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Aliases for USP1 Gene

Aliases for USP1 Gene

  • Ubiquitin Specific Peptidase 1 2 3 5
  • Ubiquitin-Specific-Processing Protease 1 3 4
  • Ubiquitin Specific Protease 1 2 3
  • Deubiquitinating Enzyme 1 3 4
  • Ubiquitin Thioesterase 1 3 4
  • HUBP 3 4
  • Ubiquitin Specific Processing Protease 1 3
  • Ubiquitin Carboxyl Terminal Hydrolase 1 3
  • Ubiquitin Thiolesterase 1 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • UBP 3

External Ids for USP1 Gene

Previous GeneCards Identifiers for USP1 Gene

  • GC01P062837
  • GC01P061825
  • GC01P062259
  • GC01P062272
  • GC01P062614
  • GC01P062674
  • GC01P061014

Summaries for USP1 Gene

Entrez Gene Summary for USP1 Gene

  • This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for USP1 Gene

USP1 (Ubiquitin Specific Peptidase 1) is a Protein Coding gene. Diseases associated with USP1 include fanconi anemia, complementation group a. Among its related pathways are Fanconi anemia pathway and DNA Damage. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP1 Gene

  • Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).

Gene Wiki entry for USP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP1 Gene

Genomics for USP1 Gene

Regulatory Elements for USP1 Gene

Enhancers for USP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP1 on UCSC Golden Path with GeneCards custom track

Promoters for USP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP1 Gene

Chromosome:
1
Start:
62,436,297 bp from pter
End:
62,451,804 bp from pter
Size:
15,508 bases
Orientation:
Plus strand

Genomic View for USP1 Gene

Genes around USP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP1 Gene

Proteins for USP1 Gene

  • Protein details for USP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94782-UBP1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 1
    Protein Accession:
    O94782
    Secondary Accessions:
    • A0PJ95
    • D3DQ57
    • Q05BX7
    • Q59H66
    • Q9UFR0
    • Q9UNJ3

    Protein attributes for USP1 Gene

    Size:
    785 amino acids
    Molecular mass:
    88207 Da
    Quaternary structure:
    • Interacts with FANCD2 and PCNA (PubMed:15694335, PubMed:16531995). Interacts with WDR48 (PubMed:18082604, PubMed:26388029).
    Miscellaneous:
    • HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.
    SequenceCaution:
    • Sequence=AAH18745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH32364.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD92130.1; Type=Frameshift; Positions=230; Evidence={ECO:0000305};

neXtProt entry for USP1 Gene

Proteomics data for USP1 Gene at MOPED

Selected DME Specific Peptides for USP1 Gene

Post-translational modifications for USP1 Gene

  • Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
  • Ubiquitinated; leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 73, Lys 110, Lys 689, Lys 746, and Lys 761
  • Modification sites at PhosphoSitePlus

Other Protein References for USP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for USP1 (USP1)

Domains & Families for USP1 Gene

Gene Families for USP1 Gene

Protein Domains for USP1 Gene

Suggested Antigen Peptide Sequences for USP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94782

UniProtKB/Swiss-Prot:

UBP1_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP1: view

Function for USP1 Gene

Molecular function for USP1 Gene

GENATLAS Biochemistry:
ubiquitin-specific protease 1,88.2kDa,ubiquitin specific processing family member,involved in cleavage beta galactosidase,deubiquitin enzyme family
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.7 uM for ubiquitin vinyl sulfone (in presence of WDR48) {ECO:0000269 PubMed:18082604}; KM=1.4 uM for ubiquitin vinyl sulfone (in absence of WDR48) {ECO:0000269 PubMed:18082604};
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
UniProtKB/Swiss-Prot Induction:
Down-regulated following DNA damage.

Enzyme Numbers (IUBMB) for USP1 Gene

Gene Ontology (GO) - Molecular Function for USP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
genes like me logo Genes that share ontologies with USP1: view
genes like me logo Genes that share phenotypes with USP1: view

Animal Models for USP1 Gene

MGI Knock Outs for USP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP1 Gene

Localization for USP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP1 Gene COMPARTMENTS Subcellular localization image for USP1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for USP1 Gene

Pathways & Interactions for USP1 Gene

genes like me logo Genes that share pathways with USP1: view

Pathways by source for USP1 Gene

1 Cell Signaling Technology pathway for USP1 Gene
1 KEGG pathway for USP1 Gene
1 GeneGo (Thomson Reuters) pathway for USP1 Gene
1 Qiagen pathway for USP1 Gene

Gene Ontology (GO) - Biological Process for USP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006282 regulation of DNA repair IDA 18082604
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0035520 monoubiquitinated protein deubiquitination IMP 20129063
GO:0036297 interstrand cross-link repair TAS --
genes like me logo Genes that share ontologies with USP1: view

No data available for SIGNOR curated interactions for USP1 Gene

Drugs & Compounds for USP1 Gene

(2) Drugs for USP1 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SJB2-043 Pharma USP1 inhibitor 0
ML323 Pharma 0

(1) Additional Compounds for USP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for USP1 Gene

Compound Action Cas Number
SJB2-043 USP1 inhibitor 63388-44-3
genes like me logo Genes that share compounds with USP1: view

Transcripts for USP1 Gene

Unigene Clusters for USP1 Gene

Ubiquitin specific peptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP1 Gene

No ASD Table

Relevant External Links for USP1 Gene

GeneLoc Exon Structure for
USP1
ECgene alternative splicing isoforms for
USP1

Expression for USP1 Gene

mRNA expression in normal human tissues for USP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP1 Gene

This gene is overexpressed in Serum (40.3) and Liver (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP1 Gene



SOURCE GeneReport for Unigene cluster for USP1 Gene Hs.35086

genes like me logo Genes that share expression patterns with USP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP1 Gene

Orthologs for USP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP1 35
  • 93.4 (n)
  • 92.34 (a)
USP1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP1 35
  • 94.44 (n)
  • 94.39 (a)
USP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp1 35
  • 86.93 (n)
  • 88.76 (a)
Usp1 16
Usp1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP1 35
  • 99.66 (n)
  • 99.62 (a)
USP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp1 35
  • 87.07 (n)
  • 88.78 (a)
oppossum
(Monodelphis domestica)
Mammalia USP1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP1 35
  • 72.74 (n)
  • 74.36 (a)
USP1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2887 35
usp1 35
  • 63.2 (n)
  • 59.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398530 35
zebrafish
(Danio rerio)
Actinopterygii usp1 35
  • 58.57 (n)
  • 55.53 (a)
wufb43a02 35
usp1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15817 36
  • 15 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 36
  • 13 (a)
ManyToMany
UBP9 36
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToOne
Species with no ortholog for USP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP1 Gene

ENSEMBL:
Gene Tree for USP1 (if available)
TreeFam:
Gene Tree for USP1 (if available)

Paralogs for USP1 Gene

genes like me logo Genes that share paralogs with USP1: view

Variants for USP1 Gene

Sequence variations from dbSNP and Humsavar for USP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs593519 -- 62,444,037(-) aaatg(A/C)cccac intron-variant
rs597076 -- 62,452,194(+) ACACT(A/T)TAATA downstream-variant-500B
rs597078 -- 62,452,186(+) TTGGG(A/C/G/T)TAACA downstream-variant-500B
rs597277 -- 62,445,916(-) ctgca(A/C)cttcc intron-variant
rs597470 -- 62,452,125(+) GTTAA(G/T)GGACA downstream-variant-500B

Variation tolerance for USP1 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP1 Gene

HapMap Linkage Disequilibrium report
USP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP1 Gene

Disorders for USP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association - COSMIC cancer census association via MalaCards
Search USP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP1

Genetic Association Database (GAD)
USP1
Human Genome Epidemiology (HuGE) Navigator
USP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP1
genes like me logo Genes that share disorders with USP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP1 Gene

Publications for USP1 Gene

  1. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. (PMID: 9806842) Fjiwara T. … Tanaka K. (Genomics 1998) 3 4 23 67
  2. CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. (PMID: 20129063) Terai K. … Dutta A. (Mol. Cell 2010) 3 23
  3. Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. (PMID: 20147293) Lee K.Y. … Myung K. (J. Biol. Chem. 2010) 3 23
  4. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. (PMID: 18082604) Cohn M.A. … D'Andrea A.D. (Mol. Cell 2007) 3 23
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3

Products for USP1 Gene

Sources for USP1 Gene

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