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Aliases for URB1 Gene

Aliases for URB1 Gene

  • URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2 3
  • Nucleolar Preribosomal-Associated Protein 1 2 3
  • Nucleolar Protein 254 KDa 3 4
  • C21orf108 3 4
  • NPA1 3 4
  • Chromosome 21 Open Reading Frame 108 2
  • URB1 Ribosome Biogenesis 1 Homolog 4
  • KIAA0539 4
  • NOP254 4

External Ids for URB1 Gene

Previous HGNC Symbols for URB1 Gene

  • C21orf108

Previous GeneCards Identifiers for URB1 Gene

  • GC21M032607
  • GC21M033683
  • GC21M019092

Summaries for URB1 Gene

GeneCards Summary for URB1 Gene

URB1 (URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URB1 Gene

Genomics for URB1 Gene

Regulatory Elements for URB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for URB1 Gene

Chromosome:
21
Start:
32,311,018 bp from pter
End:
32,393,026 bp from pter
Size:
82,009 bases
Orientation:
Minus strand

Genomic View for URB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for URB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URB1 Gene

Proteins for URB1 Gene

  • Protein details for URB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60287-NPA1P_HUMAN
    Recommended name:
    Nucleolar pre-ribosomal-associated protein 1
    Protein Accession:
    O60287
    Secondary Accessions:
    • D3DSE5
    • Q96NX1
    • Q9NYQ1

    Protein attributes for URB1 Gene

    Size:
    2271 amino acids
    Molecular mass:
    254389 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URB1 Gene

Proteomics data for URB1 Gene at MOPED

Post-translational modifications for URB1 Gene

  • Ubiquitination at Lys 23, Lys 185, Lys 376, Lys 399, Lys 616, Lys 1085, Lys 1336, Lys 1786, and Lys 1909
  • Modification sites at PhosphoSitePlus

Other Protein References for URB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URB1 Gene

Domains & Families for URB1 Gene

Protein Domains for URB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for URB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with URB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for URB1 Gene

Function for URB1 Gene

Gene Ontology (GO) - Molecular Function for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with URB1: view

Animal Model Products

CRISPR Products

miRNA for URB1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for URB1 Gene

Localization for URB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URB1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for URB1 Gene COMPARTMENTS Subcellular localization image for URB1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus NAS 12429849
genes like me logo Genes that share ontologies with URB1: view

Pathways & Interactions for URB1 Gene

SuperPathways for URB1 Gene

No Data Available

Interacting Proteins for URB1 Gene

Gene Ontology (GO) - Biological Process for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with URB1: view

No data available for Pathways by source and SIGNOR curated interactions for URB1 Gene

Drugs & Compounds for URB1 Gene

No Compound Related Data Available

Transcripts for URB1 Gene

mRNA/cDNA for URB1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for URB1 Gene

URB1 ribosome biogenesis 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for URB1 Gene

No ASD Table

Relevant External Links for URB1 Gene

GeneLoc Exon Structure for
URB1
ECgene alternative splicing isoforms for
URB1

Expression for URB1 Gene

mRNA expression in normal human tissues for URB1 Gene

Protein differential expression in normal tissues from HIPED for URB1 Gene

This gene is overexpressed in Synovial fluid (45.5) and Vitreous humor (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for URB1 Gene



SOURCE GeneReport for Unigene cluster for URB1 Gene Hs.473611

genes like me logo Genes that share expression patterns with URB1: view

Protein tissue co-expression partners for URB1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for URB1 Gene

Orthologs for URB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for URB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia URB1 35
  • 81.11 (n)
  • 78.47 (a)
URB1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia URB1 35
  • 84.84 (n)
  • 82.77 (a)
URB1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Urb1 35
  • 79.31 (n)
  • 76.8 (a)
Urb1 16
Urb1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia URB1 35
  • 99 (n)
  • 98.94 (a)
C21ORF108 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Urb1 35
  • 78.9 (n)
  • 76.54 (a)
oppossum
(Monodelphis domestica)
Mammalia URB1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC100857673 35
  • 62.74 (n)
  • 57.65 (a)
URB1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia URB1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia urb1 35
  • 58.8 (n)
  • 52.31 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333650 35
  • 54.9 (n)
  • 47.82 (a)
URB1 (1 of 2) 36
  • 39 (a)
OneToMany
URB1 (2 of 2) 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12499 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T05H4.10 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for URB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for URB1 Gene

ENSEMBL:
Gene Tree for URB1 (if available)
TreeFam:
Gene Tree for URB1 (if available)

Paralogs for URB1 Gene

Pseudogenes.org Pseudogenes for URB1 Gene

genes like me logo Genes that share paralogs with URB1: view

No data available for Paralogs for URB1 Gene

Variants for URB1 Gene

Sequence variations from dbSNP and Humsavar for URB1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_059705 -
VAR_060586 -

Structural Variations from Database of Genomic Variants (DGV) for URB1 Gene

Variant ID Type Subtype PubMed ID
nsv834084 CNV Gain 17160897
nsv510795 CNV Loss 20534489
nsv834085 CNV Gain 17160897
esv272059 CNV Insertion 20981092

Variation tolerance for URB1 Gene

Gene Damage Index Score: 5.68; 72.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URB1 Gene

HapMap Linkage Disequilibrium report
URB1
Human Gene Mutation Database (HGMD)
URB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URB1 Gene

Disorders for URB1 Gene

Relevant External Links for URB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
URB1
genes like me logo Genes that share disorders with URB1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for URB1 Gene

Publications for URB1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for URB1 Gene

Sources for URB1 Gene

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