Aliases for URM1 Gene
External Ids for URM1 Gene
Previous HGNC Symbols for URM1 Gene
Previous GeneCards Identifiers for URM1 Gene
GeneCards Summary for URM1 Gene
URM1 (Ubiquitin Related Modifier 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include sulfurtransferase activity.
UniProtKB/Swiss-Prot for URM1 Gene
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.