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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

URGCP Gene

protein-coding   GIFtS: 48
GCID: GC07M043883

upregulator of cell proliferation

 Explore 7 diseases affiliated with
URGCP via our new
 Human Malady Compendium 
Biological research products
for URGCP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Upregulator Of Cell Proliferation1 2     DKFZp666G1661
URG41 2 3 5     DKFZp686O04571
KIAA15071 3     FLJ206541
HBV X Protein Up-Regulated Gene 4 Protein2 3     Up-Regulated Gene 42
HBxAg Up-Regulated Gene 4 Protein2 3     Up-Regulator Of Cell Proliferation2

External Ids:    HGNC: 308901   Entrez Gene: 556652   Ensembl: ENSG000001066087   OMIM: 6103375   UniProtKB: Q8TCY93   

Export aliases for URGCP gene to outside databases

Previous GC identifer: GC07M043801


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for URGCP:
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the
development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 (PubMed
12082552)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: URGCP_HUMAN, Q8TCY9
Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in
the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an
important role in development of gastric cancer

Gene Wiki entry for URGCP (URG4)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for URGCP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): URGCP promoter sequence
   Search SABiosciences Chromatin IP Primers for URGCP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URGCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

URGCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URGCP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M043883:  view genomic region     (about GC identifiers)

Start:
43,915,493 bp from pter      End:
43,966,010 bp from pter
Size:
50,518 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 43,955,001-44,005,497     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: URGCP_HUMAN, Q8TCY9 (See protein sequence)
Recommended Name: Up-regulator of cell proliferation  
Size: 931 amino acids; 104987 Da
Subcellular location: Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and
occasionally in nuclei
Sequence caution: Sequence=BAA91312.1; Type=Erroneous initiation; Sequence=BAA96031.1; Type=Erroneous initiation;
Sequence=CAE45880.1; Type=Erroneous initiation; Sequence=CAH18244.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=CAH18244.1; Type=Frameshift; Positions=5;
Secondary accessions: Q658M4 Q68DH6 Q6MZZ5 Q8WV98 Q9NWR7 Q9P221
Alternative splicing: 3 isoforms:  Q8TCY9-1   Q8TCY9-2   Q8TCY9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for URGCP: NX_Q8TCY9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCY9

  • URGCP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001071131.1  NP_001071132.1  NP_060390.3  

    ENSEMBL proteins: 
     ENSP00000336872   ENSP00000384955   ENSP00000392136   ENSP00000396918   ENSP00000412599  
     ENSP00000389990   ENSP00000392963   ENSP00000409496   ENSP00000223341   ENSP00000402803  

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    Uscn Proteins for URGCP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    URGCP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    URGCP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006073 GTP_binding_domain

    Graphical View of Domain Structure for InterPro Entry Q8TCY9

    ProtoNet protein and cluster: Q8TCY9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: URGCP_HUMAN, Q8TCY9
    Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in
    the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an
    important role in development of gastric cancer
    Induction: By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level)

    miRNA
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    hsa-miR-4303 hsa-miR-27a hsa-miR-200a hsa-miR-516b* hsa-miR-3921 hsa-miR-664 hsa-miR-141 hsa-miR-516a-3p
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--


    URGCP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for URGCP:
     Increased G1 DNA content  Increased circadian rhythm amp 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for URGCP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for URGCP (Q8TCY93 ENSP000003969184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP5Q9NZZ33, ENSP000002235004I2D: score=1 STRING: ENSP00000223500
    FAM107BENSP000001817964STRING: ENSP00000181796
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--


    URGCP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for URGCP
    Search CenterWatch for drugs/clinical trials and news about URGCP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for URGCP gene (3 alternative transcripts): 
    NM_001077663.1  NM_001077664.1  NM_017920.3  

    Unigene Cluster for URGCP:

    Upregulator of cell proliferation
    Hs.663312  [show with all ESTs]
    Unigene Representative Sequence: AL832134
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497914(uc003tiv.3) ENST00000336086(uc003tiu.3) ENST00000402306
    ENST00000443736 ENST00000453200(uc003tiw.3 uc003tix.3 uc003tiy.3)
    ENST00000439702 ENST00000426198 ENST00000467410 ENST00000455877 ENST00000474376
    ENST00000446958 ENST00000478747 ENST00000477768 ENST00000223341(uc003tiz.3 uc011kbj.2)
    ENST00000447717

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    hsa-miR-4303 hsa-miR-27a hsa-miR-200a hsa-miR-516b* hsa-miR-3921 hsa-miR-664 hsa-miR-141 hsa-miR-516a-3p
    SwitchGear 3'UTR luciferase reporter plasmidURGCP 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB040940.1 AK000661.1 AK026185.1 AK302459.1 AK314339.1 AL832134.1 AL833744.1 AY078404.1 
    BC018426.1 BX640797.1 BX648505.1 CR749398.1 

    24 DOTS entries:

    DT.213427  DT.101981878  DT.95376112  DT.100754928  DT.91746835  DT.100754924  DT.40129175  DT.95370728 
    DT.99954345  DT.121040855  DT.40300890  DT.102838250  DT.121040848  DT.121040914  DT.121040916  DT.121040969 
    DT.121040997  DT.121041185  DT.40188572  DT.91649127  DT.91746837  DT.95148974  DT.99994967  DT.40129176 

    1 AceView cDNA sequence:

    AB040940 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for URGCP (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
    SP1:                    -           -           -           -                                             
    SP2:                                -           -                                                         
    SP3:              -     -           -           -           -                                             
    SP4:                                -           -           -                                             
    SP5:              -     -     -     -           -           -                                             


    ECgene alternative splicing isoforms for URGCP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    URGCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGTCCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See URGCP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for URGCP

    SOURCE GeneReport for Unigene cluster: Hs.663312

    UniProtKB/Swiss-Prot: URGCP_HUMAN, Q8TCY9
    Tissue specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in
    well-differentiated gastric cancer tissues and various gastric cancer cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for URGCP gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii BX005336.36
    si:dkey-204a24.106
    (see all 3)
    si:dkey-204a24.10
    (see all 3)
    20(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    7(23101878-23106404)
    19(8304645-8313511)


    ENSEMBL Gene Tree for URGCP (if available)
    TreeFam Gene Tree for URGCP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for URGCP gene
    CARD62  

    URGCP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for URGCP
    PGOHUM00000242161


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 NCBI SNPs in URGCP are shown (see all 802    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809331291,2
    --43915010(+) TGGTTC/TGAATG 4 -- ds5001 int10--------
    rs27306141,2
    C,F,A,H,--43915042(+) AGGTCG/AGGGGG 4 -- int1 ds500115Minor allele frequency- A:0.45NS EA NA WA CSA 738
    rs27306151,2
    C,H,--43915046(+) CGGGGA/GGGATG 4 -- ds5001 int112Minor allele frequency- G:0.01NA WA CSA EA 374
    rs1863753721,2
    --43915081(+) TGGCTG/TCCCAG 4 -- ds5001 int10--------
    rs1164268181,2
    C,F,--43915147(+) CTGGGC/TGTGAC 4 -- ds5001 int11Minor allele frequency- T:0.15WA 118
    rs1384658051,2
    --43915203(+) CTCTGC/GGGCAG 4 -- ds5001 int10--------
    rs1403254331,2
    C,--43915262(+) ACAGT-/GGAAAG 4 -- ds5001 int10--------
    rs1419692501,2
    --43915367(+) TTAAGG/TGGTGC 4 -- ds5001 int10--------
    rs1506927301,2
    --43915379(+) TCTCTA/GTGCTA 4 -- int1 ds50010--------
    rs733218971,2
    C,--43915394(+) CCATTC/ACAGAT 4 -- ds5001 int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for URGCP (43915493 - 43966010 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for URGCP
         2 CNVs: 3677 4531

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    URGCP for disorders           About GeneDecksing

    OMIM gene information: 610337    OMIM disorders: --

    7 diseases for URGCP:    About MalaCards
    hepatocellular carcinoma    hepatitis b    hepatitis    carcinoma
    gastric cancer    osteosarcoma    hepatitis b virus infection


    Export disorders for URGCP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for URGCP gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with URGCP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. (PubMed id 12082552)1, 2, 3 Tufan N.L.S.... Feitelson M.A. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Enhanced cell survival of gastric cancer cells by a novel gene URG4. (PubMed id 17217616)1, 2, 9 Song J.... Fan D. (2006)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Higher expression of the novel gene upregulated gene 4 in two acute lymphoblastic leukemia patients with poor prednisolone response. (PubMed id 22677619)1 Oymak Y....Vergin C. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. RNA interference-mediated URG4 gene silencing diminis hes cyclin D1 mRNA expression in HepG2 cells. (PubMed id 20714998)1 Satiroglu-Tufan N.L....Feitelson M.A. (2010)
    9. [Expression of URG4 in hepatocellular carcinoma and i ts correlation with HBx] (PubMed id 20491173)1 Wang Y....Xie H.H. (2010)
    10. The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis. (PubMed id 18972316)1 Huang J....Luo Z. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55665 HGNC: 30890 AceView: URG4 Ensembl:ENSG00000106608 euGenes: HUgn55665
    ECgene: URGCP H-InvDB: URGCP

    (According to HUGE)
    About This Section
    HUGE: KIAA1507

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for URGCP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for URGCP gene:
    Search GeneIP for patents involving URGCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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