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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USF1 Gene

protein-coding   GIFtS: 56
GCID: GC01M161009

upstream transcription factor 1
 Explore 34 diseases affiliated with
USF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USF1    

Aliases
for USF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Upstream Transcription Factor 11 2     FCHL2
BHLHb111     FCHL12
MLTFI1 2     MLTF2
UEF1 2     Upstream Stimulatory Factor 12
Class B Basic Helix-Loop-Helix Protein 112 3     BHLHB113
Major Late Transcription Factor 12 3     USF3
HYPLIP12 5     

External Ids:    HGNC: 125931   Entrez Gene: 73912   Ensembl: ENSG000001587737   OMIM: 1915235   UniProtKB: P224153   

Export aliases for USF1 gene to outside databases

Previous GC identifers: GC01M158720 GC01M156741 GC01M157786 GC01M158225 GC01M158208 GC01M157822 GC01M159275 GC01M132366


Summaries
for USF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USF1:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular
transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements
and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this
gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. (provided by
RefSeq, Feb 2013)

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415
Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a
variety of viral and cellular promoters

Gene Wiki entry for USF1


Genomic Views
for USF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USF1 gene promoter:
         AP-1   ATF-2   c-Jun   ATF   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for USF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23

USF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161009:  view genomic region     (about GC identifiers)

Start:
 161,009,041 bp from pter      End:
 161,015,767 bp from pter
Size:
 6,727 bases      Orientation:
 minus strand

Proteins
for USF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: USF1_HUMAN, P22415 (See protein sequence)
Recommended Name: Upstream stimulatory factor 1  
Size: 310 amino acids; 33538 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for USF1:
1AN4 (3D)    
Secondary accessions: B2RBZ4 Q5SY46

Explore the universe of human proteins at neXtProt for USF1: NX_P22415

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22415

    • USF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001263302.1  NP_009053.1  NP_996888.1  

    ENSEMBL proteins: 
     ENSP00000356999   ENSP00000357000   ENSP00000356998   ENSP00000435671   ENSP00000433041  
     ENSP00000435005   ENSP00000432533   ENSP00000390109  

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    Novus Biologicals USF1 Proteins
    Novus Biologicals USF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USF1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15358760
    GO:0005667transcription factor complex IDA19303849


    USF1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for USF1

    Protein Domains /
    Families
    for USF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USF1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P22415

    ProtoNet protein and cluster: P22415

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: USF1_HUMAN, P22415
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for USF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: USF1_HUMAN, P22415
    Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a
    variety of viral and cellular promoters

         Genatlas biochemistry entry for USF1:
    upstream stimulatory transcription factor,ubiquitous (43 kDa),binding the AP-1/AP-4 site on the APP promoter

    10/756 SABiosciences Target genes for USF1 (see all 756):
    AACS ABCB11 ABCB8 ABHD10 ABI1 ACER2 ACOT11 ACSL4 ACTG2 ACTL6B

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate USF1 (see all 16):
    hsa-miR-148b hsa-miR-449a hsa-miR-1252 hsa-miR-4273 hsa-miR-148a hsa-miR-34c-5p hsa-miR-4271 hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmid: USF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USF1 (see all 7)
    OriGene shRNA RFP: USF1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USF1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for USF1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USF1

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IMP18234320
    GO:0005515protein binding IPI19303849


    USF1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for USF1: Usf1tm1Svl Usf1tm1Msw
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Usf1):
     behavior/neurological  mortality/aging  nervous system  normal 

    USF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for USF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling mediated by p38-alpha and p38-beta
    		Signaling mediated by p38-alpha and p38-beta1.00


    1 BioSystems Pathway for USF1 
        Signaling mediated by p38-alpha and p38-beta


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for USF1 (P224151, 3 ENSP000003569994) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT2BQ928311, 3, ENSP000002637544EBI-1054489,EBI-477430 I2D: score=2 STRING: ENSP00000263754
    PRKDCP785273, ENSP000003134204I2D: score=3 STRING: ENSP00000313420
    FOSL1P154073, ENSP000003101704I2D: score=2 STRING: ENSP00000310170
    GTF2IP783473, ENSP000003225424I2D: score=2 STRING: ENSP00000322542
    TOP2BQ028803, ENSP000003967044I2D: score=2 STRING: ENSP00000396704
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000430regulation of transcription from RNA polymerase II promoter by glucose IC8576131
    GO:0000432positive regulation of transcription from RNA polymerase II promoter by glucose ISS--
    GO:0001666response to hypoxia IMP12917334
    GO:0006006glucose metabolic process IEA--
    GO:0006351transcription, DNA-dependent ----


    USF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    USF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USF1
    10/18 Novoseek chemical compound relationships for USF1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 56.9 24 8306960 (2), 7642609 (2), 17827227 (2), 16010690 (1) (see all 16)
    oligonucleotide 30.6 9 10527831 (2), 7983715 (1), 15684402 (1), 1869565 (1) (see all 8)
    glucose 25.1 39 12200434 (4), 7852331 (4), 16376850 (3), 15175273 (3) (see all 20)
    lipid 21.4 35 18593823 (3), 19910639 (3), 15175273 (3), 15310455 (1) (see all 21)
    deoxycytidine 17 2 14514691 (1), 15729384 (1)
    cholesterol 16.6 10 18593823 (4), 17065663 (1), 15959806 (1), 18230803 (1) (see all 5)
    3-methylcholanthrene 13.5 4 9388470 (1)
    sterol 12.8 3 15814457 (1), 17493856 (1), 17313375 (1)
    chloramphenicol 12.5 2 7499336 (1), 9731700 (1)
    fatty acid 5.84 3 15814457 (1), 10103003 (1), 17313375 (1)

    Search CenterWatch for drugs/clinical trials and news about USF1 

    Transcripts
    for USF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USF1 gene (3 alternative transcripts): 
    NM_001276373.1  NM_007122.4  NM_207005.2  

    Unigene Cluster for USF1:

    Upstream transcription factor 1
    Hs.414880  [show with all ESTs]
    Unigene Representative Sequence: AL832119
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368020 ENST00000368021(uc001fxi.3 uc001fxj.3) ENST00000472217
    ENST00000368019 ENST00000473969 ENST00000528768 ENST00000531842 ENST00000496363
    ENST00000491629 ENST00000534633 ENST00000529476 ENST00000435396

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate USF1 (see all 16):
    hsa-miR-148b hsa-miR-449a hsa-miR-1252 hsa-miR-4273 hsa-miR-148a hsa-miR-34c-5p hsa-miR-4271 hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmid: USF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USF1 (see all 7)
    OriGene shRNA RFP: USF1
    OriGene siRNA: USF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USF1
    Clone
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    Additional cDNA sequence: 

    AB098540.1 AK314876.1 AL832119.1 BC035505.2 X55666.1 

    7 DOTS entries:

    DT.433299  DT.91708168  DT.91708167  DT.95172988  DT.100751470  DT.95172983  DT.100689001 

    24/44 AceView cDNA sequences (see all 44):

    T28080 BI910596 AB098540 BX284104 BM837168 NM_007122 NM_207005 AW607964 
    BG743195 BX400481 BI907062 BX400480 BC035505 BI768672 BQ951602 X55666 
    BG696772 AL558282 BX327387 BP362349 BG323427 R46312 AA449938 BP349554 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USF1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                          -                                   -                             -                           
    SP2:                                            -                 -                             -                           
    SP3:                          -                                                                                             
    SP4:                          -                 -                                                                           
    SP5:                          -                       -                                                                     


    ECgene alternative splicing isoforms for USF1

    Expression
    for USF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAGGAGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    USF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See USF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USF1

    SOURCE GeneReport for Unigene cluster: Hs.414880
        SABiosciences Expression via Pathway-Focused PCR Array including USF1: 
              JAK / STAT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for USF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USF1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves USF11 upstream transcription factor 1 78.57(n)
    87.99(a)    		   425126  NM_001007485.1  NP_001007486.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX851477.12   -- 79.42(n)    BX851477.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049481.12   -- 74.3(n)   393266  BC049481.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Usf6
    		 Usf
    		 16(a)
    		 1 → many
    		 X(4438648-4442802)


    ENSEMBL Gene Tree for USF1 (if available)
    TreeFam Gene Tree for USF1 (if available) 

    Paralogs
    for USF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USF1 gene
    USF22  
    4 SIMAP similar genes for USF1 using alignment to 6 protein entries:     USF1_HUMAN (see all proteins):
    usf1-bd    USF2    MAX    KIAA2018

    USF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USF1
    PGOHUM00000239166


    Genomic Variants
    for USF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 NCBI SNPs in USF1 are shown (see all 187)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120817411,2
    		C,H--132366641(+) CGAGTC/TTCCGG 2 -- ds50015Minor allele frequency- T:0.00NS EA NA 422
    rs758723921,2
    		F--132366737(+) CGCCTC/TCCGCG 2 -- ds50011Minor allele frequency- T:0.50NA 4
    rs37663821,2
    		C,F,A,--132366742(-) GGCGGA/CGCGGG 2 -- ds50018Minor allele frequency- C:0.48EA NS NA WA CSA 1884
    rs66565471,2
    		C,F,--132366788(+) CCCACC/AGCAGA 2 -- ds50016Minor allele frequency- A:0.03NS NA 220
    rs115852241,2
    		C,H--132366798(+) AAGCCC/TTTAAC 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs171755891,2
    		C--132366816(-) TGGCCC/TAAGCT 2 -- ds50013Minor allele frequency- T:0.01NS NA 96
    rs120818381,2
    		C,F,H,--132366831(+) CGACAC/TACCGG 2 -- ds50019Minor allele frequency- T:0.01NS EA NA WA 636
    rs120818411,2
    		H--132366838(+) CCGGTC/TTGGCC 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs75343211,2
    		C,F,H,--132366899(+) ACTTGG/ACACAG 2 -- ds50018Minor allele frequency- A:0.01NS EA NA WA 626
    rs42944361,2
    		C,H--132367254(+) AGGAAG/AAACCA 2 -- ut31 trp36Minor allele frequency- A:0.00NS EA NA 530

    HapMap Linkage Disequilibrium report for USF1 (161009041 - 161015767 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for USF1: --
    Human Gene Mutation Database (HGMD): USF1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USF1
    DNA2.0 Custom Variant and Variant Library Synthesis for USF1

    Disorders / Diseases
    for USF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USF1 for disorders           About GeneDecksing

    OMIM gene information: 191523   
    OMIM disorders: 602491  
    UniProtKB/Swiss-Prot: USF1_HUMAN, P22415
  • Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:602491]; also
    • known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total
    cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease

    20/34 diseases for USF1 (see all 34):    About MalaCards
    familial combined hyperlipidemia    hyperlipidemia    non-small cell lung carcinoma    adenomatous polyposis coli
    metabolic disorders    familial hypertriglyceridemia    familial hyperlipidemia    acute lymphoblastic leukemia
    hypertriglyceridemia    lymphoblastic leukemia    acute myeloid leukemia    myeloid leukemia
    polyposis    microphthalmia    lung carcinoma    osteosarcoma
    hypercholesterolemia    breast cancer    oral cancer    leukemia

    3 diseases from the University of Copenhagen DISEASES database for USF1:
    Familial hyperlipidemia     Familial hypertriglyceridemia     Coronary heart disease

    10/17 Novoseek disease relationships for USF1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperlipidemia familial combined 87 48 16531745 (6), 17065663 (2), 15959806 (2), 15976322 (2) (see all 21)
    dyslipidemia 38.1 16 20031629 (4), 19910639 (1), 16680034 (1), 19750004 (1) (see all 6)
    glioblastoma 21.7 3 12444925 (2), 11776974 (1)
    coronary heart disease 17.4 6 18276913 (2), 20031629 (1), 18577828 (1)
    immunodeficiency 12 5 7824954 (1), 15767439 (1), 2251256 (1), 11153081 (1) (see all 5)
    metabolic disorder 11.9 5 18303204 (1)
    carcinoma 2.78 1 17379962 (1)
    cardiovascular diseases 0 7 16699592 (2), 15310455 (1), 17885212 (1), 19403457 (1)
    niddm 0 3 18593823 (2), 16531745 (1)
    cancer lung 0 2 12403649 (2)

    Genetic Association Database (GAD): USF1
    Human Genome Epidemiology (HuGE) Navigator: USF1 (28 documents)

    Export disorders for USF1 gene to outside databases

    Publications
    for USF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USF1 gene, integrated from 9 sources (see all 333):
    (articles sorted by number of sources associating them with USF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. (PubMed id 16186412)1, 4, 9 Gibson F....Froguel P. (2005)
    2. The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. (PubMed id 16132950)1, 4, 9 Ng M.C....Chan J.C. (2005)
    3. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). (PubMed id 14991056)1, 2, 9 Pajukanta P.... Peltonen L. (2004)
    4. Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis. (PubMed id 15985485)1, 4, 9 Hoffstedt J....Arner P. (2005)
    5. Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II. (PubMed id 15175273)1, 4, 9 Putt W....Talmud P.J. (2004)
    6. Structure and function of the b/HLH/Z domain of USF. (PubMed id 8306960)1, 2, 9 Ferre-D'Amare A.R.... Burley S.K. (1994)
    7. Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23. (PubMed id 8486371)1, 3, 9 Shieh B.H....Lusis A.J. (1993)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Transcription factor USF, expressed during the entire phase of Varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication. (PubMed id 14573800)1, 2 Rahaus M.... Wolff M.H. (2003)
    10. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. (PubMed id 2249772)1, 2 Gregor P.D.... Roeder R.G. (1990)

    External Searches for USF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing USF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7391 HGNC: 12593 AceView: USF1 Ensembl:ENSG00000158773 euGenes: HUgn7391
    ECgene: USF1 H-InvDB: USF1

    Other Databases showing USF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USF1 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/usf1/

    Intellectual Property
    for USF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USF1 gene:
    Search GeneIP for patents involving USF1

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