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Aliases for USP14 Gene

Aliases for USP14 Gene

  • Ubiquitin Specific Peptidase 14 2 3
  • Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) 2 3 5
  • Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase) 2 3
  • Ubiquitin-Specific-Processing Protease 14 3 4
  • Deubiquitinating Enzyme 14 3 4
  • Ubiquitin Thioesterase 14 3 4
  • TGT 3 4
  • TRNA-Guanine Transglycosylase, 60-KD Subunit 3
  • Ubiquitin-Specific Processing Protease 14 3
  • Ubiquitin Thiolesterase 14 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63

External Ids for USP14 Gene

Previous GeneCards Identifiers for USP14 Gene

  • GC18P000442
  • GC18P000146
  • GC18P000148

Summaries for USP14 Gene

Entrez Gene Summary for USP14 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP14 Gene

USP14 (Ubiquitin Specific Peptidase 14) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for USP14 Gene

  • Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Tocris Summary for USP14 Gene

  • Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins.

Gene Wiki entry for USP14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP14 Gene

Genomics for USP14 Gene

Regulatory Elements for USP14 Gene

Promoters for USP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP14 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP14 Gene

Chromosome:
18
Start:
158,383 bp from pter
End:
214,629 bp from pter
Size:
56,247 bases
Orientation:
Plus strand

Genomic View for USP14 Gene

Genes around USP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP14 Gene

Proteins for USP14 Gene

  • Protein details for USP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54578-UBP14_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 14
    Protein Accession:
    P54578
    Secondary Accessions:
    • B7Z4N8
    • J3QRZ5
    • Q53XY5

    Protein attributes for USP14 Gene

    Size:
    494 amino acids
    Molecular mass:
    56069 Da
    Quaternary structure:
    • Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
    SequenceCaution:
    • Sequence=CR976282; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP14 Gene

    Alternative splice isoforms for USP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP14 Gene

Proteomics data for USP14 Gene at MOPED

Selected DME Specific Peptides for USP14 Gene

Post-translational modifications for USP14 Gene

  • Ubiquitination at Lys 49, Lys 62, Lys 130, Lys 214, Lys 291, Lys 348, Lys 441, Lys 443, and Lys 449
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP14 (USP14)

Domains & Families for USP14 Gene

Gene Families for USP14 Gene

Graphical View of Domain Structure for InterPro Entry

P54578

UniProtKB/Swiss-Prot:

UBP14_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
Domain:
  • Contains 1 ubiquitin-like domain.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
genes like me logo Genes that share domains with USP14: view

Function for USP14 Gene

Molecular function for USP14 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 14,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Enzyme Numbers (IUBMB) for USP14 Gene

Gene Ontology (GO) - Molecular Function for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008193 tRNA guanylyltransferase activity TAS 8579355
GO:0070628 proteasome binding IDA 18162577
genes like me logo Genes that share ontologies with USP14: view
genes like me logo Genes that share phenotypes with USP14: view

Animal Models for USP14 Gene

MGI Knock Outs for USP14:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP14 Gene

Localization for USP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP14 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP14 Gene COMPARTMENTS Subcellular localization image for USP14 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 4
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with USP14: view

Pathways & Interactions for USP14 Gene

genes like me logo Genes that share pathways with USP14: view

Pathways by source for USP14 Gene

1 Qiagen pathway for USP14 Gene

Gene Ontology (GO) - Biological Process for USP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IEA --
GO:0061136 regulation of proteasomal protein catabolic process IMP 18162577
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process IMP 19135427
genes like me logo Genes that share ontologies with USP14: view

No data available for SIGNOR curated interactions for USP14 Gene

Drugs & Compounds for USP14 Gene

(5) Drugs for USP14 Gene - From: Tocris and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IU1 Pharma Usp14 inhibitor, USP14 inhibitor 0
WP1130 Pharma Deubiquitinase (DUB) inhibitor, Cell permeable 0
LDN 57444 Pharma UCH-L1 inhibitor,reversible competitve, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 0
NSC 632839 hydrochloride Pharma Isopeptidases inhibitor, Inhibitor of ubiquitin isopeptidase activity 0
PR-619 Pharma Deubiquitylating enzymes (DBUs) inhibitor, Broad spectrum DUB inhibitor 0

(4) Additional Compounds for USP14 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
HBX 41108
924296-39-9

(5) Tocris Compounds for USP14 Gene

Compound Action Cas Number
HBX 41108 Selective USP7 inhibitor 924296-39-9
IU1 USP14 inhibitor 314245-33-5
LDN 57444 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 668467-91-2
NSC 632839 hydrochloride Inhibitor of ubiquitin isopeptidase activity 157654-67-6
PR 619 Broad spectrum DUB inhibitor 2645-32-1

(2) ApexBio Compounds for USP14 Gene

Compound Action Cas Number
IU1 Usp14 inhibitor 314245-33-5
WP1130 Deubiquitinase (DUB) inhibitor, Cell permeable 856243-80-6
genes like me logo Genes that share compounds with USP14: view

Transcripts for USP14 Gene

Unigene Clusters for USP14 Gene

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for USP14 Gene

GeneLoc Exon Structure for
USP14
ECgene alternative splicing isoforms for
USP14

Expression for USP14 Gene

mRNA expression in normal human tissues for USP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP14 Gene



SOURCE GeneReport for Unigene cluster for USP14 Gene Hs.464416

genes like me logo Genes that share expression patterns with USP14: view

Protein tissue co-expression partners for USP14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP14 Gene

Orthologs for USP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP14 35
  • 93.12 (n)
  • 97.98 (a)
USP14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP14 35
  • 94.26 (n)
  • 99.19 (a)
USP14 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp14 35
  • 91.48 (n)
  • 96.96 (a)
Usp14 16
Usp14 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP14 35
  • 99.73 (n)
  • 100 (a)
USP14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp14 35
  • 91.48 (n)
  • 96.75 (a)
oppossum
(Monodelphis domestica)
Mammalia USP14 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP14 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP14 35
  • 82.66 (n)
  • 90.45 (a)
USP14 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP14 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp14 35
  • 79.18 (n)
  • 87.14 (a)
zebrafish
(Danio rerio)
Actinopterygii usp14 35
  • 73.57 (n)
  • 82.58 (a)
wufk63d09 35
usp14 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5646 35
fruit fly
(Drosophila melanogaster)
Insecta CG5384 37
  • 55 (a)
CG5384 35
  • 57.51 (n)
  • 56.87 (a)
CG5384 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009348 35
  • 56.29 (n)
  • 59.11 (a)
worm
(Caenorhabditis elegans)
Secernentea usp-14 35
  • 51.88 (n)
  • 47.07 (a)
usp-14 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL029W 35
  • 45.28 (n)
  • 37.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10791g 35
  • 45.5 (n)
  • 36.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP6 35
  • 47.78 (n)
  • 37.39 (a)
UBP6 36
  • 31 (a)
OneToOne
UBP6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP6 35
  • 53.38 (n)
  • 46.55 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4282 35
rice
(Oryza sativa)
Liliopsida Os.9089 35
Os01g0550100 35
  • 52.95 (n)
  • 45.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01919 35
  • 50.29 (n)
  • 44.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp6 35
  • 51.85 (n)
  • 42.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for USP14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP14 Gene

ENSEMBL:
Gene Tree for USP14 (if available)
TreeFam:
Gene Tree for USP14 (if available)

Paralogs for USP14 Gene

No data available for Paralogs for USP14 Gene

Variants for USP14 Gene

Sequence variations from dbSNP and Humsavar for USP14 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs11221 -- 211,865(+) ATTGT(A/G)ATCAA utr-variant-3-prime
rs16428 -- 211,910(-) ACATC(-/AGAG)AGAGA utr-variant-3-prime
rs485211 -- 166,277(+) CCTTA(C/T)GCAGT intron-variant
rs489560 -- 165,098(+) TCACC(A/G)CCACC intron-variant
rs489577 -- 177,101(+) TTTTT(A/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP14 Gene

Variant ID Type Subtype PubMed ID
nsv909285 CNV Gain 21882294
esv2675103 CNV Deletion 23128226
nsv518642 CNV Gain 19592680
nsv512512 CNV Loss 21212237
esv2658900 CNV Deletion 23128226

Variation tolerance for USP14 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP14 Gene

HapMap Linkage Disequilibrium report
USP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP14 Gene

Disorders for USP14 Gene

Relevant External Links for USP14

Human Genome Epidemiology (HuGE) Navigator
USP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP14

No disorders were found for USP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP14 Gene

Publications for USP14 Gene

  1. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12- induced CXCR4 degradation and chemotaxis but not ERK activation. (PMID: 19106094) Mines M.A. … Fan G.H. (J. Biol. Chem. 2009) 3 4 67
  2. Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. (PMID: 16465409) Shinji S. … Tajiri T. (Oncol. Rep. 2006) 3 23
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for USP14 Gene

Sources for USP14 Gene

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