Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP12 Gene

protein-coding   GIFtS: 56
GCID: GC13M027640

Ubiquitin Specific Peptidase 12

(Previous names: ubiquitin specific protease 12 like 1, ubiquitin specific...)
(Previous symbol: USP12L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 121 2     Ubiquitin-Specific-Processing Protease 122 3
USP12L11 2 3     Ubiquitin Specific Protease 121
UBH12 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 122
Ubiquitin Specific Protease 12 Like 11 2     Ubiquitin Thiolesterase 122
Deubiquitinating Enzyme 122 3     EC 3.4.19.123
Ubiquitin Thioesterase 122 3     EC 3.1.2.158
Ubiquitin-Hydrolyzing Enzyme 12 3     

External Ids:    HGNC: 204851   Entrez Gene: 2193332   Ensembl: ENSG000001524847   OMIM: 6030915   UniProtKB: O753173   

Export aliases for USP12 gene to outside databases

Previous GC identifers: GC05U990084 GC13M026570 GC13M025440 GC13M025438 GC13M026540 GC13M008462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP12 Gene: 
USP12 (ubiquitin specific peptidase 12) is a protein-coding gene. Diseases associated with USP12 include fanconi's anemia, and ulcerative colitis. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317
Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction
with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP12 gene promoter:
         Bach1   FOXF2   Nkx2-2   FOXD3   IRF-2   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP12 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.13   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.13

USP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M027640:  view genomic region     (about GC identifiers)

Start:
27,640,287 bp from pter      End:
27,746,033 bp from pter
Size:
105,747 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 12  
Size: 370 amino acids; 42858 Da
Subunit: Interacts with WDR48
Sequence caution: Sequence=AAC23551.1; Type=Erroneous initiation;
Secondary accessions: A8K0X0 Q5VZV3 Q8TC49

Explore the universe of human proteins at neXtProt for USP12: NX_O75317

Explore proteomics data for USP12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75317

  • 4/16 DME Specific Peptides for USP12 (O75317) (see all 16)
     PNRGHYI  IGPEQFP  FQGTLTN  KQEKQNG 

    USP12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP12 Protein Expression
    REFSEQ proteins: NP_872294.2  
    ENSEMBL proteins: 
     ENSP00000282344  

    Human Recombinant Protein Products for USP12: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP12
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP12
    GenScript Custom Purified and Recombinant Proteins Services for USP12
    Novus Biologicals USP12 Proteins
    Novus Biologicals USP12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    USP12 for ontologies           About GeneDecksing



    USP12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP12
    OriGene Custom Antibody Services for USP12
    GenScript Custom Superior Antibodies Services for USP12
    Novus Biologicals USP12 Antibodies
    Abcam antibodies for USP12
    Cloud-Clone Corp. Antibodies for USP12 
    ThermoFisher Antibody for USP12
    LSBio Antibodies in human, mouse, rat for USP12 

    Assay Products for USP12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP12 
    Cloud-Clone Corp. CLIAs for USP12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry O75317

    ProtoNet protein and cluster: O75317

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317
    Similarity: Belongs to the peptidase C19 family. USP12/USP46 subfamily


    USP12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP12_HUMAN, O75317
    Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction
    with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP12:
    ubiquitin specific protease 12,mainly expressed in retina,olfactory epithelium,peripheral neuronal ganglia and
    distinct areas of the gut,involved in deubiquitina,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP19075014
    GO:0004221ubiquitin thiolesterase activity TAS9615226
    GO:0004843ubiquitin-specific protease activity IDA19075014
    GO:0005515protein binding IPI19075014
         
    USP12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP12:
     Decreased viability with cispl  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP12 

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP12:
    hsa-mir-373 (MIRT002534)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP12
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP12 (see all 87):
    hsa-miR-100* hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-3921 hsa-miR-629* hsa-miR-29a* hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidUSP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP12
    Sirion Biotech Customized adenovirus for overexpression of USP12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP12 (see all 9)
    OriGene ORF clones in mouse, rat for USP12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for USP12
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP12
    Sirion Biotech Customized lentivirus for stable overexpression of USP12 
                         Customized lentivirus expression plasmids for stable overexpression of USP12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP12
    Search LifeMap BioReagents cell lines for USP12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP12
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for USP12 (O753173 ENSP000002823444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    PAIP1Q9H0743, ENSP000003027684I2D: score=2 STRING: ENSP00000302768
    PHLPP2Q6ZVD83, ENSP000003486114I2D: score=2 STRING: ENSP00000348611
    WDR20Q8TBZ33, ENSP000003354344I2D: score=2 STRING: ENSP00000335434
    HIST2H2ACQ167773, ENSP000003321944I2D: score=1 STRING: ENSP00000332194
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process NAS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA19075014

    USP12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP12 (UBP12)

    Search CenterWatch for drugs/clinical trials and news about USP12 / UBP12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP12 gene: 
    NM_182488.3  

    Unigene Cluster for USP12:

    Ubiquitin specific peptidase 12
    Hs.42400  [show with all ESTs]
    Unigene Representative Sequence: NM_182488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282344(uc001uqy.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP12
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP12 (see all 87):
    hsa-miR-100* hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-3921 hsa-miR-629* hsa-miR-29a* hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidUSP12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP12
    Clone
    Products:
         
    OriGene clones in human, mouse for USP12 (see all 9)
    OriGene ORF clones in mouse, rat for USP12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for USP12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP12
    Sirion Biotech Customized lentivirus for stable overexpression of USP12 
                         Customized lentivirus expression plasmids for stable overexpression of USP12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP12
    OriGene qSTAR qPCR primer pairs in human, mouse for USP12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP12

    Additional mRNA sequence: 

    AF022789.1 AK289685.1 AL049221.1 BC026072.1 

    12 DOTS entries:

    DT.75187513  DT.409156  DT.101967297  DT.75127843  DT.97770033  DT.100660226  DT.120652128  DT.91913091 
    DT.95231244  DT.91740469  DT.99935569  DT.99995190 

    24/188 AceView cDNA sequences (see all 188):

    AA418174 AA832295 BM930847 AA453343 BM803688 AA459676 CD516704 AA459664 
    CA309356 CB217149 AI478322 F03956 BE504549 AA459786 AA412513 BF002096 
    AA405037 AF022793 BX099332 BU676227 W38373 AW501808 AI346242 BM021355 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USP12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:              -                                         -                           
    SP2:                                                                                    
    SP3:        -                                                                           
    SP4:                                                        -     -                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for USP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGGCTCT
    USP12 Expression
    About this image


    See USP12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP12

    SOURCE GeneReport for Unigene cluster: Hs.42400
        SABiosciences Custom PCR Arrays for USP12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USP12
    OriGene qSTAR qPCR primer pairs in human, mouse for USP12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP12 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp121 , 5 ubiquitin specific peptidase 121, 5 90.18(n)1
    98.38(a)1
      5 (86.00 cM)5
    222171  NM_011669.31  NP_035799.11 
     1467348095 
    chicken
    (Gallus gallus)
    Aves USP121 ubiquitin specific peptidase 12 89.17(n)
    99.15(a)
      428078  XM_425636.3  XP_425636.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP126
    ubiquitin specific peptidase 12
    98(a)
    1 ↔ 1
    GL343306.1(1001348-1034087)
    zebrafish
    (Danio rerio)
    Actinopterygii usp12a1 ubiquitin specific peptidase 12a 76.94(n)
    93.51(a)
      565736  NM_001083556.1  NP_001077025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70236
    --
    62(a)
    1 → many
    3R(18576614-18602096)
    worm
    (Caenorhabditis elegans)
    Secernentea usp-466
    Probable ubiquitin carboxyl-terminal hydrolase 46
    58(a)
    1 → many
    III(9776532-9778849)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP91 Ubp9p 53.23(n)
    43.87(a)
      856835   NP_011024.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP31 ubiquitin carboxyl-terminal hydrolase 3 61.05(n)
    61.71(a)
      830150  NM_120154.4  NP_568074.1 
    rice
    (Oryza sativa)
    Liliopsida AK069100.12   -- 71.44(n)    AK069100.1 


    ENSEMBL Gene Tree for USP12 (if available)
    TreeFam Gene Tree for USP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP12 gene
    USP352  USP382  USP462  USP12  
    1 SIMAP similar gene for USP12 using alignment to 1 protein entry:     UBP12_HUMAN:
    USP46

    USP12 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for USP12 (see all 8)
    PGOHUM00000240379 PGOHUM00000235832 PGOHUM00000236042 PGOHUM00000236049 PGOHUM00000236057


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2201 SNPs in USP12 are shown (see all 2201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825792141,2
    --27639874(+) AGTTAC/TTCAAT 1 -- ds50010--------
    rs1471420481,2
    C--27639943(+) TTTACA/GGGAGC 1 -- ds50010--------
    rs1877516621,2
    --27640033(+) CTATGA/GCTCTC 1 -- ds50010--------
    rs95513531,2
    C,F,A,H--27640150(+) ACACAC/TGCAAT 1 -- ds500126Minor allele frequency- T:0.11NS EA NA WA CSA 2162
    rs1931372251,2
    --27640151(+) CACATA/GCAATT 1 -- ds50010--------
    rs1403364061,2
    --27640260(+) TTAGGA/CAAAAA 1 -- ds50010--------
    rs560430821,2
    C--27640349(+) CTTCAA/GGAACC 1 -- ut310--------
    rs1441967971,2
    C--27640354(+) AGAACC/TTTAAA 1 -- ut310--------
    rs1839766051,2
    --27640448(+) TGAAGC/TACAGA 1 -- ut310--------
    rs1507521051,2
    --27640485(+) CACAGC/TTAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP12 (27640287 - 27746033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv972CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP12
    DNA2.0 Custom Variant and Variant Library Synthesis for USP12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603091    OMIM disorders: --

    5 diseases for USP12:    About MalaCards
    fanconi's anemia    ulcerative colitis    anemia    schizophrenia
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for USP12:
    Fanconi's anemia

    USP12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP12

    Export disorders for USP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP12 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with USP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. (PubMed id 9615226)1, 2, 9 Hansen-Hagge T.E....Bartram C.R. (1998)
    2. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PubMed id 19915573)1, 4 Asano K....Kubo M. (2009)
    3. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. (PubMed id 19075014)1, 2 Cohn M.A.... D'Andrea A.D. (2009)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    7. The ubiquitin-specific protease 12 (USP12) is a negati ve regulator of notch signaling acting on notch receptor trafficking toward degr adation. (PubMed id 22778262)1 Moretti J....Brou C. (2012)
    8. Genomewide association analysis of symptoms of alcoho l dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PubMed id 21314694)1 Kendler K.S....Gejman P.V. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Regulation of histone H2A and H2B deubiquitination an d Xenopus development by USP12 and USP46. (PubMed id 21183687)1 Joo H.Y....Wang H. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219333 HGNC: 20485 AceView: USP12 Ensembl:ENSG00000152484 euGenes: HUgn219333
    ECgene: USP12 H-InvDB: USP12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP12 gene:
    Search GeneIP for patents involving USP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for USP12   OriGene RNAi products in human, mouse, rat for USP12  
     OriGene qPCR primer pairs and template standards for USP12   OriGene Protein Over-expression Lysate for USP12  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for USP12  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for USP12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP12   OriGene Custom Protein Services for USP12  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP12
     QIAGEN SeqTarget long-range PCR primers for resequencing USP12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP12
     GenScript Custom Purified and Recombinant Proteins Services for USP12 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for USP12
     GenScript Custom Assay Services for USP12 GenScript Custom Superior Antibodies Services for USP12
     GenScript Custom overexpressing Cell Line Services for USP12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP12 promoter
     Search Chromatin IP Primers for USP12
     RT2 qPCR Primer Assay in human, mouse, rat USP12
     Search GNC Networks for USP12
     SABiosciences PCR Arrays including human, mouse, rat USP12
     Search Tocris compounds for USP12 (UBP12)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP12 antibodies
     USP12 proteins
     USP12 lysates
     Antibodies for USP12
     See all of Abcam's Antibodies, Kits and Proteins for USP12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for USP12
     Antibodies for USP12
     ELISAs for USP12
     CLIAs for USP12
     Search LifeMap BioReagents cell lines for USP12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP12
     SwitchGear 3'UTR luciferase reporter plasmids for USP12
     SwitchGear Promoter luciferase reporter plasmids for USP12
     ThermoFisher Antibody for USP12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP12
     inGenious Targeting Laboratory - Custom generated mouse model solutions for USP12
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP12
    Customized:
     lentivirus for stable overexpression of USP12
     lentivirus expression plasmids for stable overexpression of USP12
     adenovirus for overexpression of USP12
     LSBio Antibodies in human, mouse, rat for USP12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP12 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4