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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USE1 Gene

protein-coding   GIFtS: 52
GCID: GC19P017326

unconventional SNARE in the ER 1 homolog (S. cerevisiae)
 Explore 4 diseases affiliated with
USE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USE1    

Aliases
for USE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae)1 2     Q-SNARE2
SLT11 2     Protein P312
P312     Putative MAPK Activating Protein PM262
Putative MAPK-Activating Protein PM262 3     SNARE-Like Tail-Anchored Protein 1 Homolog2
USE1-Like Protein2 3     Vesicle Transport Protein USE12
MDS0321     USE1L3
P312     

External Ids:    HGNC: 308821   Entrez Gene: 558502   Ensembl: ENSG000000535017   OMIM: 6106755   UniProtKB: Q9NZ433   

Export aliases for USE1 gene to outside databases

Previous GC identifers: GC19P017188 GC19P016893


Summaries
for USE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER

Gene Wiki entry for USE1


Genomic Views
for USE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USE1 gene promoter:
         AML1a   Pax-5   NRSF form 1   Nkx2-5   NRSF form 2   CREB   AREB6   NRF-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for USE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

USE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USE1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017326:  view genomic region     (about GC identifiers)

Start:
 17,326,155 bp from pter      End:
 17,330,638 bp from pter
Size:
 4,484 bases      Orientation:
 plus strand

Proteins
for USE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43 (See protein sequence)
Recommended Name: Vesicle transport protein USE1  
Size: 259 amino acids; 29371 Da
Subunit: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with
STX18
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
Secondary accessions: Q8NCK1 Q9BRT4
Alternative splicing: 3 isoforms:  Q9NZ43-1   Q9NZ43-2   Q9NZ43-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USE1: NX_Q9NZ43

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZ43

    • USE1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060937.1  
    ENSEMBL proteins: 
     ENSP00000263897   ENSP00000390287   ENSP00000369101  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: USE1
    OriGene Custom Protein Services for USE1 
    GenScript Custom Purified and Recombinant Proteins Services for USE1
    Novus Biologicals USE1 Protein
    Novus Biologicals USE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USE1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764NOT lysosome ISS16354670
    GO:0005783endoplasmic reticulum IDA15029241
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    USE1 for ontologies           About GeneDecksing



    USE1 Antibody Products: 
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    Novus Biologicals USE1 Antibodies
    Search for Antibodies for USE1 at Abcam  
    Uscn Antibodies for USE1
    Search ThermoFisher Antibodies for USE1

    Assay Products for USE1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for USE1
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    Uscn ELISAs and CLIAs for USE1

    Protein Domains /
    Families
    for USE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USE1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019150 Vesicle_transport_protein_Use1

    Graphical View of Domain Structure for InterPro Entry Q9NZ43

    ProtoNet protein and cluster: Q9NZ43

    UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43
    Similarity: Belongs to the USE1 family


    Function
    for USE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43
    Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USE1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USE1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USE1
    OriGene shRNA RFP: USE1
    OriGene siRNA: USE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USE1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USE1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USE1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USE1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USE1 (NM_018467)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USE1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for USE1
    Search LifeMap BioReagents cell lines for USE1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USE1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15272311


    USE1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for USE1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Use1tm1.2Aha for USE1
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Use1):
     behavior/neurological  cellular  mortality/aging  nervous system  normal 

    USE1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for USE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		SNARE interactions in vesicular transport0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for USE1):
        SNARE interactions in vesicular transport


    USE1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for USE1 (Q9NZ432, 3 ENSP000002638974) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSCL2Q96G972, 3, ENSP000003540324MINT-66301 I2D: score=5 STRING: ENSP00000354032
    UBR2Q8IWV83, ENSP000003619904I2D: score=1 STRING: ENSP00000361990
    UBR1Q8IWV73, ENSP000002906504I2D: score=1 STRING: ENSP00000290650
    APIPQ96GX93I2D: score=1 
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888NOT ER to Golgi vesicle-mediated transport ISS16354670
    GO:0007029endoplasmic reticulum organization ----
    GO:0007041lysosomal transport ISS16354670
    GO:0015031protein transport IEA--
    GO:0030163protein catabolic process ISS16354670


    USE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USE1
    Search CenterWatch for drugs/clinical trials and news about USE1 

    Transcripts
    for USE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USE1 gene: 
    NM_018467.3  

    Unigene Cluster for USE1:

    Unconventional SNARE in the ER 1 homolog (S. cerevisiae)
    Hs.16187  [show with all ESTs]
    Unigene Representative Sequence: BM547041
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263897(uc002nfo.2 uc010eal.1) ENST00000445667(uc002nfn.2)
    ENST00000379776

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USE1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USE1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USE1
    OriGene shRNA RFP: USE1
    OriGene siRNA: USE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USE1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USE1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USE1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USE1 (NM_018467)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USE1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USE1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USE1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USE1

    Additional cDNA sequence: 

    AB097050.1 AF220052.1 BC006005.1 BC008455.1 

    8 DOTS entries:

    DT.213248  DT.95376100  DT.91838143  DT.95376102  DT.97842560  DT.121486678  DT.40132019  DT.92419593 

    24/88 AceView cDNA sequences (see all 88):

    AA888099 BM907862 W19089 BP378581 AI027564 AA714010 BU734371 BM857204 
    BM795381 AA181709 BC006005 AF220052 AK074683 BQ053966 BC008455 BM791712 
    BI857253 AB097050 AI086150 AI344442 AW628473 BG760943 H98729 BM913851 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USE1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:                    -                                                         
    SP2:                    -     -                                                   
    SP3:                    -                                                         
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for USE1

    Expression
    for USE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTAAACTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    USE1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See USE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USE1

    SOURCE GeneReport for Unigene cluster: Hs.16187
        SABiosciences Custom PCR Arrays for USE1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USE1
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USE1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USE1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USE1

    Orthologs
    for USE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USE1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Use11 , 5 unconventional SNARE in the ER 1 homolog (S. cerevisiae)1, 5 82.43(n)1
    88.76(a)1    		   8 (34.43 cM)5
    670231  NM_001145780.11  NP_001139252.11 
     713669425 
    chicken
    (Gallus gallus)    		 Aves Q5ZMW7_CHICK6
    		 similar to uncharacterized hematopoietic stem/prog...
    		 75(a)
    		 1 ↔ 1
    		 28(3709960-3714211)
    lizard
    (Anolis carolinensis)    		 Reptilia USE16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 AAWZ02038925(380-3935)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.102352 Xenopus laevis transcribed sequence with moderate similarity more 70.82(n)    BX849816.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc564022 hypothetical protein MGC56402 73.5(n)   393294  BC052105.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Use11 CG14181-PA 44.94(n)
    32.39(a)    		   39051  NM_140032.3  NP_648289.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea use-16
    		 Vesicle transport protein USE1
    		 23(a)
    		 1 ↔ 1
    		 I(5106224-5107628)


    ENSEMBL Gene Tree for USE1 (if available)
    TreeFam Gene Tree for USE1 (if available) 

    Paralogs
    for USE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USE1 gene

    USE1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USE1
    PGOHUM00000245770


    Genomic Variants
    for USE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    5 NCBI SNPs in USE1 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs782574111,2
    		F,--16893205(+) AGGTAG/AGAGTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs749599721,2
    		C,--16893267(+) CACGCG/AGGTCT 1 -- us2k12Minor allele frequency- A:0.06NA 122
    rs81035571,2
    		C,A,--16893348(+) TCGCCT/GAAGTA 1 -- us2k13Minor allele frequency- G:0.14CSA WA NA 240
    rs353535081,2
    		C,F--17324949(+) TTTTTT/-GAGAC 1 -- us2k13Minor allele frequency- -:0.50NA 6
    rs58273641,2
    		----16892993(+) GTCCA-/TTTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USE1 (17326155 - 17330638 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for USE1
         1 CNV: 30072

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USE1
    DNA2.0 Custom Variant and Variant Library Synthesis for USE1

    Disorders / Diseases
    for USE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USE1 for disorders           About GeneDecksing

    OMIM gene information: 610675    OMIM disorders: --

    4 diseases for USE1:    About MalaCards
    hemolytic-uremic syndrome    dysentery    diarrhea    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for USE1:
    hemolytic-uremic syndrome

    Export disorders for USE1 gene to outside databases

    Publications
    for USE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USE1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with USE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2, 3 Hirose H.... Tagaya M. (2004)
    2. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PubMed id 16354670)1, 3 Okumura A.J....Wada I. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2 Nakajima K.... Tagaya M. (2004)
    6. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for USE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing USE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55850 HGNC: 30882 AceView: MDS032 Ensembl:ENSG00000053501 euGenes: HUgn55850
    ECgene: USE1 Kegg: 55850 H-InvDB: USE1

    Other Databases showing USE1 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing USE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USE1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USE1 gene:
    Search GeneIP for patents involving USE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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     USE1 Proteins, Antibodies, CLIAs, and ELISAs
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