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Aliases for URB2 Gene

Aliases for URB2 Gene

  • URB2 Ribosome Biogenesis 2 Homolog (S. Cerevisiae) 2 3 5
  • KIAA0133 2 3 4
  • Nucleolar Preribosomal-Associated Protein 2 2 3
  • Unhealthy Ribosome Biogenesis Protein 2 Homolog 3
  • Nucleolar Preribosomal-Associated Protein 1 3
  • NET10 3
  • NPA2 3

External Ids for URB2 Gene

Previous HGNC Symbols for URB2 Gene

  • KIAA0133

Previous GeneCards Identifiers for URB2 Gene

  • GC01P227829
  • GC01P229761
  • GC01P200252

Summaries for URB2 Gene

GeneCards Summary for URB2 Gene

URB2 (URB2 Ribosome Biogenesis 2 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with URB2 include Buruli Ulcer.

Additional gene information for URB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URB2 Gene

Genomics for URB2 Gene

Regulatory Elements for URB2 Gene

Enhancers for URB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H229219 2 FANTOM5 Ensembl ENCODE dbSUPER 40.5 -404.3 -404259 4 HDGF PKNOX1 FOXA2 ARNT ARID4B YBX1 FEZF1 DMAP1 ZNF2 YY1 NUP133 ENSG00000269890 URB2 HMGN2P19 HIST3H3 LOC105373158 TAF5L ENSG00000233920 ENSG00000226920 LOC100421842
GH01H229267 1.6 Ensembl ENCODE dbSUPER 31.7 -355.6 -355554 5 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 NUP133 URB2 ENSG00000269890 HIST3H3 CCSAP TAF5L TMEM78 ABCB10 HMGN2P19 RAB4A
GH01H230142 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 18.4 +519.3 519308 5 HDGF PKNOX1 ARNT FEZF1 YY1 ZNF766 REST ZNF662 SMARCB1 ZNF592 NUP133 URB2 LOC105373159 COG2 HMGN2P19 GC01P230113 GC01M230200
GH01H228807 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -816.2 -816209 4 KLF1 GLI4 RAD21 ZFHX2 CTBP1 ZNF416 HNF4G ZNF280C MAFK EGR2 CICP26 NUP133 C1orf35 URB2 HIST3H3 HMGN2P19 BTNL10 ENSG00000269890 RNU6-180P ENSG00000271399
GH01H230208 1.3 Ensembl ENCODE dbSUPER 24.4 +584.6 584610 5 PKNOX1 TBL1XR1 BATF ZNF121 ATF7 ZNF548 ETV6 RUNX3 CREM IKZF2 NUP133 URB2 GALNT2 TAF5L ABCB10 HMGN2P19 LOC644006 GC01M230200 GC01P230113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around URB2 on UCSC Golden Path with GeneCards custom track

Promoters for URB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021503 -105 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207

Genomic Location for URB2 Gene

Chromosome:
1
Start:
229,626,205 bp from pter
End:
229,660,887 bp from pter
Size:
34,683 bases
Orientation:
Plus strand

Genomic View for URB2 Gene

Genes around URB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URB2 Gene

Proteins for URB2 Gene

  • Protein details for URB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14146-URB2_HUMAN
    Recommended name:
    Unhealthy ribosome biogenesis protein 2 homolog
    Protein Accession:
    Q14146
    Secondary Accessions:
    • Q5VYC9

    Protein attributes for URB2 Gene

    Size:
    1524 amino acids
    Molecular mass:
    170544 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09482.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for URB2 Gene

Post-translational modifications for URB2 Gene

  • Ubiquitination at Lys255, Lys462, Lys858, and Lys1387
  • Modification sites at PhosphoSitePlus

Other Protein References for URB2 Gene

No data available for DME Specific Peptides for URB2 Gene

Domains & Families for URB2 Gene

Gene Families for URB2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for URB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for URB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with URB2: view

No data available for UniProtKB/Swiss-Prot for URB2 Gene

Function for URB2 Gene

Phenotypes From GWAS Catalog for URB2 Gene

genes like me logo Genes that share phenotypes with URB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for URB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for URB2 Gene

Localization for URB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URB2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for URB2 gene
Compartment Confidence
nucleus 5
peroxisome 2
plasma membrane 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for URB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA,IBA --
GO:0016235 aggresome IDA --
GO:0030496 midbody IDA 19799413
genes like me logo Genes that share ontologies with URB2: view

Pathways & Interactions for URB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for URB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with URB2: view

No data available for Pathways by source and SIGNOR curated interactions for URB2 Gene

Drugs & Compounds for URB2 Gene

No Compound Related Data Available

Transcripts for URB2 Gene

mRNA/cDNA for URB2 Gene

Unigene Clusters for URB2 Gene

URB2 ribosome biogenesis 2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for URB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for URB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - -
SP3:

Relevant External Links for URB2 Gene

GeneLoc Exon Structure for
URB2
ECgene alternative splicing isoforms for
URB2

Expression for URB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for URB2 Gene

Protein differential expression in normal tissues from HIPED for URB2 Gene

This gene is overexpressed in Cervix (25.9), Heart (21.6), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for URB2 Gene



Protein tissue co-expression partners for URB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of URB2 Gene:

URB2

SOURCE GeneReport for Unigene cluster for URB2 Gene:

Hs.533628

Evidence on tissue expression from TISSUES for URB2 Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with URB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for URB2 Gene

Orthologs for URB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for URB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia URB2 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia URB2 33 34
  • 84.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
cow
(Bos Taurus)
Mammalia URB2 33 34
  • 78.49 (n)
rat
(Rattus norvegicus)
Mammalia Urb2 33
  • 78.32 (n)
mouse
(Mus musculus)
Mammalia Urb2 33 16 34
  • 77.72 (n)
oppossum
(Monodelphis domestica)
Mammalia URB2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves URB2 33 34
  • 60.01 (n)
lizard
(Anolis carolinensis)
Reptilia URB2 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia urb2 33
  • 52.89 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570267 33
  • 49.99 (n)
urb2 34
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToOne
Species where no ortholog for URB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for URB2 Gene

ENSEMBL:
Gene Tree for URB2 (if available)
TreeFam:
Gene Tree for URB2 (if available)

Paralogs for URB2 Gene

No data available for Paralogs for URB2 Gene

Variants for URB2 Gene

Sequence variations from dbSNP and Humsavar for URB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193921013 Uncertain significance 229,635,985(+) TCTTC(C/G)AGACT reference, missense
rs1000061113 -- 229,633,470(+) ATTGA(A/T)TATAA intron-variant
rs1000225365 -- 229,652,031(+) ACAAA(A/T)ATTAG intron-variant
rs1000281800 -- 229,649,180(+) AGTGT(C/T)TTGAT intron-variant
rs1000308866 -- 229,632,561(+) TAGGA(G/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for URB2 Gene

Variant ID Type Subtype PubMed ID
esv22567 CNV loss 19812545
nsv508698 CNV deletion 20534489
nsv549301 CNV gain+loss 21841781
nsv549302 CNV loss 21841781

Variation tolerance for URB2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URB2 Gene

Human Gene Mutation Database (HGMD)
URB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
URB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URB2 Gene

Disorders for URB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for URB2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
buruli ulcer
  • buruli ulcer disease
- elite association - COSMIC cancer census association via MalaCards
Search URB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for URB2

Genetic Association Database (GAD)
URB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
URB2
genes like me logo Genes that share disorders with URB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for URB2 Gene

Publications for URB2 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 60
  2. Nucleolar proteome dynamics. (PMID: 15635413) Andersen JS … Mann M (Nature 2005) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for URB2 Gene

Sources for URB2 Gene

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