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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP1 Gene

protein-coding   GIFtS: 64
GCID: GC01P062837

Ubiquitin Specific Peptidase 1

(Previous name: ubiquitin specific protease 1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 11 2     Ubiquitin Carboxyl Terminal Hydrolase 12
Ubiquitin Specific Protease 11 2     Ubiquitin Carboxyl-Terminal Hydrolase 12
Deubiquitinating Enzyme 12 3     Ubiquitin Specific Processing Protease 12
Ubiquitin Thioesterase 12 3     Ubiquitin Thiolesterase 12
Ubiquitin-Specific-Processing Protease 12 3     EC 3.4.19.123
hUBP2 3     EC 3.1.2.158
UBP2     

External Ids:    HGNC: 126071   Entrez Gene: 73982   Ensembl: ENSG000001626077   OMIM: 6034785   UniProtKB: O947823   

Export aliases for USP1 gene to outside databases

Previous GC identifers: GC01P061825 GC01P062259 GC01P062272 GC01P062614 GC01P062674 GC01P061014


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP1 Gene:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a
deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the
ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically
deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice
variants have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for USP1 Gene: 
USP1 (ubiquitin specific peptidase 1) is a protein-coding gene. Diseases associated with USP1 include hereditary pancreatitis, and fanconi's anemia, and among its related super-pathways are Fanconi Anemia pathway and DNA damage ATM/ATR regulation of G1/S checkpoint. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782
Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost
no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity

Gene Wiki entry for USP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP1 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   HFH-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

USP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P062837:  view genomic region     (about GC identifiers)

Start:
62,901,968 bp from pter      End:
62,917,475 bp from pter
Size:
15,508 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 1  
Size: 785 amino acids; 88207 Da
Subunit: Interacts with FANCD2 and PCNA. Interacts with WDR48
Subcellular location: Nucleus
Developmental stage: Cell cycle-regulated. Highest level during S phase
Miscellaneous: HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an
increase in point mutations upon UV irradiation
Sequence caution: Sequence=AAH18745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH32364.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAD92130.1; Type=Frameshift; Positions=230;
Secondary accessions: A0PJ95 D3DQ57 Q05BX7 Q59H66 Q9UFR0 Q9UNJ3

Explore the universe of human proteins at neXtProt for USP1: NX_O94782

Explore proteomics data for USP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated
    PCNA, recruitment of POLH and translesion synthesis
  • UniProtKB: Ubiquitinated; leading to its subsequent proteasomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94782

  • 2 DME Specific Peptides for USP1 (O94782)
     KQPSILSKFCS  EENQRQTRSKRKA 

    USP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001017415.1  NP_001017416.1  NP_003359.3  

    ENSEMBL proteins: 
     ENSP00000403662   ENSP00000387986   ENSP00000343526   ENSP00000360188  
    Reactome Protein details: O94782
    Human Recombinant Protein Products for USP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for USP1 (USP1/UAF1 Complex, USP1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP1
    OriGene Protein Over-expression Lysate for USP1
    OriGene MassSpec for USP1 
    OriGene Custom Protein Services for USP1
    GenScript Custom Purified and Recombinant Proteins Services for USP1
    Novus Biologicals USP1 Protein
    Novus Biologicals USP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    USP1 for ontologies           About GeneDecksing



    USP1 Antibody Products: 
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    Novus Biologicals USP1 Antibodies
    Abcam antibodies for USP1
    Cloud-Clone Corp. Antibodies for USP1 
    ThermoFisher Antibodies for USP1
    LSBio Antibodies in human, mouse, rat for USP1 

    Assay Products for USP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP1 
    Cloud-Clone Corp. CLIAs for USP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry O94782

    ProtoNet protein and cluster: O94782

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782
    Similarity: Belongs to the peptidase C19 family


    USP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP1_HUMAN, O94782
    Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.
    Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost
    no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Biophysicochemical properties: Kinetic parameters: KM=0.7 uM for ubiquitin vinyl sulfone (in presence of WDR48);
    KM=1.4 uM for ubiquitin vinyl sulfone (in absence of WDR48);
    Induction: Down-regulated following DNA damage

         Genatlas biochemistry entry for USP1:
    ubiquitin-specific protease 1,88.2kDa,ubiquitin specific processing family member,involved in cleavage beta
    galactosidase,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IDA18082604
    GO:0004843ubiquitin-specific protease activity IMP--
    GO:0005515protein binding IPI18082604
         
    USP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP1:
     Increased cell death HMECs cel  Increased circadian period len 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Usp1):
     cellular  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     mortality/aging  reproductive system 

    USP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usp1tm1.1Ada for USP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP1 (see all 9):
    hsa-miR-34c-3p hsa-miR-3163 hsa-miR-607 hsa-miR-548d-3p hsa-miR-3935 hsa-miR-124 hsa-miR-3662 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP1
    Sirion Biotech Customized adenovirus for overexpression of USP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP1 (see all 17)
    OriGene ORF clones in mouse, rat for USP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP1 (NM_004417)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP1
    Sirion Biotech Customized lentivirus for stable overexpression of USP1 
                         Customized lentivirus expression plasmids for stable overexpression of USP1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP1
    Search LifeMap BioReagents cell lines for USP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway
    Fanconi Anemia pathway0.43
    Regulation of the Fanconi anemia pathway0.42
    2DNA damage ATM/ATR regulation of G1/S checkpoint
    DNA damage ATM/ATR regulation of G1/S checkpoint0.98
    3Nucleotide Excision Repair
    DNA Repair0.46
    4DNA Damage
    DNA Damage0.32
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for USP1
        DNA damage ATM/ATR regulation of G1/S checkpoint

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP1
        Ubiquitin-Proteasome Dependent Proteolysis

    2 Cell Signaling Technology (CST) Pathways for USP1
        DNA Damage
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for USP1
        DNA damage ATM/ATR regulation of G1/S checkpoint

    3        Reactome Pathways for USP1
        DNA Repair
    Regulation of the Fanconi anemia pathway
    Fanconi Anemia pathway


    1         Kegg Pathway  (Kegg details for USP1):
        Fanconi anemia pathway


    USP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for USP1 (O947823 ENSP000003435264) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS7P479293, ENSP000003678914I2D: score=2 STRING: ENSP00000367891
    UBBP0CG473, ENSP000003046974I2D: score=3 STRING: ENSP00000304697
    ALDH16A1Q8IZ833, ENSP000002933504I2D: score=2 STRING: ENSP00000293350
    CALML3P274823, ENSP000003152994I2D: score=2 STRING: ENSP00000315299
    CALML5Q9NZT13, ENSP000003696894I2D: score=2 STRING: ENSP00000369689
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006282regulation of DNA repair IDA18082604
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0009411response to UV IDA18082604
    GO:0016579protein deubiquitination IDA18082604

    USP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP1 (UBP1)

    1 HMDB Compound for USP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP1 / UBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP1 gene (3 alternative transcripts): 
    NM_001017415.1  NM_001017416.1  NM_003368.4  

    Unigene Cluster for USP1:

    Ubiquitin specific peptidase 1
    Hs.35086  [show with all ESTs]
    Unigene Representative Sequence: NM_003368
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452143 ENST00000442679 ENST00000339950(uc001dal.2) ENST00000371146(uc001daj.2 uc001dak.2)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate USP1 (see all 9):
    hsa-miR-34c-3p hsa-miR-3163 hsa-miR-607 hsa-miR-548d-3p hsa-miR-3935 hsa-miR-124 hsa-miR-3662 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP1
    Clone
    Products:
         
    OriGene clones in human, mouse for USP1 (see all 17)
    OriGene ORF clones in mouse, rat for USP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP1 (NM_004417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP1
    Sirion Biotech Customized lentivirus for stable overexpression of USP1 
                         Customized lentivirus expression plasmids for stable overexpression of USP1 
    Primer
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    OriGene qPCR primer pairs and template standards for USP1
    OriGene qSTAR qPCR primer pairs in human, mouse for USP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP1

    Additional mRNA sequence: 

    AB014458.1 AB208893.1 AF117386.1 AK090749.1 AK312423.1 AL117503.1 AL117575.1 BC011881.1 
    BC018745.1 BC023216.1 BC032364.1 BC040140.1 BC050525.1 

    12 DOTS entries:

    DT.446236  DT.100740140  DT.100740141  DT.121374371  DT.100740139  DT.97823302  DT.91751998  DT.99930351 
    DT.101966711  DT.95172541  DT.100795769  DT.100795772 

    24/272 AceView cDNA sequences (see all 272):

    BC050525 BU509499 CB159045 BU621005 AA761280 CR593195 AA804217 AL117575 
    D79875 AA832380 H96555 AL117503 BM667838 AI891100 BM821218 CB123482 
    AI000120 NM_003368 T36059 AA281098 AA577433 BM722376 BQ130511 AI811418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP1 expression in normal human tissues (normalized intensities)      USP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAATTTG
    USP1 Expression
    About this image


    USP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   

    See USP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP1

    SOURCE GeneReport for Unigene cluster: Hs.35086
        SABiosciences Custom PCR Arrays for USP1
    Primer
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    OriGene qPCR primer pairs and template standards for USP1
    OriGene qSTAR qPCR primer pairs in human, mouse for USP1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp11 , 5 ubiquitin specific peptidase 11, 5 86.93(n)1
    88.76(a)1
      4 (45.60 cM)5
    2304841  NM_146144.31  NP_666256.21 
     989238105 
    chicken
    (Gallus gallus)
    Aves USP11 ubiquitin specific peptidase 1 72.69(n)
    74.36(a)
      424685  NM_001031290.1  NP_001026461.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP16
    Ubiquitin carboxyl-terminal hydrolase
    68(a)
    1 ↔ 1
    4(99954107-99970633)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985302 similar to ubiquitin specific protease 1 74.94(n)    BC044050.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb43a022 wufb43a02 75.83(n)   322007  BC045507.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG158171 CG15817 38.49(n)
    27.98(a)
      43462  NM_170403.2  NP_733282.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP136
    UBP96
    Putative ubiquitin carboxyl-terminal hydrolase, ub...
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    II(93639-95882)
    V(355466-357730)


    ENSEMBL Gene Tree for USP1 (if available)
    TreeFam Gene Tree for USP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP1 gene
    USP352  USP122  USP382  USP462  

    USP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/444 SNPs in USP1 are shown (see all 444)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171236151,2
    C,F,H--62900128(+) GCTAAG/AACTGA 2 -- us2k117Minor allele frequency- A:0.08NA NS EA WA 1958
    rs1391194121,2
    --62900232(+) AAGAAC/TGATGA 2 -- us2k10--------
    rs1494519021,2
    --62900247(+) TCCCAC/TTGAGC 2 -- us2k10--------
    rs1438951771,2
    C--62900289(+) CACTGA/TGTTGC 2 -- us2k10--------
    rs112079661,2
    --62900357(+) GTGGAA/GGGCAG 2 -- us2k10--------
    rs6124551,2
    C,F--62900383(+) cccagG/Actgga 3 -- us2k11Minor allele frequency- A:0.10WA 118
    rs772104641,2
    C,F--62900469(+) GCACGT/CGCCAC 3 -- us2k12Minor allele frequency- C:0.16WA 120
    rs2015371951,2
    C--62900496(+) TGGAG-/TTTTTT 3 -- us2k10--------
    rs1828022211,2
    --62900687(+) CATCTC/TATTCC 3 -- us2k10--------
    rs1444806021,2
    C--62900777(+) ACAGAA/GTTTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP1 (62901968 - 62917475 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP1
    DNA2.0 Custom Variant and Variant Library Synthesis for USP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603478    OMIM disorders: --

    13 diseases for USP1:    About MalaCards
    hereditary pancreatitis    fanconi's anemia    tauopathy    breast cancer susceptibility
    anemia    osteosarcoma    renal cell carcinoma    pancreatic cancer
    pancreatitis    alzheimer's disease    colorectal cancer    breast cancer
    lung cancer

    1 disease from the University of Copenhagen DISEASES database for USP1:
    Fanconi's anemia

    USP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for USP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12507430 (1)

    Genetic Association Database (GAD): USP1
    Human Genome Epidemiology (HuGE) Navigator: USP1 (2 documents)

    Export disorders for USP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP1 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with USP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. (PubMed id 9806842)1, 2, 9 Fjiwara T....Tanaka K. (1998)
    2. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. (PubMed id 18082604)1, 2, 9 Cohn M.A....D'Andrea A.D. (2007)
    3. The Fanconi anemia family of genes and its correlatio n with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4 Barroso E....Ribas G. (2009)
    4. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (2009)
    5. Regulation of monoubiquitinated PCNA by DUB autocleavage. (PubMed id 16531995)1, 2 Huang T.T.... D'Andrea A.D. (2006)
    6. The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway. (PubMed id 15694335)1, 2 Nijman S.M.B.... Bernards R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. Human ELG1 regulates the level of ubiquitinated proli ferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP 1. (PubMed id 20147293)1, 9 Lee K.Y....Myung K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7398 HGNC: 12607 AceView: USP1 Ensembl:ENSG00000162607 euGenes: HUgn7398
    ECgene: USP1 Kegg: 7398 H-InvDB: USP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP1 gene:
    Search GeneIP for patents involving USP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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