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Aliases for USMG5 Gene

Aliases for USMG5 Gene

  • Up-Regulated During Skeletal Muscle Growth 5 Homolog (Mouse) 2 3 5
  • Diabetes Associated Protein In Insulin-Sensitive Tissues 2 3
  • Diabetes-Associated Protein In Insulin-Sensitive Tissues 3 4
  • HCV F-Transactivated Protein 2 3 4
  • HCVFTP2 3 4
  • DAPIT 3 4
  • Upregulated During Skeletal Muscle Growth 5 Homolog (Mouse) 2
  • Up-Regulated During Skeletal Muscle Growth Protein 5 3
  • Upregulated During Skeletal Muscle Growth 5 Homolog 3
  • Upregulated During Skeletal Muscle Growth 5 2
  • BA792D24.4 3

External Ids for USMG5 Gene

Previous GeneCards Identifiers for USMG5 Gene

  • GC10M104814
  • GC10M105138
  • GC10M098779

Summaries for USMG5 Gene

GeneCards Summary for USMG5 Gene

USMG5 (Up-Regulated During Skeletal Muscle Growth 5 Homolog (Mouse)) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

UniProtKB/Swiss-Prot for USMG5 Gene

  • Plays a critical role in maintaining the ATP synthase population in mitochondria.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USMG5 Gene

Genomics for USMG5 Gene

Regulatory Elements for USMG5 Gene

Enhancers for USMG5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G103349 1 ENCODE 11.5 +45.6 45614 1.9 HDGF ZNF133 SIN3A DMAP1 GLI4 ZNF2 ZNF48 ETS1 GLIS2 ZNF143 SLK MIR1307 USMG5 PDCD11 RNU11-3P ENSG00000260461 NEURL1-AS1 CALHM2 PCGF6 GC10M103313
GH10G103244 1 Ensembl ENCODE 9.9 +151.7 151746 0.3 CTCF ARID4B MAX CEBPG ZNF2 RAD21 RFX5 TEAD3 ZNF143 SMC3 INA RNU11-3P CNNM2 CYP17A1 MIR1307 PDCD11 USMG5 AS3MT PFN1P11 PTGES3P4
GH10G103771 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -375.9 -375908 2.0 PKNOX1 ATF1 SIN3A ZNF2 TCF12 GLIS2 GATA2 ELK1 FOS KLF7 USMG5 GSTO2 SH3PXD2A-AS1 SH3PXD2A
GH10G103417 0.6 ENCODE 11.7 -20.5 -20506 0.2 CTCF ZNF654 TRIM22 SMC3 REST RAD21 CALHM2 ENSG00000234699 NEURL1 USMG5 MIR1307 PDCD11 CALHM1 NEURL1-AS1 GC10M103406 ENSG00000273485
GH10G103416 0.4 ENCODE 11.7 -20.3 -20306 0.2 CTCF TRIM22 CALHM2 ENSG00000234699 NEURL1 USMG5 MIR1307 PDCD11 CALHM1 NEURL1-AS1 GC10M103406 ENSG00000273485
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USMG5 on UCSC Golden Path with GeneCards custom track

Promoters for USMG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032874 -87 2001 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for USMG5 Gene

103,389,041 bp from pter
103,396,513 bp from pter
7,473 bases
Minus strand

Genomic View for USMG5 Gene

Genes around USMG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USMG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USMG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USMG5 Gene

Proteins for USMG5 Gene

  • Protein details for USMG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Up-regulated during skeletal muscle growth protein 5
    Protein Accession:
    Secondary Accessions:
    • B2R4N2
    • D3DR92

    Protein attributes for USMG5 Gene

    58 amino acids
    Molecular mass:
    6458 Da
    Quaternary structure:
    • Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.

neXtProt entry for USMG5 Gene

Post-translational modifications for USMG5 Gene

  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

Other Protein References for USMG5 Gene

No data available for DME Specific Peptides for USMG5 Gene

Domains & Families for USMG5 Gene

Protein Domains for USMG5 Gene


Suggested Antigen Peptide Sequences for USMG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with USMG5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for USMG5 Gene

Function for USMG5 Gene

Molecular function for USMG5 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in maintaining the ATP synthase population in mitochondria.
UniProtKB/Swiss-Prot Induction:
Transactivated by SBP1.
genes like me logo Genes that share phenotypes with USMG5: view

Animal Models for USMG5 Gene

MGI Knock Outs for USMG5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USMG5 Gene

Localization for USMG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USMG5 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USMG5 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for USMG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005753 mitochondrial proton-transporting ATP synthase complex IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with USMG5: view

Pathways & Interactions for USMG5 Gene

genes like me logo Genes that share pathways with USMG5: view

Pathways by source for USMG5 Gene

1 BioSystems pathway for USMG5 Gene

Gene Ontology (GO) - Biological Process for USMG5 Gene


No data available for SIGNOR curated interactions for USMG5 Gene

Transcripts for USMG5 Gene

Unigene Clusters for USMG5 Gene

Up-regulated during skeletal muscle growth 5 homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USMG5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for USMG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USMG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USMG5 Gene

Protein differential expression in normal tissues from HIPED for USMG5 Gene

This gene is overexpressed in Nasal epithelium (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USMG5 Gene

Protein tissue co-expression partners for USMG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USMG5 Gene:


SOURCE GeneReport for Unigene cluster for USMG5 Gene:


Evidence on tissue expression from TISSUES for USMG5 Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Lung(4.3)
  • Heart(2.4)
  • Kidney(2.1)
  • Adrenal gland(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with USMG5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USMG5 Gene

Orthologs for USMG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USMG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USMG5 34 35
  • 100 (n)
(Mus musculus)
Mammalia Usmg5 34 16 35
  • 90.8 (n)
(Bos Taurus)
Mammalia USMG5 34 35 35
  • 90.23 (n)
(Canis familiaris)
Mammalia USMG5 34 35
  • 89.66 (n)
(Rattus norvegicus)
Mammalia Usmg5 34
  • 89.66 (n)
(Monodelphis domestica)
Mammalia USMG5 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia USMG5 35
  • 77 (a)
(Gallus gallus)
Aves USMG5 35
  • 64 (a)
(Danio rerio)
Actinopterygii USMG5 35
  • 64 (a)
Species where no ortholog for USMG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USMG5 Gene

Gene Tree for USMG5 (if available)
Gene Tree for USMG5 (if available)

Paralogs for USMG5 Gene Pseudogenes for USMG5 Gene

genes like me logo Genes that share paralogs with USMG5: view

No data available for Paralogs for USMG5 Gene

Variants for USMG5 Gene

Sequence variations from dbSNP and Humsavar for USMG5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000296052 -- 103,395,727(+) TTTCC(C/T)TTCTA intron-variant, upstream-variant-2KB
rs1001056807 -- 103,396,992(+) AAATT(A/G)TCAGC intron-variant, upstream-variant-2KB
rs1001124857 -- 103,390,492(+) CTCAA(A/G)AAGAA intron-variant
rs1001297268 -- 103,396,721(+) GACGC(C/T)GTGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001468382 -- 103,398,212(+) AGGTG(A/G)GTGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USMG5 Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
nsv7529 CNV insertion 18451855

Variation tolerance for USMG5 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USMG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USMG5 Gene

Disorders for USMG5 Gene

Relevant External Links for USMG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USMG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USMG5 Gene

Publications for USMG5 Gene

  1. Cellular and tissue expression of DAPIT, a phylogenetically conserved peptide. (PMID: 22688299) Kontro H. … Kainulainen H. (Eur J Histochem 2012) 2 3 64
  2. Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria. (PMID: 21345788) Ohsakaya S. … Yoshida M. (J. Biol. Chem. 2011) 3 4 64
  3. Association of two proteolipids of unknown function with ATP synthase from bovine heart mitochondria. (PMID: 17570365) Chen R. … Walker J.E. (FEBS Lett. 2007) 2 3 64
  4. Identification of two proteins associated with mammalian ATP synthase. (PMID: 17575325) Meyer B. … SchAogger H. (Mol. Cell Proteomics 2007) 2 3 64
  5. Study of transactivating effect of pre-S2 protein of hepatitis B virus and cloning of genes transactivated by pre-S2 protein with suppression subtractive hybridization. (PMID: 16222733) Ji D. … Guo J. (World J. Gastroenterol. 2005) 3 4 64

Products for USMG5 Gene

Sources for USMG5 Gene

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