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Aliases for URI1 Gene

Aliases for URI1 Gene

  • URI1 Prefoldin-Like Chaperone 2 3 5
  • RPB5-Mediating Protein 2 3 4
  • RNA Polymerase II Subunit 5-Mediating Protein 3 4
  • Protein Phosphatase 1 Regulatory Subunit 19 3 4
  • C19orf2 3 4
  • PPP1R19 3 4
  • NNX3 3 4
  • RMP 3 4
  • URI 3 4
  • Protein Phosphatase 1, Regulatory Subunit 19 3
  • Unconventional Prefoldin RPB5 Interactor 2
  • Chromosome 19 Open Reading Frame 2 2
  • URI1, Prefoldin-Like Chaperone 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 19 2
  • Protein NNX3 4

External Ids for URI1 Gene

Previous HGNC Symbols for URI1 Gene

  • C19orf2

Previous GeneCards Identifiers for URI1 Gene

  • GC19P030415

Summaries for URI1 Gene

Entrez Gene Summary for URI1 Gene

  • This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

GeneCards Summary for URI1 Gene

URI1 (URI1 Prefoldin-Like Chaperone) is a Protein Coding gene. Diseases associated with URI1 include hepatocellular carcinoma. GO annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for URI1 Gene

  • Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.

  • Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Gene Wiki entry for URI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URI1 Gene

Genomics for URI1 Gene

Genomic Location for URI1 Gene

Chromosome:
19
Start:
29,923,644 bp from pter
End:
30,016,612 bp from pter
Size:
92,969 bases
Orientation:
Plus strand

Genomic View for URI1 Gene

Genes around URI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URI1 Gene

No data available for Regulatory Elements for URI1 Gene

Proteins for URI1 Gene

  • Protein details for URI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94763-RMP_HUMAN
    Recommended name:
    Unconventional prefoldin RPB5 interactor 1
    Protein Accession:
    O94763
    Secondary Accessions:
    • A8K805
    • H7BY42
    • Q8TC23
    • Q9UNU3

    Protein attributes for URI1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT.
    SequenceCaution:
    • Sequence=AAH26184.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for URI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for URI1 Gene

Proteomics data for URI1 Gene at MOPED

Post-translational modifications for URI1 Gene

  • Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling.
  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for URI1 (RMP)

No data available for DME Specific Peptides for URI1 Gene

Domains & Families for URI1 Gene

Protein Domains for URI1 Gene

Graphical View of Domain Structure for InterPro Entry

O94763

UniProtKB/Swiss-Prot:

RMP_HUMAN :
  • Belongs to the RNA polymerase II subunit 5-mediating protein family.
Family:
  • Belongs to the RNA polymerase II subunit 5-mediating protein family.
genes like me logo Genes that share domains with URI1: view

Function for URI1 Gene

Molecular function for URI1 Gene

UniProtKB/Swiss-Prot Function:
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.
UniProtKB/Swiss-Prot Function:
Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Gene Ontology (GO) - Molecular Function for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IMP 9819440
GO:0003682 chromatin binding IDA 21730289
genes like me logo Genes that share ontologies with URI1: view
genes like me logo Genes that share phenotypes with URI1: view

Animal Models for URI1 Gene

MGI Knock Outs for URI1:
  • Uri1 tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for URI1 Gene

miRTarBase miRNAs that target URI1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for URI1 Gene

Localization for URI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URI1 Gene

Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for URI1 Gene COMPARTMENTS Subcellular localization image for URI1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with URI1: view

Pathways & Interactions for URI1 Gene

SuperPathways for URI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 21730289
GO:0006351 transcription, DNA-templated IEA --
GO:0010923 negative regulation of phosphatase activity IMP 17936702
GO:0071363 cellular response to growth factor stimulus IDA 17936702
GO:0071383 cellular response to steroid hormone stimulus IDA 21730289
genes like me logo Genes that share ontologies with URI1: view

No data available for Pathways by source and SIGNOR curated interactions for URI1 Gene

Drugs & Compounds for URI1 Gene

No Compound Related Data Available

Transcripts for URI1 Gene

Unigene Clusters for URI1 Gene

URI1, prefoldin-like chaperone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for URI1 Gene

No ASD Table

Relevant External Links for URI1 Gene

GeneLoc Exon Structure for
URI1
ECgene alternative splicing isoforms for
URI1

Expression for URI1 Gene

mRNA expression in normal human tissues for URI1 Gene

Protein differential expression in normal tissues from HIPED for URI1 Gene

This gene is overexpressed in Fetal Brain (12.9), Testis (11.6), Plasma (10.6), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for URI1 Gene



SOURCE GeneReport for Unigene cluster for URI1 Gene Hs.466391

mRNA Expression by UniProt/SwissProt for URI1 Gene

O94763-RMP_HUMAN
Tissue specificity: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
genes like me logo Genes that share expression patterns with URI1: view

Protein tissue co-expression partners for URI1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for URI1 Gene

Orthologs for URI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for URI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia URI1 35
  • 88.53 (n)
  • 87.5 (a)
URI1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URI1 35
  • 87.11 (n)
  • 86.27 (a)
NNX3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uri1 35
  • 81.23 (n)
  • 76.77 (a)
Uri1 16
Uri1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia URI1 35
  • 98.57 (n)
  • 97.75 (a)
URI1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uri1 35
  • 80.93 (n)
  • 76.33 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia URI1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves URI1 35
  • 75.68 (n)
  • 75.11 (a)
URI1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia URI1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uri1 35
  • 66.95 (n)
  • 64.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1937 35
zebrafish
(Danio rerio)
Actinopterygii uri1 35
  • 62.7 (n)
  • 59.96 (a)
uri1 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5067 36
  • 31 (a)
OneToOne
Species with no ortholog for URI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URI1 Gene

ENSEMBL:
Gene Tree for URI1 (if available)
TreeFam:
Gene Tree for URI1 (if available)

Paralogs for URI1 Gene

Pseudogenes.org Pseudogenes for URI1 Gene

genes like me logo Genes that share paralogs with URI1: view

No data available for Paralogs for URI1 Gene

Variants for URI1 Gene

Sequence variations from dbSNP and Humsavar for URI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs189187 - 29,942,612(+) TGCCC(C/T)GGTTC intron-variant, nc-transcript-variant, reference, missense
rs10756 -- 30,013,909(+) AGTGG(C/T)GGGGC intron-variant
rs366246 -- 29,994,327(+) ttccc(C/T)tcatt intron-variant
rs440697 -- 29,970,783(-) ATGAC(G/T)GTAGT intron-variant
rs371031 -- 29,970,056(+) CAAAA(A/G)AGGAC intron-variant

Variation tolerance for URI1 Gene

Residual Variation Intolerance Score: 6.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URI1 Gene

HapMap Linkage Disequilibrium report
URI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for URI1 Gene

Disorders for URI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for URI1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search URI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for URI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
URI1
genes like me logo Genes that share disorders with URI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for URI1 Gene

Publications for URI1 Gene

  1. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. (PMID: 9819440) Dorjsuren D. … Murakami S. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W. … Murakami S. (Cell Res. 2003) 3 23
  3. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. (PMID: 9878255) Van Leuven F. … Delabie J. (Genomics 1998) 2 3
  4. Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes. (PMID: 25527175) Noske A. … Moch H. (Exp. Mol. Pathol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for URI1 Gene

Sources for URI1 Gene

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