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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

URM1 Gene

protein-coding   GIFtS: 53
GCID: GC09P131133

Ubiquitin Related Modifier 1

(Previous names: chromosome 9 open reading frame 74, ubiquitin related modifier...)
(Previous symbol: C9orf74)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Related Modifier 11 2
C9orf741 2 3
Chromosome 9 Open Reading Frame 741
Ubiquitin Related Modifier 1 Homolog (S. Cerevisiae)1
Ubiquitin Related Modifier 1 Homolog2
Ubiquitin-Related Modifier 1 Homolog2

External Ids:    HGNC: 283781   Entrez Gene: 816052   Ensembl: ENSG000001671187   OMIM: 6126935   UniProtKB: Q9BTM93   

Export aliases for URM1 gene to outside databases

Previous GC identifers: GC09P130174 GC09P100747


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for URM1 Gene: 
URM1 (ubiquitin related modifier 1) is a protein-coding gene. Diseases associated with URM1 include diphtheria, and among its related super-pathways are Molybdenum cofactor biosynthesis. GO annotations related to this gene include protein binding and sulfurtransferase activity.

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys),
tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its
C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as
an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is
however unclear in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the URM1 gene promoter:
         ER-alpha   NF-1   Nkx2-5   E47   C/EBPalpha   PPAR-alpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidURM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for URM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

URM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131133:  view genomic region     (about GC identifiers)

Start:
131,133,598 bp from pter      End:
131,153,015 bp from pter
Size:
19,418 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9 (See protein sequence)
Recommended Name: Ubiquitin-related modifier 1 homolog  
Size: 101 amino acids; 11380 Da
Subunit: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3
Subcellular location: Cytoplasm
Caution: It has not been determined whether conjugation with target proteins involves the formation of
thioester-type bonds or isopeptide bonds. The formation of a free thiocarboxylate group for sulfur transfer is an
alternate catalytic path
Sequence caution: Sequence=CAI13492.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KMH3 B4DV08 Q5T4B4
Alternative splicing: 2 isoforms:  Q9BTM9-1   Q9BTM9-2   

Explore the universe of human proteins at neXtProt for URM1: NX_Q9BTM9

Explore proteomics data for URM1 at MOPED 

Post-translational modifications:

  • UniProtKB: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part
    of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BTM9

  • URM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    URM1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129419.1  NP_001252511.1  NP_112176.1  

    ENSEMBL proteins: 
     ENSP00000361944   ENSP00000435186   ENSP00000361941   ENSP00000361938   ENSP00000412922  

    Human Recombinant Protein Products for URM1: 
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    Novus Biologicals URM1 Proteins
    Novus Biologicals URM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for URM1
    Cloud-Clone Corp. Proteins for URM1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IC19017811

    URM1 for ontologies           About GeneDecksing



    URM1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for URM1 
    Cloud-Clone Corp. CLIAs for URM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016155 Mopterin_synth/thiamin_S_b
     IPR012675 Beta-grasp_dom
     IPR015221 Urm1

    Graphical View of Domain Structure for InterPro Entry Q9BTM9

    ProtoNet protein and cluster: Q9BTM9

    UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
    Similarity: Belongs to the URM1 family


    URM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: URM1_HUMAN, Q9BTM9
    Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys),
    tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its
    C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as
    an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is
    however unclear in vivo

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19017811
    GO:0016783contributes to sulfurtransferase activity IDA19017811
         
    URM1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for URM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for URM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for URM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for URM1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat URM1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate URM1 (see all 26):
    hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidURM1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of URM1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for URM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Molybdenum cofactor biosynthesis
    Sulfur relay system0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for URM1):
        Sulfur relay system

    UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
    Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis


    URM1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for URM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/15 Interacting proteins for URM1 (Q9BTM92, 3 ENSP000004129224) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCC2Q9H1I82, 3MINT-65478 I2D: score=5 
    TBL3Q127882, 3MINT-65333 I2D: score=4 
    CDK11BP211272, 3MINT-63553 I2D: score=3 
    ELP3ENSP000002563984STRING: ENSP00000256398
    MOCS3ENSP000002440514STRING: ENSP00000244051
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002098tRNA wobble uridine modification IMP19017811
    GO:0034227tRNA thio-modification IMP19017811

    URM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for URM1

    Search CenterWatch for drugs/clinical trials and news about URM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for URM1 gene (3 alternative transcripts): 
    NM_001135947.2  NM_001265582.1  NM_030914.3  

    Unigene Cluster for URM1:

    Ubiquitin related modifier 1
    Hs.495229  [show with all ESTs]
    Unigene Representative Sequence: NM_001265582
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372853 ENST00000470840 ENST00000372850 ENST00000372847 ENST00000483206
    ENST00000452446(uc004buv.2 uc011may.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat URM1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate URM1 (see all 26):
    hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidURM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for URM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat URM1
    Clone
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    OriGene clones in human, mouse for URM1 (see all 11)
    OriGene ORF clones in mouse, rat for URM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): URM1 (NM_030914)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URM1
    Sirion Biotech Customized lentivirus for stable overexpression of URM1 
                         Customized lentivirus expression plasmids for stable overexpression of URM1 
    Primer
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    OriGene qPCR primer pairs and template standards for URM1
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat URM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URM1
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URM1

    Additional mRNA sequence: 

    AK001880.1 AK097029.1 AK300877.1 BC003581.1 BC011620.2 D83200.1 NR_049743.1 

    17 DOTS entries:

    DT.445765  DT.207048  DT.100043851  DT.100822348  DT.91774078  DT.100822354  DT.443486  DT.95168338 
    DT.100822353  DT.97766879  DT.100808651  DT.100822345  DT.100822361  DT.121198286  DT.95117900  DT.95168342 
    DT.121198306 

    24/455 AceView cDNA sequences (see all 455):

    AI911555 BI823098 CB268425 AA312576 BC011620 BM703399 BQ020280 BU624386 
    BI753933 BQ064559 AA293590 AK097029 CR609902 BM682528 BE797434 BU728012 
    BG036168 CB154420 BI910648 D81308 AW771607 AW024349 CD370268 AA303492 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for URM1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
    SP1:                    -     -                 -     -           -                                       
    SP2:                    -                       -     -           -                                       
    SP3:                          -                 -     -           -                                       
    SP4:                    -     -                 -     -                                                   
    SP5:                                            -     -           -                                       


    ECgene alternative splicing isoforms for URM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    URM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGATGA
    URM1 Expression
    About this image


    See URM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for URM1

    SOURCE GeneReport for Unigene cluster: Hs.495229
        SABiosciences Custom PCR Arrays for URM1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for URM1 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Urm11 , 5 ubiquitin related modifier 1 homolog (S. cerevisiae)1, 5 89.11(n)1
    93.07(a)1
      2 (20.67 cM)5
    682051  NM_026615.41  NP_080891.11 
     298200755 
    chicken
    (Gallus gallus)
    Aves URM11 ubiquitin related modifier 1 76.24(n)
    86.14(a)
      417221  NM_001007843.1  NP_001007844.1 
    lizard
    (Anolis carolinensis)
    Reptilia URM16
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL344072.1(46733-64407)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57912 Xenopus laevis transcribed sequence with moderate similarity more 74.55(n)    48018812 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.98872 Danio rerio cDNA clone IMAGE6792209, partial cds 75.25(n)    BC056580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332761 CG33276 61.81(n)
    66.67(a)
      2768949  NM_206296.3  NP_996018.2 
    worm
    (Caenorhabditis elegans)
    Secernentea urm-16
    Protein URM-1
    27(a)
    1 ↔ 1
    III(10505480-10506096)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URM1(YIL008W)4 Ubiquitin-like protein involved in thiolation of cytoplasmic more   --   9(342536-342835) 854809  NP_012258.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G611131 ubiquitin-related modifier 1-2 58.42(n)
    56.99(a)
      6241165  NM_001125400.1  NP_001118872.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04663001 hypothetical protein 56.36(n)
    56.7(a)
      4343175  NM_001066123.1  NP_001059588.1 


    ENSEMBL Gene Tree for URM1 (if available)
    TreeFam Gene Tree for URM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 SNPs in URM1 are shown (see all 400)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505024351,2
    C--131131635(+) TTTTGA/GAGAAA 4 -- us2k10--------
    rs750238661,2
    F--131131742(+) TTACAG/AGTGTG 4 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs1830999531,2
    --131131879(+) ATACCA/CATAGG 4 -- us2k10--------
    rs1396238131,2
    --131132141(+) CCCATC/TGTGGC 4 -- us2k10--------
    rs789439161,2
    C,F--131132171(+) ACAGGC/TATAAG 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs101196301,2
    C,F--131132266(+) ggagtT/Gcagtg 4 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1393562271,2
    --131132321(+) GATTCC/TTCTGC 4 -- us2k10--------
    rs117912571,2
    C,F,H--131132531(+) CGCGCC/ACGGCC 4 -- us2k11Minor allele frequency- A:0.07NA 120
    rs283727701,2
    C,F--131132706(+) GAAATG/ATTTAC 4 -- us2k13Minor allele frequency- A:0.08MN EA 1372
    rs70193821,2
    C,F,H--131132758(+) CTCCCT/CCTCTA 4 -- us2k1 trp319Minor allele frequency- C:0.07NS EA NA 2352

    HapMap Linkage Disequilibrium report for URM1 (131133598 - 131153015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for URM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294
    nsv893898CNV Loss21882294
    dgv8295n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612693    OMIM disorders: --

    2 diseases for URM1:    About MalaCards
    diphtheria    


    URM1 for disorders           About GeneDecksing


    Export disorders for URM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for URM1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with URM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PubMed id 19017811)1, 2 Schlieker C.D....Ploegh H.L. (2008)
    2. Solution structure of Urm1 and its implications for the origin of protein modifiers. (PubMed id 16864801)1, 3 Xu J....Shi Y. (2006)
    3. Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. (PubMed id 16046629)1, 3 Singh S....Markley J.L. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Urm1 couples sulfur transfer to ubiquitin-like protei n function in oxidative stress. (PubMed id 21245332)1 Petroski M.D....Wolf D.A. (2011)
    9. Role of the ubiquitin-like protein Urm1 as a noncanon ical lysine-directed protein modifier. (PubMed id 21209336)1 Van der Veen A.G....Jentsch S. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81605 HGNC: 28378 AceView: C9orf74 Ensembl:ENSG00000167118 euGenes: HUgn81605
    ECgene: URM1 Kegg: 81605 H-InvDB: URM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for URM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for URM1 gene:
    Search GeneIP for patents involving URM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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