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Aliases for USP14 Gene

Aliases for USP14 Gene

  • Ubiquitin Specific Peptidase 14 2 3 5
  • Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) 2 3
  • Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase) 2 3
  • Deubiquitinating Enzyme 14 3 4
  • Ubiquitin Thioesterase 14 3 4
  • TGT 3 4
  • TRNA-Guanine Transglycosylase, 60-KD Subunit 3
  • Ubiquitin-Specific Processing Protease 14 3
  • Ubiquitin-Specific-Processing Protease 14 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 14 3
  • Ubiquitin Thiolesterase 14 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61

External Ids for USP14 Gene

Previous GeneCards Identifiers for USP14 Gene

  • GC18P000442
  • GC18P000146
  • GC18P000148

Summaries for USP14 Gene

Entrez Gene Summary for USP14 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP14 Gene

USP14 (Ubiquitin Specific Peptidase 14) is a Protein Coding gene. Among its related pathways are Deubiquitination and Neuroscience. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for USP14 Gene

  • Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Tocris Summary for USP14 Gene

  • Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins.

Gene Wiki entry for USP14 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP14 Gene

Genomics for USP14 Gene

Regulatory Elements for USP14 Gene

Enhancers for USP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G000157 1.5 FANTOM5 ENCODE 11.4 +0.6 570 2.3 HDGF PKNOX1 CREB3L1 MLX ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 CETN1 ROCK1P1 THOC1 USP14 GC18M000160
GH18G000267 1.2 ENCODE 11 +110.0 109971 2.6 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ZNF610 ROCK1P1 USP14 THOC1 GC18P000270 ENSG00000263884
GH18G000474 1.3 Ensembl ENCODE dbSUPER 4.6 +317.2 317179 2.4 CTCF ELF3 SAP130 ZNF792 JUN TEAD4 ZNF7 RARA TEAD3 ETS1 COLEC12 THOC1 CLUL1 CETN1 USP14 GC18P000435
GH18G000478 1.2 Ensembl ENCODE dbSUPER 4.6 +320.8 320815 2.3 ELF3 ESRRA SAP130 ZFP64 JUN TEAD3 FOSL1 EGR1 NR2F6 FOS CLUL1 USP14 COLEC12 GC18P000435
GH18G000306 0.7 ENCODE 5.1 +148.4 148413 0.2 PKNOX1 RFX1 TAL1 DPF2 ZEB2 EP300 TFDP1 ARID1B TCF12 GATA2 CLUL1 USP14 ENSG00000264514 GC18P000274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP14 on UCSC Golden Path with GeneCards custom track

Promoters for USP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099769 618 2000 HDGF PKNOX1 CREB3L1 MLX ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for USP14 Gene

Chromosome:
18
Start:
158,383 bp from pter
End:
214,629 bp from pter
Size:
56,247 bases
Orientation:
Plus strand

Genomic View for USP14 Gene

Genes around USP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP14 Gene

Proteins for USP14 Gene

  • Protein details for USP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54578-UBP14_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14
    Protein Accession:
    P54578
    Secondary Accessions:
    • B7Z4N8
    • J3QRZ5
    • Q53XY5

    Protein attributes for USP14 Gene

    Size:
    494 amino acids
    Molecular mass:
    56069 Da
    Quaternary structure:
    • Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
    SequenceCaution:
    • Sequence=CR976282; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP14 Gene

    Alternative splice isoforms for USP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP14 Gene

Selected DME Specific Peptides for USP14 Gene

P54578:
  • NLGNTCYMN
  • PPMVFKAQLFALT
  • SGGGDWH
  • QMMRVLQQKLEAIEDD
  • LMMGSADALPEEPSAKTVFVEDMTEEQLA

Post-translational modifications for USP14 Gene

  • Ubiquitination at Lys49, Lys62, posLast=130130, posLast=214214, Lys291, Lys348, posLast=441441, isoforms=2, 3443, and Lys449
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP14 (USP14)

Domains & Families for USP14 Gene

Gene Families for USP14 Gene

Graphical View of Domain Structure for InterPro Entry

P54578

UniProtKB/Swiss-Prot:

UBP14_HUMAN :
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
Family:
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
genes like me logo Genes that share domains with USP14: view

Function for USP14 Gene

Molecular function for USP14 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 14,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Enzyme Numbers (IUBMB) for USP14 Gene

Gene Ontology (GO) - Molecular Function for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS,IDA 23958854
GO:0004866 endopeptidase inhibitor activity IMP 18162577
GO:0005515 protein binding IPI 19106094
GO:0008193 tRNA guanylyltransferase activity TAS 8579355
genes like me logo Genes that share ontologies with USP14: view
genes like me logo Genes that share phenotypes with USP14: view

Animal Models for USP14 Gene

MGI Knock Outs for USP14:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP14

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP14 Gene

Localization for USP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP14 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP14 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 19106094
genes like me logo Genes that share ontologies with USP14: view

Pathways & Interactions for USP14 Gene

genes like me logo Genes that share pathways with USP14: view

Pathways by source for USP14 Gene

1 Cell Signaling Technology pathway for USP14 Gene
1 Qiagen pathway for USP14 Gene

Gene Ontology (GO) - Biological Process for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with USP14: view

No data available for SIGNOR curated interactions for USP14 Gene

Drugs & Compounds for USP14 Gene

(7) Drugs for USP14 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
HBX 41108 Pharma Selective USP7 inhibitor 0
IU1 Pharma Usp14 inhibitor, USP14 inhibitor 0
WP1130 Pharma Deubiquitinase (DUB) inhibitor, Cell permeable 0
LDN 57444 Pharma UCH-L1 inhibitor,reversible competitve, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 0

(2) Additional Compounds for USP14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for USP14 Gene

Compound Action Cas Number
HBX 41108 Selective USP7 inhibitor 924296-39-9
IU1 USP14 inhibitor 314245-33-5
LDN 57444 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 668467-91-2
PR 619 Broad spectrum DUB inhibitor 2645-32-1
Spautin 1 USP10 and USP13 inhibitor; inhibits autophagy 1262888-28-7

(3) ApexBio Compounds for USP14 Gene

Compound Action Cas Number
HBX 41108 924296-39-9
IU1 Usp14 inhibitor 314245-33-5
WP1130 Deubiquitinase (DUB) inhibitor, Cell permeable 856243-80-6
genes like me logo Genes that share compounds with USP14: view

Drug Products

Transcripts for USP14 Gene

Unigene Clusters for USP14 Gene

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP14

Alternative Splicing Database (ASD) splice patterns (SP) for USP14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for USP14 Gene

GeneLoc Exon Structure for
USP14
ECgene alternative splicing isoforms for
USP14

Expression for USP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP14 Gene



Protein tissue co-expression partners for USP14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP14 Gene:

USP14

SOURCE GeneReport for Unigene cluster for USP14 Gene:

Hs.464416

Evidence on tissue expression from TISSUES for USP14 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Skin(4.5)
  • Blood(4.3)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with USP14: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP14 Gene

Orthologs for USP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP14 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia USP14 34 35
  • 94.26 (n)
cow
(Bos Taurus)
Mammalia USP14 34 35
  • 93.12 (n)
oppossum
(Monodelphis domestica)
Mammalia USP14 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP14 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp14 34 16 35
  • 91.48 (n)
rat
(Rattus norvegicus)
Mammalia Usp14 34
  • 91.48 (n)
chicken
(Gallus gallus)
Aves USP14 34 35
  • 82.66 (n)
lizard
(Anolis carolinensis)
Reptilia USP14 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp14 34
  • 79.18 (n)
zebrafish
(Danio rerio)
Actinopterygii usp14 34 35
  • 73.57 (n)
wufk63d09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5646 34
fruit fly
(Drosophila melanogaster)
Insecta CG5384 36 34 35
  • 57.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009348 34
  • 56.29 (n)
worm
(Caenorhabditis elegans)
Secernentea usp-14 34 35
  • 51.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP6 34 35 37
  • 47.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10791g 34
  • 45.5 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL029W 34
  • 45.28 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP6 34
  • 53.38 (n)
rice
(Oryza sativa)
Liliopsida Os01g0550100 34
  • 52.95 (n)
Os.9089 34
barley
(Hordeum vulgare)
Liliopsida Hv.4282 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp6 34
  • 51.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01919 34
  • 50.29 (n)
Species where no ortholog for USP14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP14 Gene

ENSEMBL:
Gene Tree for USP14 (if available)
TreeFam:
Gene Tree for USP14 (if available)

Paralogs for USP14 Gene

No data available for Paralogs for USP14 Gene

Variants for USP14 Gene

Sequence variations from dbSNP and Humsavar for USP14 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000019764 -- 190,969(+) GTTAC(-/A)AAAAA intron-variant
rs1000031482 -- 157,992(+) ATATA(A/T)AAATA intron-variant, upstream-variant-2KB
rs1000075097 -- 176,915(+) TTTTA(G/T)TCTCT intron-variant
rs1000124573 -- 208,850(+) AAGCA(A/G)TTCTC intron-variant
rs1000179329 -- 166,074(+) CGTTA(G/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP14 Gene

Variant ID Type Subtype PubMed ID
dgv1534n106 CNV deletion 24896259
dgv3300n100 CNV gain 25217958
dgv3301n100 CNV gain 25217958
dgv3302n100 CNV gain 25217958
esv2658900 CNV deletion 23128226
esv2675103 CNV deletion 23128226
esv3554936 CNV deletion 23714750
esv3573886 CNV gain 25503493
esv3641472 CNV loss 21293372
esv3641473 CNV gain 21293372
esv3641475 CNV gain 21293372
esv3641476 CNV loss 21293372
esv3641477 CNV loss 21293372
nsv1064150 CNV gain 25217958
nsv1071821 CNV deletion 25765185
nsv1160503 CNV duplication 26073780
nsv482935 CNV loss 15286789
nsv512512 CNV loss 21212237
nsv518642 CNV gain 19592680
nsv576227 CNV gain 21841781
nsv576228 CNV loss 21841781

Variation tolerance for USP14 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP14 Gene

Disorders for USP14 Gene

Relevant External Links for USP14

Human Genome Epidemiology (HuGE) Navigator
USP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP14

No disorders were found for USP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP14 Gene

Publications for USP14 Gene

  1. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12- induced CXCR4 degradation and chemotaxis but not ERK activation. (PMID: 19106094) Mines M.A. … Fan G.H. (J. Biol. Chem. 2009) 3 4 64
  2. USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (PMID: 19135427) Nagai A. … Ichijo H. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  3. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. (PMID: 18162577) Koulich E. … DeMartino G.N. (Mol. Biol. Cell 2008) 3 4 64
  4. Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. (PMID: 16465409) Shinji S. … Tajiri T. (Oncol. Rep. 2006) 3 22 64
  5. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. (PMID: 16211010) Hu M. … Shi Y. (EMBO J. 2005) 3 4 64

Products for USP14 Gene

  • Addgene plasmids for USP14

Sources for USP14 Gene

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