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Aliases for URGCP Gene

Aliases for URGCP Gene

  • Upregulator Of Cell Proliferation 2 3 5
  • HBV X Protein Up-Regulated Gene 4 Protein 3 4
  • HBxAg Up-Regulated Gene 4 Protein 3 4
  • Up-Regulated Gene 4 2 3
  • URG4 3 4
  • KIAA1507 4

External Ids for URGCP Gene

Previous GeneCards Identifiers for URGCP Gene

  • GC07M043883
  • GC07M043801
  • GC07M043918

Summaries for URGCP Gene

Entrez Gene Summary for URGCP Gene

  • URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]

GeneCards Summary for URGCP Gene

URGCP (Upregulator Of Cell Proliferation) is a Protein Coding gene. Diseases associated with URGCP include Hepatocellular Carcinoma and Gastric Cancer. GO annotations related to this gene include GTP binding. An important paralog of this gene is CARD6.

UniProtKB/Swiss-Prot for URGCP Gene

  • May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.

Gene Wiki entry for URGCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URGCP Gene

Genomics for URGCP Gene

Regulatory Elements for URGCP Gene

Enhancers for URGCP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around URGCP on UCSC Golden Path with GeneCards custom track

Promoters for URGCP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around URGCP on UCSC Golden Path with GeneCards custom track

Genomic Location for URGCP Gene

Chromosome:
7
Start:
43,875,894 bp from pter
End:
43,926,411 bp from pter
Size:
50,518 bases
Orientation:
Minus strand

Genomic View for URGCP Gene

Genes around URGCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URGCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URGCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URGCP Gene

Proteins for URGCP Gene

  • Protein details for URGCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCY9-URGCP_HUMAN
    Recommended name:
    Up-regulator of cell proliferation
    Protein Accession:
    Q8TCY9
    Secondary Accessions:
    • E9PFF6
    • Q658M4
    • Q68DH6
    • Q6MZZ5
    • Q8WV98
    • Q9NWR7
    • Q9P221

    Protein attributes for URGCP Gene

    Size:
    931 amino acids
    Molecular mass:
    104987 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96031.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45880.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18244.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18244.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};

    Alternative splice isoforms for URGCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for URGCP Gene

Proteomics data for URGCP Gene at MOPED

Post-translational modifications for URGCP Gene

  • Ubiquitination at Lys 121 and Lys 563
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for URG4

No data available for DME Specific Peptides for URGCP Gene

Domains & Families for URGCP Gene

Protein Domains for URGCP Gene

Suggested Antigen Peptide Sequences for URGCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCY9

UniProtKB/Swiss-Prot:

URGCP_HUMAN :
  • Contains 1 VLIG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
Domain:
  • Contains 1 VLIG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
genes like me logo Genes that share domains with URGCP: view

No data available for Gene Families for URGCP Gene

Function for URGCP Gene

Molecular function for URGCP Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.
UniProtKB/Swiss-Prot Induction:
By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).
genes like me logo Genes that share phenotypes with URGCP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for URGCP Gene

Localization for URGCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for URGCP Gene

Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for URGCP Gene COMPARTMENTS Subcellular localization image for URGCP gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for URGCP Gene

Pathways & Interactions for URGCP Gene

SuperPathways for URGCP Gene

No Data Available

Interacting Proteins for URGCP Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000396918%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000224237%0d%0a9606.ENSP00000223500%0d%0a
Selected Interacting proteins: ENSP00000396918 Q8TCY9-URGCP_HUMAN for URGCP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for URGCP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for URGCP Gene

Drugs & Compounds for URGCP Gene

No Compound Related Data Available

Transcripts for URGCP Gene

mRNA/cDNA for URGCP Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for URGCP Gene

Upregulator of cell proliferation:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for URGCP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: -

Relevant External Links for URGCP Gene

GeneLoc Exon Structure for
URGCP
ECgene alternative splicing isoforms for
URGCP

Expression for URGCP Gene

mRNA expression in normal human tissues for URGCP Gene

Protein differential expression in normal tissues from HIPED for URGCP Gene

This gene is overexpressed in Testis (24.0), Placenta (18.2), Pancreas (13.9), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for URGCP Gene



SOURCE GeneReport for Unigene cluster for URGCP Gene Hs.663312

mRNA Expression by UniProt/SwissProt for URGCP Gene

Q8TCY9-URGCP_HUMAN
Tissue specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
genes like me logo Genes that share expression patterns with URGCP: view

Protein tissue co-expression partners for URGCP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for URGCP Gene

Orthologs for URGCP Gene

This gene was present in the common ancestor of chordates.

Orthologs for URGCP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia URGCP 35
  • 84.74 (n)
  • 86.01 (a)
URGCP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URGCP 35
  • 83.82 (n)
  • 86.68 (a)
URGCP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Urgcp 35
  • 84.05 (n)
  • 86.93 (a)
Urgcp 16
Urgcp 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100610816 35
  • 99.81 (n)
  • 100 (a)
URGCP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Urgcp 35
  • 83.32 (n)
  • 86.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 10 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia URGCP 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 10 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 1 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX005336.3 36
  • 21 (a)
ManyToMany
si:dkey-202l22.6 36
  • 14 (a)
ManyToMany
si:dkey-204a24.10 36
  • 16 (a)
ManyToMany
si:dkey-204a24.11 36
  • 17 (a)
ManyToMany
Species with no ortholog for URGCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URGCP Gene

ENSEMBL:
Gene Tree for URGCP (if available)
TreeFam:
Gene Tree for URGCP (if available)

Paralogs for URGCP Gene

Paralogs for URGCP Gene

(1) SIMAP similar genes for URGCP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for URGCP Gene

genes like me logo Genes that share paralogs with URGCP: view

Variants for URGCP Gene

Sequence variations from dbSNP and Humsavar for URGCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_043668 -
VAR_051479 -
VAR_051480 -
rs1072203 -- 43,912,089(-) aaata(C/T)aggca intron-variant
rs1181502 -- 43,915,774(-) gcctc(A/G)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for URGCP Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
dgv2079e1 CNV Complex 17122850

Variation tolerance for URGCP Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for URGCP Gene

Disorders for URGCP Gene

MalaCards: The human disease database

(2) MalaCards diseases for URGCP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search URGCP in MalaCards View complete list of genes associated with diseases

Relevant External Links for URGCP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
URGCP
genes like me logo Genes that share disorders with URGCP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for URGCP Gene

Publications for URGCP Gene

  1. Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. (PMID: 12082552) Tufan N.L.S. … Feitelson M.A. (Neoplasia 2002) 2 3 4 67
  2. Enhanced cell survival of gastric cancer cells by a novel gene URG4. (PMID: 17217616) Song J. … Fan D. (Neoplasia 2006) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  4. Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cells. (PMID: 25835972) A8A+tA+A9lA+ V. … A9atA+roA9lu-Tufan N.L. (Tumour Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for URGCP Gene

Sources for URGCP Gene

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