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Aliases for URGCP Gene

Aliases for URGCP Gene

  • Upregulator Of Cell Proliferation 2 3
  • URG4 3 4 6
  • HBV X Protein Up-Regulated Gene 4 Protein 3 4
  • HBxAg Up-Regulated Gene 4 Protein 3 4
  • Up-Regulated Gene 4 2 3
  • Up-Regulator Of Cell Proliferation 3
  • KIAA1507 4

External Ids for URGCP Gene

Previous GeneCards Identifiers for URGCP Gene

  • GC07M043883
  • GC07M043801
  • GC07M043918

Summaries for URGCP Gene

Entrez Gene Summary for URGCP Gene

  • URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]

GeneCards Summary for URGCP Gene

URGCP (Upregulator Of Cell Proliferation) is a Protein Coding gene. Diseases associated with URGCP include hepatitis b and hepatitis. GO annotations related to this gene include GTP binding. An important paralog of this gene is CARD6.

UniProtKB/Swiss-Prot for URGCP Gene

  • May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.

Gene Wiki entry for URGCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URGCP Gene

Genomics for URGCP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for URGCP Gene

Start:
43,875,894 bp from pter
End:
43,926,411 bp from pter
Size:
50,518 bases
Orientation:
Minus strand

Genomic View for URGCP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URGCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URGCP Gene

No data available for Regulatory Elements for URGCP Gene

Proteins for URGCP Gene

  • Protein details for URGCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCY9-URGCP_HUMAN
    Recommended name:
    Up-regulator of cell proliferation
    Protein Accession:
    Q8TCY9
    Secondary Accessions:
    • E9PFF6
    • Q658M4
    • Q68DH6
    • Q6MZZ5
    • Q8WV98
    • Q9NWR7
    • Q9P221

    Protein attributes for URGCP Gene

    Size:
    931 amino acids
    Molecular mass:
    104987 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96031.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45880.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18244.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18244.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};

    Alternative splice isoforms for URGCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for URGCP Gene

Proteomics data for URGCP Gene at MOPED

Post-translational modifications for URGCP Gene

  • Ubiquitination at Lys121 and Lys563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for URGCP Gene

Domains for URGCP Gene

Protein Domains for URGCP Gene

Suggested Antigen Peptide Sequences for URGCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCY9

UniProtKB/Swiss-Prot:

URGCP_HUMAN :
  • Q8TCY9
Domain:
  • Contains 1 VLIG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
genes like me logo Genes that share domains with URGCP: view

No data available for Gene Families for URGCP Gene

Function for URGCP Gene

Molecular function for URGCP Gene

UniProtKB/Swiss-Prot Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.
UniProtKB/Swiss-Prot Induction: By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).

Gene Ontology (GO) - Molecular Function for URGCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with URGCP: view

Phenotypes for URGCP Gene

GenomeRNAi human phenotypes for URGCP:
genes like me logo Genes that share phenotypes with URGCP: view

Animal Model Products

CRISPR Products

miRNA for URGCP Gene

miRTarBase miRNAs that target URGCP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for URGCP Gene

Localization for URGCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for URGCP Gene

Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for URGCP Gene COMPARTMENTS Subcellular localization image for URGCP gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for URGCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with URGCP: view

Pathways for URGCP Gene

SuperPathways for URGCP Gene

No Data Available

Interacting Proteins for URGCP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000396918%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000224237%0d%0a9606.ENSP00000223500%0d%0a
Selected Interacting proteins: ENSP00000396918 Q8TCY9-URGCP_HUMAN for URGCP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for URGCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with URGCP: view

No data available for Pathways by source for URGCP Gene

Transcripts for URGCP Gene

mRNA/cDNA for URGCP Gene

(12) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for URGCP Gene

Upregulator of cell proliferation:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for URGCP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for URGCP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for URGCP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: -

Relevant External Links for URGCP Gene

GeneLoc Exon Structure for
URGCP
ECgene alternative splicing isoforms for
URGCP

Expression for URGCP Gene

mRNA expression in normal human tissues for URGCP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for URGCP Gene

SOURCE GeneReport for Unigene cluster for URGCP Gene Hs.663312

mRNA Expression by UniProt/SwissProt for URGCP Gene

Q8TCY9-URGCP_HUMAN
Tissue specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
genes like me logo Genes that share expressions with URGCP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for URGCP Gene

Orthologs for URGCP Gene

This gene was present in the common ancestor of chordates.

Orthologs for URGCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610816 35
  • 99.81 (n)
  • 100 (a)
URGCP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia URGCP 35
  • 84.74 (n)
  • 86.01 (a)
URGCP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URGCP 35
  • 83.82 (n)
  • 86.68 (a)
URGCP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Urgcp 35
  • 84.05 (n)
  • 86.93 (a)
Urgcp 16
Urgcp 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 10 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia URGCP 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Urgcp 35
  • 83.32 (n)
  • 86.52 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 10 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 1 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX005336.3 36
  • 21 (a)
ManyToMany
si:dkey-202l22.6 36
  • 14 (a)
ManyToMany
si:dkey-204a24.10 36
  • 16 (a)
ManyToMany
si:dkey-204a24.11 36
  • 17 (a)
ManyToMany
Species with no ortholog for URGCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URGCP Gene

ENSEMBL:
Gene Tree for URGCP (if available)
TreeFam:
Gene Tree for URGCP (if available)

Paralogs for URGCP Gene

Paralogs for URGCP Gene

Selected SIMAP similar genes for URGCP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for URGCP Gene

genes like me logo Genes that share paralogs with URGCP: view

Variants for URGCP Gene

Sequence variations from dbSNP and Humsavar for URGCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1072203 -- 43,912,089(-) aaata(C/T)aggca intron-variant
rs1181502 -- 43,915,774(-) gcctc(A/G)gcctc intron-variant
rs1894748 -- 43,914,314(-) atgtt(G/T)cccag intron-variant
rs2528384 -- 43,922,125(-) atcgc(A/G)ccact intron-variant
rs2595707 -- 43,922,752(-) aaaaa(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for URGCP Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
dgv2079e1 CNV Complex 17122850

Relevant External Links for URGCP Gene

HapMap Linkage Disequilibrium report
URGCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URGCP Gene

Disorders for URGCP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for URGCP Gene including...

Search for URGCP Gene in MalaCards »
genes like me logo Genes that share disorders with URGCP: view

No data available for UniProtKB/Swiss-Prot for URGCP Gene

Publications for URGCP Gene

  1. Enhanced cell survival of gastric cancer cells by a novel gene URG4. (PMID: 17217616) Song J. … Fan D. (Neoplasia 2006) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. (PMID: 12082552) Tufan N.L.S. … Feitelson M.A. (Neoplasia 2002) 2 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3

Products for URGCP Gene

Sources for URGCP Gene

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