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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP11 Gene

protein-coding   GIFtS: 62
GCID: GC0XP047093

Ubiquitin Specific Peptidase 11

(Previous name: ubiquitin specific protease 11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 111 2     Ubiquitin Carboxyl-Terminal Hydrolase 112
UHX12 3 5     Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked2
Deubiquitinating Enzyme 112 3     Ubiquitin Thiolesterase 112
Ubiquitin Thioesterase 112 3     Ubiquitin-Specific Processing Protease 112
Ubiquitin-Specific-Processing Protease 112 3     EC 3.4.19.123
Ubiquitin Specific Protease 111     EC 3.1.2.158

External Ids:    HGNC: 126091   Entrez Gene: 82372   Ensembl: ENSG000001022267   OMIM: 3000505   UniProtKB: P517843   

Export aliases for USP11 gene to outside databases

Previous GC identifers: GC0XP045895 GC0XP045352 GC0XP045918 GC0XP046138 GC0XP046848 GC0XP046977 GC0XP044802


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP11 Gene:
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional
activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and
deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that
specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating
enzyme which lies in a gene cluster on chromosome Xp11.23 (provided by RefSeq, Jul 2008)

GeneCards Summary for USP11 Gene: 
USP11 (ubiquitin specific peptidase 11) is a protein-coding gene. Diseases associated with USP11 include congenital stationary night blindness, and night blindness, and among its related super-pathways are Chaperonin-mediated protein folding and Post-translational protein modification. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784
Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits
the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to
NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks

Gene Wiki entry for USP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP11 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   E2F-2   GATA-2   E2F   E2F-1   POU2F1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP11 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

USP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047093:  view genomic region     (about GC identifiers)

Start:
47,092,089 bp from pter      End:
47,107,727 bp from pter
Size:
15,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 11  
Size: 963 amino acids; 109817 Da
Subunit: Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA. Interacts with papilloma virus
protein 16E7
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin
Caution: It is uncertain whether Met-1 or Met-44 is the initiator
Sequence caution: Sequence=AAC50450.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC50450.1; Type=Frameshift; Positions=65, 117, 134, 146; Sequence=BAC20463.1; Type=Erroneous
initiation; Sequence=CAD20056.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RTX1 Q8IUG6 Q9BWE1

Explore the universe of human proteins at neXtProt for USP11: NX_P51784

Explore proteomics data for USP11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51784

  • 4/11 DME Specific Peptides for USP11 (P51784) (see all 11)
     FLLDGLH  CIELFTT  PLLVSVP  NLGNTCF 

    USP11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP11 Protein Expression
    REFSEQ proteins: NP_004642.2  
    ENSEMBL proteins: 
     ENSP00000366311   ENSP00000366282   ENSP00000366279   ENSP00000218348  
    Reactome Protein details: P51784
    Human Recombinant Protein Products for USP11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for USP11
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    Novus Biologicals USP11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15314155
    GO:0005737cytoplasm IDA--

    USP11 for ontologies           About GeneDecksing



    USP11 Antibody Products: 
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    Novus Biologicals USP11 Antibodies
    Abcam antibodies for USP11
    Cloud-Clone Corp. Antibodies for USP11 
    ThermoFisher Antibodies for USP11
    LSBio Antibodies in human, mouse, rat for USP11 

    Assay Products for USP11: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for USP11 
    Cloud-Clone Corp. CLIAs for USP11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR006615 Pept_C19_DUSP
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry P51784

    ProtoNet protein and cluster: P51784

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP
    IPB010460 Ubiquitin carboxyl-terminal hydrolase


    UniProtKB/Swiss-Prot: UBP11_HUMAN, P51784
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 DUSP domain


    USP11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP11_HUMAN, P51784
    Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits
    the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to
    NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP11:
    ubiquitin specific protease 11,highly expressed in the retina,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0004843ubiquitin-specific protease activity IDA15314155
    GO:0005515protein binding IPI15314155
    GO:0008234cysteine-type peptidase activity ----
         
    USP11 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for USP11:
     Decreased Salmonella enterica   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  G0/1 arrest 
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP11 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP11
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate USP11:
    hsa-miR-124* hsa-miR-3664-5p
    SwitchGear 3'UTR luciferase reporter plasmidUSP11 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: USP11 (NM_004651)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP11
    Sirion Biotech Customized lentivirus for stable overexpression of USP11 
                         Customized lentivirus expression plasmids for stable overexpression of USP11 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP11
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP11
        TNF-alpha/NF-kB Signaling Pathway

    4        Reactome Pathways for USP11
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Metabolism of proteins
    Protein folding



    USP11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/152 Interacting proteins for USP11 (P517841, 2, 3 ENSP000002183484) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 STRING: ENSP00000396439
    ENSG00000206287Q065872, 3MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000226788Q065872, 3MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000228520Q065872, 3MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    ENSG00000231115Q065872, 3MINT-7999769 MINT-7999820 MINT-8010390 MINT-8001946 MINT-8010325 MINT-8012708 MINT-8010231 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA15314155

    USP11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP11 (UBP11)

    1 HMDB Compound for USP11    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP11 / UBP11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP11 gene: 
    NM_004651.3  

    Unigene Cluster for USP11:

    Ubiquitin specific peptidase 11
    Hs.171501  [show with all ESTs]
    Unigene Representative Sequence: BC140849
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377107(uc004dhp.3 uc004dhq.3) ENST00000478596 ENST00000469080
    ENST00000377080 ENST00000377078 ENST00000489111 ENST00000489030 ENST00000480104
    ENST00000488848 ENST00000497179 ENST00000467378 ENST00000218348
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP11
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate USP11:
    hsa-miR-124* hsa-miR-3664-5p
    SwitchGear 3'UTR luciferase reporter plasmidUSP11 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP11
    Clone
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    OriGene clones in human, mouse for USP11 (see all 5)
    OriGene ORF clones in mouse, rat for USP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP11 (NM_004651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP11
    Sirion Biotech Customized lentivirus for stable overexpression of USP11 
                         Customized lentivirus expression plasmids for stable overexpression of USP11 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP11

    Additional mRNA sequence: 

    AB073597.1 AK098394.1 AK294635.1 BC000350.2 BC063668.1 BC140849.1 U44839.1 

    24/50 DOTS entries (see all 50):

    DT.100886395  DT.40240774  DT.121286822  DT.121286751  DT.100842634  DT.91774475  DT.100886387  DT.100886384 
    DT.91774493  DT.100886386  DT.95175404  DT.100886385  DT.99965606  DT.97855317  DT.100886391  DT.97855318 
    DT.100720012  DT.121286744  DT.95175436  DT.100886392  DT.100038861  DT.121286761  DT.121286759  DT.121286720 

    24/815 AceView cDNA sequences (see all 815):

    BP344624 CD619087 BQ055906 BQ935545 AA378795 BM661904 BU850211 AA442350 
    BP347967 AA446913 BQ955687 CA396064 AL079755 AA350012 AU143251 BP357418 
    CD619082 AI638367 BU785244 BF763058 BE261365 AK055588 BM548697 CF243147 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for USP11 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ·
    SP1:                    -                                                                 -                                   -                                 
    SP2:                                                                                      -                                   -                                 
    SP3:                                                                                      -                                   -                                 
    SP4:                                                                                                              -           -                                 
    SP5:                    -           -     -                                                                                                                     

    ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                          -                                 
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for USP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP11 expression in normal human tissues (normalized intensities)      USP11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTTAATT
    USP11 Expression
    About this image


    USP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   
     
     Endothelium (Cardiovascular System)
             colon ; endothelial cells   
     
     Adrenal Gland (Endocrine System)
             adrenal gland ; glandular cells   

    See USP11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP11

    SOURCE GeneReport for Unigene cluster: Hs.171501
        SABiosciences Expression via Pathway-Focused PCR Array including USP11: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP11 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp111 , 5 ubiquitin specific peptidase 111, 5 84.09(n)1
    83.17(a)1
      X (16.20 cM)5
    2367331  NM_145628.41  NP_663603.31 
     207039065 
    lizard
    (Anolis carolinensis)
    Reptilia USP116
    --
    (see all 11)
    Uncharacterized protein
    (see all 11)
    64(a)
    35(a)
    (see all 11)
    1 ↔ 1
    possible ortholog
    (see all 11)
    2(68552689-68586685)
    3(171068802-171069311)
    zebrafish
    (Danio rerio)
    Actinopterygii usp111 ubiquitin specific peptidase 11 58.58(n)
    54.71(a)
      568334  XM_002663073.2  XP_002663119.2 
    worm
    (Caenorhabditis elegans)
    Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 54(a)
    (best of 2)
      IV(6757531-6761964)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP126
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    20(a)
    1 → many
    X(63805-67569)
    soybean
    (Glycine max)
    eudicotyledons Gma.155652 Transcribed sequence with moderate similarity to protein more 71.01(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.459462 Oryza sativa (japonica cultivar-group) OJ1714_H10.17 more 69.62(n)    NM_186392.1 


    ENSEMBL Gene Tree for USP11 (if available)
    TreeFam Gene Tree for USP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP11 gene
    USP452  USP192  USP62  USP152  USP162  USP312  USP432  USP322  
    USP42  
    12 SIMAP similar genes for USP11 using alignment to 6 protein entries:     UBP11_HUMAN (see all proteins):
    USP8    USP4    USP15    USP2    USP32    USP33
    USP22    USP31    USP19    DKFZp761E10121    USP50    USP27X

    USP11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in USP11 are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379841121,2
    C--47009602(+) CACAAC/TCACGC 1 -- us2k10--------
    rs1920690181,2
    --47009606(+) ACCACA/GCCCAC 1 -- us2k10--------
    rs1410170901,2
    --47009636(+) AAAGAC/TGGGGT 1 -- us2k10--------
    rs1831588811,2
    --47009750(+) GCCTCC/TACCGT 1 -- us2k10--------
    rs2021081171,2
    --47010106(+) AAGGT-/GGGAAA 1 -- us2k10--------
    rs732019961,2
    C--47010109(+) GGTGGA/GAAAAA 1 -- us2k10--------
    rs1921471371,2
    --47010737(+) AGTCCA/GAGGGT 1 -- us2k10--------
    rs1431591491,2
    --47010923(+) ACCCCA/GAGAGG 1 -- us2k10--------
    rs59530161,2
    C,F,A,H--47011279(+) AACAAC/TAGCCC 1 -- us2k113Minor allele frequency- T:0.21NS EA NA WA CSA 1276
    rs1497577471,2
    C,F--47011670(+) TGGCTG/ATAGAA 2 /Y /C mis11Minor allele frequency- A:0.00NA 4306

    HapMap Linkage Disequilibrium report for USP11 (47092089 - 47107727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1746874CNV Deletion17803354
    esv2740138CNV Deletion23290073
    esv988260CNV Deletion20482838
    esv2740137CNV Deletion23290073


    Locus Specific Mutation Databases (LSDB): USP11
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP11
    DNA2.0 Custom Variant and Variant Library Synthesis for USP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300050    OMIM disorders: --

    6 diseases for USP11:    About MalaCards
    congenital stationary night blindness    night blindness    blindness    retinal disease
    papilloma    retinitis


    USP11 for disorders           About GeneDecksing


    Export disorders for USP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP11 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with USP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PubMed id 12084015)1, 2, 9 Ideguchi H.... Ishigatsubo Y. (2002)
    2. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. (PubMed id 19874889)1, 2, 9 Sun W....Yang J. (2010)
    3. USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity. (PubMed id 18408009)1, 2 Lin C.H....Yu W.C. (2008)
    4. The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). (PubMed id 17897950)1, 2 Yamaguchi T....Yoshida K. (2007)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. (PubMed id 15314155)1, 2 Schoenfeld A.R....Aaronson S.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    9. A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders. (PubMed id 8845848)1, 2 Swanson D.A.... Valle D. (1996)
    10. UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2. (PubMed id 9801870)1, 9 Brandau O....Meindl A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8237 HGNC: 12609 AceView: USP11 Ensembl:ENSG00000102226 euGenes: HUgn8237
    ECgene: USP11 H-InvDB: USP11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP11 gene:
    Search GeneIP for patents involving USP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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