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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP12 Gene

protein-coding   GIFtS: 54
GCID: GC13M027640

ubiquitin specific peptidase 12

(Previous names: ubiquitin specific protease 12 like 1, ubiquitin specific...)
(Previous symbol: USP12L1)
 Explore 3 diseases affiliated with
USP12 via our new
 Human Malady Compendium 
Biological research products
for USP12
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 121 2     Ubiquitin-Specific-Processing Protease 122 3
USP12L11 2 3     Ubiquitin Specific Protease 121
UBH12 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 122
Ubiquitin Specific Protease 12 Like 11 2     Ubiquitin Thiolesterase 122
Deubiquitinating Enzyme 122 3     EC 3.4.19.123
Ubiquitin Thioesterase 122 3     EC 3.1.2.158
Ubiquitin-Hydrolyzing Enzyme 12 3     

External Ids:    HGNC: 204851   Entrez Gene: 2193332   Ensembl: ENSG000001524847   OMIM: 6030915   UniProtKB: O753173   

Export aliases for USP12 gene to outside databases

Previous GC identifers: GC05U990084 GC13M026570 GC13M025440 GC13M025438 GC13M026540 GC13M008462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317
Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with
WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP12 gene promoter:
         Bach1   FOXF2   Nkx2-2   FOXD3   IRF-2   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP12 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.13   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.13

USP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M027640:  view genomic region     (about GC identifiers)

Start:
27,640,287 bp from pter      End:
27,746,033 bp from pter
Size:
105,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 12  
Size: 370 amino acids; 42858 Da
Subunit: Interacts with WDR48
Sequence caution: Sequence=AAC23551.1; Type=Erroneous initiation;
Secondary accessions: A8K0X0 Q5VZV3 Q8TC49

Explore the universe of human proteins at neXtProt for USP12: NX_O75317

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75317

  • 4/16 DME Specific Peptides for USP12 (O75317) (see all 16)
     PNRGHYI  IGPEQFP  FQGTLTN  KQEKQNG 

    USP12 Protein expression data from MOPED and PaxDb:    About this image 
    USP12 Protein Expression
    REFSEQ proteins: NP_872294.2  
    ENSEMBL proteins: 
     ENSP00000282344  

    Human Recombinant Protein Products for USP12: 
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    OriGene Protein Over-expression Lysate: USP12
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    Novus Biologicals USP12 Proteins
    Novus Biologicals USP12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP12

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    USP12 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    USP12 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry O75317

    ProtoNet protein and cluster: O75317

    1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP12_HUMAN, O75317
    Similarity: Belongs to the peptidase C19 family. USP12/USP46 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP12_HUMAN, O75317
    Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with
    WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP12:
    ubiquitin specific protease 12,mainly expressed in retina,olfactory epithelium,peripheral neuronal ganglia and distinct
    areas of the gut,involved in deubiquitina,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP19075014
    GO:0004221ubiquitin thiolesterase activity TAS9615226
    GO:0004843ubiquitin-specific protease activity IDA19075014
    GO:0005515protein binding IPI19075014
         
    USP12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP12:
     Decreased viability with cispl  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP12 

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP12:
    hsa-mir-373 (MIRT002534)

    OriGene 3'-UTR Clone: USP12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP12
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP12 (see all 87):
    hsa-miR-100* hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-3921 hsa-miR-629* hsa-miR-29a* hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidUSP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP12 (see all 4)
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    Sirion Biotech Custom design and validation of potent shRNA sequences against USP12 

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP12 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for USP12

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP12
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for USP12 (O753173 ENSP000002823444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    PAIP1Q9H0743, ENSP000003027684I2D: score=2 STRING: ENSP00000302768
    PHLPP2Q6ZVD83, ENSP000003486114I2D: score=2 STRING: ENSP00000348611
    WDR20Q8TBZ33, ENSP000003354344I2D: score=2 STRING: ENSP00000335434
    HIST2H2ACQ167773, ENSP000003321944I2D: score=1 STRING: ENSP00000332194
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process NAS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA19075014

    USP12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP12
    Search CenterWatch for drugs/clinical trials and news about USP12 / UBP12 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP12 gene: 
    NM_182488.3  

    Unigene Cluster for USP12:

    Ubiquitin specific peptidase 12
    Hs.42400  [show with all ESTs]
    Unigene Representative Sequence: NM_182488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282344(uc001uqy.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: USP12
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP12
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP12 (see all 87):
    hsa-miR-100* hsa-miR-520f hsa-miR-300 hsa-miR-15a hsa-miR-3921 hsa-miR-629* hsa-miR-29a* hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidUSP12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP12 (see all 4)
    Browse OriGene siRNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against USP12 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP12 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP12 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP12
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP12

    Additional cDNA sequence: 

    AF022789.1 AK289685.1 AL049221.1 BC026072.1 

    12 DOTS entries:

    DT.75187513  DT.409156  DT.101967297  DT.75127843  DT.97770033  DT.100660226  DT.120652128  DT.91913091 
    DT.95231244  DT.91740469  DT.99935569  DT.99995190 

    24/188 AceView cDNA sequences (see all 188):

    AA412513 BX099332 BU676227 AA459676 AA459786 BM930847 AA418174 BM803688 
    CB217149 CA309356 F03956 BM021355 AF022793 AA405037 BF002096 AA832295 
    AI346242 AI478322 BE504549 W38373 AA459664 AW501808 CD516704 AA453343 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USP12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:              -                                         -                           
    SP2:                                                                                    
    SP3:        -                                                                           
    SP4:                                                        -     -                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for USP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCTGGCTCT
    USP12 Expression
    About this image
    See USP12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP12

    SOURCE GeneReport for Unigene cluster: Hs.42400
        SABiosciences Custom PCR Arrays for USP12

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP12 gene from 8/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves USP121 ubiquitin specific peptidase 12 89.17(n)
    99.15(a)
      428078  XM_425636.3  XP_425636.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP126
    --
    95(a)
    1 ↔ 1
    GL343306.1(1003521-1014270)
    zebrafish
    (Danio rerio)
    Actinopterygii usp12a1 ubiquitin specific peptidase 12a 76.94(n)
    93.51(a)
      565736  NM_001083556.1  NP_001077025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70236
    --
    62(a)
    1 → many
    3R(18576614-18602096)
    worm
    (Caenorhabditis elegans)
    Secernentea usp-466
    Probable ubiquitin carboxyl-terminal hydrolase 46
    57(a)
    1 → many
    III(9776446-9778763)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP91 Ubp9p 53.23(n)
    43.87(a)
      856835   NP_011024.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP31 ubiquitin carboxyl-terminal hydrolase 3 61.05(n)
    61.71(a)
      830150  NM_120154.4  NP_568074.1 
    rice
    (Oryza sativa)
    Liliopsida AK069100.12   -- 71.44(n)    AK069100.1 


    ENSEMBL Gene Tree for USP12 (if available)
    TreeFam Gene Tree for USP12 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP12 gene
    USP352  USP382  USP462  USP12  
    2 SIMAP similar genes for USP12 using alignment to 1 protein entry:     UBP12_HUMAN:
    USP46    USP3

    USP12 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for USP12 (see all 8)
    PGOHUM00000240379 PGOHUM00000235832 PGOHUM00000236042 PGOHUM00000236049 PGOHUM00000236057


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1860 NCBI SNPs in USP12 are shown (see all 1860    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825792141,2
    --27639874(+) AGTTAC/TTCAAT 1 -- ds50010--------
    rs1471420481,2
    --27639943(+) TTTACA/GGGAGC 1 -- ds50010--------
    rs1877516621,2
    --27640033(+) CTATGA/GCTCTC 1 -- ds50010--------
    rs95513531,2
    C,F,A,H--27640150(+) ACACAC/TGCAAT 1 -- ds500126Minor allele frequency- T:0.11NS EA NA WA CSA 2162
    rs1931372251,2
    --27640151(+) CACATA/GCAATT 1 -- ds50010--------
    rs1403364061,2
    --27640260(+) TTAGGA/CAAAAA 1 -- ds50010--------
    rs560430821,2
    C--27640349(+) CTTCAA/GGAACC 1 -- ut310--------
    rs1441967971,2
    C--27640354(+) AGAACC/TTTAAA 1 -- ut310--------
    rs1839766051,2
    --27640448(+) TGAAGC/TACAGA 1 -- ut310--------
    rs1507521051,2
    --27640485(+) CACAGC/TTAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP12 (27640287 - 27746033 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for USP12: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP12
    DNA2.0 Custom Variant and Variant Library Synthesis for USP12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    USP12 for disorders           About GeneDecksing

    OMIM gene information: 603091    OMIM disorders: --

    3 diseases for USP12:    About MalaCards
    ulcerative colitis    schizophrenia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for USP12:
    Fanconi's anemia

    Export disorders for USP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP12 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with USP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. (PubMed id 9615226)1, 2, 9 Hansen-Hagge T.E....Bartram C.R. (1998)
    2. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. (PubMed id 19075014)1, 2 Cohn M.A.... D'Andrea A.D. (2009)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    6. The ubiquitin-specific protease 12 (USP12) is a negati ve regulator of notch signaling acting on notch receptor trafficking toward degr adation. (PubMed id 22778262)1 Moretti J....Brou C. (2012)
    7. Genomewide association analysis of symptoms of alcoho l dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PubMed id 21314694)1 Kendler K.S....Gejman P.V. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Regulation of histone H2A and H2B deubiquitination an d Xenopus development by USP12 and USP46. (PubMed id 21183687)1 Joo H.Y....Wang H. (2011)
    10. WDR20 regulates activity of the USP12 x UAF1 deubiqui tinating enzyme complex. (PubMed id 20147737)1 Kee Y....D'Andrea A.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219333 HGNC: 20485 AceView: USP12 Ensembl:ENSG00000152484 euGenes: HUgn219333
    ECgene: USP12 H-InvDB: USP12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP12 gene:
    Search GeneIP for patents involving USP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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