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Aliases for USO1 Gene

Aliases for USO1 Gene

  • USO1 Vesicle Transport Factor 2 3
  • TAP 3 4 6
  • Transcytosis Associated Protein 2 3
  • P115 3 6
  • VDP 3 4
  • USO1 Homolog, Vesicle Docking Protein (Yeast) 2
  • USO1 Vesicle Docking Protein Homolog (Yeast) 2
  • General Vesicular Transport Factor P115 3
  • USO1 Vesicle Docking Protein Homolog 3
  • Transcytosis-Associated Protein 4
  • Vesicle Docking Protein P115 3
  • Vesicle Docking Protein 2
  • Vesicle-Docking Protein 4
  • Protein USO1 Homolog 4

External Ids for USO1 Gene

Previous GeneCards Identifiers for USO1 Gene

  • GC04P076868
  • GC04P076649
  • GC04P072397

Summaries for USO1 Gene

Entrez Gene Summary for USO1 Gene

  • The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for USO1 Gene

USO1 (USO1 Vesicle Transport Factor) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for USO1 Gene

  • General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).

Gene Wiki entry for USO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USO1 Gene

Genomics for USO1 Gene

Regulatory Elements for USO1 Gene

Genomic Location for USO1 Gene

Start:
75,724,587 bp from pter
End:
75,814,286 bp from pter
Size:
89,700 bases
Orientation:
Plus strand

Genomic View for USO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USO1 Gene

Proteins for USO1 Gene

  • Protein details for USO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60763-USO1_HUMAN
    Recommended name:
    General vesicular transport factor p115
    Protein Accession:
    O60763
    Secondary Accessions:
    • B2RAQ0
    • Q6PK63
    • Q86TB8
    • Q8N592

    Protein attributes for USO1 Gene

    Size:
    962 amino acids
    Molecular mass:
    107895 Da
    Quaternary structure:
    • Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF.
    SequenceCaution:
    • Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USO1 Gene

    Alternative splice isoforms for USO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USO1 Gene

Proteomics data for USO1 Gene at MOPED

Post-translational modifications for USO1 Gene

  • Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.
  • Ubiquitination at Lys202, Lys580, Lys705, and Lys919
  • Modification sites at PhosphoSitePlus

Other Protein References for USO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for USO1 Gene

Domains for USO1 Gene

Suggested Antigen Peptide Sequences for USO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60763

UniProtKB/Swiss-Prot:

USO1_HUMAN :
  • O60763
Domain:
  • Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain.
Family:
  • Belongs to the VDP/USO1/EDE1 family.
Similarity:
  • Contains 12 ARM repeats.
genes like me logo Genes that share domains with USO1: view

No data available for Gene Families for USO1 Gene

Function for USO1 Gene

Molecular function for USO1 Gene

UniProtKB/Swiss-Prot Function:
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).

Gene Ontology (GO) - Molecular Function for USO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with USO1: view

Phenotypes for USO1 Gene

genes like me logo Genes that share phenotypes with USO1: view

Animal Model Products

miRNA for USO1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for USO1 Gene

Localization for USO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USO1 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USO1 Gene COMPARTMENTS Subcellular localization image for USO1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for USO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IBA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with USO1: view

Pathways for USO1 Gene

genes like me logo Genes that share pathways with USO1: view

Pathways by source for USO1 Gene

Gene Ontology (GO) - Biological Process for USO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport --
GO:0045056 transcytosis IBA --
genes like me logo Genes that share ontologies with USO1: view

Compounds for USO1 Gene

(2) Novoseek inferred chemical compound relationships for USO1 Gene

Compound -log(P) Hits PubMed IDs
atp 19.3 8
alanine 0 2
genes like me logo Genes that share compounds with USO1: view

Transcripts for USO1 Gene

Unigene Clusters for USO1 Gene

USO1 vesicle transport factor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USO1 Gene

No ASD Table

Relevant External Links for USO1 Gene

GeneLoc Exon Structure for
USO1
ECgene alternative splicing isoforms for
USO1

Expression for USO1 Gene

mRNA expression in normal human tissues for USO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USO1 Gene

This gene is overexpressed in Muscle - Skeletal (7.2).

Protein differential expression in normal tissues for USO1 Gene

This gene is overexpressed in Nasal epithelium (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for USO1 Gene

SOURCE GeneReport for Unigene cluster for USO1 Gene Hs.744877

genes like me logo Genes that share expressions with USO1: view

Expression partners for USO1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for USO1 Gene

Orthologs for USO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USO1 35
  • 93.02 (n)
  • 95.52 (a)
USO1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USO1 35
  • 92.64 (n)
  • 95.22 (a)
USO1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uso1 35
  • 86.65 (n)
  • 93.08 (a)
Uso1 16
Uso1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USO1 35
  • 99.76 (n)
  • 99.58 (a)
USO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uso1 35
  • 86.65 (n)
  • 92.44 (a)
oppossum
(Monodelphis domestica)
Mammalia USO1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USO1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves USO1 35
  • 72.31 (n)
  • 82.42 (a)
USO1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USO1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uso1 35
  • 72.97 (n)
  • 76.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29972 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334773 35
  • 70.09 (n)
  • 76.41 (a)
zgc55298 35
uso1 36
  • 71 (a)
OneToMany
USO1 (2 of 2) 36
  • 75 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9145 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009840 35
  • 52.89 (n)
  • 53.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta p115 35
  • 52.87 (n)
  • 51.41 (a)
p115 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea uso-1 35
  • 47.54 (n)
  • 36.27 (a)
uso-1 36
  • 22 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER045C 35
  • 43.83 (n)
  • 31.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05281g 35
  • 42.3 (n)
  • 28.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes USO1 35
  • 42.11 (n)
  • 27.92 (a)
USO1 36
  • 10 (a)
OneToOne
USO1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4156 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01644 35
  • 40.75 (n)
  • 29.51 (a)
Species with no ortholog for USO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USO1 Gene

ENSEMBL:
Gene Tree for USO1 (if available)
TreeFam:
Gene Tree for USO1 (if available)

Paralogs for USO1 Gene

No data available for Paralogs for USO1 Gene

Variants for USO1 Gene

Sequence variations from dbSNP and Humsavar for USO1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs178939 -- 75,796,989(+) ACTTA(A/C/G)AAAAG intron-variant
rs186563 -- 75,797,171(+) CTCCA(A/C/G)TCCCC intron-variant
rs188969 -- 75,768,707(-) aagat(C/G)agaag intron-variant
rs226416 -- 75,771,745(-) AAATC(A/G)GAATG intron-variant
rs324684 -- 75,805,916(+) AATGT(C/T)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USO1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
esv2657151 CNV Deletion 23128226
nsv509008 CNV Insertion 20534489
nsv4392 CNV Insertion 18451855
esv990235 CNV Insertion 20482838

Relevant External Links for USO1 Gene

HapMap Linkage Disequilibrium report
USO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USO1 Gene

Disorders for USO1 Gene

(6) Novoseek inferred disease relationships for USO1 Gene

Disease -log(P) Hits PubMed IDs
virus infection 0 1
autoimmune diseases 0 2
diabetes mellitus insulin-dependent 0 1
tumors 0 4
cancer 0 3

Relevant External Links for USO1

Genetic Association Database (GAD)
USO1
genes like me logo Genes that share disorders with USO1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for USO1 Gene

Publications for USO1 Gene

  1. Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane. (PMID: 9478999) Sohda M. … Ikehara Y. (J. Biol. Chem. 1998) 2 3 4 23
  2. Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis. (PMID: 14736916) Puthenveedu M.A. … Linstedt A.D. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 23
  3. Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. (PMID: 10903204) Allan B.B. … Balch W.E. (Science 2000) 3 23
  4. Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments. (PMID: 10931861) Dirac-Svejstrup A.B. … Warren G. (J. Cell Biol. 2000) 3 23
  5. Coat-tether interaction in Golgi organization. (PMID: 18434597) Guo Y. … Linstedt A.D. (Mol. Biol. Cell 2008) 3 23

Products for USO1 Gene

Sources for USO1 Gene

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