Aliases for USP12 Gene
External Ids for USP12 Gene
Previous HGNC Symbols for USP12 Gene
Previous GeneCards Identifiers for USP12 Gene
GeneCards Summary for USP12 Gene
USP12 (Ubiquitin Specific Peptidase 12) is a Protein Coding gene. Among its related pathways are Deubiquitination and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP46.
UniProtKB/Swiss-Prot for USP12 Gene
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).