Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USF3 Gene

Aliases for USF3 Gene

  • Upstream Transcription Factor Family Member 3 2 3 5
  • KIAA2018 2 3 4
  • Upstream Transcription Factor 3 3 4

External Ids for USF3 Gene

Previous HGNC Symbols for USF3 Gene

  • KIAA2018

Summaries for USF3 Gene

GeneCards Summary for USF3 Gene

USF3 (Upstream Transcription Factor Family Member 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USF3 Gene

Genomics for USF3 Gene

Regulatory Elements for USF3 Gene

Enhancers for USF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for USF3 Gene

Chromosome:
3
Start:
113,648,385 bp from pter
End:
113,696,646 bp from pter
Size:
48,262 bases
Orientation:
Minus strand

Genomic View for USF3 Gene

Genes around USF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USF3 Gene

Proteins for USF3 Gene

  • Protein details for USF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DE3-USF3_HUMAN
    Recommended name:
    Basic helix-loop-helix domain-containing protein USF3
    Protein Accession:
    Q68DE3
    Secondary Accessions:
    • Q7Z3L9
    • Q8IVF3
    • Q9H8T4

    Protein attributes for USF3 Gene

    Size:
    2245 amino acids
    Molecular mass:
    241681 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14518.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=CAH18277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for USF3 Gene

Proteomics data for USF3 Gene at MOPED

Post-translational modifications for USF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USF3 Gene

Domains & Families for USF3 Gene

Protein Domains for USF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for USF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DE3

UniProtKB/Swiss-Prot:

USF3_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with USF3: view

No data available for Gene Families for USF3 Gene

Function for USF3 Gene

Gene Ontology (GO) - Molecular Function for USF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with USF3: view

Phenotypes for USF3 Gene

GenomeRNAi human phenotypes for USF3:
genes like me logo Genes that share phenotypes with USF3: view

Animal Model Products

miRNA for USF3 Gene

miRTarBase miRNAs that target USF3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USF3 Gene

Localization for USF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USF3 Gene

Gene Ontology (GO) - Cellular Components for USF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with USF3: view

No data available for Subcellular locations from COMPARTMENTS for USF3 Gene

Pathways & Interactions for USF3 Gene

SuperPathways for USF3 Gene

No Data Available

Interacting Proteins for USF3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320794%0d%0a9606.ENSP00000396620%0d%0a
Selected Interacting proteins: ENSP00000320794 Q68DE3-USF3_HUMAN for USF3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for USF3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for USF3 Gene

Drugs & Compounds for USF3 Gene

No Compound Related Data Available

Transcripts for USF3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for USF3 Gene

No ASD Table

Relevant External Links for USF3 Gene

GeneLoc Exon Structure for
USF3
ECgene alternative splicing isoforms for
USF3

Expression for USF3 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USF3 Gene

Orthologs for USF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA2018 35
  • 89.14 (n)
  • 87.96 (a)
KIAA2018 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA2018 35
  • 90.16 (n)
  • 90.34 (a)
KIAA2018 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm608 35
  • 85.82 (n)
  • 83.79 (a)
Usf3 16
Gm608 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA2018 35
  • 99.44 (n)
  • 99.28 (a)
KIAA2018 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560175 35
  • 85.14 (n)
  • 82.74 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA2018 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA2018 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA2018 35
  • 71.89 (n)
  • 68.92 (a)
KIAA2018 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA2018 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145754 35
  • 59.73 (n)
  • 55.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33642 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-196k8.2 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for USF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USF3 Gene

ENSEMBL:
Gene Tree for USF3 (if available)
TreeFam:
Gene Tree for USF3 (if available)

Paralogs for USF3 Gene

No data available for Paralogs for USF3 Gene

Variants for USF3 Gene

Sequence variations from dbSNP and Humsavar for USF3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9866806 - 113,661,018(+) AACAG(C/G)CTGGT intron-variant, reference, missense
rs2290477 - 113,655,786(+) TACAG(A/C)AGGGC intron-variant, reference, missense
rs9852318 - 113,658,962(+) ATTTT(G/T)CTGCG intron-variant, reference, missense
rs6770105 - 113,658,854(+) TCAAT(A/C)CATTG intron-variant, reference, missense
rs930818 - 113,655,083(+) GAAGC(A/G)CTGTG intron-variant, reference, missense

Variation tolerance for USF3 Gene

Residual Variation Intolerance Score: 4.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for USF3 Gene

Disorders for USF3 Gene

Relevant External Links for USF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USF3

No disorders were found for USF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USF3 Gene

Publications for USF3 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 67
  2. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for USF3 Gene

Sources for USF3 Gene

Content