USMG5 Gene
protein-coding GIFtS: 44
GCID: GC10M105138
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|
up-regulated during skeletal muscle growth 5 homolog (mouse)(Previous names: upregulated during skeletal muscle growth 5, upregulated...)
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Aliases
for USMG5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Up-Regulated During Skeletal Muscle Growth 5 Homolog (Mouse)1 2 | | MGC146971 | | DAPIT1 2 3 | | Upregulated During Skeletal Muscle Growth 51 | | BA792D24.41 | | Upregulated During Skeletal Muscle Growth 5 Homolog (Mouse)1 | | Diabetes-Associated Protein In Insulin-Sensitive Tissues2 3 | | Up-Regulated During Skeletal Muscle Growth Protein 52 | | HCVFTP22 3 | | Upregulated During Skeletal Muscle Growth 5 Homolog2 | | HCV F-Transactivated Protein 22 3 | | |
Export aliases for USMG5 gene to outside databasesPrevious GC identifers: GC10M104814 GC10M098779 |
Summaries
for USMG5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: USMG5_HUMAN, Q96IX5Function: Plays a critical role in maintaining the ATP synthase population in mitochondria
|
Genomic Views
for USMG5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USMG5 gene promoter:
RFX1 RP58 AML1a FOXO3 POU3F2 Evi-1 FOXO3b SRY FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USMG5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USMG5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.33 Ensembl cytogenetic band: 10q24.33 HGNC cytogenetic band: 10q24.33USMG5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M105138: view genomic region
(about GC identifiers)
Start:
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105,148,798 bp from pter |
End:
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105,156,223 bp from pter |
Size:
|
7,426 bases |
Orientation:
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minus strand |
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Proteins
for USMG5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: USMG5_HUMAN, Q96IX5 (See
protein sequence)Recommended Name: Up-regulated during skeletal muscle growth protein 5 Size: 58 amino acids; 6458 Da
Subunit: Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6,MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Subcellular location: Mitochondrion membrane; Single-pass membrane protein (By similarity)
Secondary accessions: B2R4N2 D3DR92Explore the universe of human proteins at neXtProt for USMG5: NX_Q96IX5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IX5
USMG5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001193355.1 NP_001193356.1 NP_116136.1
ENSEMBL proteins: ENSP00000358840 ENSP00000358830 ENSP00000311245 ENSP00000337705 ENSP00000358826
Human Recombinant Protein Products for USMG5:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
ISS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
USMG5 for ontologies About GeneDecksing
USMG5 Antibody Products:
Assay Products for USMG5: |
Protein
Domains /
Families
for USMG5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USMG5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96IX5ProtoNet protein and cluster: Q96IX5 |
Function
for USMG5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: USMG5_HUMAN, Q96IX5Function: Plays a critical role in maintaining the ATP synthase population in mitochondriaInduction: Transactivated by SBP1Phenotypes:
1 GenomeRNAi human phenotype for USMG5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for USMG5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USMG5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USMG5 |
|
Pathways & Interactions
for USMG5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USMG5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for USMG5 (Q96IX52, 3 ENSP000003112454) via UniProtKB, MINT, STRING, and/or I2D (see all 57)About this table
|
Drugs & Compounds
for USMG5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USMG5
Search CenterWatch for drugs/clinical trials and news about USMG5
|
Transcripts
for USMG5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USMG5 gene (3 alternative transcripts): NM_001206426.1 NM_001206427.1 NM_032747.3 Unigene Cluster for USMG5: Up-regulated during skeletal muscle growth 5 homolog (mouse) Hs.500921 [show with all ESTs]Unigene Representative Sequence: BE8899625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369825 ENST00000369815(uc021pxl.1) ENST00000309579(uc001kwx.2)
ENST00000337003(uc001kww.2) ENST00000369811
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): USMG5 (NM_032747) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USMG5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USMG5 |
Additional cDNA sequence: AJ272056.1 AK311888.1 AL110185.1 AY740522.1 BC007087.1 BC072683.1 BC091507.1 16 DOTS entries: DT.101985833 DT.121272568 DT.87046000 DT.100044262 DT.101986246 DT.100715445 DT.95274793 DT.121309801 DT.97760567 DT.121272511 DT.87045999 DT.121272503 DT.121272526 DT.92440774 DT.95238978 DT.95300736 24/233 AceView cDNA sequences (see all 233): AJ712776 BX109200 BM842118 CB108019 AJ272056 AA722455 AI133475 AA749507 AW358546 BM784503 BQ011420 BM461842 AI459928 BM786566 AI207976 AA862808 H87273 F25953 BM765916 BM661719 AI719475 BU940960 W84725 BE771230
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for USMG5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for USMG5
|
Expression
for USMG5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USMG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATAATTCA
About this image
See USMG5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USMG5
SOURCE GeneReport for Unigene cluster: Hs.500921
SABiosciences Custom PCR Arrays for USMG5
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USMG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USMG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USMG5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USMG5 |
Orthologs
for USMG5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for USMG5 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Usmg51 , 5 |
upregulated during skeletal muscle growth 51, 5 |
90.8(n)1
89.66(a)1 |
|
19 (39.23 cM)5
664771 NM_023211.41 NP_075700.21
470834715 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkeyp-80c12.106 |
si:dkeyp-80c12.10 |
64(a) |
1 ↔ 1 |
1(49938536-49941291) |
ENSEMBL Gene Tree for USMG5 (if available)
TreeFam Gene Tree for USMG5 (if available) |
Paralogs
for USMG5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USMG5 gene
USMG5 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for USMG5
PGOHUM00000237159 PGOHUM00000243791 PGOHUM00000241853
|
Genomic Variants
for USMG5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USMG5 (105148798 - 105156223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USMG5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USMG5 |
|
Disorders
/ Diseases
for USMG5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USMG5 for disorders About GeneDecksing
3  diseases for USMG5: About MalaCardshepatitis b ataxia hepatitis
Export disorders for USMG5 gene to outside databases
|
Publications
for USMG5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USMG5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with USMG5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Knockdown of DAPIT (diabetes-associated protein in in sulin-sensitive tissue) results in loss of ATP synthase in mitochondria. (PubMed id 21345788)1, 2 Ohsakaya S....Yoshida M. (2011)
- Study of transactivating effect of pre-S2 protein of hepatitis B virus and cloning of genes transactivated by pre-S2 protein with suppression subtractive hybridization. (PubMed id 16222733)1, 2 Ji D.... Guo J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Cellular and tissue expression of DAPIT, a phylogeneti cally conserved peptide. (PubMed id 22688299)1 Kontro H....Kainulainen H. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
|
External Searches for USMG5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USMG5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USMG5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USMG5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USMG5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USMG5 gene:
Search GeneIP for patents involving USMG5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USMG5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USMG5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USMG5 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for USMG5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USMG5 | | OriGene 3'-UTR Clone for USMG5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USMG5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USMG5 | | OriGene Custom Protein Services for USMG5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USMG5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USMG5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USMG5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USMG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USMG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USMG5 |
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 | | | USMG5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USMG5 |
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