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USP11 Gene

protein-coding   GIFtS: 63
GCID: GC0XP047093

Ubiquitin Specific Peptidase 11

(Previous name: ubiquitin specific protease 11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 111 2     Ubiquitin Carboxyl-Terminal Hydrolase 112
UHX12 3 5     Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked2
Deubiquitinating Enzyme 112 3     Ubiquitin Thiolesterase 112
Ubiquitin Thioesterase 112 3     Ubiquitin-Specific Processing Protease 112
Ubiquitin-Specific-Processing Protease 112 3     EC 3.4.19.123
Ubiquitin Specific Protease 111     EC 3.1.2.158

External Ids:    HGNC: 126091   Entrez Gene: 82372   Ensembl: ENSG000001022267   OMIM: 3000505   UniProtKB: P517843   

Export aliases for USP11 gene to outside databases

Previous GC identifers: GC0XP045895 GC0XP045352 GC0XP045918 GC0XP046138 GC0XP046848 GC0XP046977 GC0XP044802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP11 Gene:
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional
activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and
deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that
specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating
enzyme which lies in a gene cluster on chromosome Xp11.23 (provided by RefSeq, Jul 2008)

GeneCards Summary for USP11 Gene:
USP11 (ubiquitin specific peptidase 11) is a protein-coding gene. Diseases associated with USP11 include congenital stationary night blindness, and night blindness. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784
Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits
the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to
NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks

Gene Wiki entry for USP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP11 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   E2F-2   GATA-2   E2F   E2F-1   POU2F1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP11 promoter sequence
   Search Chromatin IP Primers for USP11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

USP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047093:  view genomic region     (about GC identifiers)

Start:
47,092,089 bp from pter      End:
47,107,727 bp from pter
Size:
15,639 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 11  
Size: 963 amino acids; 109817 Da
Subunit: Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA. Interacts with papilloma virus
protein 16E7
Caution: It is uncertain whether Met-1 or Met-44 is the initiator
Sequence caution: Sequence=AAC50450.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC50450.1; Type=Frameshift; Positions=65, 117, 134, 146; Sequence=BAC20463.1; Type=Erroneous
initiation; Sequence=CAD20056.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RTX1 Q8IUG6 Q9BWE1

Explore the universe of human proteins at neXtProt for USP11: NX_P51784

Explore proteomics data for USP11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107, Lys191, Lys245, Lys355, Lys367, Lys447, Lys493, Lys531, Lys714, Lys766,
                                 Lys835, Lys840, Lys896, Lys920
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP11 (P51784) (see all 11)
     FLLDGLH  CIELFTT  PLLVSVP  NLGNTCF 


    See USP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004642.2  
    ENSEMBL proteins: 
     ENSP00000366311   ENSP00000366282   ENSP00000366279   ENSP00000218348  
    Reactome Protein details: P51784

    USP11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for USP11
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP11
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    Novus Biologicals USP11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP11

    USP11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP11
    OriGene Custom Antibody Services for USP11
    Novus Biologicals USP11 Antibodies
    Abcam antibodies for USP11
    Cloud-Clone Corp. Antibodies for USP11
    ThermoFisher Antibodies for USP11
    LSBio Antibodies in human, mouse, rat for USP11

    USP11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP11
    Cloud-Clone Corp. CLIAs for USP11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR001394 Peptidase_C19_UCH
     IPR028134 USP
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028135 Ub_USP-typ
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry P51784

    ProtoNet protein and cluster: P51784

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP
    IPB010460 Ubiquitin carboxyl-terminal hydrolase


    UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 DUSP domain
    Similarity: Contains 1 USP domain


    USP11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP11_HUMAN, P51784
    Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits
    the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to
    NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP11:
    ubiquitin specific protease 11,highly expressed in the retina,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA15314155
    GO:0005515protein binding IPI15314155
    GO:0008234cysteine-type peptidase activity ----
         
    USP11 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for USP11:
     Decreased Salmonella enterica   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest 
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP11:
    hsa-mir-10a-5p (MIRT047695)

    Block miRNA regulation of human, mouse, rat USP11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate USP11:
    hsa-miR-124* hsa-miR-3664-5p
    SwitchGear 3'UTR luciferase reporter plasmidUSP11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP11
    Predesigned siRNA for gene silencing in human, mouse, rat USP11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP11

    Clone
    Products:
         
    OriGene clones in human, mouse for USP11 (see all 7)
    OriGene ORF clones in mouse, rat for USP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP11 (NM_004651)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP11
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP11_HUMAN, P51784: Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15314155
    GO:0005737cytoplasm IDA--

    USP11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP11
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP11
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for USP11
        Association of TriC/CCT with target proteins during biosynthesis



    USP11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including USP11: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for USP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP11 (P517841, 2, 3 ENSP000002183484) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-306876,EBI-752313 MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 STRING: ENSP00000396439
    ENSG00000206287Q065871, 2, 3EBI-306876,EBI-752313 MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000226788Q065871, 2, 3EBI-306876,EBI-752313 MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000228520Q065871, 2, 3EBI-306876,EBI-752313 MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000231115Q065871, 2, 3EBI-306876,EBI-752313 MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA15314155

    USP11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP11 (UBP11)

    1 HMDB Compound for USP11    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP11 gene: 
    NM_004651.3  

    Unigene Cluster for USP11:

    Ubiquitin specific peptidase 11
    Hs.171501  [show with all ESTs]
    Unigene Representative Sequence: BC140849
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377107(uc004dhp.3 uc004dhq.3) ENST00000478596 ENST00000469080
    ENST00000377080 ENST00000377078 ENST00000489111 ENST00000489030 ENST00000480104
    ENST00000488848 ENST00000497179 ENST00000467378 ENST00000218348
    miRNA
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    Block miRNA regulation of human, mouse, rat USP11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate USP11:
    hsa-miR-124* hsa-miR-3664-5p
    SwitchGear 3'UTR luciferase reporter plasmidUSP11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP11
    Predesigned siRNA for gene silencing in human, mouse, rat USP11
    Clone
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    OriGene clones in human, mouse for USP11 (see all 7)
    OriGene ORF clones in mouse, rat for USP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP11 (NM_004651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP11
      QuantiTect SYBR Green Assays in human, mouse, rat USP11
      QuantiFast Probe-based Assays in human, mouse, rat USP11

    Additional mRNA sequence: 

    AB073597.1 AK098394.1 AK294635.1 BC000350.2 BC063668.1 BC140849.1 U44839.1 

    Selected DOTS entries (see all 50):

    DT.100886395  DT.40240774  DT.121286822  DT.121286751  DT.100842634  DT.91774475  DT.100886387  DT.100886384 
    DT.91774493  DT.100886386  DT.95175404  DT.100886385  DT.99965606  DT.97855317  DT.100886391  DT.97855318 
    DT.100720012  DT.121286744  DT.95175436  DT.100886392  DT.100038861  DT.121286761  DT.121286759  DT.121286720 

    Selected AceView cDNA sequences (see all 815):

    BQ955556 BM548697 BC063668 F04842 AI903798 BU728398 BM827845 CB155819 
    CD619083 BE890067 AW250821 BP368114 AU123551 CD619082 BF763058 H56694 
    BG287834 BM509041 BM832602 AU123457 BX385395 BQ878536 BQ277640 BP348528 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP11 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ·
    SP1:                    -                                                                 -                                   -                                 
    SP2:                                                                                      -                                   -                                 
    SP3:                                                                                      -                                   -                                 
    SP4:                                                                                                              -           -                                 
    SP5:                    -           -     -                                                                                                                     

    ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                          -                                 
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for USP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP11 expression in normal human tissues (normalized intensities)      USP11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTTAATT
    USP11 Expression
    About this image


    USP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    USP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171501
        Pathway & Disease-focused RT2 Profiler PCR Array including USP11: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP11
    QuantiTect SYBR Green Assays in human, mouse, rat USP11
    QuantiFast Probe-based Assays in human, mouse, rat USP11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp111 , 5 ubiquitin specific peptidase 111, 5 83.86(n)1
    82.55(a)1
      X (16.20 cM)5
    2367331  NM_145628.41  NP_663603.31 
     207039065 
    lizard
    (Anolis carolinensis)
    Reptilia USP116
    ubiquitin specific peptidase 11
    64(a)
    1 ↔ 1
    2(68552689-68586685)
    zebrafish
    (Danio rerio)
    Actinopterygii usp111 ubiquitin specific peptidase 11 63.3(n)
    62.25(a)
      568334  XM_002663073.3  XP_002663119.3 
    worm
    (Caenorhabditis elegans)
    Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 54(a)
    (best of 2)
      IV(6757531-6761964)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP126
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    20(a)
    1 → many
    X(63805-67569) YJL197W
    soybean
    (Glycine max)
    eudicotyledons Gma.155652 Transcribed sequence with moderate similarity to protein pirT04192 (A.thaliana) T04192 hypothetical protein T4F9.30 - Arabidopsis thaliana less 71.01(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.459462 Oryza sativa (japonica cultivar-group) OJ1714_H10.17 (OJ1714_H10.17), mRNA less 69.62(n)    NM_186392.1 


    ENSEMBL Gene Tree for USP11 (if available)
    TreeFam Gene Tree for USP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP11 gene
    USP452  USP192  USP62  USP152  USP162  USP312  USP432  USP322  
    USP42  
    12 SIMAP similar genes for USP11 using alignment to 6 protein entries:     UBP11_HUMAN (see all proteins):
    USP8    USP4    USP2    USP15    USP32    USP33
    USP22    USP31    USP19    DKFZp761E10121    USP50    USP27X

    USP11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP11 (see all 334)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379841121,2
    C--47009602(+) CACAAC/TCACGC 1 -- us2k10--------
    rs1920690181,2
    --47009606(+) ACCACA/GCCCAC 1 -- us2k10--------
    rs1410170901,2
    --47009636(+) AAAGAC/TGGGGT 1 -- us2k10--------
    rs1831588811,2
    --47009750(+) GCCTCC/TACCGT 1 -- us2k10--------
    rs2021081171,2
    --47010106(+) AAGGT-/GGGAAA 1 -- us2k10--------
    rs732019961,2
    C--47010109(+) GGTGGA/GAAAAA 1 -- us2k10--------
    rs1921471371,2
    --47010737(+) AGTCCA/GAGGGT 1 -- us2k10--------
    rs1431591491,2
    --47010923(+) ACCCCA/GAGAGG 1 -- us2k10--------
    rs59530161,2
    C,F,A,H--47011279(+) AACAAC/TAGCCC 1 -- us2k113Minor allele frequency- T:0.21NS EA NA WA CSA 1276
    rs1497577471,2
    C,F--47011670(+) TGGCTG/ATAGAA 2 /Y /C mis11Minor allele frequency- A:0.00NA 4306

    HapMap Linkage Disequilibrium report for USP11 (47092089 - 47107727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1746874CNV Deletion17803354
    esv2740138CNV Deletion23290073
    esv988260CNV Deletion20482838
    esv2740137CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): USP11

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP11
    DNA2.0 Custom Variant and Variant Library Synthesis for USP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300050    OMIM disorders: --

    8 diseases for USP11:    About MalaCards
    congenital stationary night blindness    night blindness    blindness    retinal disease
    papilloma    retinitis    breast cancer    endotheliitis


    USP11 for disorders           About GeneDecksing


    Export disorders for USP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP11 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with USP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PubMed id 12084015)1, 2, 9 Ideguchi H.... Ishigatsubo Y. (Biochem. J. 2002)
    2. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. (PubMed id 19874889)1, 2, 9 Sun W.... Yang J. (Cell. Signal. 2010)
    3. USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity. (PubMed id 18408009)1, 2 Lin C.H.... Yu W.C. (J. Biol. Chem. 2008)
    4. The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). (PubMed id 17897950)1, 2 Yamaguchi T.... Yoshida K. (J. Biol. Chem. 2007)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. (PubMed id 15314155)1, 2 Schoenfeld A.R.... Aaronson S.A. (Mol. Cell. Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders. (PubMed id 8845848)1, 2 Swanson D.A.... Valle D. (Hum. Mol. Genet. 1996)
    10. UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2. (PubMed id 9801870)1, 9 Brandau O....Meindl A. (Eur. J. Hum. Genet. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8237 HGNC: 12609 AceView: USP11 Ensembl:ENSG00000102226 euGenes: HUgn8237
    ECgene: USP11 H-InvDB: USP11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP11 gene:
    Search GeneIP for patents involving USP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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