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Aliases for URB1 Gene

Aliases for URB1 Gene

  • URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2 3 5
  • Nucleolar Preribosomal-Associated Protein 1 2 3
  • Nucleolar Protein 254 KDa 3 4
  • C21orf108 3 4
  • NPA1 3 4
  • Nucleolar Pre-Ribosomal-Associated Protein 1 3
  • Chromosome 21 Open Reading Frame 108 2
  • URB1 Ribosome Biogenesis 1 Homolog 4
  • KIAA0539 4
  • NOP254 4

External Ids for URB1 Gene

Previous HGNC Symbols for URB1 Gene

  • C21orf108

Previous GeneCards Identifiers for URB1 Gene

  • GC21M032607
  • GC21M033683
  • GC21M019092

Summaries for URB1 Gene

GeneCards Summary for URB1 Gene

URB1 (URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for URB1 Gene

Genomics for URB1 Gene

Regulatory Elements for URB1 Gene

Enhancers for URB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around URB1 on UCSC Golden Path with GeneCards custom track

Promoters for URB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around URB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for URB1 Gene

32,311,018 bp from pter
32,393,026 bp from pter
82,009 bases
Minus strand

Genomic View for URB1 Gene

Genes around URB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
URB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for URB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for URB1 Gene

Proteins for URB1 Gene

  • Protein details for URB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar pre-ribosomal-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DSE5
    • Q96NX1
    • Q9NYQ1

    Protein attributes for URB1 Gene

    2271 amino acids
    Molecular mass:
    254389 Da
    Quaternary structure:
    No Data Available

neXtProt entry for URB1 Gene

Post-translational modifications for URB1 Gene

  • Ubiquitination at Lys 23, Lys 185, Lys 376, Lys 399, Lys 616, Lys 1085, Lys 1336, Lys 1786, and Lys 1909
  • Modification sites at PhosphoSitePlus

Other Protein References for URB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for URB1 Gene

Domains & Families for URB1 Gene

Protein Domains for URB1 Gene


Suggested Antigen Peptide Sequences for URB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with URB1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for URB1 Gene

Function for URB1 Gene

Gene Ontology (GO) - Molecular Function for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with URB1: view

Animal Model Products

CRISPR Products

miRNA for URB1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for URB1 Gene

Localization for URB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for URB1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for URB1 Gene COMPARTMENTS Subcellular localization image for URB1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus NAS 12429849
genes like me logo Genes that share ontologies with URB1: view

Pathways & Interactions for URB1 Gene

SuperPathways for URB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for URB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with URB1: view

No data available for Pathways by source and SIGNOR curated interactions for URB1 Gene

Drugs & Compounds for URB1 Gene

No Compound Related Data Available

Transcripts for URB1 Gene

mRNA/cDNA for URB1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for URB1 Gene

URB1 ribosome biogenesis 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for URB1 Gene

No ASD Table

Relevant External Links for URB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for URB1 Gene

mRNA expression in normal human tissues for URB1 Gene

Protein differential expression in normal tissues from HIPED for URB1 Gene

This gene is overexpressed in Synovial fluid (45.5) and Vitreous humor (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for URB1 Gene

Protein tissue co-expression partners for URB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of URB1 Gene:


SOURCE GeneReport for Unigene cluster for URB1 Gene:

genes like me logo Genes that share expression patterns with URB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for URB1 Gene

Orthologs for URB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for URB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia URB1 34
  • 81.11 (n)
  • 78.47 (a)
URB1 35
  • 77 (a)
(Canis familiaris)
Mammalia URB1 34
  • 84.84 (n)
  • 82.77 (a)
URB1 35
  • 82 (a)
(Mus musculus)
Mammalia Urb1 34
  • 79.31 (n)
  • 76.8 (a)
Urb1 16
Urb1 35
  • 76 (a)
(Pan troglodytes)
Mammalia URB1 34
  • 99 (n)
  • 98.94 (a)
C21ORF108 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Urb1 34
  • 78.9 (n)
  • 76.54 (a)
(Monodelphis domestica)
Mammalia URB1 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
-- 35
  • 55 (a)
-- 35
  • 44 (a)
-- 35
  • 48 (a)
(Gallus gallus)
Aves LOC100857673 34
  • 62.74 (n)
  • 57.65 (a)
URB1 35
  • 56 (a)
(Anolis carolinensis)
Reptilia URB1 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia urb1 34
  • 58.8 (n)
  • 52.31 (a)
(Danio rerio)
Actinopterygii LOC100333650 34
  • 54.9 (n)
  • 47.82 (a)
URB1 (1 of 2) 35
  • 39 (a)
URB1 (2 of 2) 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12499 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea T05H4.10 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for URB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for URB1 Gene

Gene Tree for URB1 (if available)
Gene Tree for URB1 (if available)

Paralogs for URB1 Gene Pseudogenes for URB1 Gene

genes like me logo Genes that share paralogs with URB1: view

No data available for Paralogs for URB1 Gene

Variants for URB1 Gene

Sequence variations from dbSNP and Humsavar for URB1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs762225 - 32,316,888(+) GACCA(C/G)GGATC reference, missense
rs3761342 - 32,321,914(+) CAGAA(C/G)GCCAA reference, missense
rs7276783 -- 32,368,328(+) CTCCC(A/G)AAGTG intron-variant
rs7276902 -- 32,382,996(+) CCTCT(C/T)TGAGG intron-variant
rs7277593 -- 32,368,367(+) CCAGC(C/T)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for URB1 Gene

Variant ID Type Subtype PubMed ID
esv3307785 CNV mobile element insertion 20981092
esv3405236 CNV insertion 20981092
esv3646883 CNV loss 21293372
nsv1139016 CNV deletion 24896259
nsv510795 CNV deletion 20534489
nsv834084 CNV gain 17160897
nsv834085 CNV gain 17160897

Variation tolerance for URB1 Gene

Gene Damage Index Score: 5.68; 72.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for URB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for URB1 Gene

Disorders for URB1 Gene

Relevant External Links for URB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for URB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for URB1 Gene

Publications for URB1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 65
  2. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T. … Nishimoto T. (Nucleic Acids Res. 2006) 3 4 65
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 65
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 65
  5. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D. … Gardiner K. (Gene 2000) 3 4 65

Products for URB1 Gene

Sources for URB1 Gene