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Aliases for USE1 Gene

Aliases for USE1 Gene

  • Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae) 2 3
  • Putative MAPK-Activating Protein PM26 3 4
  • USE1-Like Protein 3 4
  • Q-SNARE 2 3
  • P31 3 4
  • SNARE-Like Tail-Anchored Protein 1 Homolog (S. Cerevisiae) 2
  • SNARE-Like Tail-Anchored Protein 1 Homolog 3
  • Putative MAPK Activating Protein PM26 3
  • Protein P31 3
  • MDS032 3
  • USE1L 4
  • SLT1 3
  • D12 3

External Ids for USE1 Gene

Previous GeneCards Identifiers for USE1 Gene

  • GC19P017188
  • GC19P017326
  • GC19P016893
  • GC19P017270

Summaries for USE1 Gene

GeneCards Summary for USE1 Gene

USE1 (Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics.

UniProtKB/Swiss-Prot for USE1 Gene

  • SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Wiki entry for USE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USE1 Gene

Genomics for USE1 Gene

Regulatory Elements for USE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USE1 Gene

Chromosome:
19
Start:
17,215,346 bp from pter
End:
17,219,829 bp from pter
Size:
4,484 bases
Orientation:
Plus strand

Genomic View for USE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USE1 Gene

Proteins for USE1 Gene

  • Protein details for USE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ43-USE1_HUMAN
    Recommended name:
    Vesicle transport protein USE1
    Protein Accession:
    Q9NZ43
    Secondary Accessions:
    • Q8NCK1
    • Q9BRT4

    Protein attributes for USE1 Gene

    Size:
    259 amino acids
    Molecular mass:
    29371 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18.

    Alternative splice isoforms for USE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USE1 Gene

Proteomics data for USE1 Gene at MOPED

Post-translational modifications for USE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for USE1 Gene

Domains & Families for USE1 Gene

Protein Domains for USE1 Gene

Suggested Antigen Peptide Sequences for USE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ43

UniProtKB/Swiss-Prot:

USE1_HUMAN :
  • Belongs to the USE1 family.
Family:
  • Belongs to the USE1 family.
genes like me logo Genes that share domains with USE1: view

No data available for Gene Families for USE1 Gene

Function for USE1 Gene

Molecular function for USE1 Gene

UniProtKB/Swiss-Prot Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

Gene Ontology (GO) - Molecular Function for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15029241
genes like me logo Genes that share ontologies with USE1: view
genes like me logo Genes that share phenotypes with USE1: view

Animal Models for USE1 Gene

MGI Knock Outs for USE1:

Animal Model Products

CRISPR Products

miRNA for USE1 Gene

miRTarBase miRNAs that target USE1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for USE1 Gene

Localization for USE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USE1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USE1 Gene COMPARTMENTS Subcellular localization image for USE1 gene
Compartment Confidence
endoplasmic reticulum 4
endosome 2
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 NOT lysosome ISS 16354670
GO:0005783 endoplasmic reticulum IDA 15029241
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with USE1: view

Pathways & Interactions for USE1 Gene

genes like me logo Genes that share pathways with USE1: view

Pathways by source for USE1 Gene

1 KEGG pathway for USE1 Gene

Gene Ontology (GO) - Biological Process for USE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 NOT ER to Golgi vesicle-mediated transport ISS 16354670
GO:0007029 endoplasmic reticulum organization --
GO:0007041 lysosomal transport ISS 16354670
GO:0015031 protein transport IEA --
GO:0030163 protein catabolic process ISS 16354670
genes like me logo Genes that share ontologies with USE1: view

No data available for SIGNOR curated interactions for USE1 Gene

Drugs & Compounds for USE1 Gene

No Compound Related Data Available

Transcripts for USE1 Gene

mRNA/cDNA for USE1 Gene

Unigene Clusters for USE1 Gene

Unconventional SNARE in the ER 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for USE1 Gene

GeneLoc Exon Structure for
USE1
ECgene alternative splicing isoforms for
USE1

Expression for USE1 Gene

mRNA expression in normal human tissues for USE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USE1 Gene

This gene is overexpressed in Bone (36.4) and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USE1 Gene



SOURCE GeneReport for Unigene cluster for USE1 Gene Hs.16187

genes like me logo Genes that share expression patterns with USE1: view

Protein tissue co-expression partners for USE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USE1 Gene

Orthologs for USE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for USE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USE1 35
  • 88.29 (n)
  • 94.59 (a)
-- 36
  • 92 (a)
OneToMany
USE1 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia USE1 35
  • 88.67 (n)
  • 93.05 (a)
USE1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Use1 35
  • 82.43 (n)
  • 88.76 (a)
Use1 16
Use1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USE1 35
  • 99.49 (n)
  • 100 (a)
USE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Use1 35
  • 82.43 (n)
  • 89.53 (a)
oppossum
(Monodelphis domestica)
Mammalia USE1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves USE1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USE1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5446 35
use1 35
  • 66.41 (n)
  • 72.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10235 35
zebrafish
(Danio rerio)
Actinopterygii use1 35
  • 65.36 (n)
  • 66.67 (a)
zgc56402 35
use1 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9046 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005893 35
  • 50.93 (n)
  • 36.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Use1 35
  • 46.01 (n)
  • 34.3 (a)
Use1 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea use-1 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7185 36
  • 39 (a)
OneToOne
Species with no ortholog for USE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USE1 Gene

ENSEMBL:
Gene Tree for USE1 (if available)
TreeFam:
Gene Tree for USE1 (if available)

Paralogs for USE1 Gene

Pseudogenes.org Pseudogenes for USE1 Gene

genes like me logo Genes that share paralogs with USE1: view

No data available for Paralogs for USE1 Gene

Variants for USE1 Gene

Sequence variations from dbSNP and Humsavar for USE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15495 -- 17,219,672(-) AGTTT(A/C)TCCAG reference, missense
rs414528 - 17,219,251(-) CTGCC(A/G)ACTGC reference, missense
rs2343616 -- 17,218,540(-) CCTTT(G/T)ACTTC intron-variant
rs3745162 -- 17,219,842(+) CTTCC(A/G/T)TCTGT downstream-variant-500B
rs8100885 -- 17,216,892(+) agaat(C/T)gcttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USE1 Gene

Variant ID Type Subtype PubMed ID
dgv3756n71 CNV Loss 21882294
nsv458373 CNV Loss 19166990
dgv3757n71 CNV Loss 21882294
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294

Variation tolerance for USE1 Gene

Residual Variation Intolerance Score: 34.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USE1 Gene

HapMap Linkage Disequilibrium report
USE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USE1 Gene

Disorders for USE1 Gene

Relevant External Links for USE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USE1
genes like me logo Genes that share disorders with USE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USE1 Gene

Publications for USE1 Gene

  1. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PMID: 16354670) Okumura A.J. … Wada I. (J. Biol. Chem. 2006) 2 67
  2. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment. (PMID: 25184340) Nieradka A. … von Lindern M. (PLoS ONE 2014) 67

Products for USE1 Gene

Sources for USE1 Gene

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