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USP1 Gene

protein-coding   GIFtS: 65
GCID: GC01P062837

Ubiquitin Specific Peptidase 1

(Previous name: ubiquitin specific protease 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 11 2     Ubiquitin Carboxyl Terminal Hydrolase 12
Ubiquitin Specific Protease 11 2     Ubiquitin Carboxyl-Terminal Hydrolase 12
Deubiquitinating Enzyme 12 3     Ubiquitin Specific Processing Protease 12
Ubiquitin Thioesterase 12 3     Ubiquitin Thiolesterase 12
Ubiquitin-Specific-Processing Protease 12 3     EC 3.4.19.123
hUBP2 3     EC 3.1.2.158
UBP2     

External Ids:    HGNC: 126071   Entrez Gene: 73982   Ensembl: ENSG000001626077   OMIM: 6034785   UniProtKB: O947823   

Export aliases for USP1 gene to outside databases

Previous GC identifers: GC01P061825 GC01P062259 GC01P062272 GC01P062614 GC01P062674 GC01P061014


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP1 Gene:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a
deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the
ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically
deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice
variants have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for USP1 Gene:
USP1 (ubiquitin specific peptidase 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782
Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost
no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity

Gene Wiki entry for USP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP1 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   HFH-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP1 promoter sequence
   Search Chromatin IP Primers for USP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

USP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P062837:  view genomic region     (about GC identifiers)

Start:
62,901,968 bp from pter      End:
62,917,475 bp from pter
Size:
15,508 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 1  
Size: 785 amino acids; 88207 Da
Subunit: Interacts with FANCD2 and PCNA. Interacts with WDR48
Developmental stage: Cell cycle-regulated. Highest level during S phase
Miscellaneous: HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an
increase in point mutations upon UV irradiation
Sequence caution: Sequence=AAH18745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH32364.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAD92130.1; Type=Frameshift; Positions=230;
Secondary accessions: A0PJ95 D3DQ57 Q05BX7 Q59H66 Q9UFR0 Q9UNJ3

Explore the universe of human proteins at neXtProt for USP1: NX_O94782

Explore proteomics data for USP1 at MOPED

Post-translational modifications: 

  • Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated
    PCNA, recruitment of POLH and translesion synthesis1
  • Ubiquitinated; leading to its subsequent proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys73, Lys110, Lys689, Lys746, Lys761
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP1 (O94782)
     KQPSILSKFCS  EENQRQTRSKRKA 


    See USP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001017415.1  NP_001017416.1  NP_003359.3  

    ENSEMBL proteins: 
     ENSP00000403662   ENSP00000387986   ENSP00000343526   ENSP00000360188  
    Reactome Protein details: O94782

    USP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals USP1 Protein
    Novus Biologicals USP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for USP1

     
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    antibodies-online proteins for USP1 (5 products) 

     
    antibodies-online peptides for USP1

    USP1 Antibody Products:

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    USP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for USP1
    Cloud-Clone Corp. CLIAs for USP1
    Search eBioscience for ELISAs for USP1 
    antibodies-online kits for USP1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry O94782

    ProtoNet protein and cluster: O94782

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP1_HUMAN, O94782
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP1_HUMAN, O94782
    Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.
    Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost
    no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Biophysicochemical properties: Kinetic parameters: KM=0.7 uM for ubiquitin vinyl sulfone (in presence of WDR48);
    KM=1.4 uM for ubiquitin vinyl sulfone (in absence of WDR48);
    Induction: Down-regulated following DNA damage

         Genatlas biochemistry entry for USP1:
    ubiquitin-specific protease 1,88.2kDa,ubiquitin specific processing family member,involved in cleavage beta
    galactosidase,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IDA18082604
    GO:0004843ubiquitin-specific protease activity IMP--
    GO:0005515protein binding IPI18082604
         
    Find genes that share ontologies with USP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP1:
     Increased cell death HMECs cel  Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp1):
     cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     mortality/aging  reproductive system  skeleton 

    Find genes that share phenotypes with USP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Usp1tm1.1Ada for USP1

       genOway: Develop your customized and physiologically relevant rodent model for USP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP1:
    hsa-mir-215-5p (MIRT024602), hsa-mir-100-5p (MIRT048468), hsa-mir-375 (MIRT001747), hsa-mir-192-5p (MIRT026803)

    Block miRNA regulation of human, mouse, rat USP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP1 (see all 9):
    hsa-miR-34c-3p hsa-miR-3163 hsa-miR-607 hsa-miR-548d-3p hsa-miR-3935 hsa-miR-124 hsa-miR-3662 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP1
    Predesigned siRNA for gene silencing in human, mouse, rat USP1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for USP1 (see all 16)
    OriGene ORF clones in mouse, rat for USP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP1 (NM_004417)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP1
    Addgene plasmids for USP1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP1_HUMAN, O94782: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with USP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway (REACTOME)
    Fanconi Anemia pathway
    Regulation of the Fanconi anemia pathway0.00
    2DNA Repair
    DNA Repair0.45
    3Cell Cycle / Checkpoint Control
    DNA Damage0.32
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Protein Stability
    Protein Stability


    Find genes that share SuperPaths with USP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP1
        Ubiquitin-Proteasome Dependent Proteolysis

    2 Cell Signaling Technology (CST) Pathways for USP1
        DNA Damage
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for USP1
        DNA damage ATM/ATR regulation of G1/S checkpoint

    1 Reactome Pathway for USP1
        Regulation of the Fanconi anemia pathway


    1 Kegg Pathway  (Kegg details for USP1):
        Fanconi anemia pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP1
    Interactions:

        GeneGlobe Interaction Network for USP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP1 (O947823 ENSP000003435264) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS7P479293, ENSP000003678914I2D: score=2 STRING: ENSP00000367891
    UBBP0CG473, ENSP000003046974I2D: score=3 STRING: ENSP00000304697
    ALDH16A1Q8IZ833, ENSP000002933504I2D: score=2 STRING: ENSP00000293350
    CALML3P274823, ENSP000003152994I2D: score=2 STRING: ENSP00000315299
    CALML5Q9NZT13, ENSP000003696894I2D: score=2 STRING: ENSP00000369689
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006282regulation of DNA repair IDA18082604
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0009411response to UV IDA18082604
    GO:0016579protein deubiquitination IDA18082604

    Find genes that share ontologies with USP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for USP1     About this table
    CompoundAction CAS #
    IU1potent and selective small-molecule inhibitor of Usp14[314245-33-5]
    LDN 57444Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity[668467-91-2]
    NSC 632839 hydrochlorideInhibitor of ubiquitin isopeptidase activity[157654-67-6]
    P 22077Inhibitor of ubiquitin-specific protease (USP) 7[1247819-59-5]
    P005091Ubiquitin-specific protease 7 (USP7) inhibitor[882257-11-6]
    PR-619Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor[2645-32-1]
    SJB2-043novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
    Vialinin AInhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity[858134-23-3]
    WP1130Cell permeable deubiquitinase (DUB) inhibitor[856243-80-6]

    Browse Tocris compounds for USP1 (UBP1)

    1 HMDB Compound for USP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP1 gene (3 alternative transcripts): 
    NM_001017415.1  NM_001017416.1  NM_003368.4  

    Unigene Cluster for USP1:

    Ubiquitin specific peptidase 1
    Hs.35086  [show with all ESTs]
    Unigene Representative Sequence: NM_003368
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452143 ENST00000442679 ENST00000339950(uc001dal.2) ENST00000371146(uc001daj.2 uc001dak.2)

    miRNA
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    hsa-miR-34c-3p hsa-miR-3163 hsa-miR-607 hsa-miR-548d-3p hsa-miR-3935 hsa-miR-124 hsa-miR-3662 hsa-miR-506
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      QuantiTect SYBR Green Assays in human, mouse, rat USP1
      QuantiFast Probe-based Assays in human, mouse, rat USP1

    Additional mRNA sequence: 

    AB014458.1 AB208893.1 AF117386.1 AK090749.1 AK312423.1 AL117503.1 AL117575.1 BC011881.1 
    BC018745.1 BC023216.1 BC032364.1 BC040140.1 BC050525.1 

    12 DOTS entries:

    DT.446236  DT.100740140  DT.100740141  DT.121374371  DT.100740139  DT.97823302  DT.91751998  DT.99930351 
    DT.101966711  DT.95172541  DT.100795769  DT.100795772 

    Selected AceView cDNA sequences (see all 272):

    AI435166 AA804217 AL117503 AA832380 BU621005 BC040140 CB159045 BQ018843 
    BM821218 AI090415 BX099799 AL117575 CB122842 T36059 BQ771823 BQ130511 
    BM705862 AA761280 CF454926 NM_003368 AB014458 AA361227 AA281098 BC023216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAATTTG
    USP1 Expression
    About this image


    USP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    USP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35086
        Custom PCR Arrays for USP1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat USP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp11 , 5 ubiquitin specific peptidase 11, 5 86.93(n)1
    88.76(a)1
      4 (45.60 cM)5
    2304841  NM_146144.31  NP_666256.21 
     989238105 
    chicken
    (Gallus gallus)
    Aves USP11 ubiquitin specific peptidase 1 72.74(n)
    74.36(a)
      424685  NM_001031290.1  NP_001026461.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP16
    ubiquitin specific peptidase 1
    68(a)
    1 ↔ 1
    4(99954107-99970633)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985302 similar to ubiquitin specific protease 1 74.94(n)    BC044050.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb43a022 wufb43a02 75.83(n)   322007  BC045507.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG158176
    --
    15(a)
    1 ↔ 1
    3R(25054883-25061024)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP96
    UBP136
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    Putative ubiquitin carboxyl-terminal hydrolase, ub...
    13(a)
    13(a)
    many ↔ many
    many ↔ many
    V(355466-357730) YER098W
    II(93639-95882) YBL067C


    ENSEMBL Gene Tree for USP1 (if available)
    TreeFam Gene Tree for USP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP1 gene
    USP352  USP122  USP382  USP462  

    Find genes that share paralogs with USP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP1 (see all 444)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171236151,2
    C,F,H--62900128(+) GCTAAG/AACTGA 2 -- us2k117Minor allele frequency- A:0.08NA NS EA WA 1958
    rs1391194121,2
    --62900232(+) AAGAAC/TGATGA 2 -- us2k10--------
    rs1494519021,2
    --62900247(+) TCCCAC/TTGAGC 2 -- us2k10--------
    rs1438951771,2
    C--62900289(+) CACTGA/TGTTGC 2 -- us2k10--------
    rs112079661,2
    --62900357(+) GTGGAA/GGGCAG 2 -- us2k10--------
    rs6124551,2
    C,F--62900383(+) cccagG/Actgga 3 -- us2k11Minor allele frequency- A:0.10WA 118
    rs772104641,2
    C,F--62900469(+) GCACGT/CGCCAC 3 -- us2k12Minor allele frequency- C:0.16WA 120
    rs2015371951,2
    C--62900496(+) TGGAG-/TTTTTT 3 -- us2k10--------
    rs1828022211,2
    --62900687(+) CATCTC/TATTCC 3 -- us2k10--------
    rs1444806021,2
    C--62900777(+) ACAGAA/GTTTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP1 (62901968 - 62917475 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for USP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP1
    DNA2.0 Custom Variant and Variant Library Synthesis for USP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603478    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for USP1:
    Fanconi's anemia

    Find genes that share disorders with USP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for USP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12507430 (1)

    Genetic Association Database (GAD): USP1
    Human Genome Epidemiology (HuGE) Navigator: USP1 (2 documents)

    Export disorders for USP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with USP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. (PubMed id 9806842)1, 2, 9 Fjiwara T....Tanaka K. (Genomics 1998)
    2. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. (PubMed id 18082604)1, 2, 9 Cohn M.A....D'Andrea A.D. (Mol. Cell 2007)
    3. The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4 Barroso E....Ribas G. (Breast Cancer Res. Treat. 2009)
    4. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    5. Regulation of monoubiquitinated PCNA by DUB autocleavage. (PubMed id 16531995)1, 2 Huang T.T.... D'Andrea A.D. (Nat. Cell Biol. 2006)
    6. The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway. (PubMed id 15694335)1, 2 Nijman S.M.B.... Bernards R. (Mol. Cell 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. (PubMed id 20147293)1, 9 Lee K.Y....Myung K. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7398 HGNC: 12607 AceView: USP1 Ensembl:ENSG00000162607 euGenes: HUgn7398
    ECgene: USP1 Kegg: 7398 H-InvDB: USP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP1 gene:
    Search GeneIP for patents involving USP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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