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Aliases for URB2 Gene

Aliases for URB2 Gene

  • URB2 Ribosome Biogenesis 2 Homolog (S. Cerevisiae) 2 3
  • KIAA0133 2 3 4
  • Nucleolar Preribosomal-Associated Protein 1 2 3
  • Unhealthy Ribosome Biogenesis Protein 2 Homolog 3
  • NET10 3
  • NPA2 3

External Ids for URB2 Gene

Previous HGNC Symbols for URB2 Gene

  • KIAA0133

Previous GeneCards Identifiers for URB2 Gene

  • GC01P227829
  • GC01P229761
  • GC01P200252

Summaries for URB2 Gene

GeneCards Summary for URB2 Gene

URB2 (URB2 Ribosome Biogenesis 2 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with URB2 include buruli ulcer.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URB2 Gene

Genomics for URB2 Gene

Regulatory Elements for URB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for URB2 Gene

229,626,234 bp from pter
229,660,199 bp from pter
33,966 bases
Plus strand

Genomic View for URB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URB2 Gene

Proteins for URB2 Gene

  • Protein details for URB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Unhealthy ribosome biogenesis protein 2 homolog
    Protein Accession:
    Secondary Accessions:
    • Q5VYC9

    Protein attributes for URB2 Gene

    1524 amino acids
    Molecular mass:
    170544 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA09482.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for URB2 Gene

Proteomics data for URB2 Gene at MOPED

Post-translational modifications for URB2 Gene

  • Ubiquitination at Lys255, Lys462, Lys858, and Lys1387
  • Modification sites at PhosphoSitePlus

Other Protein References for URB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URB2 Gene

Domains for URB2 Gene

Protein Domains for URB2 Gene


Suggested Antigen Peptide Sequences for URB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with URB2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for URB2 Gene

Function for URB2 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for URB2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for URB2 Gene

Localization for URB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URB2 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for URB2 Gene COMPARTMENTS Subcellular localization image for URB2 gene
Compartment Confidence
nucleus 5
peroxisome 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for URB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with URB2: view

Pathways for URB2 Gene

SuperPathways for URB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for URB2 Gene


No data available for Pathways by source for URB2 Gene

Transcripts for URB2 Gene

Unigene Clusters for URB2 Gene

URB2 ribosome biogenesis 2 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for URB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for URB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - -

Relevant External Links for URB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for URB2 Gene

mRNA expression in normal human tissues for URB2 Gene

Protein differential expression in normal tissues for URB2 Gene

This gene is overexpressed in Cervix (25.9), Heart (21.6), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for URB2 Gene

SOURCE GeneReport for Unigene cluster for URB2 Gene Hs.533628

genes like me logo Genes that share expressions with URB2: view

Expression partners for URB2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for URB2 Gene

Orthologs for URB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for URB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia URB2 35
  • 78.49 (n)
  • 73.75 (a)
URB2 36
  • 74 (a)
(Canis familiaris)
Mammalia URB2 35
  • 84.66 (n)
  • 82.31 (a)
URB2 36
  • 82 (a)
(Mus musculus)
Mammalia Urb2 35
  • 77.72 (n)
  • 71.91 (a)
Urb2 16
Urb2 36
  • 71 (a)
(Pan troglodytes)
Mammalia URB2 35
  • 99.13 (n)
  • 98.69 (a)
URB2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Urb2 35
  • 78.32 (n)
  • 73.34 (a)
(Monodelphis domestica)
Mammalia URB2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 53 (a)
(Gallus gallus)
Aves URB2 35
  • 60.01 (n)
  • 52.94 (a)
URB2 36
  • 51 (a)
(Anolis carolinensis)
Reptilia URB2 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urb2 35
  • 52.89 (n)
  • 43.59 (a)
(Danio rerio)
Actinopterygii LOC570267 35
  • 49.99 (n)
  • 39.14 (a)
urb2 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for URB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URB2 Gene

Gene Tree for URB2 (if available)
Gene Tree for URB2 (if available)

Paralogs for URB2 Gene

No data available for Paralogs for URB2 Gene

Variants for URB2 Gene

Sequence variations from dbSNP and Humsavar for URB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs881694 -- 229,645,785(-) AGAAG(A/C)CTGCT intron-variant
rs1048306 -- 229,659,323(+) GCCAG(G/T)GACAC utr-variant-3-prime
rs1473719 -- 229,632,550(+) AAATA(C/T)TAAGG intron-variant
rs1473720 -- 229,632,749(+) TTCTT(C/T)ACCTT intron-variant
rs1923145 -- 229,630,781(+) CCAGG(C/T)GTTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for URB2 Gene

Variant ID Type Subtype PubMed ID
esv22567 CNV Loss 19812545
nsv508698 CNV Loss 20534489

Relevant External Links for URB2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URB2 Gene

Disorders for URB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for URB2 Gene in MalaCards »

(1) Diseases for URB2 Gene including...

(1) University of Copenhagen DISEASES for URB2 Gene

Relevant External Links for URB2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with URB2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for URB2 Gene

Publications for URB2 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for URB2 Gene

Sources for URB2 Gene

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