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URM1 Gene

protein-coding   GIFtS: 53
GCID: GC09P131133

Ubiquitin Related Modifier 1

(Previous names: chromosome 9 open reading frame 74, ubiquitin related modifier...)
(Previous symbol: C9orf74)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Related Modifier 11 2     Ubiquitin Related Modifier 1 Homolog2
C9orf741 2 3     Ubiquitin-Related Modifier 12
Chromosome 9 Open Reading Frame 741     Ubiquitin-Related Modifier 1 Homolog2
Ubiquitin Related Modifier 1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 283781   Entrez Gene: 816052   Ensembl: ENSG000001671187   OMIM: 6126935   UniProtKB: Q9BTM93   

Export aliases for URM1 gene to outside databases

Previous GC identifers: GC09P130174 GC09P100747


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for URM1 Gene:
URM1 (ubiquitin related modifier 1) is a protein-coding gene. GO annotations related to this gene include sulfurtransferase activity.

UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic
tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being
thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation
of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond
to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form
serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein
conjugates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the URM1 gene promoter:
         ER-alpha   NF-1   Nkx2-5   E47   C/EBPalpha   PPAR-alpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidURM1 promoter sequence
   Search Chromatin IP Primers for URM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat URM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

URM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131133:  view genomic region     (about GC identifiers)

Start:
131,133,598 bp from pter      End:
131,153,015 bp from pter
Size:
19,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9 (See protein sequence)
Recommended Name: Ubiquitin-related modifier 1  
Size: 101 amino acids; 11380 Da
Subunit: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3
Sequence caution: Sequence=CAI13492.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KMH3 B4DV08 Q5T4B4
Alternative splicing: 2 isoforms:  Q9BTM9-1   Q9BTM9-2   

Explore the universe of human proteins at neXtProt for URM1: NX_Q9BTM9

Explore proteomics data for URM1 at MOPED

Post-translational modifications: 

  • C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part
    of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS31
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See URM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129419.1  NP_001252511.1  NP_112176.1  

    ENSEMBL proteins: 
     ENSP00000361944   ENSP00000435186   ENSP00000361941   ENSP00000361938   ENSP00000412922  

    URM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for URM1
    OriGene Purified Protein for URM1
    OriGene Protein Over-expression Lysate for URM1
    OriGene MassSpec for URM1
    OriGene Custom Protein Services for URM1
    GenScript Custom Purified and Recombinant Proteins Services for URM1
    Novus Biologicals URM1 Proteins
    Novus Biologicals URM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for URM1
    Cloud-Clone Corp. Proteins for URM1

     
    Search eBioscience for Proteins for URM1 

    URM1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for URM1
    Cloud-Clone Corp. Antibodies for URM1
    ThermoFisher Antibodies for URM1
    LSBio Antibodies in human, mouse, rat for URM1

    URM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for URM1
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    Search eBioscience for ELISAs for URM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016155 Mopterin_synth/thiamin_S_b
     IPR012675 Beta-grasp_dom
     IPR015221 Urm1

    Graphical View of Domain Structure for InterPro Entry Q9BTM9

    ProtoNet protein and cluster: Q9BTM9

    UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
    Similarity: Belongs to the URM1 family


    Find genes that share domains with URM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: URM1_HUMAN, Q9BTM9
    Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic
    tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being
    thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation
    of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond
    to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form
    serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein
    conjugates

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19017811
    GO:0016783contributes to sulfurtransferase activity IDA19017811
         
    Find genes that share ontologies with URM1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for URM1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for URM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for URM1

    miRNA
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    miRTarBase miRNAs that target URM1:
    hsa-mir-24-3p (MIRT030374), hsa-mir-30a-5p (MIRT028530)

    Block miRNA regulation of human, mouse, rat URM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate URM1 (see all 26):
    hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidURM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for URM1
    Predesigned siRNA for gene silencing in human, mouse, rat URM1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for URM1 (see all 11)
    OriGene ORF clones in mouse, rat for URM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): URM1 (NM_030914)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URM1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for URM1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    URM1_HUMAN, Q9BTM9: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IC19017811

    Find genes that share ontologies with URM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for URM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Sulfur relay system
    Sulfur relay system


    Find genes that share SuperPaths with URM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for URM1):
        Sulfur relay system

    UniProtKB/Swiss-Prot: URM1_HUMAN, Q9BTM9
    Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for URM1
    Interactions:

        Search GeneGlobe Interaction Network for URM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for URM1 (Q9BTM92, 3 ENSP000004129224) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCC2Q9H1I82, 3MINT-65478 I2D: score=5 
    TBL3Q127882, 3MINT-65333 I2D: score=4 
    CDK11BP211272, 3MINT-63553 I2D: score=3 
    MOCS3ENSP000002440514STRING: ENSP00000244051
    CTU2ENSP000003883204STRING: ENSP00000388320
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002098tRNA wobble uridine modification IMP19017811
    GO:0032447protein urmylation IEA--
    GO:0034227tRNA thio-modification IMP19017811

    Find genes that share ontologies with URM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for URM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for URM1 gene (3 alternative transcripts): 
    NM_001135947.2  NM_001265582.1  NM_030914.3  

    Unigene Cluster for URM1:

    Ubiquitin related modifier 1
    Hs.495229  [show with all ESTs]
    Unigene Representative Sequence: NM_001265582
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372853 ENST00000470840 ENST00000372850 ENST00000372847 ENST00000483206
    ENST00000452446(uc004buv.2 uc011may.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat URM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate URM1 (see all 26):
    hsa-miR-1178 hsa-miR-29c hsa-miR-29a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-141* hsa-miR-23b* hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidURM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for URM1
    Predesigned siRNA for gene silencing in human, mouse, rat URM1
    Clone
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    OriGene clones in human, mouse for URM1 (see all 11)
    OriGene ORF clones in mouse, rat for URM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): URM1 (NM_030914)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URM1
    Primer
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    OriGene qPCR primer pairs and template standards for URM1
    OriGene qSTAR qPCR primer pairs in human, mouse for URM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat URM1
      QuantiTect SYBR Green Assays in human, mouse, rat URM1
      Search QuantiFast Probe-based Assays in human, mouse, rat URM1

    Additional mRNA sequence: 

    AK001880.1 AK097029.1 AK300877.1 BC003581.1 BC011620.2 D83200.1 NR_049743.1 

    17 DOTS entries:

    DT.445765  DT.207048  DT.100043851  DT.100822348  DT.91774078  DT.100822354  DT.443486  DT.95168338 
    DT.100822353  DT.97766879  DT.100808651  DT.100822345  DT.100822361  DT.121198286  DT.95117900  DT.95168342 
    DT.121198306 

    Selected AceView cDNA sequences (see all 455):

    BQ213877 BG676013 AA308410 AA293590 AI677963 CF127976 BI753933 AA312576 
    BM677661 BX115462 D81308 CR594010 CR609902 AW058290 AI183849 AI126384 
    BC011620 CR592013 AK097029 AW770141 CD370268 BF793225 BM703399 CR609073 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for URM1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b
    SP1:                    -     -                 -     -           -                                       
    SP2:                    -                       -     -           -                                       
    SP3:                          -                 -     -           -                                       
    SP4:                    -     -                 -     -                                                   
    SP5:                                            -     -           -                                       


    ECgene alternative splicing isoforms for URM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    URM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGATGA
    URM1 Expression
    About this image

    URM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    URM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495229
        Custom PCR Arrays for URM1
    Primer
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    Search QuantiFast Probe-based Assays in human, mouse, rat URM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for URM1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Urm11 , 5 ubiquitin related modifier 1 homolog (S. cerevisiae)1, 5 89.11(n)1
    93.07(a)1
      2 (20.67 cM)5
    682051  NM_026615.41  NP_080891.11 
     298200755 
    chicken
    (Gallus gallus)
    Aves URM11 ubiquitin related modifier 1 76.24(n)
    86.14(a)
      417221  NM_001007843.1  NP_001007844.1 
    lizard
    (Anolis carolinensis)
    Reptilia URM16
    ubiquitin related modifier 1
    65(a)
    1 ↔ 1
    GL344072.1(46733-64407)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57912 Xenopus laevis transcribed sequence with moderate similarity more 74.55(n)    48018812 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.98872 Danio rerio cDNA clone IMAGE6792209, partial cds 75.25(n)    BC056580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332761 CG33276 62(n)
    66(a)
      2768949  NM_206296.3  NP_996018.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URM1(YIL008W)4 Ubiquitin-like protein involved in thiolation of cytoplasmic more   --   9(342536-342835) 854809  NP_012258.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G456951 AT2G45695 57.73(n)
    55.67(a)
      5007965  NM_001084595.2  NP_001078064.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04663001 Os07g0466300 56.36(n)
    56.7(a)
      4343175  NM_001066123.1  NP_001059588.1 


    ENSEMBL Gene Tree for URM1 (if available)
    TreeFam Gene Tree for URM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for URM1 (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505024351,2
    C--131131635(+) TTTTGA/GAGAAA 4 -- us2k10--------
    rs750238661,2
    F--131131742(+) TTACAG/AGTGTG 4 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs1830999531,2
    --131131879(+) ATACCA/CATAGG 4 -- us2k10--------
    rs1396238131,2
    --131132141(+) CCCATC/TGTGGC 4 -- us2k10--------
    rs789439161,2
    C,F--131132171(+) ACAGGC/TATAAG 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs101196301,2
    C,F--131132266(+) ggagtT/Gcagtg 4 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1393562271,2
    --131132321(+) GATTCC/TTCTGC 4 -- us2k10--------
    rs117912571,2
    C,F,H--131132531(+) CGCGCC/ACGGCC 4 -- us2k11Minor allele frequency- A:0.07NA 120
    rs283727701,2
    C,F--131132706(+) GAAATG/ATTTAC 4 -- us2k13Minor allele frequency- A:0.08MN EA 1372
    rs70193821,2
    C,F,H--131132758(+) CTCCCT/CCTCTA 4 -- us2k1 trp319Minor allele frequency- C:0.07NS EA NA 2352

    HapMap Linkage Disequilibrium report for URM1 (131133598 - 131153015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for URM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294
    nsv893898CNV Loss21882294
    dgv8295n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612693    OMIM disorders: --


    Find genes that share disorders with URM1           About GenesLikeMe


    Export disorders for URM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for URM1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with URM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. (PubMed id 21209336)1, 2 Van der Veen A.G....Jentsch S. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    2. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PubMed id 19017811)1, 2 Schlieker C.D....Ploegh H.L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    3. Solution structure of Urm1 and its implications for the origin of protein modifiers. (PubMed id 16864801)1, 3 Xu J....Shi Y. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    4. Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. (PubMed id 16046629)1, 3 Singh S....Markley J.L. (Protein Sci. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. (PubMed id 21245332)1 Petroski M.D....Wolf D.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81605 HGNC: 28378 AceView: C9orf74 Ensembl:ENSG00000167118 euGenes: HUgn81605
    ECgene: URM1 Kegg: 81605 H-InvDB: URM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for URM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for URM1 gene:
    Search GeneIP for patents involving URM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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