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USP13 Gene

protein-coding   GIFtS: 57
GCID: GC03P179370

Ubiquitin Specific Peptidase 13 (Isopeptidase T-3)

(Previous name: ubiquitin specific protease 13 (isopeptidase T-3))
  Search for USP13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 13 (Isopeptidase T-3)1 2     IsoT-32
ISOT32 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 132
Ubiquitin Specific Protease 13 (Isopeptidase T-3)1 2     Ubiquitin Thiolesterase 132
Deubiquitinating Enzyme 132 3     EC 3.4.19.123
Isopeptidase T-32 3     ISOT-33
Ubiquitin Thioesterase 132 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 132 3     

External Ids:    HGNC: 126111   Entrez Gene: 89752   Ensembl: ENSG000000580567   OMIM: 6035915   UniProtKB: Q929953   

Export aliases for USP13 gene to outside databases

Previous GC identifers: GC03P176137 GC03P180213 GC03P180772 GC03P180691 GC03P180853 GC03P176774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP13 Gene:
USP13 (ubiquitin specific peptidase 13 (isopeptidase T-3)) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitin protein ligase binding. An important paralog of this gene is USP5.

UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995
Function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and
is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a
key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates
USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13
stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate
p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2,
thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2
independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2
autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked
polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able
to cleave ISG15 in vitro; however, additional experiments are required to confirm such data

Gene Wiki entry for USP13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP13 gene promoter:
         Bach1   Brachyury   POU6F1 (c2)   Nkx2-5   Cdc5   LCR-F1   Evi-1   Pax-3   Zic1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP13 promoter sequence
   Search Chromatin IP Primers for USP13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-q26.3   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q26.2-q26.3

USP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP13 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P179370:  view genomic region     (about GC identifiers)

Start:
179,370,543 bp from pter      End:
179,507,189 bp from pter
Size:
136,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 13  
Size: 863 amino acids; 97327 Da
Subunit: Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated)
2 PDB 3D structures from and Proteopedia for USP13:
2L80 (3D)        2LBC (3D)    
Secondary accessions: A8K2S3 B4DYF3 D3DNS2 Q96B25
Alternative splicing: 2 isoforms:  Q92995-1   Q92995-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP13: NX_Q92995

Explore proteomics data for USP13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys176, Lys190, Lys259, Lys326, Lys328, Lys389, Lys405, Lys538, Lys565,
                                 Lys587, Lys598, Lys640
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP13 (Q92995) (see all 9)
     VKLGTIT  ACRKAVY  NLGNSCY  KEGRWVI 


    See USP13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003931.2  
    ENSEMBL proteins: 
     ENSP00000263966   ENSP00000418651   ENSP00000417146   ENSP00000420057  

    USP13 Human Recombinant Protein Products:

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    Novus Biologicals USP13 Protein
    Novus Biologicals USP13 Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for USP13

     
    Search eBioscience for Proteins for USP13 

    USP13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for USP13 
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    Novus Biologicals USP13 Antibodies
    Abcam antibodies for USP13
    Cloud-Clone Corp. Antibodies for USP13
    ThermoFisher Antibody for USP13
    LSBio Antibodies in human, mouse, rat for USP13

    USP13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP13
    Cloud-Clone Corp. CLIAs for USP13
    Search eBioscience for ELISAs for USP13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 9):
     IPR001394 Peptidase_C19_UCH
     IPR016652 Ubiquitinyl_hydrolase
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q92995

    ProtoNet protein and cluster: Q92995

    3 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995
    Domain: The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored
    ubiquitin. Swapping with the UBP-type zinc finger from USP5 restores ability to bind unanchored ubiquitin and
    subsequent activation of the protein (PubMed:22216260)
    Domain: The UBA domains mediate binding to ubiquitin (PubMed:22216260)
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP13_HUMAN, Q92995
    Function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and
    is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
    Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a
    key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates
    USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13
    stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate
    p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2,
    thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2
    independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2
    autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked
    polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able
    to cleave ISG15 in vitro; however, additional experiments are required to confirm such data
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative
    of MBCQ that binds to USP13 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes.
    The weak deubiquitinase activity in vitro suggests the existence of some mechanism that activates the enzyme

         Genatlas biochemistry entry for USP13:
    ubiquitin specific protease 13,expressed in testis and ovary,ubiquitin C terminal hydrolase family
    member,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI--
    GO:0008242omega peptidase activity IEA--
         
    Find genes that share ontologies with USP13           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP13
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP13
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    miRNA
    Products:
        
    miRTarBase miRNAs that target USP13:
    hsa-mir-92a-3p (MIRT049674)

    Block miRNA regulation of human, mouse, rat USP13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP13 (see all 82):
    hsa-miR-106a hsa-miR-134 hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3142 hsa-miR-93 hsa-miR-155* hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP13
    Predesigned siRNA for gene silencing in human, mouse, rat USP13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP13

    Clone
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    OriGene clones in human, mouse for USP13 (see all 7)
    OriGene ORF clones in mouse, rat for USP13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP13 (NM_003940)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP13
    Addgene plasmids for USP13 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP13 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Protein Stability
    Protein Stability


    Find genes that share SuperPaths with USP13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP13
        Ubiquitin-Proteasome Dependent Proteolysis

    1 Cell Signaling Technology (CST) Pathway for USP13
        Protein Stability


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP13
    Interactions:

        Search GeneGlobe Interaction Network for USP13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP13 (Q929952, 3 ENSP000002639664) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL1O146402, 3MINT-65081 I2D: score=5 
    FNBP1LQ5T0N52, 3MINT-65085 I2D: score=5 
    FUNDC2Q9BWH22, 3MINT-65084 I2D: score=5 
    MRPL20Q9BYC92, 3MINT-65083 I2D: score=5 
    LAPTM5Q135712, 3MINT-62177 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IMP--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006914autophagy IEA--
    GO:0008283cell proliferation IMP--
    GO:0010506regulation of autophagy IDA--

    Find genes that share ontologies with USP13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP13 (UBP13)

    1 HMDB Compound for USP13    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP13 gene: 
    NM_003940.2  

    Unigene Cluster for USP13:

    Ubiquitin specific peptidase 13 (isopeptidase T-3)
    Hs.175322  [show with all ESTs]
    Unigene Representative Sequence: NM_003940
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263966(uc003fkh.3) ENST00000482333 ENST00000497380 ENST00000496897
    ENST00000497155
    miRNA
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    Block miRNA regulation of human, mouse, rat USP13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP13 (see all 82):
    hsa-miR-106a hsa-miR-134 hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3142 hsa-miR-93 hsa-miR-155* hsa-miR-130b
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP13
    Addgene plasmids for USP13 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat USP13
      QuantiFast Probe-based Assays in human, mouse, rat USP13

    Additional mRNA sequence: 

    AK091484.1 AK290338.1 AK302404.1 BC016146.1 BC049199.1 BC062766.1 U75362.1 

    8 DOTS entries:

    DT.212478  DT.312419  DT.100008025  DT.100714935  DT.100780389  DT.100806935  DT.100676001  DT.95186063 

    Selected AceView cDNA sequences (see all 164):

    BU683248 F29207 BM974597 CR591494 AW304039 AA701289 CR623689 AA506150 
    R07668 BQ775545 CB164791 AA993458 AI193905 AI279566 AI804164 BU629359 
    AA932764 AI125572 AI633726 BQ880738 BQ009180 BQ222207 AL596734 BQ014945 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGGGGTA
    USP13 Expression
    About this image

    USP13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.175322

    UniProtKB/Swiss-Prot: UBP13_HUMAN, Q92995
    Tissue specificity: Highly expressed in ovary and testes

        Custom PCR Arrays for USP13
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    QuantiFast Probe-based Assays in human, mouse, rat USP13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP13 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp131 , 5 ubiquitin specific peptidase 13 (isopeptidase T-3)1, 5 88.69(n)1
    96.15(a)1
      3 (15.88 cM)5
    726071  NM_001013024.21  NP_001013042.11 
     328175465 
    chicken
    (Gallus gallus)
    Aves USP131 ubiquitin specific peptidase 13 (isopeptidase T-3) 78.22(n)
    84.01(a)
      429286  XM_426842.4  XP_426842.2 
    lizard
    (Anolis carolinensis)
    Reptilia USP136
    ubiquitin specific peptidase 13 (isopeptidase T-3)...
    77(a)
    1 ↔ 1
    3(1983249-2089070)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161882 Xenopus laevis transcribed sequence with moderate similarity more 76.24(n)    BJ048181.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp131 ubiquitin specific peptidase 13 (isopeptidase T-3) 72.36(n)
    76.39(a)
      558011  NM_001098386.1  NP_001091856.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120823 protein deubiquitination ubiquitin
    isopeptidase more
    43(a)   63B6   --
    worm
    (Caenorhabditis elegans)
    Secernentea T27A3.23 ubiquitin carboxyl-terminal hydrolase 31(a)   I(6118275-6122458)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP146
    Ubiquitin-specific protease that specifically disa...
    28(a)
    1 → many
    II(353672-356017) YBR058C


    ENSEMBL Gene Tree for USP13 (if available)
    TreeFam Gene Tree for USP13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP13 gene
    USP52  
    1 SIMAP similar gene for USP13 using alignment to 3 protein entries:     UBP13_HUMAN (see all proteins):
    USP5

    Find genes that share paralogs with USP13           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP13
    PGOHUM00000239780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP13 (see all 2858)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407752081,2
    Cuntested1179449656(+) TGTCTA/C/GAAGTG 1 -- int10--------
    rs576200881,2
    C--176801400(+) TTTTT-/TT/TTT/
    TTTTTTTTTT
    GATAC
    1 -- int11NA 2
    rs1507068931,2
    --179368948(+) TTACTA/GCAAGT 1 -- us2k10--------
    rs1379142311,2
    --179368952(+) TACAAA/GTACAA 1 -- us2k10--------
    rs1432799171,2
    --179368978(+) GCCCAC/TGGTAT 1 -- us2k10--------
    rs777991561,2
    C--179368997(+) TGCCAA/GAATGC 1 -- us2k14Minor allele frequency- G:0.09NA WA EA 360
    rs98268931,2
    C,H--179369119(+) AGAGCC/AACTTC 1 -- us2k18Minor allele frequency- A:0.36EA NS NA WA 642
    rs1400598301,2
    --179369170(+) AAGGAA/TCTTTA 1 -- us2k10--------
    rs1913337251,2
    --179369404(+) TCAATA/GTATCT 1 -- us2k10--------
    rs777171331,2
    C,F--179369407(+) ATATAT/CCTTTA 1 -- us2k11Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for USP13 (179370543 - 179507189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP13:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726257CNV Deletion23290073
    esv2656680CNV Deletion23128226
    nsv522327CNV Loss19592680
    nsv4140CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP13
    DNA2.0 Custom Variant and Variant Library Synthesis for USP13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603591    OMIM disorders: --


    Find genes that share disorders with USP13           About GenesLikeMe

    Genetic Association Database (GAD): USP13
    Human Genome Epidemiology (HuGE) Navigator: USP13 (1 document)

    Export disorders for USP13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP13 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with USP13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). (PubMed id 9841226)1, 2, 9 Timms K.M.... Gibbs R.A. (Gene 1998)
    2. Regulation of MITF stability by the USP13 deubiquitinase. (PubMed id 21811243)1, 2 Zhao X.... Fisher D.E. (Nat. Commun. 2011)
    3. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PubMed id 21571647)1, 2 Chen M.... Ronai Z.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    4. USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains. (PubMed id 21659512)1, 2 Scortegagna M....Ronai Z.A. (J. Biol. Chem. 2011)
    5. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J.... Yuan J. (Cell 2011)
    6. Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. (PubMed id 22216260)1, 2 Zhang Y.H.... Hu H.Y. (PLoS ONE 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    10. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PubMed id 11927605)1, 9 McElhinny A.S.... Gregorio C.C. (J. Cell Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8975 HGNC: 12611 AceView: USP13 Ensembl:ENSG00000058056 euGenes: HUgn8975
    ECgene: USP13 H-InvDB: USP13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP13 gene:
    Search GeneIP for patents involving USP13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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