URI1 Gene
protein-coding GIFtS: 50
GCID: GC19P030415
|
|
URI1, prefoldin-like chaperone(Previous name: chromosome 19 open reading frame 2 )
(Previous symbol: C19orf2)
| |
Aliases
for URI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| URI1, Prefoldin-Like Chaperone1 2 | | RNA Polymerase II Subunit 5-Mediating Protein2 3 | | NNX31 2 3 5 | | RPB5-Mediating Protein2 3 | | RMP1 2 3 5 | | FLJ105751 | | C19orf21 2 3 | | Chromosome 19 Open Reading Frame 21 | | PPP1R191 2 3 | | Protein Phosphatase 1, Regulatory Subunit 192 | | URI1 2 3 | | Unconventional Prefoldin RPB5 Interactor 12 | | Protein Phosphatase 1 Regulatory Subunit 192 3 | | Protein NNX33 |
Export aliases for URI1 gene to outside databases |
Summaries
for URI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for URI1:
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as ascaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNApolymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer andhepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed forthis gene, and a pseudogene of this gene is located on the long arm of chromosome 22. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: RMP_HUMAN, O94763Function: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with thecorepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediatedgene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival inovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizestranscriptional modulation via hepatitis B virus X proteinFunction: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditionsthereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex actsas a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD inresponse to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates theregulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffoldingprotein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription andubiquitination
Gene Wiki entry for URI1 (C19orf2)
|
Genomic Views
for URI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for URI1
Other transcription factors
Search SABiosciences Chromatin IP Primers for URI1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URI1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q12 HGNC cytogenetic band: 19q12URI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P030415: view genomic region
(about GC identifiers)
Start:
|
30,414,551 bp from pter |
End:
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30,506,616 bp from pter |
Size:
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92,066 bases |
Orientation:
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plus strand |
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Proteins
for URI1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RMP_HUMAN, O94763 (See
protein sequence)Recommended Name: Unconventional prefoldin RPB5 interactor 1 Size: 535 amino acids; 59832 Da
Subunit: Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interactswith PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interactswith PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner inthe mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and GTF2F2. Interacts with DMAP1,POLR2E/RPB5 and UXT
Subcellular location: Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite (By similarity). Note=Colocalizeswith PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion
Sequence caution: Sequence=AAH26184.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K805 H7BY42 Q8TC23 Q9UNU3Alternative splicing: 4 isoforms: O94763-1 O94763-2 O94763-3 O94763-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for URI1: NX_O94763
Post-translational modifications:
Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgentreatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in amTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependentmanner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion,relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinaseactivity, preventing sustained S6K1-dependent signaling1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94763
URI1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001239570.1 NP_003787.2
ENSEMBL proteins: ENSP00000353817 ENSP00000459966 ENSP00000458480 ENSP00000468048 ENSP00000442436 ENSP00000461003 ENSP00000458533 ENSP00000461895 ENSP00000459450 ENSP00000458161 ENSP00000312530 ENSP00000376097
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
URI1 for ontologies About GeneDecksing
URI1 Antibody Products:
Assay Products for URI1: |
Protein
Domains /
Families
for URI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
URI1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94763ProtoNet protein and cluster: O94763 1 Blocks protein family: IPB004127 Putative prefoldin chaperone
UniProtKB/Swiss-Prot: RMP_HUMAN, O94763Similarity: Belongs to the RNA polymerase II subunit 5-mediating protein family |
Function
for URI1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RMP_HUMAN, O94763Function: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with thecorepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediatedgene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival inovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizestranscriptional modulation via hepatitis B virus X proteinFunction: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditionsthereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex actsas a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD inresponse to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates theregulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffoldingprotein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription andubiquitination
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for URI1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for URI1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URI1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URI1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
URI1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for URI1:
|
Pathways & Interactions
for URI1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and Autophagy | | | 2 | Translational Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for URI1
URI1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for URI1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for URI1 (O947631, 2, 3 ENSP000003760974) via UniProtKB, MINT, STRING, and/or I2D (see all 46)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| POLR2E | P193881, 3, ENSP000002155874 | EBI-2683009,EBI-395189 I2D:
score=4 STRING: ENSP00000215587 | | GTF2F2 | P139841, 3, ENSP000003408234 | EBI-2683009,EBI-1030560 I2D:
score=3 STRING: ENSP00000340823 | | PPP1CC | P368731, 3, ENSP000003350844 | EBI-2683009,EBI-356283 I2D:
score=1 STRING: ENSP00000335084 | | MAP3K3 | Q997592, 3 | MINT-48429 I2D:
score=2 | | ITCH | Q96J023, ENSP000003639984 | I2D:
score=2 STRING: ENSP00000363998 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
URI1 for ontologies About GeneDecksing
|
Drugs & Compounds
for URI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for URI1
Search CenterWatch for drugs/clinical trials and news about URI1 / RMP
|
Transcripts
for URI1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for URI1 gene (3 alternative transcripts): NM_001252641.1 NM_003796.3 NM_134447.1 Unigene Cluster for URI1: URI1, prefoldin-like chaperone Hs.466391 [show with all ESTs]Unigene Representative Sequence: NM_00379615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360605(uc002nsq.3) ENST00000570564 ENST00000574233 ENST00000574766
ENST00000585655 ENST00000542441 ENST00000574110 ENST00000574666 ENST00000576442
ENST00000570704 ENST00000574176 ENST00000575242 ENST00000573052 ENST00000312051(uc002nst.3)
ENST00000392271(uc002nsr.3 uc002nss.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for URI1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for URI1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URI1 |
Additional cDNA sequence: AF091095.1 AK001437.1 AK226173.1 AK292170.1 AK314313.1 BC014933.2 BC026184.2 BC067259.1 NR_045557.1 14 DOTS entries: DT.454949 DT.92440205 DT.436903 DT.99957962 DT.100793926 DT.97855699 DT.100793924 DT.100793925 DT.121421870 DT.40200468 DT.91880582 DT.92440208 DT.92440211 DT.92440214 24/294 AceView cDNA sequences (see all 294): AA031442 BE220152 AW150675 AA814617 AI917665 BU607803 Z41049 AI805883 BQ011866 AI871731 AA430525 AI080168 BF439835 AW013948 AA385099 AA731343 AI219300 BF515680 AI143202 CK300443 BI087741 N42674 BE671632 NM_134447
GeneLoc Exon Structure
|
Expression
for URI1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| URI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTAATTGT
About this image
See URI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for URI1
SOURCE GeneReport for Unigene cluster: Hs.466391
UniProtKB/Swiss-Prot: RMP_HUMAN, O94763Tissue specificity: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle.Expressed weakly in brain, heart, pancreas and in prostate epithelial cells
SABiosciences Custom PCR Arrays for URI1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for URI1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat URI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URI1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URI1 |
Orthologs
for URI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for URI1 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Uri15
C809131 |
expressed sequence C809131, 5 |
80.57(n)1
76(a)1 |
|
7 (25.29 cM)5
197771 NM_011274.51 NP_035404.41
379600025 |
chicken
(Gallus gallus) |
Aves |
C11H19orf21 |
chromosome 11 open reading frame, human C19orf2 |
73.68(n)
72.82(a) |
|
415759 XM_414123.3 XP_414123.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C19orf26 |
-- |
69(a) |
1 ↔ 1 |
GL343299.1(1471755-1499309) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.19372 |
Xenopus laevis transcribed sequence with weak similarity more |
74.75(n) |
|
48042974 |
zebrafish
(Danio rerio) |
Actinopterygii |
uri11 |
URI1, prefoldin-like chaperone |
63.06(n)
60.39(a) |
|
560572 NM_001030145.1 NP_001025316.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
uri6 |
unconventional prefoldin RPB5 interactor |
11(a) |
1 ↔ 1 |
2R(20453082-20455605) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G037606 |
Prefoldin chaperone subunit family protein |
25(a) |
1 ↔ 1 |
1(941062-943377) |
rice
(Oryza sativa) |
Liliopsida |
-- |
prefoldin subunit family protein, expressed |
23(a) |
1 ↔ 1 |
1(40738034-40742717) |
ENSEMBL Gene Tree for URI1 (if available)
TreeFam Gene Tree for URI1 (if available) |
Paralogs
for URI1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for URI1 gene
1 SIMAP similar gene for URI1 using alignment to 10 protein entries: RMP_HUMAN (see all proteins):C19orf2
URI1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for URI1
PGOHUM00000246270
|
Genomic Variants
for URI1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for URI1 (30414551 - 30506616 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for URI1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing URI1 |
|
Disorders
/ Diseases
for URI1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
URI1 for disorders About GeneDecksing
OMIM gene information: 603494
OMIM disorders: --
7  diseases for URI1: About MalaCardshepatocellular carcinoma ovarian cancer carcinoma hepatitis b
prostate cancer hepatitis prostatitis
Export disorders for URI1 gene to outside databases
|
Publications
for URI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for URI1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with URI1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. (PubMed id 9819440)1, 2, 3 Dorjsuren D....Murakami S. (1998)
- Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. (PubMed id 9878255)1, 2, 3 Van Leuven F.... Delabie J. (1998)
- Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)1, 2, 9 Wei W....Murakami S. (2003)
- Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PubMed id 21730289)1, 2 Mita P.... Logan S.K. (2011)
- URI is an oncogene amplified in ovarian cancer cells and is required for their survival. (PubMed id 21397856)1, 2 Theurillat J.P....Krek W. (2011)
- S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PubMed id 17936702)1, 2 Djouder N....Krek W. (2007)
- Subcellular localization of RPB5-mediating protein and its putative functional partner. (PubMed id 15367675)1, 2 Delgermaa L....Murakami S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. (PubMed id 14615539)1, 2 Gstaiger M.... Krek W. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for URI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing URI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing URI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing URI1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for URI1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for URI1 gene:
Search GeneIP for patents involving URI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for URI1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for URI1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for URI1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for URI1 | | | OriGene Protein Over-expression Lysate for URI1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for URI1 | | OriGene 3'-UTR Clone for URI1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URI1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for URI1 | | OriGene Custom Protein Services for URI1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat URI1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing URI1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URI1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat URI1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URI1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URI1 |
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| | Antibodies & Assays for URI1 (RMP) |
| | | | Search Tocris compounds for URI1 |
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 | | | URI1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URI1 |
|  |  |  | | | | ThermoFisher Antibodies for URI1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URI1 |
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