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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USO1 Gene

protein-coding   GIFtS: 54
GCID: GC04P076649

USO1 Vesicle Transport Factor

(Previous names: USO1 homolog, vesicle docking protein (yeast), USO1 vesicle...)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
USO1 Vesicle Transport Factor1 2     Vesicle Docking Protein1
Transcytosis Associated Protein1 2     P1152
Protein USO1 Homolog2 3     General Vesicular Transport Factor P1152
Vesicle-Docking Protein2 3     USO1 Homolog, Vesicle Docking Protein2
TAP2 3     USO1 Vesicle Docking Protein Homolog2
VDP2 3     Vesicle Docking Protein P1152
USO1 Homolog, Vesicle Docking Protein (Yeast)1     Transcytosis-Associated Protein3
USO1 Vesicle Docking Protein Homolog (Yeast)1     

External Ids:    HGNC: 309041   Entrez Gene: 86152   Ensembl: ENSG000001387687   OMIM: 6033445   UniProtKB: O607633   

Export aliases for USO1 gene to outside databases

Previous GC identifers: GC04P076868 GC04P072397


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USO1 Gene:
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi
apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the
Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this
protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it
interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to
the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene
product, GM130 and giantin in a sequential manner. (provided by RefSeq, Jul 2008)

GeneCards Summary for USO1 Gene: 
USO1 (USO1 vesicle transport factor) is a protein-coding gene. Diseases associated with USO1 include spondylitis, and ankylosing spondylitis, and among its related super-pathways are Mitotic M-M/G1 phases and Cell Cycle, Mitotic. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: USO1_HUMAN, O60763
Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is
required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act
as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in
proximity (By similarity)

Gene Wiki entry for USO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USO1 gene promoter:
         AhR   Brachyury   IRF-1   E47   GATA-1   AREB6   HFH-1   Hand1   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for USO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

USO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USO1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P076649:  view genomic region     (about GC identifiers)

Start:
76,649,777 bp from pter      End:
76,735,382 bp from pter
Size:
85,606 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: USO1_HUMAN, O60763 (See protein sequence)
Recommended Name: General vesicular transport factor p115  
Size: 962 amino acids; 107895 Da
Subunit: Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two
globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF
Subcellular location: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles
between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is
found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes
Sequence caution: Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
1 PDB 3D structure from and Proteopedia for USO1:
2W3C (3D)    
Secondary accessions: B2RAQ0 Q6PK63 Q86TB8 Q8N592
Alternative splicing: 2 isoforms:  O60763-1   O60763-2   

Explore the universe of human proteins at neXtProt for USO1: NX_O60763

Explore proteomics data for USO1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells.
    Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60763

  • USO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USO1 Protein Expression
    REFSEQ proteins: NP_003706.1  
    ENSEMBL proteins: 
     ENSP00000474837   ENSP00000264904   ENSP00000411698   ENSP00000440586   ENSP00000444850  
    Reactome Protein details: O60763
    Human Recombinant Protein Products for USO1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm ----

    USO1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR024095 Vesicle_P115-like
     IPR000225 Armadillo
     IPR006955 Uso1_p115_C
     IPR016024 ARM-type_fold
     IPR006953 Vesicle_Uso1_P115_head

    Graphical View of Domain Structure for InterPro Entry O60763

    ProtoNet protein and cluster: O60763

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB006953 Uso1/p115 like vesicle tethering protein


    UniProtKB/Swiss-Prot: USO1_HUMAN, O60763
    Domain: Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain
    Similarity: Belongs to the VDP/USO1/EDE1 family
    Similarity: Contains 12 ARM repeats


    USO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USO1_HUMAN, O60763
    Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is
    required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act
    as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in
    proximity (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008565protein transporter activity IEA--
         
    USO1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Uso1):
     cellular  mortality/aging 

    USO1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USO1 
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    miRNA
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    miRTarBase miRNAs that target USO1:
    hsa-mir-197 (MIRT003825)

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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate USO1 (see all 13):
    hsa-miR-579 hsa-miR-548p hsa-miR-3152-3p hsa-miR-545 hsa-miR-138-2* hsa-miR-124 hsa-miR-514 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSO1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USO1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Mitotic Prophase0.70
    4Golgi Cisternae Pericentriolar Stack Reorganization
    Golgi Cisternae Pericentriolar Stack Reorganization
    5Arf1 pathway
    Arf1 pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for USO1
        Arf1 pathway

    5/6        Reactome Pathways for USO1 (see all 6)
        Golgi Cisternae Pericentriolar Stack Reorganization
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases



    USO1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/683 Interacting proteins for USO1 (O607632, 3 ENSP000004116984) via UniProtKB, MINT, STRING, and/or I2D (see all 683)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006886intracellular protein transport IEA--
    GO:0016192vesicle-mediated transport ----
    GO:0045056transcytosis ----
    GO:0048280vesicle fusion with Golgi apparatus IEA--

    USO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    USO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USO1

    2 Novoseek inferred chemical compound relationships for USO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 19.3 13 11290739 (3), 15577206 (1), 15900495 (1), 7895159 (1) (see all 6)
    alanine 0 2 15900495 (1), 15634919 (1)

    Search CenterWatch for drugs/clinical trials and news about USO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USO1 gene: 
    NM_003715.2  

    Unigene Cluster for USO1:

    USO1 vesicle transport factor
    Hs.744877  [show with all ESTs]
    Unigene Representative Sequence: AL832010
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603759 ENST00000264904 ENST00000512893 ENST00000441296 ENST00000508454
    ENST00000538159 ENST00000514213
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate USO1 (see all 13):
    hsa-miR-579 hsa-miR-548p hsa-miR-3152-3p hsa-miR-545 hsa-miR-138-2* hsa-miR-124 hsa-miR-514 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSO1 3' UTR sequence
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    Additional mRNA sequence: 

    AK002093.1 AK314289.1 AL832010.2 AL833753.1 BC006398.2 BC016672.1 BC032654.1 D86326.1 

    23 DOTS entries:

    DT.91825578  DT.95187138  DT.87024804  DT.100725586  DT.100678530  DT.100869589  DT.70104256  DT.91987770 
    DT.40249199  DT.91732272  DT.95187137  DT.100798016  DT.99993156  DT.100798019  DT.121228568  DT.121228621 
    DT.121271527  DT.87024816  DT.91836604  DT.40107278  DT.91909094  DT.95187151  DT.95229639 

    24/367 AceView cDNA sequences (see all 367):

    AU135545 CB270082 Z44401 BM820820 BF796790 N76450 CA867650 AV715367 
    AU132783 BE887021 AL833753 CD243166 BM723930 BG618876 AW504324 AW241400 
    BE773308 BM826672 AA948155 AU123709 BG286981 AU132153 AA279604 BU073251 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USO1 expression in normal human tissues (normalized intensities)      USO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGACAAT
    USO1 Expression
    About this image


    USO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   

    See USO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USO1

    SOURCE GeneReport for Unigene cluster: Hs.744877
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USO1 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uso11 , 5 USO1 homolog, vesicle docking protein (yeast)1, 5 86.5(n)1
    92.59(a)1
      5 (46.05 cM)5
    560411  NM_019490.11  NP_062363.11 
     921379385 
    chicken
    (Gallus gallus)
    Aves USO11 USO1 vesicle docking protein homolog (yeast) 72.27(n)
    81.81(a)
      422575  NM_001031139.1  NP_001026310.1 
    lizard
    (Anolis carolinensis)
    Reptilia USO16
    USO1 vesicle transport factor
    72(a)
    1 ↔ 1
    6(59045791-59095089)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.299722 Xenopus laevis transcribed sequence with moderate similarity more 77.04(n)    CA793946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc552982 similar to vesicle docking protein p115 75(n)   393124  BC045300.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p1151 CG1422-PA 51.41(n)
    49.69(a)
      31698  NM_132189.2  NP_572417.1 
    worm
    (Caenorhabditis elegans)
    Secernentea uso-11 Protein USO-1 46.64(n)
    35.42(a)
      178311  NM_001047509.1  NP_001040974.1 
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AER045C1 AER045Cp 42.14(n)
    29.25(a)
      4621107  NM_210259.1  NP_984905.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GC61 golgin candidate 6 42.34(n)
    31.2(a)
      822375  NM_113669.2  NP_566820.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05389001 hypothetical protein 43.34(n)
    30.02(a)
      4352428  NM_001073477.1  NP_001066945.1 


    ENSEMBL Gene Tree for USO1 (if available)
    TreeFam Gene Tree for USO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1589 SNPs in USO1 are shown (see all 1589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140704551,2
    F--72395788(+) GTCTAC/TGGTAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1459912161,2
    --72395836(+) TTAGCA/GCACAG 1 -- us2k10--------
    rs1165503151,2
    F--72396040(+) GAGACA/GGTGGT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs726494691,2
    C--72396160(+) ACATAC/TAGATG 1 -- us2k10--------
    rs1883014511,2
    --72396175(+) CCTACA/CTTTTA 1 -- us2k10--------
    rs76913851,2
    C,F,H--72396214(+) TTGAGT/CCTTAA 1 -- us2k128Minor allele frequency- C:0.08NS EA NA WA CSA 2783
    rs1434640401,2
    --72396298(+) AGTATA/GTGGGG 1 -- us2k10--------
    rs119340861,2
    C,F,H--72396339(+) taaatC/Tataac 1 -- us2k113Minor allele frequency- T:0.08NS EA NA WA 1320
    rs1466769891,2
    --72396368(+) AAGGAC/GTTTGC 1 -- us2k10--------
    rs76962411,2
    C,H--72396373(+) GTTTGG/CACTTT 1 -- us2k1 tfbs315Minor allele frequency- C:0.04NS EA NA WA 782

    HapMap Linkage Disequilibrium report for USO1 (76649777 - 76735382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657151CNV Deletion23128226
    nsv509008CNV Insertion20534489
    nsv4392CNV Insertion18451855
    esv990235CNV Insertion20482838
    nsv7363OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603344    OMIM disorders: --

    15 diseases for USO1:    About MalaCards
    spondylitis    ankylosing spondylitis    measles    kaposi's sarcoma
    herpes simplex    inflammatory bowel disease    diabetes mellitus    hypertension
    renal cell carcinoma    sarcoma    multiple sclerosis    hepatitis c
    melanoma    hepatitis    endotheliitis


    USO1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for USO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0 1 9195970 (1)
    autoimmune diseases 0 2 9278325 (1), 8847232 (1)
    diabetes mellitus insulin-dependent 0 1 8157258 (1)
    tumors 0 4 11222495 (2), 9216736 (1), 18385764 (1)
    cancer 0 4 8980397 (2), 17951169 (1)
    carcinoma renal cell 0 2 9216736 (1), 9816317 (1)

    Genetic Association Database (GAD): USO1

    Export disorders for USO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USO1 gene, integrated from 9 sources (see all 172):
    (articles sorted by number of sources associating them with USO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane. (PubMed id 9478999)1, 2, 3, 9 Sohda M.... Ikehara Y. (1998)
    2. Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis. (PubMed id 14736916)1, 3, 9 Puthenveedu M.A. and Linstedt A.D. (2004)
    3. The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. (PubMed id 19454686)1, 2 Merk M.... Bucala R. (2009)
    4. Unusual armadillo fold in the human general vesicular transport factor p115. (PubMed id 19247479)1, 2 Striegl H.... Heinemann U. (2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Golgins and GTPases, giving identity and structure to the Golgi apparatus. (PubMed id 15979508)1, 3 Short B....Barr F.A. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Vesicle tethering complexes in membrane traffic. (PubMed id 12077354)1, 3 Whyte J.R. and Munro S. (2002)
    10. The vesicle docking protein p115 binds GM130, a cis-G olgi matrix protein, in a mitotically regulated manner. (PubMed id 9150144)1, 3 Nakamura N....Warren G. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8615 HGNC: 30904 AceView: VDP Ensembl:ENSG00000138768 euGenes: HUgn8615
    ECgene: USO1 H-InvDB: USO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USO1 gene:
    Search GeneIP for patents involving USO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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