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Aliases for URI1 Gene

Aliases for URI1 Gene

  • URI1, Prefoldin-Like Chaperone 2 3
  • RPB5-Mediating Protein 2 3 4
  • NNX3 3 4 6
  • RMP 3 4 6
  • RNA Polymerase II Subunit 5-Mediating Protein 3 4
  • Protein Phosphatase 1 Regulatory Subunit 19 3 4
  • C19orf2 3 4
  • PPP1R19 3 4
  • URI 3 4
  • Protein Phosphatase 1, Regulatory Subunit 19 3
  • Unconventional Prefoldin RPB5 Interactor 1 3
  • Unconventional Prefoldin RPB5 Interactor 2
  • Chromosome 19 Open Reading Frame 2 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 19 2
  • Protein NNX3 4

External Ids for URI1 Gene

Previous Symbols for URI1 Gene

  • C19orf2

Summaries for URI1 Gene

Entrez Gene Summary for URI1 Gene

  • This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

GeneCards Summary for URI1 Gene

URI1 (URI1, Prefoldin-Like Chaperone) is a Protein Coding gene. Diseases associated with URI1 include hepatocellular carcinoma. Among its related pathways are Translational Control and Apoptosis and Autophagy. GO annotations related to this gene include chromatin binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for URI1 Gene

  • Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein

  • Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination

Gene Wiki entry for URI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URI1 Gene

Genomics for URI1 Gene

Genomic Location for URI1 Gene

Start:
29,923,644 bp from pter
End:
30,016,612 bp from pter
Size:
92,969 bases
Orientation:
Plus strand

Genomic View for URI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URI1 Gene

No data available for Regulatory Elements for URI1 Gene

Proteins for URI1 Gene

  • Protein details for URI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94763-RMP_HUMAN
    Recommended name:
    Unconventional prefoldin RPB5 interactor 1
    Protein Accession:
    O94763
    Secondary Accessions:
    • A8K805
    • H7BY42
    • Q8TC23
    • Q9UNU3

    Protein attributes for URI1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Homodimer. Component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 and URI1. Interacts with PPP1CC; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with PFDN2, PFDN4 and STAP1; the interactions are phosphorylation-dependent and occur in a growth-dependent manner in the mitochondrion. Interacts (via the middle C-terminal region) with GTF2F1 and GTF2F2. Interacts with DMAP1, POLR2E/RPB5 and UXT.
    SequenceCaution:
    • Sequence=AAH26184.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for URI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for URI1 Gene

Proteomics data for URI1 Gene at MOPED

Post-translational modifications for URI1 Gene

  • Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated; hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys208

No data available for DME Specific Peptides for URI1 Gene

Domains for URI1 Gene

Gene Families for URI1 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for URI1 Gene

UniProtKB/Swiss-Prot:

RMP_HUMAN
Family:
  • Belongs to the RNA polymerase II subunit 5-mediating protein family.:
    • O94763
genes like me logo Genes that share domains with URI1: view

Function for URI1 Gene

Molecular function for URI1 Gene

UniProtKB/Swiss-Prot Function: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein
UniProtKB/Swiss-Prot Function: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination

Gene Ontology (GO) - Molecular Function for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IMP 9819440
GO:0003682 chromatin binding IDA 21730289
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 12737519
GO:0019212 phosphatase inhibitor activity IBA --
genes like me logo Genes that share ontologies with URI1: view

Phenotypes for URI1 Gene

GenomeRNAi human phenotypes for URI1:
genes like me logo Genes that share phenotypes with URI1: view

miRNA for URI1 Gene

miRTarBase miRNAs that target URI1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for URI1 Gene

Localization for URI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URI1 Gene

Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.

Gene Ontology (GO) - Cellular Components for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15367675
GO:0005665 DNA-directed RNA polymerase II, core complex IDA 9819440
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0016272 prefoldin complex --
genes like me logo Genes that share ontologies with URI1: view

Pathways for URI1 Gene

genes like me logo Genes that share pathways with URI1: view

Pathways by source for URI1 Gene

2 Cell Signaling Technology pathways for URI1 Gene

Gene Ontology (GO) - Biological Process for URI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12737519
GO:0001558 regulation of cell growth IDA 21730289
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IMP 9819440
GO:0006457 protein folding --
genes like me logo Genes that share ontologies with URI1: view

Transcripts for URI1 Gene

Unigene Clusters for URI1 Gene

URI1, prefoldin-like chaperone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for URI1 Gene

No ASD Table

Relevant External Links for URI1 Gene

GeneLoc Exon Structure for
URI1
ECgene alternative splicing isoforms for
URI1

Expression for URI1 Gene

mRNA expression in normal human tissues for URI1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for URI1 Gene

SOURCE GeneReport for Unigene cluster for URI1 Gene Hs.466391

mRNA Expression by UniProt/SwissProt for URI1 Gene

O94763-RMP_HUMAN
Tissue specificity: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
genes like me logo Genes that share expressions with URI1: view

Orthologs for URI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for URI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia URI1 36
  • 98.57 (n)
  • 97.75 (a)
URI1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia URI1 36
  • 88.53 (n)
  • 87.5 (a)
URI1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NNX3 37
  • 85 (a)
OneToOne
URI1 36
  • 87.11 (n)
  • 86.27 (a)
mouse
(Mus musculus)
Mammalia Uri1 36
  • 81.23 (n)
  • 76.77 (a)
Uri1 16
Uri1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia URI1 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uri1 36
  • 80.93 (n)
  • 76.33 (a)
chicken
(Gallus gallus)
Aves URI1 36
  • 75.68 (n)
  • 75.11 (a)
URI1 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia URI1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1937 36
tropical clawed frog
(Silurana tropicalis)
Amphibia uri1 36
  • 66.95 (n)
  • 64.51 (a)
zebrafish
(Danio rerio)
Actinopterygii uri1 36
  • 62.7 (n)
  • 59.96 (a)
uri1 37
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5067 37
  • 31 (a)
OneToOne
Species with no ortholog for URI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URI1 Gene

ENSEMBL:
Gene Tree for URI1 (if available)
TreeFam:
Gene Tree for URI1 (if available)

Paralogs for URI1 Gene

Selected SIMAP similar genes for URI1 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for URI1 Gene

genes like me logo Genes that share paralogs with URI1: view

No data available for Paralogs for URI1 Gene

Variants for URI1 Gene

Sequence variations from dbSNP and Humsavar for URI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10756 -- 30,013,909(+) AGTGG(C/T)GGGGC intron-variant
rs156821 -- 29,975,143(+) tcttt(C/G)agaaa intron-variant
rs162919 -- 29,980,529(+) TTCCC(A/C)GTTAG intron-variant
rs162920 -- 29,978,080(+) CTTTT(C/T)CTTCT intron-variant
rs162921 -- 29,978,069(+) AATGC(A/T)TTTTT intron-variant

Relevant External Links for URI1 Gene

HapMap Linkage Disequilibrium report
URI1

No data available for Structural Variations from Database of Genomic Variants (DGV) for URI1 Gene

Disorders for URI1 Gene

(1) MalaCards Diseases for URI1 Gene

Search for URI1 Gene in MalaCards »
genes like me logo Genes that share disorders with URI1: view

No data available for UniProtKB/Swiss-Prot for URI1 Gene

Publications for URI1 Gene

  1. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. (PMID: 9819440) Dorjsuren D. … Murakami S. (Mol. Cell. Biol. 1998) 2 3 4
  2. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. (PMID: 9878255) Van Leuven F. … Delabie J. (Genomics 1998) 2 3 4
  3. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W. … Murakami S. (Cell Res. 2003) 3 4 23
  4. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. (PMID: 17936702) Djouder N. … Krek W. (Mol. Cell 2007) 3 4
  5. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. (PMID: 14615539) Gstaiger M. … Krek W. (Science 2003) 3 4

Products for URI1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate URI1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for URI1
    • Block miRNA regulation of URI1 using miScript Target Protectors

    Sources for URI1 Gene

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