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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP10 Gene

protein-coding   GIFtS: 62
GCID: GC16P084734

Ubiquitin Specific Peptidase 10

(Previous name: ubiquitin specific protease 10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 101 2     KIAA01903 5
Ubiquitin Specific Protease 101 2     UBPO2
Deubiquitinating Enzyme 102 3     Ubiquitin Carboxyl-Terminal Hydrolase 102
Ubiquitin Thioesterase 102 3     Ubiquitin Thiolesterase 102
Ubiquitin-Specific-Processing Protease 102 3     EC 3.4.19.123

External Ids:    HGNC: 126081   Entrez Gene: 91002   Ensembl: ENSG000001031947   OMIM: 6098185   UniProtKB: Q146943   

Export aliases for USP10 gene to outside databases

Previous GC identifers: GC16M075919 GC16P085700 GC16P084472 GC16P084513 GC16P083291 GC16P070487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP10 Gene:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and
degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The
enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the
nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited
by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.
Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene.
(provided by RefSeq, Jan 2013)

GeneCards Summary for USP10 Gene: 
USP10 (ubiquitin specific peptidase 10) is a protein-coding gene. Diseases associated with USP10 include cystic fibrosis, and renal cell carcinoma, and among its related super-pathways are Cell Cycle / Checkpoint Control. GO annotations related to this gene include p53 binding and ubiquitin thiolesterase activity.

UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and
CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates
p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage,
translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage
response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination
of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn,
PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by
which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not
deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling

Gene Wiki entry for USP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP10 gene promoter:
         Egr-2   Sox5   POU2F1   HTF   POU2F1a   MyoD   c-Myb   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP10 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q

USP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084734:  view genomic region     (about GC identifiers)

Start:
84,733,555 bp from pter      End:
84,813,528 bp from pter
Size:
79,974 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 10  
Size: 798 amino acids; 87134 Da
Subunit: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR
Subcellular location: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage,
translocates to the nucleus following phosphorylation by ATM
Sequence caution: Sequence=CAD97644.1; Type=Erroneous initiation;
Secondary accessions: B2RDJ8 B4DS84 Q9BWG7 Q9NSL7
Alternative splicing: 3 isoforms:  Q14694-1   Q14694-2   Q14694-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP10: NX_Q14694

Explore proteomics data for USP10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus
  • UniProtKB: Ubiquitinated. Deubiquitinated by USP13
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14694

  • USP10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001259004.1  NP_005144.2  

    ENSEMBL proteins: 
     ENSP00000219473   ENSP00000458089   ENSP00000445589   ENSP00000455712   ENSP00000454902  
     ENSP00000457411   ENSP00000454943   ENSP00000462762   ENSP00000454751   ENSP00000454987  
     ENSP00000455865  

    Human Recombinant Protein Products for USP10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for USP10
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    Novus Biologicals USP10 Proteins
    Novus Biologicals USP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP10 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IDA19398555
    GO:0045111intermediate filament cytoskeleton IDA--

    USP10 for ontologies           About GeneDecksing



    USP10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Custom Superior Antibodies Services for USP10
    Novus Biologicals USP10 Antibodies
    Abcam antibodies for USP10
    Cloud-Clone Corp. Antibodies for USP10 
    ThermoFisher Antibodies for USP10
    LSBio Antibodies in human, mouse, rat for USP10 

    Assay Products for USP10: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP10 
    Cloud-Clone Corp. CLIAs for USP10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR009818 Ataxin-2_C
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q14694

    ProtoNet protein and cluster: Q14694

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB009818 Ataxin-2


    UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
    Similarity: Belongs to the peptidase C19 family. USP10 subfamily


    USP10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP10_HUMAN, Q14694
    Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and
    CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates
    p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage,
    translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage
    response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination
    of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn,
    PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by
    which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not
    deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative
    of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes
    Induction: Following DNA damage. Down-regulated in renal cell carcinomas

         Genatlas biochemistry entry for USP10:
    ubiquitin specific protease 10,deubiquitin enzyme family

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IMP19398555
    GO:0004843ubiquitin-specific protease activity IMP19398555
    GO:0005515protein binding IPI19398555
         
    USP10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP10:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Usp10):
     cellular 

    USP10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usp10tm1Fuj for USP10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP10
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP10 (see all 9):
    hsa-miR-549 hsa-miR-34c-3p hsa-miR-577 hsa-miR-1273 hsa-miR-3914 hsa-miR-548g hsa-miR-138 hsa-miR-548q
    SwitchGear 3'UTR luciferase reporter plasmidUSP10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP10

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10
    Sirion Biotech Customized lentivirus for stable overexpression of USP10 
                         Customized lentivirus expression plasmids for stable overexpression of USP10 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    2Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    3Protein Stability
    Protein Stability
    4Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP10
        Ubiquitin-Proteasome Dependent Proteolysis

    3 Cell Signaling Technology (CST) Pathways for USP10
        Apoptosis and Autophagy
    DNA Damage
    Protein Stability



    USP10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/587 Interacting proteins for USP10 (Q146942, 3 ENSP000002194734) via UniProtKB, MINT, STRING, and/or I2D (see all 587)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ULK1O753853, ENSP000003245604I2D: score=3 STRING: ENSP00000324560
    EIF4G3O434323, ENSP000002642114I2D: score=2 STRING: ENSP00000264211
    SNX3O604933, ENSP000002300854I2D: score=2 STRING: ENSP00000230085
    EIF4G1Q046373, ENSP000003168794I2D: score=1 STRING: ENSP00000316879
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006914autophagy IEA--
    GO:0010506regulation of autophagy IDA--
    GO:0016579protein deubiquitination IMP19398555

    USP10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP10 (UBP10)

    1 HMDB Compound for USP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP10 / UBP10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP10 gene (2 alternative transcripts): 
    NM_001272075.1  NM_005153.2  

    Unigene Cluster for USP10:

    Ubiquitin specific peptidase 10
    Hs.136778  [show with all ESTs]
    Unigene Representative Sequence: NM_001272075
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000219473 ENST00000562743 ENST00000569511 ENST00000562092 ENST00000563892
    ENST00000540269(uc002fii.3 uc010voe.2 uc010vof.2 uc002fij.3)
    ENST00000564566 ENST00000562283 ENST00000563048 ENST00000570191 ENST00000563386
    ENST00000569038 ENST00000570053 ENST00000566512 ENST00000563023 ENST00000563433
    ENST00000566378 ENST00000569925
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP10 (see all 9):
    hsa-miR-549 hsa-miR-34c-3p hsa-miR-577 hsa-miR-1273 hsa-miR-3914 hsa-miR-548g hsa-miR-138 hsa-miR-548q
    SwitchGear 3'UTR luciferase reporter plasmidUSP10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10
    Sirion Biotech Customized lentivirus for stable overexpression of USP10 
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP10

    Additional mRNA sequence: 

    AK293304.1 AK299618.1 AK315570.1 AL162049.1 BC000263.1 BX537402.1 D80012.1 NR_073577.1 
    NR_073578.1 

    24/36 DOTS entries (see all 36):

    DT.451863  DT.99955728  DT.97847924  DT.95210975  DT.120685319  DT.95333449  DT.95338568  DT.100820968 
    DT.100809229  DT.70104284  DT.100820969  DT.91749502  DT.100738452  DT.120685326  DT.100820972  DT.120685374 
    DT.91762493  DT.95338558  DT.100031449  DT.100659355  DT.100673362  DT.100820967  DT.100820973  DT.100820974 

    24/354 AceView cDNA sequences (see all 354):

    AA777582 AI391637 BF223845 BP345574 BU149291 BE891142 Z42253 AU118378 
    N22308 AW513983 AA233270 AI480229 BM455960 BE764316 CB125961 BM068842 
    BQ186516 CK301022 BE543108 CB123891 AA243869 BM713466 D80012 CR619417 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for USP10 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                          -     -     -     -     -     -                 -                                                                                 
    SP2:                          -     -     -     -     -     -                 -           -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                          -     -     -     -           -                 -                                                                                 
    SP4:                          -     -     -     -           -     -           -                                                                                 
    SP5:                          -     -     -     -     -     -                                                                                                   

    ExUns: 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d
    SP1:        -                                                                     
    SP2:  -     -     -     -     -     -     -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for USP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP10 expression in normal human tissues (normalized intensities)      USP10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGTGTA
    USP10 Expression
    About this image


    USP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             leukocytes   

    See USP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP10

    SOURCE GeneReport for Unigene cluster: Hs.136778

    UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP10 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp101 , 5 ubiquitin specific peptidase 101, 5 81.33(n)1
    84.07(a)1
      8 (68.61 cM)5
    222241  NM_009462.11  NP_033488.11 
     1199103605 
    chicken
    (Gallus gallus)
    Aves USP101 ubiquitin specific peptidase 10 78.63(n)
    79.82(a)
      415817  NM_001006130.1  NP_001006130.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    USP106
    ubiquitin specific peptidase 10
    93(a)
    68(a)
    possible ortholog
    1 ↔ 1
    GL343617.1(346722-360808)
    AAWZ02036254(966-19857)
    African clawed frog
    (Xenopus laevis)
    Amphibia usp10-prov2 ubiquitin specific protease 10 76.73(n)    BC044285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc19h082 wufc19h08 76.65(n)   324138  57052497 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG324796
    --
    14(a)
    1 ↔ 1
    3L(871899-895313)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP3(YER151C)4 Ubiquitin-specific protease that interacts with Bre5p more   --   5(472424-469686) 856895  NP_011078.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP241 ubiquitin carboxyl-terminal hydrolase 24 48.56(n)
    39.66(a)
      829213  NM_001203946.1  NP_001190875.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06613001 hypothetical protein 46.89(n)
    32.9(a)
      4344181  NM_001067071.1  NP_001060536.1 


    ENSEMBL Gene Tree for USP10 (if available)
    TreeFam Gene Tree for USP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP10 gene
    18/53 SIMAP similar genes for USP10 using alignment to 10 protein entries:     UBP10_HUMAN (see all proteins) (see all similar genes):
    DKFZp686E14181    DCTN5    AURA2    LYRM4    BTBD2    UTY
    FOPNL    CHID1    FAM210A    NF2    CATSPERG    ERBB2
    SEPT2    UBIAD1    ZNF212    ZNF564    ZNF585B    ZNF737

    USP10 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for USP10
    PGOHUM00000247696 PGOHUM00000248031 PGOHUM00000246370


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2618 SNPs in USP10 are shown (see all 2618)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351554991,2
    C--70498241(+) TTTTT-/T/TT  
            
    GTCTG
    4 -- int12NA 4
    rs133135541,2
    C--84731562(+) tgatcC/Gaccca 4 -- us2k1 tfbs30--------
    rs1837394751,2
    --84731614(+) CGCACC/TGAGCC 4 -- us2k10--------
    rs1494642861,2
    --84731615(+) GCACCA/GAGCCA 4 -- us2k10--------
    rs1438824201,2
    C--84731633(+) AACCAG/TAAATC 4 -- us2k10--------
    rs1122554551,2
    F--84731658(+) ACGTCC/TCCCAG 4 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs99298131,2
    C,F,A--84731729(+) TGTATT/GGTTTT 4 -- us2k18Minor allele frequency- G:0.20NA WA CSA EA 368
    rs1807364101,2
    --84731910(+) CATTAA/TGGCCT 4 -- us2k10--------
    rs1854730061,2
    --84731919(+) CTTCAC/GTCCTC 4 -- us2k10--------
    rs1910055321,2
    --84732114(+) ACACAC/TTGTAT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP10 (84733555 - 84813528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USP10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714837CNV Deletion23290073
    esv2714836CNV Deletion23290073
    nsv510429CNV Loss20534489
    esv22326CNV Loss19812545
    esv28029CNV Loss19812545
    nsv907081CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609818    OMIM disorders: --

    6 diseases for USP10:    About MalaCards
    cystic fibrosis    renal cell carcinoma    glioblastoma    prostate cancer
    breast cancer    prostatitis


    USP10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP10
    Human Genome Epidemiology (HuGE) Navigator: USP10 (1 document)

    Export disorders for USP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP10 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with USP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The deubiquitinating enzyme USP10 regulates the post- endocytic sorting of cystic fibrosis transmembrane conductance regulator in air way epithelial cells. (PubMed id 19398555)1, 2, 9 Bomberger J.M....Stanton B.A. (2009)
    2. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J....Yuan J. (2011)
    3. USP10 regulates p53 localization and stability by deubiquitinating p53. (PubMed id 20096447)1, 2 Yuan J.... Lou Z. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. (PubMed id 18632802)1, 2 Boulkroun S....Staub O. (2008)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9100 HGNC: 12608 AceView: USP10 Ensembl:ENSG00000103194 euGenes: HUgn9100
    ECgene: USP10 H-InvDB: USP10

    (According to HUGE)
    About This Section
    HUGE: KIAA0190

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP10 gene:
    Search GeneIP for patents involving USP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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