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USE1 Gene

protein-coding   GIFtS: 56
GCID: GC19P017326

Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Unconventional SNARE In The ER 1 Homolog (S. Cerevisiae)1 2     Protein P312
Q-SNARE1 2     Putative MAPK Activating Protein PM262
Putative MAPK-Activating Protein PM262 3     SNARE-Like Tail-Anchored Protein 1 Homolog2
USE1-Like Protein2 3     Vesicle Transport Protein USE12
SNARE-Like Tail-Anchored Protein 1 Homolog (S. Cerevisiae)1     USE1L3
P312     p313
SLT12     

External Ids:    HGNC: 308821   Entrez Gene: 558502   Ensembl: ENSG000000535017   OMIM: 6106755   UniProtKB: Q9NZ433   

Export aliases for USE1 gene to outside databases

Previous GC identifers: GC19P017188 GC19P016893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USE1 Gene:
USE1 (unconventional SNARE in the ER 1 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with
the ER

Gene Wiki entry for USE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the USE1 gene promoter:
         AML1a   Pax-5   NRSF form 1   Nkx2-5   NRSF form 2   CREB   AREB6   NRF-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSE1 promoter sequence
   Search Chromatin IP Primers for USE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

USE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USE1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017326:  view genomic region     (about GC identifiers)

Start:
17,326,155 bp from pter      End:
17,330,638 bp from pter
Size:
4,484 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43 (See protein sequence)
Recommended Name: Vesicle transport protein USE1  
Size: 259 amino acids; 29371 Da
Subunit: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with
STX18
Secondary accessions: Q8NCK1 Q9BRT4
Alternative splicing: 3 isoforms:  Q9NZ43-1   Q9NZ43-2   Q9NZ43-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USE1: NX_Q9NZ43

Explore proteomics data for USE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See USE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060937.1  
    ENSEMBL proteins: 
     ENSP00000469658   ENSP00000263897   ENSP00000470487   ENSP00000472362   ENSP00000473239  
     ENSP00000470882   ENSP00000470065   ENSP00000390287   ENSP00000369101  

    USE1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for USE1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USE1
    GenScript Custom Purified and Recombinant Proteins Services for USE1
    Novus Biologicals USE1 Proteins
    Novus Biologicals USE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for USE1
    Cloud-Clone Corp. Proteins for USE1

     
    Search eBioscience for Proteins for USE1 

    USE1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for USE1

    USE1 Assay Products:

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    Search eBioscience for ELISAs for USE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019150 Vesicle_transport_protein_Use1

    Graphical View of Domain Structure for InterPro Entry Q9NZ43

    ProtoNet protein and cluster: Q9NZ43

    UniProtKB/Swiss-Prot: USE1_HUMAN, Q9NZ43
    Similarity: Belongs to the USE1 family


    Find genes that share domains with USE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USE1_HUMAN, Q9NZ43
    Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with
    the ER

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15029241
         
    Find genes that share ontologies with USE1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USE1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Use1):
     behavior/neurological  cellular  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with USE1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Use1tm1.2Aha for USE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target USE1:
    hsa-let-7e-5p (MIRT051637), hsa-mir-30a-5p (MIRT028623)

    Block miRNA regulation of human, mouse, rat USE1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate USE1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USE1
    Predesigned siRNA for gene silencing in human, mouse, rat USE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USE1

    Clone
    Products:
         
    OriGene clones in human, mouse for USE1 (see all 6)
    OriGene ORF clones in mouse, rat for USE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USE1 (NM_018467)
    Sino Biological Human cDNA Clone for USE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USE1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for USE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    USE1_HUMAN, Q9NZ43: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome2
    nucleus2
    peroxisome2
    vacuole2
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764NOT lysosome ISS16354670
    GO:0005783endoplasmic reticulum IDA15029241
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with USE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USE1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40


    Find genes that share SuperPaths with USE1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for USE1):
        SNARE interactions in vesicular transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USE1
    Interactions:

        Search GeneGlobe Interaction Network for USE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USE1 (Q9NZ432, 3 ENSP000002638974) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BSCL2Q96G972, 3, ENSP000003540324MINT-66301 I2D: score=5 STRING: ENSP00000354032
    UBR2Q8IWV83, ENSP000003619904I2D: score=1 STRING: ENSP00000361990
    UBR1Q8IWV73, ENSP000002906504I2D: score=1 STRING: ENSP00000290650
    APIPQ96GX93I2D: score=1 
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888NOT ER to Golgi vesicle-mediated transport ISS16354670
    GO:0007029endoplasmic reticulum organization ----
    GO:0007041lysosomal transport ISS16354670
    GO:0015031protein transport IEA--
    GO:0030163protein catabolic process ISS16354670

    Find genes that share ontologies with USE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USE1 gene: 
    NM_018467.3  

    Unigene Cluster for USE1:

    Unconventional SNARE in the ER 1 homolog (S. cerevisiae)
    Hs.16187  [show with all ESTs]
    Unigene Representative Sequence: BM547041
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601662 ENST00000263897(uc002nfo.2 uc010eal.1) ENST00000600970
    ENST00000595101 ENST00000596136 ENST00000601592 ENST00000594724 ENST00000593597
    ENST00000594399 ENST00000445667(uc002nfn.2) ENST00000379776
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USE1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate USE1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USE1
    Predesigned siRNA for gene silencing in human, mouse, rat USE1
    Clone
    Products:
         
    OriGene clones in human, mouse for USE1 (see all 6)
    OriGene ORF clones in mouse, rat for USE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USE1 (NM_018467)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USE1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USE1
    OriGene qSTAR qPCR primer pairs in human, mouse for USE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USE1
      QuantiTect SYBR Green Assays in human, mouse, rat USE1
      QuantiFast Probe-based Assays in human, mouse, rat USE1

    Additional mRNA sequence: 

    AB097050.1 AF220052.1 BC006005.1 BC008455.1 

    8 DOTS entries:

    DT.213248  DT.95376100  DT.91838143  DT.95376102  DT.97842560  DT.121486678  DT.40132019  DT.92419593 

    Selected AceView cDNA sequences (see all 88):

    W19089 AI027564 BM795381 BU734371 AA888099 BM907862 BM857204 AA714010 
    BP378581 BQ053966 BQ432062 BX107181 AB097050 AW628473 BC006005 AI344442 
    BM791712 BI758045 NM_018467 AA181709 AF220052 CA431340 BM549056 AI086150 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USE1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:                    -                                                         
    SP2:                    -     -                                                   
    SP3:                    -                                                         
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for USE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAAACTCA
    USE1 Expression
    About this image


    USE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    USE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16187
        Custom PCR Arrays for USE1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USE1
    OriGene qSTAR qPCR primer pairs in human, mouse for USE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USE1
    QuantiTect SYBR Green Assays in human, mouse, rat USE1
    QuantiFast Probe-based Assays in human, mouse, rat USE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USE1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Use11 , 5 unconventional SNARE in the ER 1 homolog (S. cerevisiae)1, 5 82.43(n)1
    88.76(a)1
      8 (34.43 cM)5
    670231  NM_001145780.11  NP_001139252.11 
     713669425 
    chicken
    (Gallus gallus)
    Aves USE16
    Gallus gallus unconventional SNARE in the ER 1 hom...
    59(a)
    1 ↔ 1
    28(3920735-3924954)
    lizard
    (Anolis carolinensis)
    Reptilia USE16
    unconventional SNARE in the ER 1 homolog (S. cerev...
    78(a)
    1 ↔ 1
    AAWZ02038925(380-3935)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102352 Xenopus laevis transcribed sequence with moderate similarity more 70.82(n)    BX849816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564022 hypothetical protein MGC56402 73.5(n)   393294  BC052105.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Use11 Use1 46.01(n)
    34.3(a)
      39051  NM_140032.3  NP_648289.2 
    worm
    (Caenorhabditis elegans)
    Secernentea use-16
    Protein USE-1 (use-1) mRNA, complete cds
    25(a)
    1 ↔ 1
    I(5106221-5107625) WBGene00022460


    ENSEMBL Gene Tree for USE1 (if available)
    TreeFam Gene Tree for USE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USE1 gene

    Find genes that share paralogs with USE1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USE1
    PGOHUM00000245770


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USE1 (see all 176)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468578531,2
    C--17256949(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1406455221,2
    --17257011(+) CTCTCA/GGGTTC 1 -- us2k10--------
    rs1459070551,2
    C--17257042(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs48086001,2
    C,F--17257199(+) ACAGGC/G/TGTGAG 1 -- us2k14NA WA 8
    rs1869481501,2
    C--17257206(+) TGAGCC/TACCGC 1 -- us2k10--------
    rs2019984601,2
    C--17257249(+) TTTTT-/CTTTTG 1 -- us2k10--------
    rs1927023671,2
    C--17257287(+) CTGGAA/GTGCAG 1 -- us2k10--------
    rs38437561,2
    C,F,A--17257318(+) GCAACG/ATCCAC 1 -- us2k15Minor allele frequency- A:0.33NA WA CSA 9
    rs1856554511,2
    --17257354(+) CCTCAG/TTCTCC 1 -- us2k10--------
    rs1177511771,2
    C--17257740(+) GTTCTC/GCATGG 1 -- us2k11Minor allele frequency- G:0.01EA 120

    HapMap Linkage Disequilibrium report for USE1 (17326155 - 17330638 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for USE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911182CNV Loss21882294
    dgv3756n71CNV Loss21882294
    dgv3757n71CNV Loss21882294
    nsv458373CNV Loss19166990
    nsv911185CNV Loss21882294
    nsv470129CNV Loss18288195
    dgv3758n71CNV Loss21882294
    nsv911186CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USE1
    DNA2.0 Custom Variant and Variant Library Synthesis for USE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610675    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for USE1:
    hemolytic-uremic syndrome

    Find genes that share disorders with USE1           About GenesLikeMe


    Export disorders for USE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USE1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with USE1)
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    1. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2, 3 Hirose H.... Tagaya M. (EMBO J. 2004)
    2. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. (PubMed id 16354670)1, 3 Okumura A.J....Wada I. (J. Biol. Chem. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2 Nakajima K.... Tagaya M. (EMBO J. 2004)
    6. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55850 HGNC: 30882 AceView: MDS032 Ensembl:ENSG00000053501 euGenes: HUgn55850
    ECgene: USE1 Kegg: 55850 H-InvDB: USE1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USE1 gene:
    Search GeneIP for patents involving USE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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