USP13 Gene
protein-coding GIFtS: 56
GCID: GC03P179370
|
|
ubiquitin specific peptidase 13 (isopeptidase T-3)(Previous name: ubiquitin specific protease 13 (isopeptidase T-3) )
| |
Aliases
for USP13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 13 (Isopeptidase T-3)1 2 | | Ubiquitin-Specific-Processing Protease 132 3 | | ISOT32 3 5 | | Ubiquitin Carboxyl-Terminal Hydrolase 132 | | IsoT-31 2 | | Ubiquitin Thiolesterase 132 | | Ubiquitin Specific Protease 13 (Isopeptidase T-3)1 2 | | EC 3.4.19.123 | | Deubiquitinating Enzyme 132 3 | | ISOT-33 | | Isopeptidase T-32 3 | | EC 3.1.2.158 | | Ubiquitin Thioesterase 132 3 | | |
Export aliases for USP13 gene to outside databasesPrevious GC identifers: GC03P176137 GC03P180213 GC03P180772 GC03P180691 GC03P180853 GC03P176774 |
Summaries
for USP13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995Function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and isinvolved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component ofa regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator ofautophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essentialregulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting theexistence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmicreticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity:binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitroand preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediateunanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required toconfirm such data
Gene Wiki entry for USP13
|
Genomic Views
for USP13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP13 gene promoter:
Bach1 Brachyury POU6F1 (c2) Nkx2-5 Cdc5 LCR-F1 Evi-1 Pax-3 Zic1 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.2-q26.3 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q26.2-q26.3USP13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P179370: view genomic region
(about GC identifiers)
Start:
|
179,370,543 bp from pter |
End:
|
179,507,189 bp from pter |
Size:
|
136,647 bases |
Orientation:
|
plus strand |
|
Proteins
for USP13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 13 Size: 863 amino acids; 97327 Da
Subunit: Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated)
2 PDB 3D structures from  and Proteopedia  for USP13:2L80 (3D)
2LBC (3D)
Secondary accessions: A8K2S3 B4DYF3 D3DNS2 Q96B25Alternative splicing: 2 isoforms: Q92995-1 Q92995-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP13: NX_Q92995
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92995
4/9 DME Specific Peptides for USP13 (Q92995) (see all 9)
USP13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003931.2
ENSEMBL proteins: ENSP00000263966 ENSP00000418651 ENSP00000417146 ENSP00000420057
Human Recombinant Protein Products:
USP13 Antibody Products:
Assay Products for USP13: |
Protein
Domains /
Families
for USP13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP13 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92995ProtoNet protein and cluster: Q92995 3 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995Domain: The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchoredubiquitin. Swapping with the UBP-type zinc finger from USP5 restores ability to bind unanchored ubiquitin andsubsequent activation of the protein (PubMed:22216260)Domain: The UBA domains mediate binding to ubiquitin (PubMed:22216260)Similarity: Belongs to the peptidase C19 familySimilarity: Contains 2 UBA domainsSimilarity: Contains 1 UBP-type zinc finger |
Function
for USP13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995Function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and isinvolved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component ofa regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator ofautophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essentialregulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting theexistence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmicreticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity:binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitroand preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediateunanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required toconfirm such dataCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme regulation: Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative ofMBCQ that binds to USP13 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes. Theweak deubiquitinase activity in vitro suggests the existence of some mechanism that activates the enzyme Genatlas biochemistry entry for USP13:ubiquitin specific protease 13,expressed in testis and ovary,ubiquitin C terminal hydrolase family member,deubiquitinenzyme family
Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP13 (NM_003940) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP13 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004197 | cysteine-type endopeptidase activity |
IMP | -- | | GO:0004221 | ubiquitin thiolesterase activity |
IDA | -- | | GO:0004843 | ubiquitin-specific protease activity |
IDA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0008242 | omega peptidase activity |
IEA | -- |
USP13 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP13
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP13
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for USP13 (Q929952, 3 ENSP000002639664) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IMP | -- | | GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0006914 | autophagy |
IEA | -- | | GO:0008283 | cell proliferation |
IMP | -- | | GO:0010506 | regulation of autophagy |
IDA | -- |
USP13 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP13
1 HMDB Compound for USP13 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP13 / UBP13
|
Transcripts
for USP13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP13 gene: NM_003940.2 Unigene Cluster for USP13: Ubiquitin specific peptidase 13 (isopeptidase T-3) Hs.175322 [show with all ESTs]Unigene Representative Sequence: NM_0039405 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263966(uc003fkh.3) ENST00000482333 ENST00000497380 ENST00000496897
ENST00000497155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP13 (NM_003940) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP13 |
Additional cDNA sequence: AK091484.1 AK290338.1 AK302404.1 BC016146.1 BC049199.1 BC062766.1 U75362.1 8 DOTS entries: DT.212478 DT.312419 DT.100008025 DT.100714935 DT.100780389 DT.100806935 DT.100676001 DT.95186063 24/164 AceView cDNA sequences (see all 164): AA644364 R07668 BU164934 BU619563 BE892755 AA993458 AA629108 BX102558 BU683248 AA932764 AA506150 AW304039 BQ775545 AI804164 F29207 BM974597 AL596734 BQ009180 AI125572 CR591494 BQ222207 AI872417 BM803817 CR623689
GeneLoc Exon Structure
|
Expression
for USP13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGGGGTA
About this image
See USP13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP13
SOURCE GeneReport for Unigene cluster: Hs.175322
UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995Tissue specificity: Highly expressed in ovary and testes
SABiosciences Custom PCR Arrays for USP13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP13 |
Orthologs
for USP13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP13 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP131 |
ubiquitin specific peptidase 13 (isopeptidase T-3) |
78.22(n)
84.01(a) |
|
429286 XM_426842.3 XP_426842.2 |
lizard
(Anolis carolinensis) |
Reptilia |
USP136 |
-- |
85(a) |
1 ↔ 1 |
3(2001427-2088232) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.161882 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.24(n) |
|
BJ048181.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wu:fc61g081 |
wu:fc61g08 |
72.32(n)
76.39(a) |
|
558011 NM_001098386.1 NP_001091856.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG120823 |
protein deubiquitination ubiquitin
isopeptidase more |
43(a) |
|
63B6 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
T27A3.23 |
ubiquitin carboxyl-terminal hydrolase |
31(a) |
|
I(6118275-6122458) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PER16 |
ubiquitin carboxyl-terminal hydrolase 14 |
43(a) |
1 → many |
3(7202773-7208402) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ubiquitin carboxyl-terminal hydrolase 14, putative... |
43(a) |
1 → many |
1(3985612-3994398) |
ENSEMBL Gene Tree for USP13 (if available)
TreeFam Gene Tree for USP13 (if available) |
Paralogs
for USP13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP13 gene
- USP52
1 SIMAP similar gene for USP13 using alignment to 3 protein entries: UBP13_HUMAN (see all proteins):USP5
USP13 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for USP13
PGOHUM00000239780
|
Genomic Variants
for USP13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP13 (179370543 - 179507189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP13 |
|
Disorders
/ Diseases
for USP13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP13 for disorders About GeneDecksing
OMIM gene information: 603591
OMIM disorders: --
1  disease for USP13: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: USP13 (1 document)
Export disorders for USP13 gene to outside databases
|
Publications
for USP13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP13 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with USP13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). (PubMed id 9841226)1, 2, 9 Timms K.M.... Gibbs R.A. (1998)
- Regulation of MITF stability by the USP13 deubiquitin ase. (PubMed id 21811243)1, 2 Zhao X....Fisher D.E. (2011)
- Ubiquitin-recognition protein Ufd1 couples the endopl asmic reticulum (ER) stress response to cell cycle control. (PubMed id 21571647)1, 2 Chen M....Ronai Z.A. (2011)
- USP13 enzyme regulates Siah2 ligase stability and act ivity via noncatalytic ubiquitin-binding domains. (PubMed id 21659512)1, 2 Scortegagna M....Ronai Z.A. (2011)
- Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J....Yuan J. (2011)
- Domain analysis reveals that a deubiquitinating enzym e USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. (PubMed id 22216260)1, 2 Zhang Y.H....Hu H.Y. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PubMed id 11927605)1, 9 McElhinny A.S.... Gregorio C.C. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for USP13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP13 gene:
Search GeneIP for patents involving USP13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for USP13 | | OriGene shRNA RFP for USP13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP13 | | | OriGene Protein Over-expression Lysate for USP13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP13 | | OriGene 3'-UTR Clone for USP13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP13 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP13 | | OriGene Custom Protein Services for USP13 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP13 |
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| | | | Search Tocris compounds for USP13 |
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 | | | USP13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP13 |
|  |  |  | | | | ThermoFisher Antibody for USP13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP13 |
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