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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP14 Gene

protein-coding   GIFtS: 62
GCID: GC18P000148

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

(Previous name: ubiquitin specific protease 14 (tRNA-guanine transglycosylase)...)
 Explore 15 diseases affiliated with
USP14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP14    

Aliases
for USP14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase)1 2     TRNA-Guanine Transglycosylase, 60-KD Subunit2
TGT1 2 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 142
Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase)1 2     Ubiquitin Thiolesterase 142
Deubiquitinating Enzyme 142 3     Ubiquitin-Specific Processing Protease 142
Ubiquitin Thioesterase 142 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 142 3     EC 3.1.2.158

External Ids:    HGNC: 126121   Entrez Gene: 90972   Ensembl: ENSG000001015577   OMIM: 6072745   UniProtKB: P545783   

Export aliases for USP14 gene to outside databases

Previous GC identifers: GC18P000442 GC18P000146


Summaries
for USP14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USP14:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating
enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from
ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of
the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by
hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBP14_HUMAN, P54578
Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated
proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the
proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the
chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological
inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the
degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic
development and function at neuromuscular junctions (NMJs)

Gene Wiki entry for USP14


Genomic Views
for USP14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP14 gene promoter:
         AP-1   RREB-1   FOXD1   CUTL1   MIF-1   LCR-F1   NF-E2 p45   HNF-1A   HNF-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.32

USP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP14 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P000148:  view genomic region     (about GC identifiers)

Start:
 158,383 bp from pter      End:
 214,622 bp from pter
Size:
 56,240 bases      Orientation:
 plus strand

Proteins
for USP14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBP14_HUMAN, P54578 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 14  
Size: 494 amino acids; 56069 Da
Subunit: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein
Caution: Was originally (Ref.1) thought to be a guanine tRNA-ribosyltransferase
2 PDB 3D structures from and Proteopedia for USP14:
2AYN (3D)        2AYO (3D)    
Secondary accessions: Q53XY5

Explore the universe of human proteins at neXtProt for USP14: NX_P54578

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54578

    • 4/5 DME Specific Peptides for USP14 (P54578) (see all 5)
     SGGGDWH  NLGNTCYMN  PPMVFKAQLFALT  QMMRVLQQKLEAIEDD 

    USP14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032411.1  NP_005142.1  

    ENSEMBL proteins: 
     ENSP00000464447   ENSP00000383125   ENSP00000463891   ENSP00000373083   ENSP00000261601  
     ENSP00000462315  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for USP14
    Enzo Life Sciences proteins for USP14
    OriGene Purified Protein: USP14
    OriGene Protein Over-expression Lysate: USP14
    OriGene Custom Protein Services for USP14 
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    Novus Biologicals USP14 Proteins
    Novus Biologicals USP14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP14

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA19106094


    USP14 for ontologies           About GeneDecksing



    USP14 Antibody Products: 
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    ThermoFisher Antibody for USP14

    Assay Products for USP14: 
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    Uscn ELISAs and CLIAs for USP14

    Protein Domains /
    Families
    for USP14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP14 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P54578

    ProtoNet protein and cluster: P54578

    2 Blocks protein families:
    IPB000626 Ubiquitin domain
    IPB001394 Ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP14_HUMAN, P54578
    Similarity: Belongs to the peptidase C19 family. USP14/UBP6 subfamily
    Similarity: Contains 1 ubiquitin-like domain


    Function
    for USP14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBP14_HUMAN, P54578
    Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated
    proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the
    proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the
    chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological
    inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the
    degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic
    development and function at neuromuscular junctions (NMJs)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP14:
    ubiquitin specific protease 14,deubiquitin enzyme family

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): USP14
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP14
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate USP14 (see all 53):
    hsa-miR-26a-2* hsa-miR-15a hsa-miR-200a hsa-miR-219-5p hsa-miR-488 hsa-miR-508-3p hsa-miR-141 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: USP14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP14 (see all 7)
    OriGene shRNA RFP: USP14
    OriGene siRNA: USP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USP14

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP14 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP14 (NM_001037334)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP14 

    Cell Line
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    Search LifeMap BioReagents cell lines for USP14

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP14

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IDA19106094
    GO:0004843ubiquitin-specific protease activity TAS8579355
    GO:0004866endopeptidase inhibitor activity IMP18162577
    GO:0005515protein binding IPI19106094


    USP14 for ontologies           About GeneDecksing


    Animal Models:
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Usp14):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  mortality/aging 
     muscle  nervous system  reproductive system  skeleton 

    USP14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for USP14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    3Protein Stability
    		Protein Stability1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP14
        Ubiquitin-Proteasome Dependent Proteolysis

    2 Cell Signaling Technology (CST) Pathways for USP14
        Neuroscience
    Protein Stability



    USP14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/224 Interacting proteins for USP14 (P545782, 3 ENSP000002616014) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007268synaptic transmission IEA--
    GO:0010951negative regulation of endopeptidase activity IMP18162577
    GO:0050920regulation of chemotaxis IMP19106094
    GO:0061136regulation of proteasomal protein catabolic process IMP18162577


    USP14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    USP14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for USP14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IU1Usp14 inhibitor[314245-33-5]

    1 HMDB Compound for USP14    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    2 Novoseek chemical compound relationships for USP14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    queuine 92.8 4 20354154 (2), 12877882 (1)
    trna 54.5 4 12877882 (2), 17673081 (1)

    Search CenterWatch for drugs/clinical trials and news about USP14 / UBP14 

    Transcripts
    for USP14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP14 gene (2 alternative transcripts): 
    NM_001037334.1  NM_005151.3  

    Unigene Cluster for USP14:

    Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
    Hs.464416  [show with all ESTs]
    Unigene Representative Sequence: NM_005151
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582707 ENST00000400266 ENST00000580410 ENST00000578942 ENST00000383589
    ENST00000261601(uc002kkf.1 uc002kkg.1 uc010wyr.1) ENST00000581983
    ENST00000583119 ENST00000578786

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP14
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate USP14 (see all 53):
    hsa-miR-26a-2* hsa-miR-15a hsa-miR-200a hsa-miR-219-5p hsa-miR-488 hsa-miR-508-3p hsa-miR-141 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: USP14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP14 (see all 7)
    OriGene shRNA RFP: USP14
    OriGene siRNA: USP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP14
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP14 (NM_001037334)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP14 
    Primer
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    Additional cDNA sequence: 

    AK098497.1 AK297605.1 AK315438.1 BC003556.1 BT007183.1 U30888.1 

    24 DOTS entries:

    DT.100817195  DT.91707912  DT.100817205  DT.455834  DT.100639435  DT.100817207  DT.95309692  DT.92448768 
    DT.95133414  DT.95133370  DT.92447230  DT.92448763  DT.92448767  DT.121091275  DT.40305664  DT.95139503 
    DT.100032014  DT.100817197  DT.101965453  DT.92447215  DT.92448759  DT.100786553  DT.216965  DT.403432 

    24/403 AceView cDNA sequences (see all 403):

    BQ929948 AW275278 AL515903 AK095516 BF511587 BM801075 CA422710 AI536829 
    AL546236 BG287436 AA039512 AW877768 BX490182 BE672915 AI682732 AW276418 
    AA236222 AI281650 BM987237 BQ050858 CB146274 AI337312 AI697478 CR617599 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USP14 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                        -     -                                                                                 
    SP2:                                      -                 -     -                                                                                 
    SP3:                                                                                                                          -                     
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for USP14

    Expression
    for USP14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    USP14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See USP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP14

    SOURCE GeneReport for Unigene cluster: Hs.464416
        SABiosciences Expression via Pathway-Focused PCR Array including USP14: 
              Unfolded Protein Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP14

    Orthologs
    for USP14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP14 gene from 10/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Usp141 , 5 ubiquitin specific peptidase 141, 5 91.48(n)1
    96.96(a)1    		   18 (4.91 cM)5
    590251  NM_021522.41  NP_067497.21 
     99954325 
    chicken
    (Gallus gallus)    		 Aves USP141 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 82.72(n)
    90.65(a)    		   421063  XM_419150.3  XP_419150.1 
    lizard
    (Anolis carolinensis)    		 Reptilia USP146
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(39294303-39316560)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU914627.12   -- 82.38(n)    BU914627.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk63d092 wufk63d09 77.75(n)   335736  BC044553.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG53841 , 3 protein deubiquitination ubiquitin-specific
    protease3
    CG53841    		 55(a)3
    57.29(n)1
    56.87(a)1    		   343871  NM_135533.11  NP_609377.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea usp-141 Protein USP-14 51.04(n)
    46.65(a)    		   175105  NM_064605.7  NP_497006.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes UBP6(YFR010W)4
    UBP61    		 Ubiquitin-specific protease situated in the base subcomplex more4
    Ubp6p1    		 47.71(n)1
    37.39(a)1    		   6(165067-166566)4
    8505621, 4  NP_116665.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UBP61 ubiquitin carboxyl-terminal hydrolase 6 53.46(n)
    46.75(a)    		   841596  NM_104049.3  NP_564596.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.90892 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.4(n)    AK066233.1 


    ENSEMBL Gene Tree for USP14 (if available)
    TreeFam Gene Tree for USP14 (if available) 

    Paralogs
    for USP14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for USP14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/987 NCBI SNPs in USP14 are shown (see all 987)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1176388891,2
    		F,--156619(+) GTCCTT/CATAAC 2 -- us2k11Minor allele frequency- C:0.02NA 120
    rs5572491,2
    		C,F,A,H,--156739(-) GGAAAC/ACAAAA 2 -- us2k18Minor allele frequency- A:0.44NA WA CSA EA 368
    rs118735921,2
    		C,H,--156771(+) ttctaC/Ttatac 2 -- us2k13Minor allele frequency- T:0.17NA WA 6
    rs1842055621,2
    		--156876(+) GAGTTA/CAACAC 2 -- us2k10--------
    rs1870365231,2
    		--156916(+) TTTACA/GAAACA 2 -- us2k10--------
    rs1127072291,2
    		C,F,--156976(+) TGAGAG/AGATAG 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs5621171,2
    		C,F,H,--157065(-) tgtttT/Ggagac 2 -- us2k1 tfbs35Minor allele frequency- G:0.13NA CSA WA 244
    rs1928628141,2
    		--157256(+) GCCACA/GTCGAT 2 -- us2k10--------
    rs65059301,2
    		C,F,A,H,--157275(+) CCTTTC/TATGAA 2 -- us2k1 trp311Minor allele frequency- T:0.31NA WA CSA EA 376
    rs116654731,2
    		H--157301(+) atgcaG/Ttgctg 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP14 (158383 - 214622 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for USP14: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP14
    DNA2.0 Custom Variant and Variant Library Synthesis for USP14

    Disorders / Diseases
    for USP14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP14 for disorders           About GeneDecksing

    OMIM gene information: 607274    OMIM disorders: --

    15 diseases for USP14:    About MalaCards
    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    tremor    cystadenocarcinoma
    paralysis    fanconi's anemia    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    hepatitis b    anemia    colorectal cancer    ataxia
    hepatitis    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for USP14:
    Ovarian serous cystadenocarcinoma
    Human Genome Epidemiology (HuGE) Navigator: USP14 (1 document)

    Export disorders for USP14 gene to outside databases

    Publications
    for USP14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP14 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with USP14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12- induced CXCR4 degradation and chemotaxis but not ERK ativation. (PubMed id 19106094)1, 2 Mines M.A.... Fan G.H. (2009)
    2. USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PubMed id 19135427)1, 2 Nagai A.... Ichijo H. (2009)
    3. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. (PubMed id 18162577)1, 2 Koulich E.... DeMartino G.N. (2008)
    4. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. (PubMed id 16211010)1, 2 Hu M.... Shi Y. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)1, 2 Reuter T.Y....Huber P.A. (2003)
    7. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    8. Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. (PubMed id 16465409)1, 9 Shinji S....Tajiri T. (2006)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)

    External Searches for USP14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9097 HGNC: 12612 AceView: USP14 Ensembl:ENSG00000101557 euGenes: HUgn9097
    ECgene: USP14 H-InvDB: USP14

    Other Databases showing USP14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP14 gene:
    Search GeneIP for patents involving USP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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