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Aliases for USE1 Gene

Aliases for USE1 Gene

  • Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae) 2 3
  • Putative MAPK-Activating Protein PM26 3 4
  • USE1-Like Protein 3 4
  • Q-SNARE 2 3
  • P31 3 4
  • SNARE-Like Tail-Anchored Protein 1 Homolog (S. Cerevisiae) 2
  • SNARE-Like Tail-Anchored Protein 1 Homolog 3
  • Putative MAPK Activating Protein PM26 3
  • Vesicle Transport Protein USE1 3
  • Protein P31 3
  • MDS032 3
  • USE1L 4
  • SLT1 3
  • D12 3

External Ids for USE1 Gene

Summaries for USE1 Gene

GeneCards Summary for USE1 Gene

USE1 (Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics.

UniProtKB/Swiss-Prot for USE1 Gene

  • SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Wiki entry for USE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USE1 Gene

Genomics for USE1 Gene

Genomic Location for USE1 Gene

17,215,346 bp from pter
17,219,829 bp from pter
4,484 bases
Plus strand

Genomic View for USE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USE1 Gene

Regulatory Elements for USE1 Gene

Proteins for USE1 Gene

  • Protein details for USE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein USE1
    Protein Accession:
    Secondary Accessions:
    • Q8NCK1
    • Q9BRT4

    Protein attributes for USE1 Gene

    259 amino acids
    Molecular mass:
    29371 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.

    Alternative splice isoforms for USE1 Gene


neXtProt entry for USE1 Gene

Proteomics data for USE1 Gene at MOPED

Post-translational modifications for USE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USE1 Gene

Domains for USE1 Gene

Protein Domains for USE1 Gene


  • Belongs to the USE1 family.:
    • Q9NZ43
genes like me logo Genes that share domains with USE1: view

No data available for Gene Families for USE1 Gene

Function for USE1 Gene

Molecular function for USE1 Gene

UniProtKB/Swiss-Prot Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15029241
genes like me logo Genes that share ontologies with USE1: view
genes like me logo Genes that share phenotypes with USE1: view

Animal Models for USE1 Gene

MGI Knock Outs for USE1:

miRNA for USE1 Gene

miRTarBase miRNAs that target USE1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for USE1 Gene

Localization for USE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USE1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for USE1 Gene COMPARTMENTS Subcellular localization image for USE1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 2
nucleus 2
peroxisome 2
vacuole 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 NOT lysosome ISS 16354670
GO:0005783 endoplasmic reticulum IDA 15029241
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with USE1: view

Pathways for USE1 Gene

genes like me logo Genes that share pathways with USE1: view

Pathways by source for USE1 Gene

1 KEGG pathway for USE1 Gene

Gene Ontology (GO) - Biological Process for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 NOT ER to Golgi vesicle-mediated transport ISS 16354670
GO:0007029 endoplasmic reticulum organization --
GO:0007041 lysosomal transport ISS 16354670
GO:0015031 protein transport IEA --
GO:0030163 protein catabolic process ISS 16354670
genes like me logo Genes that share ontologies with USE1: view

Transcripts for USE1 Gene

Unigene Clusters for USE1 Gene

Unconventional SNARE in the ER 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: -

Relevant External Links for USE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USE1 Gene

mRNA expression in normal human tissues for USE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USE1 Gene

SOURCE GeneReport for Unigene cluster for USE1 Gene Hs.16187

genes like me logo Genes that share expressions with USE1: view

Orthologs for USE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for USE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USE1 36
  • 99.49 (n)
  • 100 (a)
USE1 37
  • 99 (a)
(Bos Taurus)
Mammalia -- 37
  • 92 (a)
USE1 36
  • 88.29 (n)
  • 94.59 (a)
USE1 37
  • 94 (a)
(Canis familiaris)
Mammalia USE1 36
  • 88.67 (n)
  • 93.05 (a)
USE1 37
  • 92 (a)
(Mus musculus)
Mammalia Use1 36
  • 82.43 (n)
  • 88.76 (a)
Use1 16
Use1 37
  • 80 (a)
(Monodelphis domestica)
Mammalia USE1 37
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 51 (a)
-- 37
  • 85 (a)
(Rattus norvegicus)
Mammalia Use1 36
  • 82.43 (n)
  • 89.53 (a)
(Gallus gallus)
Aves USE1 37
  • 59 (a)
(Anolis carolinensis)
Reptilia USE1 37
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10235 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5446 36
use1 36
  • 66.41 (n)
  • 72.16 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9046 36
(Danio rerio)
Actinopterygii use1 36
  • 65.36 (n)
  • 66.67 (a)
use1 37
  • 64 (a)
zgc56402 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005893 36
  • 50.93 (n)
  • 36.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Use1 36
  • 46.01 (n)
  • 34.3 (a)
Use1 37
  • 30 (a)
(Caenorhabditis elegans)
Secernentea use-1 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7185 37
  • 39 (a)
Species with no ortholog for USE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USE1 Gene

Gene Tree for USE1 (if available)
Gene Tree for USE1 (if available)

Paralogs for USE1 Gene Pseudogenes for USE1 Gene

genes like me logo Genes that share paralogs with USE1: view

No data available for Paralogs for USE1 Gene

Variants for USE1 Gene

Sequence variations from dbSNP and Humsavar for USE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15495 -- 17,219,672(-) AGTTT(A/C)TCCAG reference, missense
rs388484 -- 17,215,758(-) CCATG(A/T)CCTGA intron-variant
rs2343616 -- 17,218,540(-) CCTTT(G/T)ACTTC intron-variant
rs3745162 -- 17,219,842(+) CTTCC(G/T)TCTGT downstream-variant-500B
rs3760631 -- 17,214,652(+) ATGGG(C/G)GTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for USE1 Gene

Variant ID Type Subtype PubMed ID
dgv3756n71 CNV Loss 21882294
nsv458373 CNV Loss 19166990
dgv3757n71 CNV Loss 21882294
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294

Relevant External Links for USE1 Gene

HapMap Linkage Disequilibrium report

Disorders for USE1 Gene

(1) University of Copenhagen DISEASES for USE1 Gene

genes like me logo Genes that share disorders with USE1: view

No data available for UniProtKB/Swiss-Prot for USE1 Gene

Publications for USE1 Gene

  1. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 2 3 4
  2. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for USE1 Gene

Sources for USE1 Gene

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