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USO1 Gene

protein-coding   GIFtS: 50
GCID: GC04P076649

USO1 Vesicle Transport Factor

(Previous names: USO1 homolog, vesicle docking protein (yeast), USO1 vesicle...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
USO1 Vesicle Transport Factor1 2     General Vesicular Transport Factor P1152
TAP2 3 5     USO1 Vesicle Docking Protein Homolog2
Transcytosis Associated Protein1 2     Vesicle Docking Protein P1152
VDP2 3     Protein USO1 Homolog3
USO1 Homolog, Vesicle Docking Protein (Yeast)1     Transcytosis-Associated Protein3
USO1 Vesicle Docking Protein Homolog (Yeast)1     Vesicle-Docking Protein3
Vesicle Docking Protein1     p1155
P1152     

External Ids:    HGNC: 309041   Entrez Gene: 86152   Ensembl: ENSG000001387687   OMIM: 6033445   UniProtKB: O607633   

Export aliases for USO1 gene to outside databases

Previous GC identifers: GC04P076868 GC04P072397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USO1 Gene:
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi
apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the
Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this
protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it
interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to
the Golgi apparatus. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2014)

GeneCards Summary for USO1 Gene:
USO1 (USO1 vesicle transport factor) is a protein-coding gene. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: USO1_HUMAN, O60763
Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is
required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act
as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in
proximity (By similarity)

Gene Wiki entry for USO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the USO1 gene promoter:
         AhR   Brachyury   IRF-1   E47   GATA-1   AREB6   HFH-1   Hand1   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSO1 promoter sequence
   Search Chromatin IP Primers for USO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

USO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USO1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P076649:  view genomic region     (about GC identifiers)

Start:
76,649,777 bp from pter      End:
76,735,382 bp from pter
Size:
85,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: USO1_HUMAN, O60763 (See protein sequence)
Recommended Name: General vesicular transport factor p115  
Size: 962 amino acids; 107895 Da
Subunit: Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two
globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF
Sequence caution: Sequence=AAH06398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
1 PDB 3D structure from and Proteopedia for USO1:
2W3C (3D)    
Secondary accessions: B2RAQ0 Q6PK63 Q86TB8 Q8N592
Alternative splicing: 2 isoforms:  O60763-1   O60763-2   

Explore the universe of human proteins at neXtProt for USO1: NX_O60763

Explore proteomics data for USO1 at MOPED

Post-translational modifications: 

  • Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells.
    Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation1
  • Ubiquitination2 at Lys202, Lys580, Lys705, Lys919
  • Modification sites at PhosphoSitePlus

  • See USO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276978.1  NP_003706.2  

    ENSEMBL proteins: 
     ENSP00000474837   ENSP00000264904   ENSP00000411698   ENSP00000440586   ENSP00000444850  
    Reactome Protein details: O60763

    USO1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for USO1 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for USO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000225 Armadillo
     IPR006955 Uso1_p115_C
     IPR006953 Vesicle_Uso1_P115_head
     IPR024095 Vesicle_P115-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O60763

    ProtoNet protein and cluster: O60763

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB006953 Uso1/p115 like vesicle tethering protein


    UniProtKB/Swiss-Prot: USO1_HUMAN, O60763
    Domain: Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain
    Similarity: Belongs to the VDP/USO1/EDE1 family
    Similarity: Contains 12 ARM repeats


    Find genes that share domains with USO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USO1_HUMAN, O60763
    Function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is
    required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act
    as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in
    proximity (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008565protein transporter activity IBA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with USO1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Uso1):
     cellular  mortality/aging 

    Find genes that share phenotypes with USO1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USO1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target USO1:
    hsa-mir-197-3p (MIRT003825), hsa-mir-421 (MIRT039355), hsa-let-7b-5p (MIRT032299), hsa-mir-335-5p (MIRT017638)

    Block miRNA regulation of human, mouse, rat USO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USO1 (see all 13):
    hsa-miR-579 hsa-miR-548p hsa-miR-3152-3p hsa-miR-545 hsa-miR-138-2* hsa-miR-124 hsa-miR-514 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USO1
    Predesigned siRNA for gene silencing in human, mouse, rat USO1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for USO1 (see all 6)
    OriGene ORF clones in mouse, rat for USO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USO1 (NM_003715)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    USO1_HUMAN, O60763: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles
    between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is
    found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IBA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with USO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USO1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56
    Golgi Cisternae Pericentriolar Stack Reorganization0.00
    3Arf1 pathway
    Arf1 pathway


    Find genes that share SuperPaths with USO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for USO1
        Arf1 pathway

    1 Reactome Pathway for USO1
        Golgi Cisternae Pericentriolar Stack Reorganization


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USO1
    Interactions:

        GeneGlobe Interaction Network for USO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USO1 (O607632, 3 ENSP000004116984) via UniProtKB, MINT, STRING, and/or I2D (see all 787)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006886intracellular protein transport IBA--
    GO:0006888ER to Golgi vesicle-mediated transport IBA--
    GO:0016192vesicle-mediated transport ----
    GO:0045056transcytosis IBA--

    Find genes that share ontologies with USO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USO1

    2 Novoseek inferred chemical compound relationships for USO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 19.3 13 11290739 (3), 15577206 (1), 15900495 (1), 7895159 (1) (see all 6)
    alanine 0 2 15900495 (1), 15634919 (1)



    Find genes that share compounds with USO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USO1 gene (2 alternative transcripts): 
    NM_001290049.1  NM_003715.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603759 ENST00000264904 ENST00000512893 ENST00000441296 ENST00000508454
    ENST00000538159 ENST00000514213
    miRNA
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    Block miRNA regulation of human, mouse, rat USO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USO1 (see all 13):
    hsa-miR-579 hsa-miR-548p hsa-miR-3152-3p hsa-miR-545 hsa-miR-138-2* hsa-miR-124 hsa-miR-514 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidUSO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USO1
    Predesigned siRNA for gene silencing in human, mouse, rat USO1
    Clone
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    OriGene clones in human, mouse for USO1 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USO1 (NM_003715)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USO1
    Primer
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    OriGene qPCR primer pairs and template standards for USO1
    OriGene qSTAR qPCR primer pairs in human, mouse for USO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USO1
      QuantiTect SYBR Green Assays in human, mouse, rat USO1
      QuantiFast Probe-based Assays in human, mouse, rat USO1

    Selected AceView cDNA sequences (see all 367):

    BM723930 AL833753 AU135545 CB270082 CD243166 BX952310 Z44401 BM820820 
    BF796790 N76450 CA867650 AV715367 AU132783 BE887021 BG618876 AW504324 
    AW241400 BE773308 BM826672 AA948155 AU123709 BG286981 AU132153 AA279604 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGACAAT
    USO1 Expression
    About this image


    USO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    USO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USO1 Protein Expression
        Custom PCR Arrays for USO1
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    QuantiFast Probe-based Assays in human, mouse, rat USO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USO1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uso11 , 5 USO1 homolog, vesicle docking protein (yeast)5
    USO1 vesicle docking factor1
    86.65(n)1
    93.08(a)1
      5 (46.05 cM)5
    560411  NM_019490.11  NP_062363.11 
     921379385 
    chicken
    (Gallus gallus)
    Aves USO11 USO1 vesicle docking protein homolog (yeast) 72.31(n)
    82.42(a)
      422575  NM_001031139.1  NP_001026310.1 
    lizard
    (Anolis carolinensis)
    Reptilia USO16
    USO1 vesicle transport factor
    72(a)
    1 ↔ 1
    6(59045791-59095089)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.299722 Xenopus laevis transcribed sequence with moderate similarity more 77.04(n)    CA793946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc552982 similar to vesicle docking protein p115 75(n)   393124  BC045300.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p1151 p115 52.87(n)
    51.41(a)
      31698  NM_132189.2  NP_572417.1 
    worm
    (Caenorhabditis elegans)
    Secernentea uso-11 uso-1 47.54(n)
    36.27(a)
      178311  NM_001047509.1  NP_001040974.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes USO1(YDL058W)4
    USO11
    Essential protein involved in the vesicle-mediated more4
    USO11
    42.11(n)1
    27.92(a)1
      4(345665-351037)4
    8515011, 4  NP_010225.11, 4 


    ENSEMBL Gene Tree for USO1 (if available)
    TreeFam Gene Tree for USO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USO1 (see all 1589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140704551,2
    F--72395788(+) GTCTAC/TGGTAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1459912161,2
    --72395836(+) TTAGCA/GCACAG 1 -- us2k10--------
    rs1165503151,2
    F--72396040(+) GAGACA/GGTGGT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs726494691,2
    C--72396160(+) ACATAC/TAGATG 1 -- us2k10--------
    rs1883014511,2
    --72396175(+) CCTACA/CTTTTA 1 -- us2k10--------
    rs76913851,2
    C,F,H--72396214(+) TTGAGT/CCTTAA 1 -- us2k128Minor allele frequency- C:0.08NS EA NA WA CSA 2783
    rs1434640401,2
    --72396298(+) AGTATA/GTGGGG 1 -- us2k10--------
    rs119340861,2
    C,F,H--72396339(+) taaatC/Tataac 1 -- us2k113Minor allele frequency- T:0.08NS EA NA WA 1320
    rs1466769891,2
    --72396368(+) AAGGAC/GTTTGC 1 -- us2k10--------
    rs76962411,2
    C,H--72396373(+) GTTTGG/CACTTT 1 -- us2k1 tfbs315Minor allele frequency- C:0.04NS EA NA WA 782

    HapMap Linkage Disequilibrium report for USO1 (76649777 - 76735382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657151CNV Deletion23128226
    nsv509008CNV Insertion20534489
    nsv4392CNV Insertion18451855
    esv990235CNV Insertion20482838
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USO1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603344    OMIM disorders: --


    Find genes that share disorders with USO1           About GenesLikeMe

    6 Novoseek inferred disease relationships for USO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0 1 9195970 (1)
    autoimmune diseases 0 2 9278325 (1), 8847232 (1)
    diabetes mellitus insulin-dependent 0 1 8157258 (1)
    tumors 0 4 11222495 (2), 9216736 (1), 18385764 (1)
    cancer 0 4 8980397 (2), 17951169 (1)
    carcinoma renal cell 0 2 9216736 (1), 9816317 (1)

    Genetic Association Database (GAD): USO1

    Export disorders for USO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USO1 gene, integrated from 10 sources (see all 173):
    (articles sorted by number of sources associating them with USO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane. (PubMed id 9478999)1, 2, 3, 9 Sohda M.... Ikehara Y. (J. Biol. Chem. 1998)
    2. Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis. (PubMed id 14736916)1, 3, 9 Puthenveedu M.A. and Linstedt A.D. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. (PubMed id 19454686)1, 2 Merk M.... Bucala R. (J. Immunol. 2009)
    4. Unusual armadillo fold in the human general vesicular transport factor p115. (PubMed id 19247479)1, 2 Striegl H.... Heinemann U. (PLoS ONE 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Golgins and GTPases, giving identity and structure to the Golgi apparatus. (PubMed id 15979508)1, 3 Short B....Barr F.A. (Biochim. Biophys. Acta 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Vesicle tethering complexes in membrane traffic. (PubMed id 12077354)1, 3 Whyte J.R. and Munro S. (J. Cell. Sci. 2002)
    10. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner. (PubMed id 9150144)1, 3 Nakamura N....Warren G. (Cell 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8615 HGNC: 30904 AceView: VDP Ensembl:ENSG00000138768 euGenes: HUgn8615
    ECgene: USO1 H-InvDB: USO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USO1 gene:
    Search GeneIP for patents involving USO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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