USP10 Gene
protein-coding GIFtS: 60
GCID: GC16P084734
|
|
ubiquitin specific peptidase 10(Previous name: ubiquitin specific protease 10 )
| |
Aliases
for USP10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 101 2 | | Ubiquitin Thioesterase 102 3 | | KIAA01901 3 5 | | Ubiquitin-Specific-Processing Protease 102 3 | | UBPO1 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 102 | | Ubiquitin Specific Protease 101 2 | | Ubiquitin Thiolesterase 102 | | Deubiquitinating Enzyme 102 3 | | EC 3.4.19.123 |
Export aliases for USP10 gene to outside databasesPrevious GC identifers: GC16M075919 GC16P085700 GC16P084472 GC16P084513 GC16P083291 GC16P070487 |
Summaries
for USP10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP10:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function anddegradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzymespecifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus andcytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein inthe Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcriptvariants, some protein-coding and others not protein-coding, have been found for this gene. (provided by RefSeq, Jan2013)
UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR.Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 inthe cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to thenucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of aregulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator ofautophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexesregulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in earlyendosomes, enhancing its endocytic recycling
Gene Wiki entry for USP10
|
Genomic Views
for USP10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP10 gene promoter:
Egr-2 Sox5 POU2F1 HTF POU2F1a MyoD c-Myb YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16qUSP10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P084734: view genomic region
(about GC identifiers)
Start:
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84,733,555 bp from pter |
End:
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84,813,528 bp from pter |
Size:
|
79,974 bases |
Orientation:
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plus strand |
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Proteins
for USP10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 10 Size: 798 amino acids; 87134 Da
Subunit: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR
Subcellular location: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage,translocates to the nucleus following phosphorylation by ATM
Sequence caution: Sequence=CAD97644.1; Type=Erroneous initiation;
Secondary accessions: B2RDJ8 B4DS84 Q9BWG7 Q9NSL7Alternative splicing: 3 isoforms: Q14694-1 Q14694-2 Q14694-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP10: NX_Q14694
Post-translational modifications:
Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus1
Ubiquitinated. Deubiquitinated by USP131
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14694
USP10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001259004.1 NP_005144.2
ENSEMBL proteins: ENSP00000219473 ENSP00000458089 ENSP00000445589 ENSP00000455712 ENSP00000454902 ENSP00000457411 ENSP00000454943 ENSP00000462762 ENSP00000454751 ENSP00000454987 ENSP00000455865
Human Recombinant Protein Products for USP10:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
USP10 for ontologies About GeneDecksing
USP10 Antibody Products:
Assay Products for USP10: |
Protein
Domains /
Families
for USP10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14694ProtoNet protein and cluster: Q14694 2 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB009818 Ataxin-2
UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694Similarity: Belongs to the peptidase C19 family. USP10 subfamily |
Function
for USP10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBP10_HUMAN, Q14694Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR.Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 inthe cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to thenucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of aregulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator ofautophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexesregulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in earlyendosomes, enhancing its endocytic recyclingCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme regulation: Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative ofMBCQ that binds to USP10 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexesInduction: Following DNA damage. Down-regulated in renal cell carcinomas Genatlas biochemistry entry for USP10:ubiquitin specific protease 10,deubiquitin enzyme family
Enzyme Number (IUBMB): EC 3.4.19.121
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
USP10 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for USP10:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP10 |
|
Pathways & Interactions
for USP10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | | | 2 | Apoptosis and Autophagy | | | 3 | Ubiquitin-Proteasome Dependent Proteolysis | | | 4 | DNA Damage | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP10
3 
Cell Signaling Technology (CST) Pathways for USP10
USP10 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/560 Interacting proteins for USP10 (Q146942, 3 ENSP000002194734) via UniProtKB, MINT, STRING, and/or I2D (see all 560)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
USP10 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP10
1 HMDB Compound for USP10 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP10 / UBP10
|
Transcripts
for USP10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP10 gene (2 alternative transcripts): NM_001272075.1 NM_005153.2 Unigene Cluster for USP10: Ubiquitin specific peptidase 10 Hs.136778 [show with all ESTs]Unigene Representative Sequence: NM_00515318/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000219473 ENST00000562743 ENST00000569511 ENST00000562092 ENST00000563892
ENST00000540269(uc002fii.3 uc010voe.2 uc010vof.2 uc002fij.3)
ENST00000564566 ENST00000562283 ENST00000563048 ENST00000570191 ENST00000563386
ENST00000569038 ENST00000570053 ENST00000566512 ENST00000563023 ENST00000563433
ENST00000566378 ENST00000569925
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP10 (NM_005153) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10 |
Additional cDNA sequence: AK293304.1 AK299618.1 AK315570.1 AL162049.1 BC000263.1 BX537402.1 D80012.1 24/36 DOTS entries (see all 36): DT.451863 DT.99955728 DT.97847924 DT.95210975 DT.120685319 DT.95333449 DT.95338568 DT.100820968 DT.100809229 DT.70104284 DT.100820969 DT.91749502 DT.100738452 DT.120685326 DT.100820972 DT.120685374 DT.91762493 DT.95338558 DT.100031449 DT.100659355 DT.100673362 DT.100820967 DT.100820973 DT.100820974 24/354 AceView cDNA sequences (see all 354): BM463132 AI689910 BX537402 AL701525 AI033341 CA396455 CR626589 AL162049 AA293619 BM757763 AW204076 BM477233 BM981981 BM678380 BE764319 AA243184 BQ049762 BE326520 CR617738 BM678687 BE543108 AA332232 CK301022 CB127944
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for USP10 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · | 10h | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP10
|
Expression
for USP10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCTGTGTA
About this image
See USP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP10
SOURCE GeneReport for Unigene cluster: Hs.136778
UniProtKB/Swiss-Prot: UBP10_HUMAN, Q14694Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for USP10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP10 |
Orthologs
for USP10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP10 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for USP10 (if available)
TreeFam Gene Tree for USP10 (if available) |
Paralogs
for USP10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP10 gene
18/40 SIMAP similar genes for USP10 using alignment to 10 protein entries: UBP10_HUMAN (see all proteins)
(see all similar genes):DKFZp686E14181 DCTN5 AURA2 LYRM4 BTBD2 UTY
FOPNL CHID1 FAM210A NF2 CATSPERG ERBB2
SEPT2 ZNF212 ZNF564 ZNF585B DNAPTP3 DNMT1
USP10 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for USP10
PGOHUM00000247696 PGOHUM00000248031 PGOHUM00000246370
|
Genomic Variants
for USP10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP10 (84733555 - 84813528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for USP10
2 CNVs: 72650 72652
1 Indel: 72651 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP10 |
|
Disorders
/ Diseases
for USP10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP10 for disorders About GeneDecksing
OMIM gene information: 609818
OMIM disorders: --
6  diseases for USP10: About MalaCardsrenal cell carcinoma cystic fibrosis fibrosis breast cancer
glioblastoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: USP10 (1 document)
Export disorders for USP10 gene to outside databases
|
Publications
for USP10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP10 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with USP10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The deubiquitinating enzyme USP10 regulates the post- endocytic sorting of cystic fibrosis transmembrane conductance regulator in air way epithelial cells. (PubMed id 19398555)1, 2, 9 Bomberger J.M....Stanton B.A. (2009)
- Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J....Yuan J. (2011)
- USP10 regulates p53 localization and stability by deubiquitinating p53. (PubMed id 20096447)1, 2 Yuan J.... Lou Z. (2010)
- Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3. (PubMed id 18632802)1, 2 Boulkroun S....Staub O. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. (PubMed id 11439350)1, 2 Soncini C.... Draetta G. (2001)
|
External Searches for USP10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP10 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for USP10 gene:
Search GeneIP for patents involving USP10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for USP10 | | OriGene shRNA RFP for USP10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP10 | | | OriGene Protein Over-expression Lysate for USP10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP10 | | OriGene 3'-UTR Clone for USP10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP10 | | OriGene Custom Protein Services for USP10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP10 |
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| | Antibodies & Assays for USP10 |
| | | | Search Tocris compounds for USP10 |
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 | | | USP10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP10 |
|  |  |  |  | | | | ThermoFisher Antibodies for USP10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP10 |
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