ubiquitin specific peptidase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for USP15 Gene

GeneLoc Exon Structure for
USP15
ECgene alternative splicing isoforms for
USP15

Expression for USP15 Gene

mRNA expression in normal human tissues for USP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP15 Gene

This gene is overexpressed in Whole Blood (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP15 Gene

SOURCE GeneReport for Unigene cluster for USP15 Gene Hs.434951

mRNA Expression by UniProt/SwissProt for USP15 Gene

Q9Y4E8-UBP15_HUMAN
Tissue specificity: Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues
genes like me logo Genes that share expressions with USP15: view

Orthologs for USP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP15 36
  • 99.68 (n)
  • 99.89 (a)
USP15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP15 36
  • 95.73 (n)
  • 98.74 (a)
USP15 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP15 36
  • 96.64 (n)
  • 99.16 (a)
USP15 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp15 36
  • 90.23 (n)
  • 97.69 (a)
Usp15 16
Usp15 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP15 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP15 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp15 36
  • 91.6 (n)
  • 97.9 (a)
chicken
(Gallus gallus)
Aves USP15 36
  • 87.17 (n)
  • 95.58 (a)
USP15 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP15 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp15 36
  • 81.47 (n)
  • 89.87 (a)
zebrafish
(Danio rerio)
Actinopterygii USP15 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30421 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea H34C03.2 37
  • 30 (a)
OneToMany
H34C03.2 38
  • 58 (a)
F07A11.4 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 37
  • 22 (a)
OneToMany
UBP12 39
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP11 36
  • 52.69 (n)
  • 46.22 (a)
rice
(Oryza sativa)
Liliopsida Os.14909 36
Os10g0160000 36
  • 51.88 (n)
  • 42.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5425 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2770 37
  • 42 (a)
OneToMany
Species with no ortholog for USP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP15 Gene

ENSEMBL:
Gene Tree for USP15 (if available)
TreeFam:
Gene Tree for USP15 (if available)

Paralogs for USP15 Gene

Paralogs for USP15 Gene

Pseudogenes.org Pseudogenes for USP15 Gene

genes like me logo Genes that share paralogs with USP15: view

Variants for USP15 Gene

Sequence variations from dbSNP and Humsavar for USP15 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8291 -- 62,404,452(+) CCACA(C/T)TAAAA utr-variant-3-prime
rs15106 -- 62,404,542(+) AAACA(C/T)AATGA utr-variant-3-prime
rs490134 -- 62,342,372(-) ctcct(C/T)tgagc intron-variant
rs490834 -- 62,408,658(+) TTCTT(C/T)TAAGT utr-variant-3-prime
rs525199 -- 62,351,991(+) CTTCA(A/G)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP15 Gene

Variant ID Type Subtype PubMed ID
nsv899153 CNV Loss 21882294
nsv738 CNV Insertion 18451855
nsv469417 CNV Gain 19166990
dgv1431n71 CNV Loss 21882294
dgv1432n71 CNV Loss 21882294
dgv1433n71 CNV Loss 21882294
nsv821671 CNV Loss 15273396

Relevant External Links for USP15 Gene

HapMap Linkage Disequilibrium report
USP15
Human Gene Mutation Database (HGMD)
USP15

Disorders for USP15 Gene

Relevant External Links for USP15

Genetic Association Database (GAD)
USP15
Human Genome Epidemiology (HuGE) Navigator
USP15
genes like me logo Genes that share disorders with USP15: view

No data available for UniProtKB/Swiss-Prot for USP15 Gene

Publications for USP15 Gene

  1. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. (PMID: 10444327) Baker R.T. … Sutherland G.R. (Genomics 1999) 3 4 23
  2. The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. (PMID: 19553310) Vos R.M. … Howley P.M. (J. Virol. 2009) 3 4 23
  3. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PMID: 19576224) Huang X. … Dubiel W. (J. Mol. Biol. 2009) 3 4 23
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 23
  5. USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis. (PMID: 19665996) Xu M. … Kuroda M. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for USP15 Gene

  • Addgene plasmids for USP15

Sources for USP15 Gene

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