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Aliases for USP10 Gene

Aliases for USP10 Gene

  • Ubiquitin Specific Peptidase 10 2 3 5
  • Ubiquitin-Specific-Processing Protease 10 3 4
  • Ubiquitin Specific Protease 10 2 3
  • Deubiquitinating Enzyme 10 3 4
  • Ubiquitin Thioesterase 10 3 4
  • Ubiquitin Thiolesterase 10 3
  • EC 3.4.19.12 4
  • KIAA0190 4
  • UBPO 3

External Ids for USP10 Gene

Previous GeneCards Identifiers for USP10 Gene

  • GC16M075919
  • GC16P085700
  • GC16P084472
  • GC16P084513
  • GC16P083291
  • GC16P070487

Summaries for USP10 Gene

Entrez Gene Summary for USP10 Gene

  • Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for USP10 Gene

USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include poly(A) RNA binding and ion channel binding.

UniProtKB/Swiss-Prot for USP10 Gene

  • Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.

Gene Wiki entry for USP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP10 Gene

Genomics for USP10 Gene

Regulatory Elements for USP10 Gene

Enhancers for USP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP10 on UCSC Golden Path with GeneCards custom track

Promoters for USP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP10 Gene

Chromosome:
16
Start:
84,699,949 bp from pter
End:
84,779,922 bp from pter
Size:
79,974 bases
Orientation:
Plus strand

Genomic View for USP10 Gene

Genes around USP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP10 Gene

Proteins for USP10 Gene

  • Protein details for USP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14694-UBP10_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10
    Protein Accession:
    Q14694
    Secondary Accessions:
    • B2RDJ8
    • B4DS84
    • Q9BWG7
    • Q9NSL7

    Protein attributes for USP10 Gene

    Size:
    798 amino acids
    Molecular mass:
    87134 Da
    Quaternary structure:
    • Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR.
    SequenceCaution:
    • Sequence=CAD97644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP10 Gene

Proteomics data for USP10 Gene at MOPED

Post-translational modifications for USP10 Gene

  • Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
  • Ubiquitinated. Deubiquitinated by USP13.
  • Ubiquitination at Lys 408
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP10 (USP10)

No data available for DME Specific Peptides for USP10 Gene

Domains & Families for USP10 Gene

Gene Families for USP10 Gene

Suggested Antigen Peptide Sequences for USP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q14694

UniProtKB/Swiss-Prot:

UBP10_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family. USP10 subfamily.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP10 subfamily.
genes like me logo Genes that share domains with USP10: view

Function for USP10 Gene

Molecular function for USP10 Gene

GENATLAS Biochemistry:
ubiquitin specific protease 10,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes.
UniProtKB/Swiss-Prot Function:
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
UniProtKB/Swiss-Prot Induction:
Following DNA damage. Down-regulated in renal cell carcinomas.

Enzyme Numbers (IUBMB) for USP10 Gene

Gene Ontology (GO) - Molecular Function for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with USP10: view
genes like me logo Genes that share phenotypes with USP10: view

Animal Models for USP10 Gene

MGI Knock Outs for USP10:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP10 Gene

Localization for USP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP10 Gene

Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269 PubMed:20096447}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP10 Gene COMPARTMENTS Subcellular localization image for USP10 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5

Gene Ontology (GO) - Cellular Components for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005769 early endosome IDA 19398555
genes like me logo Genes that share ontologies with USP10: view

Pathways & Interactions for USP10 Gene

genes like me logo Genes that share pathways with USP10: view

Pathways by source for USP10 Gene

Gene Ontology (GO) - Biological Process for USP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010506 regulation of autophagy IDA 21962518
genes like me logo Genes that share ontologies with USP10: view

No data available for SIGNOR curated interactions for USP10 Gene

Drugs & Compounds for USP10 Gene

(1) Additional Compounds for USP10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP10: view

Transcripts for USP10 Gene

Unigene Clusters for USP10 Gene

Ubiquitin specific peptidase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - - - - -
SP11: -
SP12: -
SP13:
SP14: -

ExUns: 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d
SP1: -
SP2: - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:

Relevant External Links for USP10 Gene

GeneLoc Exon Structure for
USP10
ECgene alternative splicing isoforms for
USP10

Expression for USP10 Gene

mRNA expression in normal human tissues for USP10 Gene

mRNA differential expression in normal tissues according to GTEx for USP10 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for USP10 Gene

This gene is overexpressed in Pancreas (16.1), Breast (9.7), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP10 Gene



SOURCE GeneReport for Unigene cluster for USP10 Gene Hs.136778

mRNA Expression by UniProt/SwissProt for USP10 Gene

Q14694-UBP10_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with USP10: view

Protein tissue co-expression partners for USP10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP10 Gene

Orthologs for USP10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP10 35
  • 85.55 (n)
  • 87.34 (a)
USP10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP10 35
  • 87.99 (n)
  • 89.29 (a)
USP10 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp10 35
  • 81.33 (n)
  • 84.07 (a)
Usp10 16
Usp10 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP10 35
  • 99.52 (n)
  • 99.35 (a)
USP10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp10 35
  • 82.37 (n)
  • 84.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia USP10 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP10 35
  • 78.42 (n)
  • 79.05 (a)
USP10 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.51 35
usp10 35
  • 72.06 (n)
  • 72.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia usp10-prov 35
zebrafish
(Danio rerio)
Actinopterygii usp10 35
  • 63.42 (n)
  • 65.37 (a)
wufc19h08 35
usp10 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32479 36
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP3 36
  • 16 (a)
OneToOne
UBP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP24 35
  • 49.62 (n)
  • 40.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0661300 35
  • 48.35 (n)
  • 33.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3287 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6419 36
  • 45 (a)
OneToOne
Species with no ortholog for USP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP10 Gene

ENSEMBL:
Gene Tree for USP10 (if available)
TreeFam:
Gene Tree for USP10 (if available)

Paralogs for USP10 Gene

Pseudogenes.org Pseudogenes for USP10 Gene

genes like me logo Genes that share paralogs with USP10: view

No data available for Paralogs for USP10 Gene

Variants for USP10 Gene

Sequence variations from dbSNP and Humsavar for USP10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1862792 - 84,745,079(+) GTGAC(A/G)TGCCC intron-variant, nc-transcript-variant, reference, missense
rs2326391 - 84,745,088(+) CCCCG(C/T)CAGTT intron-variant, nc-transcript-variant, reference, missense
rs1812061 - 84,745,091(-) CGTAA(C/G)TGACG intron-variant, nc-transcript-variant, reference, missense
rs3893782 -- 84,773,231(+) CAAGA(A/C)GACTT intron-variant
rs173419 -- 84,773,925(+) ATATC(A/C)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP10 Gene

Variant ID Type Subtype PubMed ID
nsv907081 CNV Gain 21882294
esv2714836 CNV Deletion 23290073
esv2714837 CNV Deletion 23290073
esv28029 CNV Loss 19812545
nsv510429 CNV Loss 20534489
esv22326 CNV Loss 19812545

Variation tolerance for USP10 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP10 Gene

Human Gene Mutation Database (HGMD)
USP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP10 Gene

Disorders for USP10 Gene

Relevant External Links for USP10

Genetic Association Database (GAD)
USP10
Human Genome Epidemiology (HuGE) Navigator
USP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP10

No disorders were found for USP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP10 Gene

Publications for USP10 Gene

  1. The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. (PMID: 19398555) Bomberger J.M. … Stanton B.A. (J. Biol. Chem. 2009) 3 4 23 67
  2. Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. (PMID: 17004105) Deng S. … Yang H. (Breast Cancer Res. Treat. 2007) 3 23
  3. Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). (PMID: 16773218) Grunda J.M. … Johnson M.R. (J. Neurooncol. 2006) 3 23
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  5. Deubiquitination and Activation of AMPK by USP10. (PMID: 26876938) Deng M. … Lou Z. (Mol. Cell 2016) 3

Products for USP10 Gene

Sources for USP10 Gene

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