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USH1G Gene

protein-coding   GIFtS: 54
GCID: GC17M072912

Usher Syndrome 1G (Autosomal Recessive)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Usher Syndrome 1G (Autosomal Recessive)1 2
SANS2 3 5
Scaffold Protein Containing Ankyrin Repeats And SAM Domain2 3
ANKS4A2
Usher Syndrome Type-1G Protein2

External Ids:    HGNC: 163561   Entrez Gene: 1245902   Ensembl: ENSG000001820407   OMIM: 6076965   UniProtKB: Q495M93   

Export aliases for USH1G gene to outside databases

Previous GC identifers: GC17U990308 GC17M075971 GC17M073376 GC17M073509 GC17M070423 GC17M068322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USH1G Gene:
This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha
motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein
plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion
of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type
1G (USH1G). Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for USH1G Gene:
USH1G (Usher syndrome 1G (autosomal recessive)) is a protein-coding gene. Diseases associated with USH1G include usher syndrome type 1g, and usher syndrome, type 1c. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is ANKS4B.

UniProtKB/Swiss-Prot: USH1G_HUMAN, Q495M9
Function: Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding
protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates
mechanotransduction in cochlear hair cells. Required for normal hearing

Gene Wiki entry for USH1G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the USH1G gene promoter:
         Nkx5-1   C/EBPalpha   CREB   CHOP-10   deltaCREB   FOXO1a   ZID   Pax-4a   FOXO1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSH1G promoter sequence
   Search Chromatin IP Primers for USH1G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USH1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

USH1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USH1G gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072912:  view genomic region     (about GC identifiers)

Start:
72,912,176 bp from pter      End:
72,919,351 bp from pter
Size:
7,176 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: USH1G_HUMAN, Q495M9 (See protein sequence)
Recommended Name: Usher syndrome type-1G protein  
Size: 461 amino acids; 51489 Da
Subunit: Interacts with CDH23 and PCDH15; these interactions may recruit USH1G to the plasma membrane (By
similarity). Interacts with USH1C (via the first PDZ domain) and with USH1G. Interacts with PDZD7. Interacts with
MYO7A. Part of a complex composed of USH1C, USH1G and MYO7A
3 PDB 3D structures from and Proteopedia for USH1G:
2L7T (3D)        3K1R (3D)        3PVL (3D)    
Secondary accessions: Q8N251

Explore the universe of human proteins at neXtProt for USH1G: NX_Q495M9

Explore proteomics data for USH1G at MOPED


See USH1G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001269418.1  NP_775748.2  

ENSEMBL proteins: 
 ENSP00000320076   ENSP00000462568  

USH1G Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing
SAMD: Sterile alpha motif (SAM) domain containing

5 InterPro protein domains:
 IPR021129 SAM_type1
 IPR002110 Ankyrin_rpt
 IPR013761 SAM/pointed
 IPR001660 SAM
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q495M9

ProtoNet protein and cluster: Q495M9

1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: USH1G_HUMAN, Q495M9
Similarity: Contains 3 ANK repeats
Similarity: Contains 1 SAM (sterile alpha motif) domain


USH1G for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: USH1G_HUMAN, Q495M9
Function: Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding
protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates
mechanotransduction in cochlear hair cells. Required for normal hearing

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI19028668
GO:0042803protein homodimerization activity IEA--
     
USH1G for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for USH1G:
 Decreased viability with pacli  Increased cell number in G2M,  

     4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ush1g):
 behavior/neurological  hearing/vestibular/ear  nervous system  vision/eye 

USH1G for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ush1gtm1.2Ugds for USH1G

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USH1G
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miRNA
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Selected qRT-PCR Assays for microRNAs that regulate USH1G (see all 21):
hsa-miR-429 hsa-miR-509-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-214* hsa-miR-133a hsa-miR-891b hsa-miR-200b
SwitchGear 3'UTR luciferase reporter plasmidUSH1G 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USH1G

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USH1G


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
USH1G_HUMAN, Q495M9: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein (By
similarity). Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via
interaction with CDH23 or PCDH15 (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
cytosol5
plasma membrane5
nucleus3

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005829cytosol IEA--
GO:0005886plasma membrane IEA--
GO:0015629actin cytoskeleton ISS12588794

USH1G for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USH1G
Interactions:

    GeneGlobe Interaction Network for USH1G

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for USH1G (Q495M92, 3 ENSP000003200764) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
USH1CQ9Y6N92, 3, ENSP000000052264MINT-58187 I2D: score=1 STRING: ENSP00000005226
MYO7AQ134023, ENSP000003863314I2D: score=1 STRING: ENSP00000386331
MYO7BENSP000004150904STRING: ENSP00000415090
--Q7RTU83I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007605sensory perception of sound IMP11398101
GO:0042472inner ear morphogenesis IEA--
GO:0045494photoreceptor cell maintenance IMP11398101
GO:0050953sensory perception of light stimulus IMP11398101
GO:0050957equilibrioception IMP12588794

USH1G for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for USH1G



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for USH1G gene (2 alternative transcripts): 
NM_001282489.2  NM_173477.4  

Unigene Cluster for USH1G:

Usher syndrome 1G (autosomal recessive)
Hs.376688  [show with all ESTs]
Unigene Representative Sequence: NM_173477
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000319642(uc002jme.1 uc010wro.1) ENST00000579243
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate USH1G (see all 21):
hsa-miR-429 hsa-miR-509-5p hsa-miR-1285 hsa-miR-4267 hsa-miR-214* hsa-miR-133a hsa-miR-891b hsa-miR-200b
SwitchGear 3'UTR luciferase reporter plasmidUSH1G 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat USH1G
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: USH1G (NM_173477)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USH1G
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USH1G
  QuantiTect SYBR Green Assays in human, mouse, rat USH1G
  QuantiFast Probe-based Assays in human, mouse, rat USH1G

Additional mRNA sequence: 

AK091243.1 AK289804.1 AK296899.1 BC101096.2 BC101097.1 BC101098.2 BC101099.1 

1 DOTS entry:

DT.100009668 

6 AceView cDNA sequences:

NM_173477 AX746872 BE735997 BM552505 AK091243 BM045386 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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USH1G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
USH1G Expression
About this image


USH1G expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Smooth Muscle (Muscoskeletal System)
         Juxtaglomerular Cells Afferent Arteriole
 
 Kidney (Urinary System)
         Juxtaglomerular Cells Afferent Arteriole
USH1G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

USH1G Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.376688

UniProtKB/Swiss-Prot: USH1G_HUMAN, Q495M9
Tissue specificity: Expressed in vestibule of the inner ear, eye and small intestine

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USH1G

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for USH1G gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ush1g1 , 5 Usher syndrome 1G homolog (human)5
Usher syndrome 1G1
90.82(n)1
96.31(a)1
  11 (80.84 cM)5
164701  NM_176847.31  NP_789817.11 
 1153151925 
chicken
(Gallus gallus)
Aves USH1G1 Usher syndrome 1G (autosomal recessive) 76.2(n)
77.95(a)
  428684  XM_426242.3  XP_426242.2 
lizard
(Anolis carolinensis)
Reptilia USH1G6
Usher syndrome 1G (autosomal recessive)
75(a)
1 ↔ 1
2(115130615-115149011)
tropical clawed frog
(Xenopus tropicalis)
Amphibia ush1g1 Usher syndrome 1G (autosomal recessive) 73.32(n)
73.46(a)
  100494764  XM_002939560.2  XP_002939606.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1003303141 Usher syndrome type-1G protein-like 69.51(n)
71.55(a)
  100330314  XM_002661269.2  XP_002661315.1 
fruit fly
(Drosophila melanogaster)
Insecta Sans1 Sans ortholog 46.97(n)
36.4(a)
  36427  NM_176160.1  NP_788340.1 


ENSEMBL Gene Tree for USH1G (if available)
TreeFam Gene Tree for USH1G (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for USH1G gene
ANKS4B2  
4 SIMAP similar genes for USH1G using alignment to 2 protein entries:     USH1G_HUMAN (see all proteins):
ANKS4B    DKFZp761E1322    MTPN    ANKRD10

USH1G for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for USH1G (see all 193)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0604684
Usher syndrome 1G (USH1G)4--see VAR_0604682 D V mis40--------
VAR_0237394
Usher syndrome 1G (USH1G)4--see VAR_0237392 L P mis40--------
rs1110334661,2
C,Fnon-pathogenic174000468(-) TCCGCG/AAGGCG 2 /K /E mis13Minor allele frequency- A:0.04WA NA EU 5953
rs1110334651,2
C,Fnon-pathogenic174000504(-) ACCCCA/GAGCTG 2 K E mis13Minor allele frequency- G:0.04WA NA EU 5989
rs1121256431,2
C,F--68325738(+) GGTGGC/TAAATA 1 -- int11Minor allele frequency- T:0.50CSA 2
rs778154411,2
C,F--68325767(+) TCATCG/AATGGC 1 -- int11Minor allele frequency- A:0.03EA 120
rs1452786941,2
--68325770(+) TCGATA/GGCCTC 1 -- int10--------
rs1147200691,2
F--68325830(+) GCAGAT/GCTGTA 1 -- int11Minor allele frequency- G:0.02WA 118
rs2013596691,2
C--68325941(+) CCTGCC/TGCCGC 2 Q R mis10--------
rs1398975061,2
C,F--68326023(+) GCACAG/CCATCA 2 /L /V mis11Minor allele frequency- C:0.00NA 4444

HapMap Linkage Disequilibrium report for USH1G (72912176 - 72919351 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for USH1G:    About this table    
Variant IDTypeSubtypePubMed ID
nsv518292CNV Loss19592680
nsv833540CNV Loss17160897
nsv908744CNV Loss21882294
dgv3254n71CNV Loss21882294
nsv457909CNV Gain19166990

Human Gene Mutation Database (HGMD): USH1G
Locus Specific Mutation Databases (LSDB): USH1G

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing USH1G
DNA2.0 Custom Variant and Variant Library Synthesis for USH1G

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607696   
OMIM disorders: 606943  
UniProtKB/Swiss-Prot: USH1G_HUMAN, Q495M9
  • Usher syndrome 1G (USH1G) [MIM:606943]: USH is a genetically heterogeneous condition characterized by the
    association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and
    vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome
    type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function
    and prepubertal onset of progressive retinitis pigmentosa leading to blindness. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 15 diseases for USH1G:    
    About MalaCards
    usher syndrome type 1g    usher syndrome, type 1c    riley-day syndrome    usher syndrome type i
    usher syndrome, type 1f    usher syndrome type 3    usher syndrome    retinal disease
    sensorineural hearing loss    retinitis pigmentosa    blindness    retinitis
    malaria    multiple myeloma    myeloma

    3 diseases from the University of Copenhagen DISEASES database for USH1G:
    Usher syndrome     Retinitis pigmentosa     Sensorineural hearing loss

    USH1G for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for USH1G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    usher syndrome 95.6 12 17896313 (3), 20142502 (1), 16283141 (1), 19270738 (1) (see all 5)

    GeneTests: USH1G
    GeneReviews: USH1G
    Genetic Association Database (GAD): USH1G
    Human Genome Epidemiology (HuGE) Navigator: USH1G (4 documents)

    Export disorders for USH1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USH1G gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with USH1G)
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    1. Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin. (PubMed id 12588794)1, 2, 3 Weil D.... Petit C. (Hum. Mol. Genet. 2003)
    2. A novel D458V mutation in the SANS PDZ binding motif causes atypical Usher syndrome. (PubMed id 16283141)1, 2, 9 Kalay E.... Kremer H. (J. Mol. Med. 2005)
    3. Screening of the USH1G gene among Spanish patients with Usher syndrome. Lack of mutations and evidence of a minor role in the pathogenesis of the syndrome. (PubMed id 17896313)1, 4, 9 Aller E....MillA!n J. (Ophthalmic Genet. 2007)
    4. The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. (PubMed id 20142502)1, 2, 9 Yan J.... Zhang M. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. (PubMed id 21311020)1, 2 Wu L.... Zhang M. (Science 2011)
    6. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    7. Microarray-based mutation analysis of 183 Spanish families with Usher syndrome. (PubMed id 19683999)1, 4 Jaijo T....MillA!n J.M. (amp 2010)
    8. Homozygous disruption of PDZD7 by reciprocal translocation in a consanguineous family: a new member of the Usher syndrome protein interactome causing congenital hearing impairment. (PubMed id 19028668)1, 2 Schneider E....Haaf T. (Hum. Mol. Genet. 2009)
    9. Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population. (PubMed id 15660226)1, 4 Ouyang X.M.... Liu X.Z. (Hum. Genet. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124590 HGNC: 16356 AceView: USH1G Ensembl:ENSG00000182040 euGenes: HUgn124590
    ECgene: USH1G H-InvDB: USH1G

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USH1G Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=USH1G[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for USH1G gene:
    Search GeneIP for patents involving USH1G

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