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USF2 Gene

protein-coding   GIFtS: 60
GCID: GC19P035759

Upstream Transcription Factor 2, C-Fos Interacting

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Upstream Transcription Factor 2, C-Fos Interacting1 2     FOS-Interacting Protein2 3
Class B Basic Helix-Loop-Helix Protein 122 3     C-Fos Interacting Protein2
Major Late Transcription Factor 22 3     Upstream Stimulatory Factor 22
FIP2 3     BHLHB123
bHLHb122 3     Upstream Transcription Factor 23

External Ids:    HGNC: 125941   Entrez Gene: 73922   Ensembl: ENSG000001056987   OMIM: 6003905   UniProtKB: Q158533   

Export aliases for USF2 gene to outside databases

Previous GC identifers: GC19P036377 GC19P036208 GC19P040435 GC19P040451 GC19P032268


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USF2 Gene:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular
transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr)
elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for USF2 Gene:
USF2 (upstream transcription factor 2, c-fos interacting) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in
a variety of viral and cellular promoters

Gene Wiki entry for USF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USF2 gene promoter:
         CREB   p53   deltaCREB   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSF2 promoter sequence
   Search Chromatin IP Primers for USF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13

USF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035759:  view genomic region     (about GC identifiers)

Start:
35,759,881 bp from pter      End:
35,770,724 bp from pter
Size:
10,844 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853 (See protein sequence)
Recommended Name: Upstream stimulatory factor 2  
Size: 346 amino acids; 36955 Da
Subunit: Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH
protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents
over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The
USF1/USF2B heterodimer accounted for almost 15% in some cell
Secondary accessions: O00671 O00709 Q05750 Q07952 Q15851 Q15852 Q6FI33 Q6YI47
Alternative splicing: 4 isoforms:  Q15853-1   Q15853-2   Q15853-3   Q15853-4   (Can bind as a homodimer to the E-box of the cathepsin B (CTSB) promoter)

Explore the universe of human proteins at neXtProt for USF2: NX_Q15853

Explore proteomics data for USF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys250
  • Modification sites at PhosphoSitePlus

  • See USF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003358.1  NP_997174.1  

    ENSEMBL proteins: 
     ENSP00000340633   ENSP00000222305   ENSP00000471099   ENSP00000368429   ENSP00000477020  
     ENSP00000471511   ENSP00000469585   ENSP00000471775   ENSP00000469364   ENSP00000470277  
     ENSP00000470081  

    USF2 Human Recombinant Protein Products:

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    Novus Biologicals USF2 Proteins
    Novus Biologicals USF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USF2

     
    Search eBioscience for Proteins for USF2 

     
    antibodies-online proteins for USF2 (4 products) 

     
    antibodies-online peptides for USF2

    USF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of USF2
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    ThermoFisher Antibodies for USF2
    antibodies-online antibodies for USF2 (70 products) 

    USF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USF2
    Cloud-Clone Corp. CLIAs for USF2
    Search eBioscience for ELISAs for USF2 
    antibodies-online kits for USF2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q15853

    ProtoNet protein and cluster: Q15853

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with USF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USF2_HUMAN, Q15853
    Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in
    a variety of viral and cellular promoters

         Genatlas biochemistry entry for USF2:
    upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal
    dysplasia (see also PUJO)

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IMP8576131
         
    Find genes that share ontologies with USF2           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usf2):
     behavior/neurological  growth/size/body  integument  limbs/digits/tail  mortality/aging 
     nervous system  normal  pigmentation  reproductive system 

    Find genes that share phenotypes with USF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Usf2tm1Msw for USF2

       genOway: Develop your customized and physiologically relevant rodent model for USF2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GTCACGTGGT 

    miRNA
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    miRTarBase miRNAs that target USF2:
    hsa-mir-339-5p (MIRT042794), hsa-mir-335-5p (MIRT018532), hsa-mir-362-3p (MIRT007350), hsa-mir-10a-5p (MIRT003896), hsa-mir-320a (MIRT044796)

    Block miRNA regulation of human, mouse, rat USF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USF2 (see all 26):
    hsa-miR-362-3p hsa-miR-642a hsa-miR-137 hsa-miR-875-5p hsa-miR-25 hsa-miR-339-5p hsa-miR-650 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidUSF2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USF2
    Predesigned siRNA for gene silencing in human, mouse, rat USF2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for USF2 (see all 11)
    OriGene ORF clones in mouse, rat for USF2
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    GenScript: all cDNA clones in your preferred vector (see all 2): USF2 (NM_003367)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USF2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    USF2_HUMAN, Q15853: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with USF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    1 BioSystems Pathway for USF2
        Validated transcriptional targets of AP1 family members Fra1 and Fra2


        Pathway & Disease-focused RT2 Profiler PCR Array including USF2: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for USF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USF2 (Q158533 ENSP000002223054) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383983, ENSP000003502834I2D: score=3 STRING: ENSP00000350283
    HSPA4LO957573, ENSP000002964644I2D: score=2 STRING: ENSP00000296464
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    SERPINB3P295083, ENSP000002837524I2D: score=2 STRING: ENSP00000283752
    SERPINB4P485943, ENSP000003434454I2D: score=2 STRING: ENSP00000343445
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000430regulation of transcription from RNA polymerase II promoter by glucose IC8576131
    GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IMP8576131

    Find genes that share ontologies with USF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USF2

    7 Novoseek inferred chemical compound relationships for USF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpa 67 20 9840809 (3), 9099698 (2), 10434034 (2)
    leucine 46.2 4 11467950 (1), 9070273 (1), 12917334 (1), 10373528 (1)
    iron 4.56 2 11447267 (1)
    pyruvate 0 1 16891625 (1)
    glucose 0 11 15184388 (4), 16891625 (2), 12086590 (1), 14757763 (1)
    fatty acid 0 1 16891625 (1)
    testosterone 0 1 15042619 (1)



    Find genes that share compounds with USF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USF2 gene (2 alternative transcripts): 
    NM_003367.2  NM_207291.1  

    Unigene Cluster for USF2:

    Upstream transcription factor 2, c-fos interacting
    Hs.454534  [show with all ESTs]
    Unigene Representative Sequence: NM_003367
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343550(uc002nyr.1 uc002nyt.1) ENST00000222305(uc010xss.1 uc002nyq.1 uc002nyv.1)
    ENST00000595068 ENST00000379134 ENST00000602164 ENST00000594064 ENST00000598058
    ENST00000593708 ENST00000607959 ENST00000596380 ENST00000599471 ENST00000597671
    ENST00000599625 ENST00000600341 ENST00000594264 ENST00000600898
    miRNA
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    Block miRNA regulation of human, mouse, rat USF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USF2 (see all 26):
    hsa-miR-362-3p hsa-miR-642a hsa-miR-137 hsa-miR-875-5p hsa-miR-25 hsa-miR-339-5p hsa-miR-650 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidUSF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USF2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): USF2 (NM_003367)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USF2
    Primer
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    OriGene qPCR primer pairs and template standards for USF2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USF2
      QuantiTect SYBR Green Assays in human, mouse, rat USF2
      QuantiFast Probe-based Assays in human, mouse, rat USF2

    Additional mRNA sequence: 

    AK297022.1 AY007087.1 AY147880.1 BC049821.1 CR536504.1 M77476.1 S50537.1 X90824.1 
    X90825.1 X90826.1 

    18 DOTS entries:

    DT.100791157  DT.97847462  DT.454984  DT.100791158  DT.99979974  DT.121415283  DT.100791160  DT.121415303 
    DT.97847461  DT.95299234  DT.95299225  DT.97763779  DT.102829673  DT.121415247  DT.121415265  DT.95085661 
    DT.100029239  DT.100791154 

    Selected AceView cDNA sequences (see all 301):

    BM718381 AI128012 BQ675992 BM724398 AI438990 BM811268 BM917032 BQ086333 
    BF989326 BM693680 BM763233 BM839749 AA953199 X90825 BI759048 BM704713 
    CR615182 BF724348 BE315348 BE893244 AI240157 BE382995 CR536504 AI955801 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USF2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:                                -                                   -           -     -     -                                                         
    SP2:                          -     -                                   -           -     -     -                                                         
    SP3:                          -     -     -     -     -     -           -           -     -     -                                                         
    SP4:                                -                                   -           -     -     -           -                                             
    SP5:                                                                                            -                                                         


    ECgene alternative splicing isoforms for USF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCCCGC
    USF2 Expression
    About this image

    USF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.454534

    UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including USF2: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USF2
    QuantiTect SYBR Green Assays in human, mouse, rat USF2
    QuantiFast Probe-based Assays in human, mouse, rat USF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usf21 , 5 upstream transcription factor 21, 5 92.49(n)1
    97.98(a)1
      7 (19.27 cM)5
    222821  NM_011680.21  NP_035810.11 
     309452525 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    78(a)
    many ↔ many
    AADN03022759.1(17-517)
    lizard
    (Anolis carolinensis)
    Reptilia USF26
    upstream transcription factor 2, c-fos interacting...
    80(a)
    1 ↔ 1
    GL343281.1(761922-789367)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149812 Transcribed sequence with moderate similarity to protein more 79.26(n)    CF239150.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK028544.12   -- 75.05(n)    CK028544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Usf6
    Usf
    16(a)
    1 → many
    X(4438648-4442802)


    ENSEMBL Gene Tree for USF2 (if available)
    TreeFam Gene Tree for USF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USF2 gene
    USF12  
    3 SIMAP similar genes for USF2 using alignment to 8 protein entries:     USF2_HUMAN (see all proteins):
    USF1    KIAA2018    MAX

    Find genes that share paralogs with USF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USF2 (see all 312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344909061,2
    C--35759374(+) CGCGC-/TCCCGG 2 -- us2k10--------
    rs25156211,2
    --35760167(+) GGCCCC/GGCTCA 2 -- int10--------
    rs22725391,2
    C--35760413(+) CGGGCC/GGGCCG 2 -- int12Minor allele frequency- G:0.00NA 4
    rs1402017281,2
    C--35760452(+) GCGGCA/CCTGAC 2 -- int10--------
    rs25156221,2
    C--35760622(+) gcgagG/Agcgaa 2 -- int12Minor allele frequency- A:0.00NA 4
    rs1500533701,2
    C--35760931(+) TGGGT-/GGGGGG 2 -- int10--------
    rs118824231,2
    H--35761078(+) GACAGT/AGCTCT 2 -- int14Minor allele frequency- A:0.00NS EA 408
    rs1178328461,2
    F--35761101(+) TTCCCG/ACAAAA 2 -- int11Minor allele frequency- A:0.02EA 120
    rs1844692011,2
    C--35761105(+) CGCAAA/GATGGG 2 -- int10--------
    rs1467880541,2
    --35761193(+) TGTTCC/TAGGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for USF2 (35759881 - 35770724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3850n71CNV Loss21882294
    nsv510765CNV Loss20534489
    esv27788CNV Loss19812545
    nsv911618CNV Loss21882294
    nsv911624CNV Loss21882294
    dgv1080e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USF2
    DNA2.0 Custom Variant and Variant Library Synthesis for USF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600390    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for USF2:
    Peritonitis

    Find genes that share disorders with USF2           About GenesLikeMe

    9 Novoseek inferred disease relationships for USF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron overload 39.5 2 11447267 (1)
    glioblastoma 20.7 1 15276216 (1)
    breast cancer 3.82 1 9731700 (1)
    tumors 1.29 11 18331200 (4), 16186802 (2), 10523835 (1), 15864740 (1) (see all 6)
    carcinoma squamous cell 0 1 15856526 (1)
    cancer lung 0 5 15856526 (4)
    adenocarcinoma 0 2 15864740 (1), 15856526 (1)
    prostate cancer 0 5 15276216 (2), 16186802 (2)
    cancer 0 1 11241666 (1)

    Genetic Association Database (GAD): USF2
    Human Genome Epidemiology (HuGE) Navigator: USF2 (3 documents)

    Export disorders for USF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USF2 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with USF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PubMed id 8954795)1, 2, 3, 9 Groenen P.M.A....van de Ven W.J.M. (Genomics 1996)
    2. Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression. (PubMed id 18970934)1, 4, 9 Huang Y.H....Chen C.L. (J. Pediatr. Surg. 2008)
    3. Isolation of a novel USF2 isoform: repressor of cathepsin B expression. (PubMed id 15276216)1, 2, 9 Yan S. and Sloane B.F. (Gene 2004)
    4. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. (PubMed id 8576131)1, 2, 9 Viollet B.... Martinez A. (J. Biol. Chem. 1996)
    5. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. (PubMed id 1450663)1, 2, 9 Sirito M.... Sawadogo M. (Gene Expr. 1992)
    6. Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. (PubMed id 1589769)1, 2, 9 Blanar M.A. and Rutter W.J. (Science 1992)
    7. Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease. (PubMed id 16870626)1, 4 Shibata N....Arai H. (J. Gerontol. A Biol. Sci. Med. Sci. 2006)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis. (PubMed id 18165439)1, 9 Utsunomiya H....Bulun S.E. (Mol. Endocrinol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7392 HGNC: 12594 AceView: USF2 Ensembl:ENSG00000105698 euGenes: HUgn7392
    ECgene: USF2 H-InvDB: USF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USF2 gene:
    Search GeneIP for patents involving USF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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