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URI1 Gene

protein-coding   GIFtS: 50
GCID: GC19P030415

URI1, Prefoldin-Like Chaperone

(Previous name: chromosome 19 open reading frame 2)
(Previous symbol: C19orf2)
  See URI1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
URI1, Prefoldin-Like Chaperone1 2     RNA Polymerase II Subunit 5-Mediating Protein2 3
C19orf21 2 3     Chromosome 19 Open Reading Frame 21
RPB5-Mediating Protein1 2 3     Protein Phosphatase 11
NNX32 3 5     Regulatory Subunit 191
RMP2 3 5     Unconventional Prefoldin RPB5 Interactor1
Protein Phosphatase 1 Regulatory Subunit 192 3     Protein Phosphatase 1, Regulatory Subunit 192
PPP1R192 3     Unconventional Prefoldin RPB5 Interactor 12
URI2 3     Protein NNX33

External Ids:    HGNC: 132361   Entrez Gene: 87252   Ensembl: ENSG000001051767   OMIM: 6034945   UniProtKB: O947633   

Export aliases for URI1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for URI1 Gene:
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a
scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA
polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and
hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. (provided by RefSeq,
Nov 2011)

GeneCards Summary for URI1 Gene:
URI1 (URI1, prefoldin-like chaperone) is a protein-coding gene. Diseases associated with URI1 include ovarian cancer, and hepatocellular carcinoma. GO annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot: RMP_HUMAN, O94763
Function: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the
corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress
AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for
cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter
region. Antagonizes transcriptional modulation via hepatitis B virus X protein
Function: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth
conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The
URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1
survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in
mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent
manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and
proteins with roles in transcription and ubiquitination

Gene Wiki entry for URI1 (C19orf2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for URI1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for URI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat URI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q12

URI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URI1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P030415:  view genomic region     (about GC identifiers)

Start:
30,414,551 bp from pter      End:
30,506,616 bp from pter
Size:
92,066 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RMP_HUMAN, O94763 (See protein sequence)
Recommended Name: Unconventional prefoldin RPB5 interactor 1  
Size: 535 amino acids; 59832 Da
Subunit: Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1.
Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent
manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a
growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminus region) with GTF2F1 and
GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT
Sequence caution: Sequence=AAH26184.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K805 H7BY42 Q8TC23 Q9UNU3
Alternative splicing: 4 isoforms:  O94763-1   O94763-2   O94763-3   O94763-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for URI1: NX_O94763

Explore proteomics data for URI1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to
    androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in
    mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and
    rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC
    complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative
    feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling1
  • Ubiquitination2 at Lys208
  • Modification sites at PhosphoSitePlus

  • See URI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239570.1  NP_003787.2  

    ENSEMBL proteins: 
     ENSP00000353817   ENSP00000459966   ENSP00000458480   ENSP00000468048   ENSP00000442436  
     ENSP00000461003   ENSP00000458533   ENSP00000461895   ENSP00000459450   ENSP00000458161  
     ENSP00000312530   ENSP00000376097  

    URI1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for URI1
    OriGene Protein Over-expression Lysate for URI1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for URI1
    GenScript Custom Purified and Recombinant Proteins Services for URI1
    Novus Biologicals URI1 Proteins
    Novus Biologicals URI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for URI1 

     
    antibodies-online proteins for URI1 (4 products) 

     
    antibodies-online peptides for URI1

    URI1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for URI1  (RMP)
    OriGene Antibodies for URI1
    OriGene Custom Antibody Services for URI1
    Novus Biologicals URI1 Antibodies
    Abcam antibodies for URI1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for URI1
    LSBio Antibodies in human, mouse, rat for URI1
    antibodies-online antibodies for URI1 (17 products) 

    URI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for URI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for URI1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for URI1 
    Search antibodies-online for kits for URI1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR004127 Prefoldin_subunit_alpha
     IPR009053 Prefoldin

    Graphical View of Domain Structure for InterPro Entry O94763

    ProtoNet protein and cluster: O94763

    1 Blocks protein domain: IPB004127 Putative prefoldin chaperone

    UniProtKB/Swiss-Prot: RMP_HUMAN, O94763
    Similarity: Belongs to the RNA polymerase II subunit 5-mediating protein family


    Find genes that share domains with URI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RMP_HUMAN, O94763
    Function: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the
    corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress
    AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for
    cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter
    region. Antagonizes transcriptional modulation via hepatitis B virus X protein
    Function: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth
    conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The
    URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1
    survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in
    mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent
    manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and
    proteins with roles in transcription and ubiquitination

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IMP9819440
    GO:0003682chromatin binding IDA--
    GO:0004864protein phosphatase inhibitor activity IEA--
    GO:0005515protein binding IPI12737519
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with URI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for URI1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for URI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for URI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for URI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for URI1

    miRNA
    Products:
        
    miRTarBase miRNAs that target URI1:
    hsa-mir-598-3p (MIRT040496)

    Block miRNA regulation of human, mouse, rat URI1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate URI1
    SwitchGear 3'UTR luciferase reporter plasmidURI1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for URI1
    Predesigned siRNA for gene silencing in human, mouse, rat URI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for URI1

    Clone
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    OriGene clones in human, mouse for URI1 (see all 12)
    OriGene ORF clones in mouse, rat for URI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for URI1
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URI1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for URI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for URI1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RMP_HUMAN, O94763: Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite (By similarity).
    Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15367675
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9819440
    GO:0005737cytoplasm IDA15367675
    GO:0005739mitochondrion IEA--
    GO:0016272prefoldin complex IEA--

    Find genes that share ontologies with URI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for URI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with URI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for URI1
        Apoptosis and Autophagy
    Translational Control


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for URI1
    Interactions:

        Search GeneGlobe Interaction Network for URI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for URI1 (O947631, 2, 3 ENSP000003760974) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2EP193881, 3, ENSP000002155874EBI-357067,EBI-395189 I2D: score=4 STRING: ENSP00000215587
    GTF2F2P139841, 3, ENSP000003408234EBI-357067,EBI-1030560 I2D: score=3 STRING: ENSP00000340823
    PPP1CCP368731, 3, ENSP000003350844EBI-357067,EBI-356283 I2D: score=1 STRING: ENSP00000335084
    MAP3K3Q997592, 3MINT-48429 I2D: score=2 
    ITCHQ96J023, ENSP000003639984I2D: score=2 STRING: ENSP00000363998
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12737519
    GO:0001558regulation of cell growth IDA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IMP9819440
    GO:0006457protein folding IEA--
    GO:0009615response to virus IMP9819440

    Find genes that share ontologies with URI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for URI1 (RMP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for URI1 gene (3 alternative transcripts): 
    NM_001252641.1  NM_003796.3  NM_134447.1  

    Unigene Cluster for URI1:

    URI1, prefoldin-like chaperone
    Hs.466391  [show with all ESTs]
    Unigene Representative Sequence: NM_003796
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360605(uc002nsq.3) ENST00000570564 ENST00000574233 ENST00000574766
    ENST00000585655 ENST00000542441 ENST00000574110 ENST00000574666 ENST00000576442
    ENST00000570704 ENST00000574176 ENST00000575242 ENST00000573052 ENST00000312051(uc002nst.3)
    ENST00000392271(uc002nsr.3 uc002nss.3)
    miRNA
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    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for URI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat URI1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for URI1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat URI1
      QuantiTect SYBR Green Assays in human, mouse, rat URI1
      QuantiFast Probe-based Assays in human, mouse, rat URI1

    Additional mRNA sequence: 

    AF091095.1 AK001437.1 AK226173.1 AK292170.1 AK314313.1 BC014933.2 BC026184.2 BC067259.1 
    NR_045557.1 

    14 DOTS entries:

    DT.454949  DT.92440205  DT.436903  DT.99957962  DT.100793926  DT.97855699  DT.100793924  DT.100793925 
    DT.121421870  DT.40200468  DT.91880582  DT.92440208  DT.92440211  DT.92440214 

    Selected AceView cDNA sequences (see all 294):

    AI080168 T31996 NM_134447 AW051111 CR591124 NM_003796 BQ017942 BE378723 
    AA678820 AA814617 AW081598 CR612965 AI361012 BE220152 BM799347 AI076009 
    AI871731 AW613357 BF726113 AI253143 BE671632 AW013948 AI264089 BF589688 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    URI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAATTGT
    URI1 Expression
    About this image

    URI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    URI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466391

    UniProtKB/Swiss-Prot: RMP_HUMAN, O94763
    Tissue specificity: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal
    muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells

        Custom PCR Arrays for URI1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for URI1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uri11 , 5 expressed sequence C809135
    URI1, prefoldin-like chaperone1
    81.23(n)1
    76.77(a)1
      7 (25.29 cM)5
    197771  NM_011274.51  NP_035404.41 
     379600025 
    chicken
    (Gallus gallus)
    Aves URI11 chromosome 11 open reading frame, human C19orf2 75.68(n)
    75.11(a)
      415759  XM_414123.4  XP_414123.4 
    lizard
    (Anolis carolinensis)
    Reptilia URI16
    URI1, prefoldin-like chaperone
    63(a)
    1 ↔ 1
    GL343299.1(1471049-1497086)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19372 Xenopus laevis transcribed sequence with weak similarity more 74.75(n)    48042974 
    zebrafish
    (Danio rerio)
    Actinopterygii uri11 URI1, prefoldin-like chaperone 62.7(n)
    59.96(a)
      560572  NM_001030145.1  NP_001025316.1 


    ENSEMBL Gene Tree for URI1 (if available)
    TreeFam Gene Tree for URI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for URI1 gene
    1 SIMAP similar gene for URI1 using alignment to 10 protein entries:     RMP_HUMAN (see all proteins):
    C19orf2

    Find genes that share paralogs with URI1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for URI1
    PGOHUM00000246270


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for URI1 (see all 1957)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28664631,2
    C--30412669(+) ACCTCC/TGCCTC 1 -- us2k12Minor allele frequency- T:0.25WA CSA 4
    rs1889584231,2
    C--30412719(+) GCTGGA/GATTAC 1 -- us2k10--------
    rs1813842501,2
    --30412772(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1858226901,2
    --30412808(+) TGAACC/TCCTGA 1 -- us2k10--------
    rs1444571561,2
    --30412949(+) CACCCC/GATTTG 1 -- us2k10--------
    rs1139575101,2
    C--30413045(+) ATTGTA/CAAGTT 1 -- us2k10--------
    rs1127087261,2
    C--30413046(+) TTGTAG/AAGTTT 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs4202861,2
    C,F,A,H--30413188(+) GGCTAA/CAATTC 1 -- us2k116Minor allele frequency- C:0.02NS EA NA WA CSA 798
    rs1117736411,2
    F--30413259(+) GACGCA/G/TCAGGA 1 -- us2k11CSA 2
    rs20769611,2
    C,F--30413288(+) CGGAAG/ATTCAG 1 -- us2k1 tfbs39Minor allele frequency- A:0.29NA WA CSA EA 488

    HapMap Linkage Disequilibrium report for URI1 (30414551 - 30506616 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for URI1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing URI1
    DNA2.0 Custom Variant and Variant Library Synthesis for URI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603494    OMIM disorders: --

    2 diseases for URI1:    
    About MalaCards
    ovarian cancer    hepatocellular carcinoma


    Find genes that share disorders with URI1           About GenesLikeMe


    Export disorders for URI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for URI1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with URI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. (PubMed id 9819440)1, 2, 3 Dorjsuren D....Murakami S. (Mol. Cell. Biol. 1998)
    2. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. (PubMed id 9878255)1, 2, 3 Van Leuven F.... Delabie J. (Genomics 1998)
    3. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PubMed id 12737519)1, 2, 9 Wei W....Murakami S. (Cell Res. 2003)
    4. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PubMed id 21730289)1, 2 Mita P.... Logan S.K. (Mol. Cell. Biol. 2011)
    5. URI is an oncogene amplified in ovarian cancer cells and is required for their survival. (PubMed id 21397856)1, 2 Theurillat J.P.... Krek W. (Cancer Cell 2011)
    6. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PubMed id 17936702)1, 2 Djouder N.... Krek W. (Mol. Cell 2007)
    7. Subcellular localization of RPB5-mediating protein and its putative functional partner. (PubMed id 15367675)1, 2 Delgermaa L....Murakami S. (Mol. Cell. Biol. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. (PubMed id 14615539)1, 2 Gstaiger M.... Krek W. (Science 2003)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8725 HGNC: 13236 AceView: C19orf2 Ensembl:ENSG00000105176 euGenes: HUgn8725
    ECgene: URI1 H-InvDB: URI1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for URI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for URI1 gene:
    Search GeneIP for patents involving URI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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