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USP10 Gene

protein-coding   GIFtS: 63
GCID: GC16P084734

Ubiquitin Specific Peptidase 10

(Previous name: ubiquitin specific protease 10)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 101 2     KIAA01903 5
Ubiquitin Specific Protease 101 2     UBPO2
Deubiquitinating Enzyme 102 3     Ubiquitin Carboxyl-Terminal Hydrolase 102
Ubiquitin Thioesterase 102 3     Ubiquitin Thiolesterase 102
Ubiquitin-Specific-Processing Protease 102 3     EC 3.4.19.123

External Ids:    HGNC: 126081   Entrez Gene: 91002   Ensembl: ENSG000001031947   OMIM: 6098185   UniProtKB: Q146943   

Export aliases for USP10 gene to outside databases

Previous GC identifers: GC16M075919 GC16P085700 GC16P084472 GC16P084513 GC16P083291 GC16P070487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP10 Gene:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and
degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The
enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the
nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited
by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.
Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene.
(provided by RefSeq, Jan 2013)

GeneCards Summary for USP10 Gene:
USP10 (ubiquitin specific peptidase 10) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitin thiolesterase activity.

UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and
CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates
p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage,
translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage
response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination
of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn,
PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by
which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not
deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling

Gene Wiki entry for USP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP10 gene promoter:
         Egr-2   Sox5   POU2F1   HTF   POU2F1a   MyoD   c-Myb   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP10 promoter sequence
   Search Chromatin IP Primers for USP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q

USP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084734:  view genomic region     (about GC identifiers)

Start:
84,733,555 bp from pter      End:
84,813,528 bp from pter
Size:
79,974 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 10  
Size: 798 amino acids; 87134 Da
Subunit: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR
Sequence caution: Sequence=CAD97644.1; Type=Erroneous initiation;
Secondary accessions: B2RDJ8 B4DS84 Q9BWG7 Q9NSL7
Alternative splicing: 3 isoforms:  Q14694-1   Q14694-2   Q14694-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP10: NX_Q14694

Explore proteomics data for USP10 at MOPED

Post-translational modifications: 

  • Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus1
  • Ubiquitinated. Deubiquitinated by USP131
  • Ubiquitination2 at Lys408
  • Modification sites at PhosphoSitePlus

  • See USP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001259004.1  NP_005144.2  

    ENSEMBL proteins: 
     ENSP00000219473   ENSP00000458089   ENSP00000445589   ENSP00000455712   ENSP00000454902  
     ENSP00000457411   ENSP00000454943   ENSP00000462762   ENSP00000454751   ENSP00000454987  
     ENSP00000455865  

    USP10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP10
    GenScript Custom Purified and Recombinant Proteins Services for USP10
    Novus Biologicals USP10 Proteins
    Novus Biologicals USP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP10

     
    Search eBioscience for Proteins for USP10 

     
    antibodies-online proteins for USP10 (4 products) 

     
    antibodies-online peptides for USP10

    USP10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of USP10
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for USP10 
    OriGene Antibodies for USP10
    OriGene Custom Antibody Services for USP10
    Novus Biologicals USP10 Antibodies
    Abcam antibodies for USP10
    Cloud-Clone Corp. Antibodies for USP10
    ThermoFisher Antibodies for USP10
    antibodies-online antibodies for USP10 (57 products) 

    USP10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP10
    Cloud-Clone Corp. CLIAs for USP10
    Search eBioscience for ELISAs for USP10 
    antibodies-online kits for USP10 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR028767 USP10
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q14694

    ProtoNet protein and cluster: Q14694

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB009818 Ataxin-2


    UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
    Similarity: Belongs to the peptidase C19 family. USP10 subfamily
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP10_HUMAN, Q14694
    Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and
    CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates
    p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage,
    translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage
    response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination
    of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn,
    PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by
    which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not
    deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative
    of MBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes
    Induction: Following DNA damage. Down-regulated in renal cell carcinomas

         Genatlas biochemistry entry for USP10:
    ubiquitin specific protease 10,deubiquitin enzyme family

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IMP19398555
    GO:0004843ubiquitin-specific protease activity IMP19398555
    GO:0005515protein binding IPI19398555
         
    Find genes that share ontologies with USP10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP10:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Usp10):
     cellular 

    Find genes that share phenotypes with USP10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Usp10tm1Fuj for USP10

       genOway: Develop your customized and physiologically relevant rodent model for USP10

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP10:
    hsa-mir-124-3p (MIRT022173), hsa-mir-181b-5p (MIRT047239), hsa-mir-455-3p (MIRT037849), hsa-mir-98-5p (MIRT027416), hsa-mir-375 (MIRT019670), hsa-mir-24-3p (MIRT030377), hsa-mir-20a-5p (MIRT050557), hsa-mir-122-5p (MIRT023247), hsa-mir-652-3p (MIRT039563), hsa-let-7b-5p (MIRT032235), hsa-mir-92a-3p (MIRT049080)

    Block miRNA regulation of human, mouse, rat USP10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP10 (see all 9):
    hsa-miR-549 hsa-miR-34c-3p hsa-miR-577 hsa-miR-1273 hsa-miR-3914 hsa-miR-548g hsa-miR-138 hsa-miR-548q
    SwitchGear 3'UTR luciferase reporter plasmidUSP10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP10
    Predesigned siRNA for gene silencing in human, mouse, rat USP10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP10

    Clone
    Products:
         
    OriGene clones in human, mouse for USP10 (see all 6)
    OriGene ORF clones in mouse, rat for USP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10
    Addgene plasmids for USP10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP10
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP10_HUMAN, Q14694: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage,
    translocates to the nucleus following phosphorylation by ATM
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IDA19398555
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with USP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    DNA Damage0.32
    2Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    3Protein Stability
    Protein Stability
    4Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with USP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP10
        Ubiquitin-Proteasome Dependent Proteolysis

    3 Cell Signaling Technology (CST) Pathways for USP10
        Apoptosis and Autophagy
    DNA Damage
    Protein Stability


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP10
    Interactions:

        GeneGlobe Interaction Network for USP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP10 (Q146942, 3 ENSP000002194734) via UniProtKB, MINT, STRING, and/or I2D (see all 836)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ULK1O753853, ENSP000003245604I2D: score=3 STRING: ENSP00000324560
    EIF4G3O434323, ENSP000002642114I2D: score=2 STRING: ENSP00000264211
    SNX3O604933, ENSP000002300854I2D: score=2 STRING: ENSP00000230085
    EIF4G1Q046373, ENSP000003168794I2D: score=1 STRING: ENSP00000316879
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006914autophagy IEA--
    GO:0010506regulation of autophagy IDA--
    GO:0016579protein deubiquitination IMP19398555

    Find genes that share ontologies with USP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP10 (UBP10)

    1 HMDB Compound for USP10    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP10 gene (2 alternative transcripts): 
    NM_001272075.1  NM_005153.2  

    Unigene Cluster for USP10:

    Ubiquitin specific peptidase 10
    Hs.136778  [show with all ESTs]
    Unigene Representative Sequence: NM_001272075
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000219473 ENST00000562743 ENST00000569511 ENST00000562092 ENST00000563892
    ENST00000540269(uc002fii.3 uc010voe.2 uc010vof.2 uc002fij.3)
    ENST00000564566 ENST00000562283 ENST00000563048 ENST00000570191 ENST00000563386
    ENST00000569038 ENST00000570053 ENST00000566512 ENST00000563023 ENST00000563433
    ENST00000566378 ENST00000569925
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP10 (see all 9):
    hsa-miR-549 hsa-miR-34c-3p hsa-miR-577 hsa-miR-1273 hsa-miR-3914 hsa-miR-548g hsa-miR-138 hsa-miR-548q
    SwitchGear 3'UTR luciferase reporter plasmidUSP10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP10
    Predesigned siRNA for gene silencing in human, mouse, rat USP10
    Clone
    Products:
         
    OriGene clones in human, mouse for USP10 (see all 6)
    OriGene ORF clones in mouse, rat for USP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10
    Addgene plasmids for USP10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP10
    OriGene qSTAR qPCR primer pairs in human, mouse for USP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP10
      QuantiTect SYBR Green Assays in human, mouse, rat USP10
      QuantiFast Probe-based Assays in human, mouse, rat USP10

    Additional mRNA sequence: 

    AK293304.1 AK299618.1 AK315570.1 AL162049.1 BC000263.1 BX537402.1 D80012.1 NR_073577.1 
    NR_073578.1 

    Selected DOTS entries (see all 36):

    DT.451863  DT.99955728  DT.97847924  DT.95210975  DT.120685319  DT.95333449  DT.95338568  DT.100820968 
    DT.100809229  DT.70104284  DT.100820969  DT.91749502  DT.100738452  DT.120685326  DT.100820972  DT.120685374 
    DT.91762493  DT.95338558  DT.100031449  DT.100659355  DT.100673362  DT.100820967  DT.100820973  DT.100820974 

    Selected AceView cDNA sequences (see all 354):

    AL701525 BE764319 AA765376 AA293619 BQ049762 BC064516 AW055061 AL162049 
    BM757763 BE326520 CB127944 CR617738 BM541328 AW204076 BM750082 AI033341 
    Z38489 AA332232 AI458528 AL079918 BX537402 BP336679 BM678687 CA396455 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP10 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                          -     -     -     -     -     -                 -                                                                                 
    SP2:                          -     -     -     -     -     -                 -           -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                          -     -     -     -           -                 -                                                                                 
    SP4:                          -     -     -     -           -     -           -                                                                                 
    SP5:                          -     -     -     -     -     -                                                                                                   

    ExUns: 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d
    SP1:        -                                                                     
    SP2:  -     -     -     -     -     -     -                                       
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for USP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGTGTA
    USP10 Expression
    About this image


    USP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    USP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.136778

    UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694
    Tissue specificity: Widely expressed

        Custom PCR Arrays for USP10
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp101 , 5 ubiquitin specific peptidase 101, 5 81.33(n)1
    84.07(a)1
      8 (68.61 cM)5
    222241  NM_009462.11  NP_033488.11 
     1199103605 
    chicken
    (Gallus gallus)
    Aves USP101 ubiquitin specific peptidase 10 78.42(n)
    79.05(a)
      415817  NM_001006130.1  NP_001006130.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    93(a)
    68(a)
    many → 1
    many → 1
    GL343617.1(346722-360808)
    AAWZ02036254(966-19857)
    African clawed frog
    (Xenopus laevis)
    Amphibia usp10-prov2 ubiquitin specific protease 10 76.73(n)    BC044285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc19h082 wufc19h08 76.65(n)   324138  57052497 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG324796
    --
    13(a)
    1 ↔ 1
    3L(871899-895313)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP3(YER151C)4 Ubiquitin-specific protease that interacts with Bre5p more   --   5(472424-469686) 856895  NP_011078.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP241 UBP24 49.62(n)
    40.23(a)
      829213  NM_202915.1  NP_974644.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06613001 Os07g0661300 48.35(n)
    33.99(a)
      4344181  NM_001067071.1  NP_001060536.1 


    ENSEMBL Gene Tree for USP10 (if available)
    TreeFam Gene Tree for USP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP10 gene
    Selected SIMAP similar genes for USP10 using alignment to 10 protein entries:     UBP10_HUMAN (see all proteins) (see all similar genes):
    DKFZp686E14181    DCTN5    AURA2    LYRM4    BTBD2    UTY
    FOPNL    CHID1    FAM210A    NF2    CATSPERG    CTSS
    ERBB2    SEPT2    UBIAD1    ZNF212    ZNF564    ZNF585B

    Find genes that share paralogs with USP10           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for USP10
    PGOHUM00000247696 PGOHUM00000248031 PGOHUM00000246370


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP10 (see all 2618)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351554991,2
    C--70498241(+) TTTTT-/T/TT  
            
    GTCTG
    4 -- int12NA 4
    rs133135541,2
    C--84731562(+) tgatcC/Gaccca 4 -- us2k1 tfbs30--------
    rs1837394751,2
    --84731614(+) CGCACC/TGAGCC 4 -- us2k10--------
    rs1494642861,2
    --84731615(+) GCACCA/GAGCCA 4 -- us2k10--------
    rs1438824201,2
    C--84731633(+) AACCAG/TAAATC 4 -- us2k10--------
    rs1122554551,2
    F--84731658(+) ACGTCC/TCCCAG 4 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs99298131,2
    C,F,A--84731729(+) TGTATT/GGTTTT 4 -- us2k18Minor allele frequency- G:0.20NA WA CSA EA 368
    rs1807364101,2
    --84731910(+) CATTAA/TGGCCT 4 -- us2k10--------
    rs1854730061,2
    --84731919(+) CTTCAC/GTCCTC 4 -- us2k10--------
    rs1910055321,2
    --84732114(+) ACACAC/TTGTAT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP10 (84733555 - 84813528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714837CNV Deletion23290073
    esv2714836CNV Deletion23290073
    nsv510429CNV Loss20534489
    esv22326CNV Loss19812545
    esv28029CNV Loss19812545
    nsv907081CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP10
    DNA2.0 Custom Variant and Variant Library Synthesis for USP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609818    OMIM disorders: --


    Find genes that share disorders with USP10           About GenesLikeMe

    Genetic Association Database (GAD): USP10
    Human Genome Epidemiology (HuGE) Navigator: USP10 (1 document)

    Export disorders for USP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP10 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with USP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. (PubMed id 19398555)1, 2, 9 Bomberger J.M.... Stanton B.A. (J. Biol. Chem. 2009)
    2. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J.... Yuan J. (Cell 2011)
    3. USP10 regulates p53 localization and stability by deubiquitinating p53. (PubMed id 20096447)1, 2 Yuan J.... Lou Z. (Cell 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. (PubMed id 18632802)1, 2 Boulkroun S.... Staub O. (Am. J. Physiol. 2008)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9100 HGNC: 12608 AceView: USP10 Ensembl:ENSG00000103194 euGenes: HUgn9100
    ECgene: USP10 H-InvDB: USP10

    (According to HUGE)
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    HUGE: KIAA0190

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP10 gene:
    Search GeneIP for patents involving USP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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