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Aliases for USP12 Gene

Aliases for USP12 Gene

  • Ubiquitin Specific Peptidase 12 2 3
  • UBH1 3 4 6
  • Ubiquitin-Specific-Processing Protease 12 3 4
  • Ubiquitin Specific Protease 12 Like 1 2 3
  • Ubiquitin-Hydrolyzing Enzyme 1 3 4
  • Deubiquitinating Enzyme 12 3 4
  • Ubiquitin Thioesterase 12 3 4
  • USP12L1 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 12 3
  • Ubiquitin Specific Protease 12 2
  • Ubiquitin Thiolesterase 12 3
  • EC 4
  • EC 63

External Ids for USP12 Gene

Previous HGNC Symbols for USP12 Gene

  • USP12L1

Previous GeneCards Identifiers for USP12 Gene

  • GC05U990084
  • GC13M026570
  • GC13M025440
  • GC13M025438
  • GC13M026540
  • GC13M027640
  • GC13M008462

Summaries for USP12 Gene

GeneCards Summary for USP12 Gene

USP12 (Ubiquitin Specific Peptidase 12) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity. An important paralog of this gene is USP1.

UniProtKB/Swiss-Prot for USP12 Gene

  • Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP12 Gene

Genomics for USP12 Gene

Regulatory Elements for USP12 Gene

Genomic Location for USP12 Gene

27,066,142 bp from pter
27,171,896 bp from pter
105,755 bases
Minus strand

Genomic View for USP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP12 Gene

Proteins for USP12 Gene

  • Protein details for USP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 12
    Protein Accession:
    Secondary Accessions:
    • A8K0X0
    • Q5VZV3
    • Q8TC49

    Protein attributes for USP12 Gene

    370 amino acids
    Molecular mass:
    42858 Da
    Quaternary structure:
    • Interacts with WDR48.
    • Sequence=AAC23551.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP12 Gene

Proteomics data for USP12 Gene at MOPED

Post-translational modifications for USP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for USP12 Gene

Gene Families for USP12 Gene

  • USP :Ubiquitin-specific peptidases

Protein Domains for USP12 Gene

Suggested Antigen Peptide Sequences for USP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75317
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP12/USP46 subfamily.
genes like me logo Genes that share domains with USP12: view

Function for USP12 Gene

Molecular function for USP12 Gene

GENATLAS Biochemistry: ubiquitin specific protease 12,mainly expressed in retina,olfactory epithelium,peripheral neuronal ganglia and distinct areas of the gut,involved in deubiquitina,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.

Enzyme Numbers (IUBMB) for USP12 Gene

Gene Ontology (GO) - Molecular Function for USP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 19075014
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 19075014
GO:0005515 protein binding IPI 19075014
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP12: view

Phenotypes for USP12 Gene

genes like me logo Genes that share phenotypes with USP12: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP12 Gene

Localization for USP12 Gene

Subcellular locations from

Jensen Localization Image for USP12 Gene COMPARTMENTS Subcellular localization image for USP12 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for USP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with USP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP12 Gene

Pathways for USP12 Gene

genes like me logo Genes that share pathways with USP12: view

Pathways by source for USP12 Gene

1 Qiagen pathway for USP12 Gene

Gene Ontology (GO) - Biological Process for USP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA 19075014
genes like me logo Genes that share ontologies with USP12: view

Transcripts for USP12 Gene

mRNA/cDNA for USP12 Gene

Unigene Clusters for USP12 Gene

Ubiquitin specific peptidase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - -
SP3: -
SP4: - -

Relevant External Links for USP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP12 Gene

mRNA expression in normal human tissues for USP12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP12 Gene

SOURCE GeneReport for Unigene cluster for USP12 Gene Hs.42400

genes like me logo Genes that share expressions with USP12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP12 Gene

Orthologs for USP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP12 35
  • 99.73 (n)
  • 100 (a)
USP12 36
  • 100 (a)
(Bos Taurus)
Mammalia USP12 35
  • 93.68 (n)
  • 99.46 (a)
USP12 36
  • 99 (a)
(Canis familiaris)
Mammalia USP12 35
  • 95.23 (n)
  • 99.19 (a)
USP12 36
  • 99 (a)
(Mus musculus)
Mammalia Usp12 35
  • 90.18 (n)
  • 98.38 (a)
Usp12 16
Usp12 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
-- 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia USP12 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Usp12 35
  • 90.72 (n)
  • 98.38 (a)
(Gallus gallus)
Aves USP12 35
  • 89.08 (n)
  • 98.87 (a)
USP12 36
  • 98 (a)
(Anolis carolinensis)
Reptilia USP12 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494517 35
  • 85.14 (n)
  • 98.92 (a)
(Danio rerio)
Actinopterygii USP12 (1 of 2) 36
  • 88 (a)
usp12a 35
  • 76.94 (n)
  • 93.51 (a)
usp12a 36
  • 93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7023 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea usp-46 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 36
  • 18 (a)
UBP9 36
  • 19 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4818 35
(Hordeum vulgare)
Liliopsida Hv.7715 35
(Oryza sativa)
Liliopsida Os03g0190800 35
  • 60.73 (n)
  • 61.49 (a)
(Triticum aestivum)
Liliopsida Ta.7011 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08378 35
  • 52.61 (n)
  • 47.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp9 35
  • 54.43 (n)
  • 49.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for USP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for USP12 Gene

Gene Tree for USP12 (if available)
Gene Tree for USP12 (if available)

Paralogs for USP12 Gene

Paralogs for USP12 Gene

Selected SIMAP similar genes for USP12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP12: view

Variants for USP12 Gene

Sequence variations from dbSNP and Humsavar for USP12 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7655 -- 27,066,377(-) AAAGC(A/G)CTCAT utr-variant-3-prime
rs9901 -- 27,072,462(-) AAACA(A/T)CTTCC intron-variant
rs472339 -- 27,109,383(+) aatca(A/T)gtctc intron-variant
rs479920 -- 27,106,790(+) TGGAT(A/G)AAAAT intron-variant
rs480523 -- 27,136,911(+) AAGAG(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP12 Gene

Variant ID Type Subtype PubMed ID
nsv972 CNV Insertion 18451855

Relevant External Links for USP12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP12 Gene

Disorders for USP12 Gene

(1) University of Copenhagen DISEASES for USP12 Gene

Relevant External Links for USP12

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with USP12: view

No data available for UniProtKB/Swiss-Prot for USP12 Gene

Publications for USP12 Gene

  1. An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. (PMID: 9615226) Hansen-Hagge T.E. … Bartram C.R. (Genomics 1998) 3 4 23
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. (PMID: 19075014) Cohn M.A. … D'Andrea A.D. (J. Biol. Chem. 2009) 3 4

Products for USP12 Gene

Sources for USP12 Gene

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