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Aliases for USP14 Gene

Aliases for USP14 Gene

  • Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) 2 3
  • TGT 3 4 6
  • Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase) 2 3
  • Ubiquitin-Specific-Processing Protease 14 3 4
  • Deubiquitinating Enzyme 14 3 4
  • Ubiquitin Thioesterase 14 3 4
  • TRNA-Guanine Transglycosylase, 60-KD Subunit 3
  • Ubiquitin-Specific Processing Protease 14 3
  • Ubiquitin Carboxyl-Terminal Hydrolase 14 3
  • Ubiquitin Thiolesterase 14 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63

External Ids for USP14 Gene

Previous GeneCards Identifiers for USP14 Gene

  • GC18P000442
  • GC18P000146

Summaries for USP14 Gene

Entrez Gene Summary for USP14 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP14 Gene

USP14 (Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase)) is a Protein Coding gene. Diseases associated with USP14 include ovarian serous cystadenocarcinoma and serous cystadenocarcinoma. Among its related pathways are Protein Stability and Neuroscience. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for USP14 Gene

  • Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Tocris Summary for USP14 Gene

  • Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins

Gene Wiki entry for USP14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP14 Gene

Genomics for USP14 Gene

Regulatory Elements for USP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP14 Gene

Start:
158,383 bp from pter
End:
214,629 bp from pter
Size:
56,247 bases
Orientation:
Plus strand

Genomic View for USP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP14 Gene

Proteins for USP14 Gene

  • Protein details for USP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54578-UBP14_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14
    Protein Accession:
    P54578
    Secondary Accessions:
    • B7Z4N8
    • J3QRZ5
    • Q53XY5

    Protein attributes for USP14 Gene

    Size:
    494 amino acids
    Molecular mass:
    56069 Da
    Quaternary structure:
    • Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
    SequenceCaution:
    • Sequence=CR976282; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP14 Gene

    Alternative splice isoforms for USP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP14 Gene

Proteomics data for USP14 Gene at MOPED

Selected DME Specific Peptides for USP14 Gene

Post-translational modifications for USP14 Gene

  • Ubiquitination at Lys49, Lys62, Lys130, Lys214, Lys291, Lys300, Lys348, Lys441, Lys443, and Lys449
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP14 (USP14)

Domains for USP14 Gene

Gene Families for USP14 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Graphical View of Domain Structure for InterPro Entry

P54578

UniProtKB/Swiss-Prot:

UBP14_HUMAN :
  • P54578
Domain:
  • Contains 1 ubiquitin-like domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
genes like me logo Genes that share domains with USP14: view

Function for USP14 Gene

Molecular function for USP14 Gene

GENATLAS Biochemistry: ubiquitin specific protease 14,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Enzyme Numbers (IUBMB) for USP14 Gene

Gene Ontology (GO) - Molecular Function for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 23958854
GO:0004866 endopeptidase inhibitor activity IMP 18162577
GO:0005515 protein binding IPI 19106094
genes like me logo Genes that share ontologies with USP14: view
genes like me logo Genes that share phenotypes with USP14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP14

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP14 Gene

Localization for USP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP14 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP14 Gene COMPARTMENTS Subcellular localization image for USP14 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19106094
genes like me logo Genes that share ontologies with USP14: view

Pathways for USP14 Gene

genes like me logo Genes that share pathways with USP14: view

Pathways by source for USP14 Gene

1 Qiagen pathway for USP14 Gene
2 Cell Signaling Technology pathways for USP14 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007268 synaptic transmission IEA --
GO:0010951 negative regulation of endopeptidase activity IMP 18162577
GO:0016579 protein deubiquitination IDA 23958854
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP14: view

Compounds for USP14 Gene

(5) Tocris Compounds for USP14 Gene

Compound Action Cas Number
HBX 41108 Selective USP7 inhibitor [924296-39-9]
IU1 USP14 inhibitor [314245-33-5]
NSC 687852 Inhibitor of UCHL5 and USP14 [1009817-63-3]
P 22077 USP7 inhibitor [1247819-59-5]
Spautin 1 USP10 and USP13 inhibitor; inhibits autophagy [1262888-28-7]

(9) ApexBio Compounds for USP14 Gene

Compound Action Cas Number
IU1 potent and selective small-molecule inhibitor of Usp14 [314245-33-5]
LDN 57444 Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity [668467-91-2]
NSC 632839 hydrochloride Inhibitor of ubiquitin isopeptidase activity [157654-67-6]
P 22077 Inhibitor of ubiquitin-specific protease (USP) 7. [1247819-59-5]
P005091 Ubiquitin-specific protease 7 (USP7) inhibitor [882257-11-6]
PR-619 Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor [2645-32-1]
SJB2-043 novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
Vialinin A Inhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity [858134-23-3]
WP1130 Cell permeable deubiquitinase (DUB) inhibitor [856243-80-6]

(1) HMDB Compounds for USP14 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5

(2) Novoseek inferred chemical compound relationships for USP14 Gene

Compound -log(P) Hits PubMed IDs
queuine 92.8 3
trna 54.5 3
genes like me logo Genes that share compounds with USP14: view

Transcripts for USP14 Gene

Unigene Clusters for USP14 Gene

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for USP14 Gene

GeneLoc Exon Structure for
USP14
ECgene alternative splicing isoforms for
USP14

Expression for USP14 Gene

mRNA expression in normal human tissues for USP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP14 Gene

SOURCE GeneReport for Unigene cluster for USP14 Gene Hs.464416

genes like me logo Genes that share expressions with USP14: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP14 Gene

Orthologs for USP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP14 35
  • 99.73 (n)
  • 100 (a)
USP14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP14 35
  • 93.12 (n)
  • 97.98 (a)
USP14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP14 35
  • 94.26 (n)
  • 99.19 (a)
USP14 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp14 35
  • 91.48 (n)
  • 96.96 (a)
Usp14 16
Usp14 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP14 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP14 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp14 35
  • 91.48 (n)
  • 96.75 (a)
chicken
(Gallus gallus)
Aves USP14 35
  • 82.66 (n)
  • 90.45 (a)
USP14 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP14 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp14 35
  • 79.18 (n)
  • 87.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5646 35
zebrafish
(Danio rerio)
Actinopterygii usp14 35
  • 73.57 (n)
  • 82.58 (a)
usp14 36
  • 82 (a)
OneToOne
wufk63d09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009348 35
  • 56.29 (n)
  • 59.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5384 35
  • 57.51 (n)
  • 56.87 (a)
CG5384 36
  • 56 (a)
OneToOne
CG5384 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea usp-14 35
  • 51.88 (n)
  • 47.07 (a)
usp-14 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL029W 35
  • 45.28 (n)
  • 37.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP6 35
  • 47.78 (n)
  • 37.39 (a)
UBP6 36
  • 31 (a)
OneToOne
UBP6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10791g 35
  • 45.5 (n)
  • 36.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP6 35
  • 53.38 (n)
  • 46.55 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4282 35
rice
(Oryza sativa)
Liliopsida Os.9089 35
Os01g0550100 35
  • 52.95 (n)
  • 45.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01919 35
  • 50.29 (n)
  • 44.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp6 35
  • 51.85 (n)
  • 42.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for USP14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP14 Gene

ENSEMBL:
Gene Tree for USP14 (if available)
TreeFam:
Gene Tree for USP14 (if available)

Paralogs for USP14 Gene

No data available for Paralogs for USP14 Gene

Variants for USP14 Gene

Sequence variations from dbSNP and Humsavar for USP14 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs11221 -- 211,865(+) ATTGT(A/G)ATCAA utr-variant-3-prime
rs16428 -- 211,910(-) ACATC(-/AGAG)AGAGA utr-variant-3-prime
rs471274 -- 203,081(-) AAATG(G/T)AAAGA intron-variant
rs477066 -- 159,281(-) AACGT(C/T)TGATG intron-variant
rs477718 -- 186,210(+) tgatc(A/C)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP14 Gene

Variant ID Type Subtype PubMed ID
nsv909285 CNV Gain 21882294
esv2675103 CNV Deletion 23128226
nsv518642 CNV Gain 19592680
nsv512512 CNV Loss 21212237
esv2658900 CNV Deletion 23128226

Relevant External Links for USP14 Gene

HapMap Linkage Disequilibrium report
USP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP14 Gene

Disorders for USP14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for USP14 Gene including...

Search for USP14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for USP14 Gene

Relevant External Links for USP14

Human Genome Epidemiology (HuGE) Navigator
USP14
genes like me logo Genes that share disorders with USP14: view

No data available for UniProtKB/Swiss-Prot for USP14 Gene

Publications for USP14 Gene

  1. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12- induced CXCR4 degradation and chemotaxis but not ERK activation. (PMID: 19106094) Mines M.A. … Fan G.H. (J. Biol. Chem. 2009) 3 4
  2. USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PMID: 19135427) Nagai A. … Ichijo H. (Biochem. Biophys. Res. Commun. 2009) 3 4
  3. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. (PMID: 18162577) Koulich E. … DeMartino G.N. (Mol. Biol. Cell 2008) 3 4
  4. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. (PMID: 16211010) Hu M. … Shi Y. (EMBO J. 2005) 3 4
  5. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PMID: 14499622) Reuter T.Y. … Huber P.A. (Exp. Cell Res. 2003) 3 4

Products for USP14 Gene

  • Addgene plasmids for USP14

Sources for USP14 Gene

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