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URB1 Gene

protein-coding   GIFtS: 45
GCID: GC21M033683

URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)

(Previous name: chromosome 21 open reading frame 108)
(Previous symbol: C21orf108)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)1 2     KIAA05393 5
C21orf1081 2 3 5     Chromosome 21 Open Reading Frame 1081
NPA12 3 5     Nucleolar Pre-Ribosomal-Associated Protein 12
Nucleolar Preribosomal-Associated Protein 11 2     NOP2543
Nucleolar Protein 254 KDa2 3     URB1 Ribosome Biogenesis 1 Homolog3

External Ids:    HGNC: 173441   Entrez Gene: 98752   Ensembl: ENSG000001422077   OMIM: 6088655   UniProtKB: O602873   

Export aliases for URB1 gene to outside databases

Previous GC identifers: GC21M032607 GC21M019092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for URB1 Gene:
URB1 (URB1 ribosome biogenesis 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with URB1 include tonsillitis, and thyroiditis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the URB1 gene promoter:
         c-Fos   AML1a   AP-1   Bach2   Brachyury   MIF-1   Egr-4   HNF-1A   HNF-1   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for URB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat URB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

URB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
URB1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M033683:  view genomic region     (about GC identifiers)

Start:
33,683,329 bp from pter      End:
33,765,335 bp from pter
Size:
82,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPA1P_HUMAN, O60287 (See protein sequence)
Recommended Name: Nucleolar pre-ribosomal-associated protein 1  
Size: 2271 amino acids; 254389 Da
Secondary accessions: D3DSE5 Q96NX1 Q9NYQ1

Explore the universe of human proteins at neXtProt for URB1: NX_O60287

Explore proteomics data for URB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys185, Lys376, Lys399, Lys616, Lys1085, Lys1336, Lys1786, Lys1909
  • Modification sites at PhosphoSitePlus

  • See URB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055640.2  
    ENSEMBL proteins: 
     ENSP00000372199  

    URB1 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    URB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals URB1 Antibodies
    Abcam antibodies for URB1
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for URB1
    LSBio Antibodies in human, mouse, rat for URB1

    URB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for URB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for URB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021714 Npa1_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O60287

    ProtoNet protein and cluster: O60287


    URB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005488binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    URB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for URB1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for URB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for URB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target URB1:
    hsa-mir-335-5p (MIRT018081), hsa-mir-744-5p (MIRT037624), hsa-mir-760 (MIRT036788), hsa-mir-106b-3p (MIRT038597)

    Block miRNA regulation of human, mouse, rat URB1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate URB1:
    hsa-miR-33a* hsa-miR-3163 hsa-miR-3121-3p hsa-miR-3909 hsa-miR-3133 hsa-miR-340 hsa-miR-490-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for URB1
    Predesigned siRNA for gene silencing in human, mouse, rat URB1

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: URB1 (NM_014825)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URB1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat URB1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for URB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPA1P_HUMAN, O60287: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus NAS12429849

    URB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for URB1
    Interactions:

        Search GeneGlobe Interaction Network for URB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for URB1 (O602872, 3 ENSP000003721994) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8262154 I2D: score=2 
    TAB1Q157502, 3MINT-8260394 I2D: score=2 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AKR1A1P145503, ENSP000003126064I2D: score=1 STRING: ENSP00000312606
    NCK1P163333, ENSP000002889864I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    URB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for URB1 (NPA1P)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for URB1 gene: 
    NM_014825.2  

    Unigene Cluster for URB1:

    URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
    Hs.473611  [show with all ESTs]
    Unigene Representative Sequence: NM_014825
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382751(uc002ypn.2) ENST00000480196 ENST00000492603
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat URB1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate URB1:
    hsa-miR-33a* hsa-miR-3163 hsa-miR-3121-3p hsa-miR-3909 hsa-miR-3133 hsa-miR-340 hsa-miR-490-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for URB1
    Predesigned siRNA for gene silencing in human, mouse, rat URB1
    Clone
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    OriGene clones in human, mouse for URB1 (see all 5)
    OriGene ORF clones in mouse, rat for URB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: URB1 (NM_014825)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for URB1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat URB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for URB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat URB1
      QuantiTect SYBR Green Assays in human, mouse, rat URB1
      QuantiFast Probe-based Assays in human, mouse, rat URB1

    Additional mRNA sequence: 

    AB011111.2 AF231919.1 AF432264.1 BC041033.1 BC062356.1 

    12 DOTS entries:

    DT.212590  DT.75181672  DT.40115247  DT.65284211  DT.86821102  DT.92042754  DT.95267660  DT.121138528 
    DT.40261222  DT.65284811  DT.91662163  DT.95128681 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    URB1 expression in normal human tissues (normalized intensities)      URB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAACTGTG
    URB1 Expression
    About this image


    URB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    URB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    URB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473611
        Custom PCR Arrays for URB1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for URB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for URB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Urb11 , 5 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)1, 5 79.31(n)1
    76.8(a)1
      16 (51.92 cM)5
    2079321  NM_029497.11  NP_083773.11 
     907515275 
    chicken
    (Gallus gallus)
    Aves LOC1008576731 nucleolar pre-ribosomal-associated protein 1-like 62.74(n)
    57.65(a)
      100857673  XM_003640479.2  XP_003640527.1 
    lizard
    (Anolis carolinensis)
    Reptilia URB16
    URB1 ribosome biogenesis 1 homolog (S. cerevisiae)...
    53(a)
    1 ↔ 1
    3(145292596-145365794)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia urb11 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 58.8(n)
    52.31(a)
      100192374  NM_001137615.1  NP_001131087.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003336501 nucleolar pre-ribosomal-associated protein 1-like 54.9(n)
    47.82(a)
      100333650  XM_002664553.3  XP_002664599.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124996
    --
    18(a)
    1 ↔ 1
    3R(18266023-18272254)
    worm
    (Caenorhabditis elegans)
    Secernentea T05H4.106
    Protein T05H4.10 (T05H4.10) mRNA, complete cds
    24(a)
    1 ↔ 1
    V(6417493-6424155) WBGene00020273


    ENSEMBL Gene Tree for URB1 (if available)
    TreeFam Gene Tree for URB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for URB1 gene

    URB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for URB1
    PGOHUM00000250160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for URB1 (see all 1631)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912381011,2
    --33687619(+) TTTCTC/TTTCTT 1 -- int10--------
    rs664748321,2
    C--33687626(+) AAAAA-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs20320991,2
    C,A,H--33687772(+) GGCATG/CTGCCA 1 -- int13Minor allele frequency- C:0.17NA 6
    rs1492876861,2
    --33687782(+) ACCACA/GCCCGG 1 -- int10--------
    rs18925731,2
    C,F,A,H--33687902(-) AATTTC/TTGCCA 1 -- int124Minor allele frequency- T:0.24NS EA NA WA CSA 2472
    rs2011311361,2
    --33687902(+) TGGCA-/GAAATT 1 -- int10--------
    rs763902251,2
    C--33687905(+) CAGAAA/GTTTAT 1 -- int10--------
    rs757559471,2
    C,F--33688014(+) TTGAGA/GAGAAC 1 -- int11Minor allele frequency- G:0.05WA 118
    rs758546991,2
    C--33688126(+) AGGGCA/GAGGTC 1 -- int13Minor allele frequency- G:0.07WA EA 240
    rs1155854201,2
    F--33688180(+) CCCTCC/TCCTGG 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for URB1 (33683329 - 33765335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for URB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272059CNV Insertion20981092
    nsv510795CNV Loss20534489
    nsv834084CNV Gain17160897
    nsv834085CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing URB1
    DNA2.0 Custom Variant and Variant Library Synthesis for URB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608865    OMIM disorders: --

    5 diseases for URB1:    About MalaCards
    tonsillitis    thyroiditis    cerebritis    endotheliitis
    prostatitis


    URB1 for disorders           About GeneDecksing


    Export disorders for URB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for URB1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with URB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T.... Nishimoto T. (Nucleic Acids Res. 2006)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PubMed id 10773462)1, 2 Slavov D.... Gardiner K. (Gene 2000)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9875 HGNC: 17344 Ensembl:ENSG00000142207 euGenes: HUgn9875 ECgene: URB1
    H-InvDB: URB1

    (According to HUGE)
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    HUGE: KIAA0539

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for URB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for URB1 gene:
    Search GeneIP for patents involving URB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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