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Aliases for USP12 Gene

Aliases for USP12 Gene

  • Ubiquitin Specific Peptidase 12 2 3 5
  • Ubiquitin-Specific-Processing Protease 12 3 4
  • Ubiquitin Specific Protease 12 Like 1 2 3
  • Ubiquitin-Hydrolyzing Enzyme 1 3 4
  • Deubiquitinating Enzyme 12 3 4
  • Ubiquitin Thioesterase 12 3 4
  • USP12L1 3 4
  • UBH1 3 4
  • Ubiquitin Specific Protease 12 2
  • Ubiquitin Thiolesterase 12 3
  • EC 4
  • EC 63

External Ids for USP12 Gene

Previous HGNC Symbols for USP12 Gene

  • USP12L1

Previous GeneCards Identifiers for USP12 Gene

  • GC05U990084
  • GC13M026570
  • GC13M025440
  • GC13M025438
  • GC13M026540
  • GC13M027640
  • GC13M008462

Summaries for USP12 Gene

GeneCards Summary for USP12 Gene

USP12 (Ubiquitin Specific Peptidase 12) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP12 Gene

  • Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP12 Gene

Genomics for USP12 Gene

Regulatory Elements for USP12 Gene

Enhancers for USP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP12 on UCSC Golden Path with GeneCards custom track

Promoters for USP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP12 Gene

27,066,142 bp from pter
27,171,896 bp from pter
105,755 bases
Minus strand

Genomic View for USP12 Gene

Genes around USP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP12 Gene

Proteins for USP12 Gene

  • Protein details for USP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 12
    Protein Accession:
    Secondary Accessions:
    • A8K0X0
    • Q5VZV3
    • Q8TC49

    Protein attributes for USP12 Gene

    370 amino acids
    Molecular mass:
    42858 Da
    Quaternary structure:
    • Interacts with WDR48.
    • Sequence=AAC23551.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP12 Gene

Proteomics data for USP12 Gene at MOPED

Post-translational modifications for USP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP12 Gene

Gene Families for USP12 Gene

Protein Domains for USP12 Gene

Suggested Antigen Peptide Sequences for USP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP12/USP46 subfamily.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP12/USP46 subfamily.
genes like me logo Genes that share domains with USP12: view

Function for USP12 Gene

Molecular function for USP12 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 12,mainly expressed in retina,olfactory epithelium,peripheral neuronal ganglia and distinct areas of the gut,involved in deubiquitina,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

Enzyme Numbers (IUBMB) for USP12 Gene

Gene Ontology (GO) - Molecular Function for USP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 19075014
genes like me logo Genes that share ontologies with USP12: view
genes like me logo Genes that share phenotypes with USP12: view

Animal Models for USP12 Gene

MGI Knock Outs for USP12:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP12

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP12 Gene

Localization for USP12 Gene

Subcellular locations from

Jensen Localization Image for USP12 Gene COMPARTMENTS Subcellular localization image for USP12 gene
Compartment Confidence
cytosol 2
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP12 Gene

Pathways & Interactions for USP12 Gene

genes like me logo Genes that share pathways with USP12: view

Pathways by source for USP12 Gene

1 Qiagen pathway for USP12 Gene

Gene Ontology (GO) - Biological Process for USP12 Gene


No data available for SIGNOR curated interactions for USP12 Gene

Drugs & Compounds for USP12 Gene

No Compound Related Data Available

Transcripts for USP12 Gene

Unigene Clusters for USP12 Gene

Ubiquitin specific peptidase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - -
SP3: -
SP4: - -

Relevant External Links for USP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP12 Gene

mRNA expression in normal human tissues for USP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP12 Gene

This gene is overexpressed in Nasal epithelium (41.2) and Lung (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP12 Gene

SOURCE GeneReport for Unigene cluster for USP12 Gene Hs.42400

genes like me logo Genes that share expression patterns with USP12: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP12 Gene

Orthologs for USP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP12 35
  • 93.68 (n)
  • 99.46 (a)
USP12 36
  • 99 (a)
(Canis familiaris)
Mammalia USP12 35
  • 95.23 (n)
  • 99.19 (a)
USP12 36
  • 99 (a)
(Mus musculus)
Mammalia Usp12 35
  • 90.18 (n)
  • 98.38 (a)
Usp12 16
Usp12 36
  • 98 (a)
(Pan troglodytes)
Mammalia USP12 35
  • 99.73 (n)
  • 100 (a)
USP12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp12 35
  • 90.72 (n)
  • 98.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
-- 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia USP12 36
  • 94 (a)
(Gallus gallus)
Aves USP12 35
  • 89.08 (n)
  • 98.87 (a)
USP12 36
  • 98 (a)
(Anolis carolinensis)
Reptilia USP12 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494517 35
  • 85.14 (n)
  • 98.92 (a)
(Danio rerio)
Actinopterygii usp12a 35
  • 76.94 (n)
  • 93.51 (a)
USP12 (1 of 2) 36
  • 88 (a)
usp12a 36
  • 93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7023 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea usp-46 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 36
  • 18 (a)
UBP9 36
  • 19 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4818 35
(Hordeum vulgare)
Liliopsida Hv.7715 35
(Oryza sativa)
Liliopsida Os03g0190800 35
  • 60.73 (n)
  • 61.49 (a)
(Triticum aestivum)
Liliopsida Ta.7011 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08378 35
  • 52.61 (n)
  • 47.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp9 35
  • 54.43 (n)
  • 49.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for USP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for USP12 Gene

Gene Tree for USP12 (if available)
Gene Tree for USP12 (if available)

Paralogs for USP12 Gene

(1) SIMAP similar genes for USP12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP12: view

Variants for USP12 Gene

Sequence variations from dbSNP and Humsavar for USP12 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7655 -- 27,066,377(-) AAAGC(A/G)CTCAT utr-variant-3-prime
rs9901 -- 27,072,462(-) AAACA(A/T)CTTCC intron-variant
rs472339 -- 27,109,383(+) aatca(A/T)gtctc intron-variant
rs479920 -- 27,106,790(+) TGGAT(A/G)AAAAT intron-variant
rs488119 -- 27,104,633(+) GGGAA(A/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP12 Gene

Variant ID Type Subtype PubMed ID
nsv972 CNV Insertion 18451855

Variation tolerance for USP12 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP12 Gene

Disorders for USP12 Gene

Relevant External Links for USP12

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP12 Gene

Publications for USP12 Gene

  1. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. (PMID: 9615226) Hansen-Hagge T.E. … Bartram C.R. (Genomics 1998) 3 4 23 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth. (PMID: 25855980) Ohashi M. … Johannsen E. (PLoS Pathog. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication. (PMID: 24850727) Lehoux M. … Archambault J. (J. Virol. 2014) 3

Products for USP12 Gene

Sources for USP12 Gene