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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

URM1 Gene

protein-coding GIFtS: 54
GCID: GC09P131133

ubiquitin related modifier 1

(Previous names: chromosome 9 open reading frame 74, ubiquitin related modifier...)
(Previous symbol: C9orf74)

Explore 2 diseases affiliated with
URM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Related Modifier 1¹ ²		Ubiquitin Related Modifier 1 Homolog (S. Cerevisiae)¹
C9orf74¹ ² ³		Ubiquitin Related Modifier 1 Homolog²
MGC2668¹		Ubiquitin-Related Modifier 1 Homolog²
Chromosome 9 Open Reading Frame 74¹

External Ids:	HGNC: 28378¹	Entrez Gene: 81605²	Ensembl: ENSG00000167118⁷	OMIM: 612693⁵	UniProtKB: Q9BTM9³

Export aliases for URM1 gene to outside databases

Previous GC identifers: GC09P130174 GC09P100747

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9

Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys),

tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its

C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an

ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however

unclear in vivo

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the URM1 gene promoter:
ER-alpha NF-1 Nkx2-5 E47 C/EBPalpha PPAR-alpha POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: URM1 promoter sequence

Search SABiosciences Chromatin IP Primers for URM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13

URM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URM1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P131133: view genomic region (about GC identifiers)

Start:	131,133,598 bp from pter	End:	131,153,015 bp from pter
Size:	19,418 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9 (See protein sequence)

Recommended Name: Ubiquitin-related modifier 1 homolog

Size: 101 amino acids; 11380 Da

Subunit: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3

Subcellular location: Cytoplasm

Caution: It has not been determined whether conjugation with target proteins involves the formation of thioester-type

bonds or isopeptide bonds. The formation of a free thiocarboxylate group for sulfur transfer is an alternate catalytic

path

Sequence caution: Sequence=CAI13492.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KMH3 B4DV08 Q5T4B4

Alternative splicing: 2 isoforms: Q9BTM9-1 Q9BTM9-2

Explore the universe of human proteins at neXtProt for URM1: NX_Q9BTM9

Post-translational modifications:

C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of

MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BTM9

URM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001129419.1 NP_001252511.1 NP_112176.1

ENSEMBL proteins:

ENSP00000361944 ENSP00000435186 ENSP00000361941 ENSP00000361938 ENSP00000412922

Human Recombinant Protein Products:

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	Novus Biologicals URM1 Proteins Novus Biologicals URM1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for URM1
	Uscn Proteins for URM1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IC	19017811

URM1 for ontologies About GeneDecksing

URM1 Antibody Products:

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	ThermoFisher Antibodies for URM1

Assay Products for URM1:

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	Uscn ELISAs and CLIAs for URM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

URM1 for domains About GeneDecksing

3 InterPro domains/families:

IPR016155 Mopterin_synth/thiamin_S_b

IPR012675 Beta-grasp_dom

IPR015221 Urm1

Graphical View of Domain Structure for InterPro Entry Q9BTM9

ProtoNet protein and cluster: Q9BTM9

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9

Similarity: Belongs to the URM1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9

Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys),

tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its

C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an

ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however

unclear in vivo

miRNA Products:		OriGene 3'-UTR Clone (see all 2): URM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat URM1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate URM1 (see all 26):
		hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: URM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for URM1 (see all 7) OriGene shRNA RFP: URM1 OriGene siRNA: URM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat URM1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for URM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URM1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URM1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): URM1 (NM_030914)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for URM1
		Search LifeMap BioReagents cell lines for URM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19017811
GO:0016783	contributes to sulfurtransferase activity	IDA	19017811

URM1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Molybdenum cofactor biosynthesis

Sulfur relay system

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for URM1):

Sulfur relay system

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9

Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis

URM1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for URM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/15 Interacting proteins for URM1 (Q9BTM9^{2, 3} ENSP00000412922⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASCC2	Q9H1I8²^,³	MINT-65478 I2D: score=5
TBL3	Q12788²^,³	MINT-65333 I2D: score=4
CDK11B	P21127²^,³	MINT-63553 I2D: score=3
ELP3	ENSP00000256398⁴	STRING: ENSP00000256398
MOCS3	ENSP00000244051⁴	STRING: ENSP00000244051

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002098	tRNA wobble uridine modification	IMP	19017811
GO:0034227	tRNA thio-modification	IMP	19017811

URM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for URM1
Search CenterWatch for drugs/clinical trials and news about URM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for URM1 gene (3 alternative transcripts):

NM_001135947.2 NM_001265582.1 NM_030914.3

Unigene Cluster for URM1:

Ubiquitin related modifier 1

Hs.495229 [show with all ESTs]

Unigene Representative Sequence: NM_001265582

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372853 ENST00000470840 ENST00000372850 ENST00000372847 ENST00000483206

ENST00000452446(uc004buv.2 uc011may.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): URM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat URM1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate URM1 (see all 26):
		hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116

		SwitchGear 3'UTR luciferase reporter plasmid: URM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for URM1 (see all 7) OriGene shRNA RFP: URM1 OriGene siRNA: URM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat URM1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URM1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URM1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): URM1 (NM_030914)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URM1
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URM1

Additional cDNA sequence:

AK001880.1 AK097029.1 AK300877.1 BC003581.1 BC011620.2 D83200.1 NR_049743.1

17 DOTS entries:

DT.445765 DT.207048 DT.100043851 DT.100822348 DT.91774078 DT.100822354 DT.443486 DT.95168338

DT.100822353 DT.97766879 DT.100808651 DT.100822345 DT.100822361 DT.121198286 DT.95117900 DT.95168342

DT.121198306

24/455 AceView cDNA sequences (see all 455):

AI858979 D81308 BU624386 BF793225 CD370268 AW024349 BQ064559 BI768920

CR604331 AW058290 BM723137 BQ020280 AI183849 CR593450 BP347465 AW771607

BX115462 BE263175 CR594010 BG479197 AI859037 BM757371 BI910648 BM847895

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for URM1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b
SP1:							-		-						-		-				-
SP2:							-								-		-				-
SP3:									-						-		-				-
SP4:							-		-						-		-
SP5:															-		-				-

ECgene alternative splicing isoforms for URM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

URM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAGATGA

About this image

URM1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See URM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for URM1

SOURCE GeneReport for Unigene cluster: Hs.495229

SABiosciences Custom PCR Arrays for URM1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for URM1 Browse OriGene validated miRNA SYBR primer pairs
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for URM1 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Urm1^{1 , 5}	ubiquitin related modifier 1 homolog (S. cerevisiae)^{1, 5}	89.11(n)¹ 93.07(a)¹		2 (20.67 cM)⁵ 68205¹ NM_026615.4¹ NP_080891.1¹ 29820075⁵
chicken (Gallus gallus)	Aves	URM1¹	ubiquitin related modifier 1	76.24(n) 86.14(a)		417221 NM_001007843.1 NP_001007844.1
lizard (Anolis carolinensis)	Reptilia	URM1⁶	--	69(a)	1 ↔ 1	GL344072.1(46733-63856)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5791²	Xenopus laevis transcribed sequence with moderate similarity more	74.55(n)		48018812
zebrafish (Danio rerio)	Actinopterygii	Dr.9887²	Danio rerio cDNA clone IMAGE6792209, partial cds	75.25(n)		BC056580.1
fruit fly (Drosophila melanogaster)	Insecta	CG33276¹	CG33276	61.81(n) 66.67(a)		2768949 NM_206296.3 NP_996018.2
worm (Caenorhabditis elegans)	Secernentea	urm-1⁶	Ubiquitin-related modifier 1 homolog	26(a)	1 ↔ 1	III(10505382-10505998)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G61113¹	ubiquitin-related modifier 1-2	58.42(n) 56.99(a)		6241165 NM_001125400.1 NP_001118872.1
rice (Oryza sativa)	Liliopsida	Os07g0466300¹	hypothetical protein	56.36(n) 56.7(a)		4343175 NM_001066123.1 NP_001059588.1

ENSEMBL Gene Tree for URM1 (if available)
TreeFam Gene Tree for URM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150502435^1,2		--	131131635(+)	`TTTTGA/GAGAAA`	4	--	us2k¹		0	--	--	--	--
rs75023866^1,2		--	131131742(+)	`TTACAG/AGTGTG`	4	--	us2k¹		2		CSA WA	120
rs183099953^1,2		--	131131879(+)	`ATACCA/CATAGG`	4	--	us2k¹		0	--	--	--	--
rs139623813^1,2		--	131132141(+)	`CCCATC/TGTGGC`	4	--	us2k¹		0	--	--	--	--
rs78943916^1,2	C,	--	131132171(+)	`ACAGGC/TATAAG`	4	--	us2k¹		1		WA	2
rs10119630^1,2	C,	--	131132266(+)	`ggagtT/Gcagtg`	4	--	us2k¹		1		CSA	1
rs139356227^1,2		--	131132321(+)	`GATTCC/TTCTGC`	4	--	us2k¹		0	--	--	--	--
rs11791257^1,2	C,F,H,	--	131132531(+)	`CGCGCC/ACGGCC`	4	--	us2k¹		1		NA	120
rs28372770^1,2	F,	--	131132706(+)	`GAAATG/ATTTAC`	4	--	us2k¹		3		MN EA	1372
rs7019382^1,2	C,F,H,	--	131132758(+)	`CTCCCT/CCTCTA`	4	--	us2k¹ trp³		19		NS EA NA	2352

HapMap Linkage Disequilibrium report for URM1 (131133598 - 131153015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for URM1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing URM1

DNA2.0 Custom Variant and Variant Library Synthesis for URM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

URM1 for disorders           About GeneDecksing

OMIM gene information: 612693    OMIM disorders: --

2 diseases for URM1:    About MalaCards

diphtheria malaria

Export disorders for URM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for URM1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with URM1)

Utopia: connect your pdf to the dynamic
world of online information

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PubMed id 19017811)^{1, 2} Schlieker C.D....Ploegh H.L. (2008)
Solution structure of Urm1 and its implications for the origin of protein modifiers. (PubMed id 16864801)^{1, 3} Xu J....Shi Y. (2006)
Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. (PubMed id 16046629)^{1, 3} Singh S....Markley J.L. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Urm1 couples sulfur transfer to ubiquitin-like protei n function in oxidative stress. (PubMed id 21245332)¹ Petroski M.D....Wolf D.A. (2011)
Role of the ubiquitin-like protein Urm1 as a noncanon ical lysine-directed protein modifier. (PubMed id 21209336)¹ Van der Veen A.G....Jentsch S. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81605	HGNC: 28378	AceView: C9orf74	Ensembl:ENSG00000167118	euGenes: HUgn81605
ECgene: URM1	Kegg: 81605	H-InvDB: URM1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for URM1	Pharmacogenomics, SNPs, Pathways

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Patent Information for URM1 gene:
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