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Aliases for USF2 Gene

Aliases for USF2 Gene

  • Upstream Transcription Factor 2, C-Fos Interacting 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 12 3 4
  • Major Late Transcription Factor 2 3 4
  • BHLHb12 3 4
  • FIP 3 4
  • Upstream Transcription Factor 2 4
  • Upstream Stimulatory Factor 2 3
  • C-Fos Interacting Protein 3
  • FOS-Interacting Protein 4

External Ids for USF2 Gene

Previous GeneCards Identifiers for USF2 Gene

  • GC19P036377
  • GC19P036208
  • GC19P040435
  • GC19P040451
  • GC19P035759
  • GC19P032268

Summaries for USF2 Gene

Entrez Gene Summary for USF2 Gene

  • This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

GeneCards Summary for USF2 Gene

USF2 (Upstream Transcription Factor 2, C-Fos Interacting) is a Protein Coding gene. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot for USF2 Gene

  • Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.

Gene Wiki entry for USF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USF2 Gene

Genomics for USF2 Gene

Regulatory Elements for USF2 Gene

Enhancers for USF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035202 1.3 FANTOM5 Ensembl ENCODE 12.6 -63.4 -63437 6.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF302 TMEM147-AS1 RBM42 ZNF792 KIAA0355 HAUS5 KMT2B ENSG00000267049 SDHAF1 LRFN3 LOC101927572
GH19F035208 1.3 FANTOM5 Ensembl ENCODE 12.5 -55.7 -55653 8.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF416 ZNF207 TMEM147-AS1 HAUS5 KMT2B KIAA0355 ZNF792 RBM42 ENSG00000267049 ENSG00000268947 LINC01766 ENSG00000270544
GH19F035290 0.5 FANTOM5 11.9 +22.0 22023 0.4 KLF1 ZIC2 GLIS2 ZFHX2 ZNF341 GLIS1 ZNF600 ZBTB17 MAG USF2 FAM187B KRTDAP DMKN FFAR2 ENSG00000233214 LGI4 HPN FXYD7
GH19F035220 0.7 Ensembl ENCODE 11.3 -48.1 -48104 1.3 PKNOX1 ATF1 ARNT CREB3L1 YY1 ZNF121 GLIS2 ELK1 GATA2 JUNB MAG USF2 HAMP SCN1B FAM187B GC19P036160 LOC105372379
GH19F035136 0.4 ENCODE 11.2 -129.5 -129521 5.4 MLX CREB3L1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 LSM14A TMEM147-AS1 KIAA0355 ZNF792 HAUS5 RBM42 KMT2B LRFN3 WTIP LINC01766
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USF2 on UCSC Golden Path with GeneCards custom track

Promoters for USF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044055 -378 3201 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for USF2 Gene

Chromosome:
19
Start:
35,268,978 bp from pter
End:
35,279,821 bp from pter
Size:
10,844 bases
Orientation:
Plus strand

Genomic View for USF2 Gene

Genes around USF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USF2 Gene

Proteins for USF2 Gene

  • Protein details for USF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15853-USF2_HUMAN
    Recommended name:
    Upstream stimulatory factor 2
    Protein Accession:
    Q15853
    Secondary Accessions:
    • O00671
    • O00709
    • Q05750
    • Q07952
    • Q15851
    • Q15852
    • Q6FI33
    • Q6YI47

    Protein attributes for USF2 Gene

    Size:
    346 amino acids
    Molecular mass:
    36955 Da
    Quaternary structure:
    • Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The USF1/USF2B heterodimer accounted for almost 15% in some cell.

    Alternative splice isoforms for USF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USF2 Gene

Post-translational modifications for USF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USF2 Gene

Domains & Families for USF2 Gene

Gene Families for USF2 Gene

Protein Domains for USF2 Gene

Suggested Antigen Peptide Sequences for USF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15853

UniProtKB/Swiss-Prot:

USF2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with USF2: view

Function for USF2 Gene

Molecular function for USF2 Gene

GENATLAS Biochemistry:
upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal dysplasia (see also PUJO)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5-CACGTG-3) that is found in a variety of viral and cellular promoters.

Gene Ontology (GO) - Molecular Function for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 1589769
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IMP 8576131
GO:0005515 protein binding IPI 19505873
GO:0042803 protein homodimerization activity IPI 8576131
genes like me logo Genes that share ontologies with USF2: view
genes like me logo Genes that share phenotypes with USF2: view

Animal Models for USF2 Gene

MGI Knock Outs for USF2:

Animal Model Products

Transcription Factor Targets for USF2 Gene

Selected GeneGlobe predicted Target genes for USF2
Targeted motifs for USF2 Gene
HOMER Transcription Factor Regulatory Elements motif USF2
  • Consensus sequence: GTCACGTGGT Submotif: canonical Cell Type: C2C12 GEO ID: GSE36030

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for USF2 Gene

Localization for USF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USF2 Gene COMPARTMENTS Subcellular localization image for USF2 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8576131
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with USF2: view

Pathways & Interactions for USF2 Gene

genes like me logo Genes that share pathways with USF2: view

Pathways by source for USF2 Gene

Gene Ontology (GO) - Biological Process for USF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose IC 8576131
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with USF2: view

No data available for SIGNOR curated interactions for USF2 Gene

Drugs & Compounds for USF2 Gene

(6) Drugs for USF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for USF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with USF2: view

Transcripts for USF2 Gene

Unigene Clusters for USF2 Gene

Upstream transcription factor 2, c-fos interacting:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:

Relevant External Links for USF2 Gene

GeneLoc Exon Structure for
USF2
ECgene alternative splicing isoforms for
USF2

Expression for USF2 Gene

mRNA expression in normal human tissues for USF2 Gene

Protein differential expression in normal tissues from HIPED for USF2 Gene

This gene is overexpressed in CD8 Tcells (16.2), Blymphocyte (11.4), Pancreas (10.3), Peripheral blood mononuclear cells (10.2), Placenta (6.9), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USF2 Gene



Protein tissue co-expression partners for USF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of USF2 Gene:

USF2

SOURCE GeneReport for Unigene cluster for USF2 Gene:

Hs.454534

mRNA Expression by UniProt/SwissProt for USF2 Gene:

Q15853-USF2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with USF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USF2 Gene

Orthologs for USF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for USF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USF2 34 35
  • 92.87 (n)
mouse
(Mus musculus)
Mammalia Usf2 34 16 35
  • 92.49 (n)
rat
(Rattus norvegicus)
Mammalia Usf2 34
  • 92.2 (n)
chimpanzee
(Pan troglodytes)
Mammalia USF2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USF2 34 35
  • 90.17 (n)
oppossum
(Monodelphis domestica)
Mammalia USF2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 78 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia USF2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usf2 34
  • 76.59 (n)
Str.14981 34
zebrafish
(Danio rerio)
Actinopterygii usf2 34 35
  • 73.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Usf 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4872 34
Species where no ortholog for USF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USF2 Gene

ENSEMBL:
Gene Tree for USF2 (if available)
TreeFam:
Gene Tree for USF2 (if available)

Paralogs for USF2 Gene

Paralogs for USF2 Gene

(3) SIMAP similar genes for USF2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with USF2: view

Variants for USF2 Gene

Sequence variations from dbSNP and Humsavar for USF2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193920819 Uncertain significance 35,270,514(+) GGCAC(A/G)ATTTG intron-variant, reference, missense
rs10402762 -- 35,274,851(+) gtgtg(C/T)gctgc intron-variant
rs10405246 -- 35,278,046(+) ATAGG(A/G)TTTGG intron-variant, utr-variant-3-prime
rs10410675 -- 35,277,925(+) GGGGA(C/T)AGCTG intron-variant, utr-variant-3-prime
rs10416869 -- 35,276,152(+) ctaca(A/G)cctcc intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USF2 Gene

Variant ID Type Subtype PubMed ID
dgv6416n54 CNV loss 21841781
dgv6417n54 CNV gain 21841781
dgv6418n54 CNV gain 21841781
dgv6419n54 CNV loss 21841781
esv2758758 CNV loss 17122850
esv27788 CNV loss 19812545
nsv1072881 CNV deletion 25765185
nsv1133449 CNV deletion 24896259
nsv510765 CNV deletion 20534489
nsv579389 CNV gain+loss 21841781
nsv579396 CNV gain 21841781
nsv579400 CNV gain+loss 21841781
nsv953283 CNV deletion 24416366

Variation tolerance for USF2 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USF2 Gene

Disorders for USF2 Gene

Relevant External Links for USF2

Genetic Association Database (GAD)
USF2
Human Genome Epidemiology (HuGE) Navigator
USF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USF2

No disorders were found for USF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USF2 Gene

Publications for USF2 Gene

  1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PMID: 8954795) Groenen P.M.A. … van de Ven W.J.M. (Genomics 1996) 2 3 4 22 64
  2. Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression. (PMID: 18970934) Huang Y.H. … Chen C.L. (J. Pediatr. Surg. 2008) 3 22 46 64
  3. Isolation of a novel USF2 isoform: repressor of cathepsin B expression. (PMID: 15276216) Yan S. … Sloane B.F. (Gene 2004) 3 4 22 64
  4. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. (PMID: 8576131) Viollet B. … Martinez A. (J. Biol. Chem. 1996) 3 4 22 64
  5. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. (PMID: 1450663) Sirito M. … Sawadogo M. (Gene Expr. 1992) 3 4 22 64

Products for USF2 Gene

Sources for USF2 Gene

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