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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USF2 Gene

protein-coding   GIFtS: 59
GCID: GC19P035759

Upstream Transcription Factor 2, C-Fos Interacting

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Upstream Transcription Factor 2, C-Fos Interacting1 2     FOS-Interacting Protein2 3
Class B Basic Helix-Loop-Helix Protein 122 3     C-Fos Interacting Protein2
Major Late Transcription Factor 22 3     Upstream Stimulatory Factor 22
FIP2 3     BHLHB123
bHLHb122 3     Upstream Transcription Factor 23

External Ids:    HGNC: 125941   Entrez Gene: 73922   Ensembl: ENSG000001056987   OMIM: 6003905   UniProtKB: Q158533   

Export aliases for USF2 gene to outside databases

Previous GC identifers: GC19P036377 GC19P036208 GC19P040435 GC19P040451 GC19P032268


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USF2 Gene:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular
transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr)
elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for USF2 Gene: 
USF2 (upstream transcription factor 2, c-fos interacting) is a protein-coding gene. Diseases associated with USF2 include renal dysplasia, and biliary atresia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is USF1.

UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in
a variety of viral and cellular promoters

Gene Wiki entry for USF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USF2 gene promoter:
         CREB   p53   deltaCREB   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for USF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13

USF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035759:  view genomic region     (about GC identifiers)

Start:
35,759,881 bp from pter      End:
35,770,718 bp from pter
Size:
10,838 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853 (See protein sequence)
Recommended Name: Upstream stimulatory factor 2  
Size: 346 amino acids; 36955 Da
Subunit: Interacts with MAF (By similarity). Efficient DNA binding requires dimerization with another bHLH
protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). In vivo, the USF1/USF2A heterodimer represents
over 66% of the usf binding activity whereas the USF1 and USF2A homodimers represent less than 10%. The
USF1/USF2B heterodimer accounted for almost 15% in some cell
Subcellular location: Nucleus
Secondary accessions: O00671 O00709 Q05750 Q07952 Q15851 Q15852 Q6FI33
Alternative splicing: 3 isoforms:  Q15853-1   Q15853-2   Q15853-3   

Explore the universe of human proteins at neXtProt for USF2: NX_Q15853

Explore proteomics data for USF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15853

  • USF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USF2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003358.1  NP_997174.1  

    ENSEMBL proteins: 
     ENSP00000340633   ENSP00000222305   ENSP00000471099   ENSP00000368429   ENSP00000471511  
     ENSP00000469585   ENSP00000471775   ENSP00000469364   ENSP00000470277   ENSP00000470081  

    Human Recombinant Protein Products for USF2: 
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    Novus Biologicals USF2 Proteins
    Novus Biologicals USF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USF2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15358760

    USF2 for ontologies           About GeneDecksing



    USF2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for USF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q15853

    ProtoNet protein and cluster: Q15853

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    USF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USF2_HUMAN, Q15853
    Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in
    a variety of viral and cellular promoters

         Genatlas biochemistry entry for USF2:
    upstream stimulatory transcription factor 2,ubiquitously expressed,disrupted in t(6;19) with multicystic renal
    dysplasia (see also PUJO)

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IMP8576131
         
    USF2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usf2):
     behavior/neurological  growth/size  integument  limbs/digits/tail  mortality/aging 
     nervous system  normal  pigmentation  reproductive system 

    USF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usf2tm1Msw for USF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for USF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USF2 

    10/166 SABiosciences Target genes for USF2 (see all 166):
    ABI1 ACTL6B ADAM2 ADAMTS2 ADI1 ADSS ADSSL1 AIF1L ALDH18A1 ALDH1B1

    miRNA
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    miRTarBase miRNAs that target USF2:
    hsa-mir-10a (MIRT003896)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USF2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate USF2 (see all 26):
    hsa-miR-362-3p hsa-miR-642a hsa-miR-137 hsa-miR-875-5p hsa-miR-25 hsa-miR-339-5p hsa-miR-650 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidUSF2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Validated transcriptional targets of AP1 family members Fra1 and Fra2
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    1 BioSystems Pathway for USF2
        Validated transcriptional targets of AP1 family members Fra1 and Fra2


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for USF2 (Q158533 ENSP000002223054) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383983, ENSP000003502834I2D: score=3 STRING: ENSP00000350283
    HSPA4LO957573, ENSP000002964644I2D: score=2 STRING: ENSP00000296464
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    SERPINB3P295083, ENSP000002837524I2D: score=2 STRING: ENSP00000283752
    SERPINB4P485943, ENSP000003434454I2D: score=2 STRING: ENSP00000343445
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000430regulation of transcription from RNA polymerase II promoter by glucose IC8576131
    GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007595lactation IEA--

    USF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    USF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USF2

    7 Novoseek inferred chemical compound relationships for USF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpa 67 20 9840809 (3), 9099698 (2), 10434034 (2)
    leucine 46.2 4 11467950 (1), 9070273 (1), 12917334 (1), 10373528 (1)
    iron 4.56 2 11447267 (1)
    pyruvate 0 1 16891625 (1)
    glucose 0 11 15184388 (4), 16891625 (2), 12086590 (1), 14757763 (1)
    fatty acid 0 1 16891625 (1)
    testosterone 0 1 15042619 (1)

    Search CenterWatch for drugs/clinical trials and news about USF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USF2 gene (2 alternative transcripts): 
    NM_003367.2  NM_207291.1  

    Unigene Cluster for USF2:

    Upstream transcription factor 2, c-fos interacting
    Hs.454534  [show with all ESTs]
    Unigene Representative Sequence: NM_003367
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343550(uc002nyr.1 uc002nyt.1) ENST00000222305(uc010xss.1 uc002nyq.1 uc002nyv.1)
    ENST00000595068 ENST00000379134 ENST00000602164 ENST00000594064 ENST00000598058
    ENST00000593708 ENST00000596380 ENST00000599471 ENST00000597671 ENST00000599625
    ENST00000600341 ENST00000594264 ENST00000600898
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate USF2 (see all 26):
    hsa-miR-362-3p hsa-miR-642a hsa-miR-137 hsa-miR-875-5p hsa-miR-25 hsa-miR-339-5p hsa-miR-650 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidUSF2 3' UTR sequence
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    Additional mRNA sequence: 

    AK297022.1 AY007087.1 AY147880.1 BC049821.1 CR536504.1 M77476.1 S50537.1 X90824.1 
    X90825.1 X90826.1 

    18 DOTS entries:

    DT.100791157  DT.97847462  DT.454984  DT.100791158  DT.99979974  DT.121415283  DT.100791160  DT.121415303 
    DT.97847461  DT.95299234  DT.95299225  DT.97763779  DT.102829673  DT.121415247  DT.121415265  DT.95085661 
    DT.100029239  DT.100791154 

    24/301 AceView cDNA sequences (see all 301):

    AI669029 BG397035 NM_003367 AI438990 NM_207291 BM477079 AI240157 BQ221624 
    CR600668 BM784641 BU176512 AJ572617 BF989326 BQ430057 BM917032 AI128012 
    BM763233 BU753609 CR609877 CA428164 BM811268 X90825 BM788253 AI955801 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for USF2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:                                -                                   -           -     -     -                                                         
    SP2:                          -     -                                   -           -     -     -                                                         
    SP3:                          -     -     -     -     -     -           -           -     -     -                                                         
    SP4:                                -                                   -           -     -     -           -                                             
    SP5:                                                                                            -                                                         


    ECgene alternative splicing isoforms for USF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCCCGC
    USF2 Expression
    About this image


    See USF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USF2

    SOURCE GeneReport for Unigene cluster: Hs.454534

    UniProtKB/Swiss-Prot: USF2_HUMAN, Q15853
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including USF2: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USF2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usf21 , 5 upstream transcription factor 21, 5 92.49(n)1
    97.98(a)1
      7 (19.27 cM)5
    222821  NM_011680.21  NP_035810.11 
     309452525 
    lizard
    (Anolis carolinensis)
    Reptilia USF26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343281.1(761922-789367)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149812 Transcribed sequence with moderate similarity to protein more 79.26(n)    CF239150.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK028544.12   -- 75.05(n)    CK028544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Usf6
    Usf
    15(a)
    1 → many
    X(4438648-4442802)


    ENSEMBL Gene Tree for USF2 (if available)
    TreeFam Gene Tree for USF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USF2 gene
    USF12  
    4 SIMAP similar genes for USF2 using alignment to 9 protein entries:     USF2_HUMAN (see all proteins):
    USF1    usf1-bd    KIAA2018    MAX

    USF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 SNPs in USF2 are shown (see all 312)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344909061,2
    C--35759374(+) CGCGC-/TCCCGG 2 -- us2k10--------
    rs25156211,2
    --35760167(+) GGCCCC/GGCTCA 2 -- int10--------
    rs22725391,2
    C--35760413(+) CGGGCC/GGGCCG 2 -- int12Minor allele frequency- G:0.00NA 4
    rs1402017281,2
    C--35760452(+) GCGGCA/CCTGAC 2 -- int10--------
    rs25156221,2
    C--35760622(+) gcgagG/Agcgaa 2 -- int12Minor allele frequency- A:0.00NA 4
    rs1500533701,2
    C--35760931(+) TGGGT-/GGGGGG 2 -- int10--------
    rs118824231,2
    H--35761078(+) GACAGT/AGCTCT 2 -- int14Minor allele frequency- A:0.00NS EA 408
    rs1178328461,2
    F--35761101(+) TTCCCG/ACAAAA 2 -- int11Minor allele frequency- A:0.02EA 120
    rs1844692011,2
    C--35761105(+) CGCAAA/GATGGG 2 -- int10--------
    rs1467880541,2
    --35761193(+) TGTTCC/TAGGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for USF2 (35759881 - 35770718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3850n71CNV Loss21882294
    nsv510765CNV Loss20534489
    esv27788CNV Loss19812545
    nsv911618CNV Loss21882294
    nsv911624CNV Loss21882294
    dgv1080e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600390    OMIM disorders: --

    20/23 diseases for USF2 (see all 23):    About MalaCards
    renal dysplasia    biliary atresia    gastroenteritis    non-small cell lung carcinoma
    microphthalmia    chronic myeloid leukemia    oral cancer    myelodysplastic syndromes
    endometriosis    hypoxia    peritonitis    mental retardation
    myeloid leukemia    lung cancer    alzheimer's disease    breast cancer
    endotheliitis    thyroiditis    prostatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for USF2:
    Peritonitis

    USF2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for USF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron overload 39.5 2 11447267 (1)
    glioblastoma 20.7 1 15276216 (1)
    breast cancer 3.82 1 9731700 (1)
    tumors 1.29 11 18331200 (4), 16186802 (2), 10523835 (1), 15864740 (1) (see all 6)
    carcinoma squamous cell 0 1 15856526 (1)
    cancer lung 0 5 15856526 (4)
    adenocarcinoma 0 2 15864740 (1), 15856526 (1)
    prostate cancer 0 5 15276216 (2), 16186802 (2)
    cancer 0 1 11241666 (1)

    Genetic Association Database (GAD): USF2
    Human Genome Epidemiology (HuGE) Navigator: USF2 (3 documents)

    Export disorders for USF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USF2 gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with USF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia. (PubMed id 8954795)1, 2, 3, 9 Groenen P.M.A....van de Ven W.J.M. (1996)
    2. Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression. (PubMed id 18970934)1, 4, 9 Huang Y.H....Chen C.L. (2008)
    3. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. (PubMed id 8576131)1, 2, 9 Viollet B.... Martinez A. (1996)
    4. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. (PubMed id 1450663)1, 2, 9 Sirito M.... Sawadogo M. (1992)
    5. Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. (PubMed id 1589769)1, 2, 9 Blanar M.A. and Rutter W.J. (1992)
    6. Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease. (PubMed id 16870626)1, 4 Shibata N....Arai H. (2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis. (PubMed id 18165439)1, 9 Utsunomiya H....Bulun S.E. (2008)
    10. Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2. (PubMed id 9099698)1, 9 Breen G.A. and Jordan E.M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7392 HGNC: 12594 AceView: USF2 Ensembl:ENSG00000105698 euGenes: HUgn7392
    ECgene: USF2 H-InvDB: USF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USF2 gene:
    Search GeneIP for patents involving USF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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