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UROC1 Gene

protein-coding   GIFtS: 52
GCID: GC03M126200

Urocanate Hydratase 1

(Previous name: urocanase domain containing 1)
  See UROC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Urocanate Hydratase 11 2     EC 4.2.1.493 8
Urocanase Domain Containing 11 2     HMFN03202
Urocanase 11 2     Urocanate Hydratase2
Imidazolonepropionate Hydrolase2 3     Urocanase3

External Ids:    HGNC: 264441   Entrez Gene: 1316692   Ensembl: ENSG000001596507   OMIM: 6130125   UniProtKB: Q96N763   

Export aliases for UROC1 gene to outside databases

Previous GC identifers: GC03M127683 GC03M123581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UROC1 Gene:
This gene encodes an enzyme involved in histidine catabolism, metabolizing urocanic acid to formiminoglutamic
acid. The gene product is known to protect the skin from ultra violet rays and is contained in human sweat.
Deficiency of this gene product in the liver is an apparent cause of mental retardation. Multiple transcript
variants encoding different isoforms have been found for this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for UROC1 Gene:
UROC1 (urocanate hydratase 1) is a protein-coding gene. Diseases associated with UROC1 include urocanase deficiency. GO annotations related to this gene include urocanate hydratase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UROC1 gene promoter:
         USF1   RP58   Pax-5   AML1a   MIF-1   E47   USF-1   Pax-4a   Zic3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUROC1 promoter sequence
   Search Chromatin IP Primers for UROC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UROC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.2

UROC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UROC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126200:  view genomic region     (about GC identifiers)

Start:
126,200,008 bp from pter      End:
126,236,616 bp from pter
Size:
36,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HUTU_HUMAN, Q96N76 (See protein sequence)
Recommended Name: Urocanate hydratase  
Size: 676 amino acids; 74831 Da
Cofactor: NAD (By similarity)
Sequence caution: Sequence=BAD38651.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: E9PE13 Q14C64 Q68CJ7
Alternative splicing: 2 isoforms:  Q96N76-1   Q96N76-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UROC1: NX_Q96N76

Explore proteomics data for UROC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for UROC1 (Q96N76)
     HNGGGVG  MYGQMTAGS  ELVTYGGNG  GFGPFRWVCTSG 


    See UROC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159446.1  NP_653240.1  

    ENSEMBL proteins: 
     ENSP00000290868   ENSP00000373073  
    Reactome Protein details: Q96N76

    UROC1 Human Recombinant Protein Products:

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    Novus Biologicals UROC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for UROC1

     
    Search eBioscience for Proteins for UROC1 

    UROC1 Antibody Products:

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    Search for Antibodies for UROC1 at Abcam
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    LSBio Antibodies in human, mouse, rat for UROC1

    UROC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UROC1
    Cloud-Clone Corp. CLIAs for UROC1
    Search eBioscience for ELISAs for UROC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023636 Urocanase_CS
     IPR023637 Urocanase

    Graphical View of Domain Structure for InterPro Entry Q96N76

    ProtoNet protein and cluster: Q96N76

    1 Blocks protein domain: IPB000193 Urocanase

    UniProtKB/Swiss-Prot: HUTU_HUMAN, Q96N76
    Similarity: Belongs to the urocanase family


    Find genes that share domains with UROC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HUTU_HUMAN, Q96N76
    Catalytic activity: 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H(2)O

         Enzyme Number (IUBMB): EC 4.2.1.491 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016153urocanate hydratase activity IDA19304569
         
    Find genes that share ontologies with UROC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UROC1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UROC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UROC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UROC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UROC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UROC1:
    hsa-let-7e-5p (MIRT051488)

    Block miRNA regulation of human, mouse, rat UROC1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate UROC1:
    hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidUROC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UROC1
    Predesigned siRNA for gene silencing in human, mouse, rat UROC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): UROC1 (NM_144639)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UROC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UROC1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UROC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UROC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with UROC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UROC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Histidine metabolism
    Histidine metabolism
    Histidine catabolism0.00
    3histidine degradation III
    histidine degradation III
    histidine degradation VI0.00
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives


    Find genes that share SuperPaths with UROC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UROC1
        histidine degradation III
    histidine degradation VI

    1 Reactome Pathway for UROC1
        Histidine catabolism


    2 Kegg Pathways  (Kegg details for UROC1):
        Histidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: HUTU_HUMAN, Q96N76
    Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from
    L-histidine: step 2/3

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UROC1
    Interactions:

        Search GeneGlobe Interaction Network for UROC1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for UROC1 (ENSP000002908684) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMDHD1ENSP000002667364STRING: ENSP00000266736
    HALENSP000002612084STRING: ENSP00000261208
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006548histidine catabolic process TAS--
    GO:0019556histidine catabolic process to glutamate and formamide IEA--
    GO:0019557histidine catabolic process to glutamate and formate IEA--
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with UROC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UROC1 (HUTU)

    6 HMDB Compounds for UROC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    4-Imidazolone-5-propionic acid4,5-dihydro-4-oxo-5-imidazolepropanoate (see all 20)17340-16-8--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Urocanic acid3-(1H-Imidazol-4-yl)-2-propenoate (see all 12)104-98-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UROC1 gene (2 alternative transcripts): 
    NM_001165974.1  NM_144639.2  

    Unigene Cluster for UROC1:

    Urocanate hydratase 1
    Hs.331148  [show with all ESTs]
    Unigene Representative Sequence: NM_001165974
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290868(uc010hsi.2 uc003eiz.2) ENST00000383579
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UROC1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate UROC1:
    hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidUROC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UROC1
    Predesigned siRNA for gene silencing in human, mouse, rat UROC1
    Clone
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    OriGene clones in human, mouse for UROC1 (see all 12)
    OriGene ORF clones in mouse, rat for UROC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UROC1 (NM_144639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UROC1
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UROC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UROC1
      QuantiTect SYBR Green Assays in human, mouse, rat UROC1
      QuantiFast Probe-based Assays in human, mouse, rat UROC1

    Additional mRNA sequence: 

    AB075869.1 AK055862.1 BC115405.1 BC115406.1 

    2 DOTS entries:

    DT.307853  DT.120894593 

    Selected AceView cDNA sequences (see all 43):

    NM_144639 AB075869 AK055862 CB141197 CB130058 CB141207 CB135588 CB139082 
    CB144256 BV181638 CB135235 CB148862 CB139076 CB137740 CB139102 CB147394 
    CB130096 CB141192 CB148856 CB147373 R01081 BX108463 CB135252 CB134885 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UROC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCCCTGA
    UROC1 Expression
    About this image


    UROC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    UROC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UROC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.331148
        Custom PCR Arrays for UROC1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UROC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UROC1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uroc11 , 5 urocanase domain containing 11, 5 87.26(n)1
    92(a)1
      6 (40.15 cM)5
    2435371  NM_144940.21  NP_659189.21 
     903332895 
    chicken
    (Gallus gallus)
    Aves UROC11 urocanase domain containing 1 72.99(n)
    81.48(a)
      416035  XM_414375.3  XP_414375.1 
    lizard
    (Anolis carolinensis)
    Reptilia UROC16
    urocanate hydratase 1
    80(a)
    1 ↔ 1
    2(169253875-169311655)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF522068.12   -- 76.49(n)    CF522068.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.119582 Transcribed sequence with weak similarity to protein more 77.1(n)    CD597444.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y51H4A.71 CELE_Y51H4A.7 57.6(n)
    62.06(a)
      178460  NM_070563.4  NP_502964.2 


    ENSEMBL Gene Tree for UROC1 (if available)
    TreeFam Gene Tree for UROC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UROC1 (see all 973)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0626494
    Urocanase deficiency (UROD)4--see VAR_0626492 L P mis40--------
    VAR_0602214
    Urocanase deficiency (UROD)4--see VAR_0602212 R C mis40--------
    rs1811886271,2
    --126199797(+) AAGGAC/TGCAGT 2 -- ds50010--------
    rs757758761,2
    C,F--126199869(+) AAATGT/CGTTTC 2 -- ds50011Minor allele frequency- C:0.13WA 118
    rs1156036331,2
    F--126199918(+) GCAGCC/TGCCCT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1854542551,2
    --126200000(+) AAAAGC/GAACCC 2 -- ds50010--------
    rs746944661,2
    F--126200006(+) AACCCC/TGCTGG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs76209461,2
    C,F--126200119(+) CAGCAA/GGGAAG 2 -- ut311Minor allele frequency- G:0.06EA 120
    rs7775131,2
    C,F,O,A,H--126200146(+) GTTTTT/ATTTAC 2 -- ut3123Minor allele frequency- A:0.42MN NS EA NA WA CSA 2509
    rs8009501,2
    C,F,A,H--126200291(+) TGCCCC/TTCTCC 2 -- ut31 ese322Minor allele frequency- T:0.41NS EA NA WA 3632

    HapMap Linkage Disequilibrium report for UROC1 (126200008 - 126236616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UROC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725868CNV Deletion23290073
    esv2725869CNV Deletion23290073
    nsv877432CNV Loss21882294
    nsv829717CNV Loss17160897
    dgv5246n71CNV Loss21882294
    dgv5247n71CNV Loss21882294
    nsv521785CNV Loss19592680
    esv24916CNV Gain19812545

    Human Gene Mutation Database (HGMD): UROC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UROC1
    DNA2.0 Custom Variant and Variant Library Synthesis for UROC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613012   
    OMIM disorders: 276880  
    UniProtKB/Swiss-Prot: HUTU_HUMAN, Q96N76
  • Urocanase deficiency (UROD) [MIM:276880]: An inborn error of histidine metabolism resulting in urocanic
    aciduria and neurological manifestations including mental retardation, ataxia, episodic aggressive behavior or
    exaggerated affection-seeking. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 1 disease for UROC1:    
    About MalaCards
    urocanase deficiency


    Find genes that share disorders with UROC1           About GenesLikeMe


    Export disorders for UROC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UROC1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with UROC1)
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    1. Mutations in the urocanase gene UROC1 are associated with urocanic aciduria. (PubMed id 19304569)1, 2, 3, 9 Espinos C.... Artuch R. (J. Med. Genet. 2009)
    2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The urocanase story: a novel role of NAD+ as electrophile. (PubMed id 7944380)1, 9 RActey J. (Arch. Biochem. Biophys. 1994)
    6. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (BMB Rep 2010)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. A liver urocanase deficiency. (PubMed id 6107814)1 Kalafatic Z....Res L. (Metab. Clin. Exp. 1980)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131669 HGNC: 26444 AceView: FLJ31300 Ensembl:ENSG00000159650 euGenes: HUgn131669
    ECgene: UROC1 Kegg: 131669 H-InvDB: UROC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UROC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UROC1 gene:
    Search GeneIP for patents involving UROC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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