URB1 Gene
protein-coding GIFtS: 39
GCID: GC21M033683
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URB1 ribosome biogenesis 1 homolog (S. cerevisiae)(Previous name: chromosome 21 open reading frame 108 )
(Previous symbol: C21orf108)
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Aliases
for URB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| URB1 Ribosome Biogenesis 1 Homolog (S. Cerevisiae)1 2 | | Chromosome 21 Open Reading Frame 1081 | | C21orf1081 2 3 | | Nucleolar Pre-Ribosomal-Associated Protein 12 | | NPA11 2 3 | | Nucleolar Preribosomal-Associated Protein 12 | | KIAA05391 3 | | NOP2543 | | Nucleolar Protein 254 KDa2 3 | | URB1 Ribosome Biogenesis 1 Homolog3 |
Export aliases for URB1 gene to outside databasesPrevious GC identifers: GC21M032607 GC21M019092 |
Summaries
for URB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for URB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the URB1 gene promoter:
c-Fos AML1a AP-1 Bach2 Brachyury MIF-1 Egr-4 HNF-1A HNF-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for URB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11URB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M033683: view genomic region
(about GC identifiers)
Start:
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33,683,329 bp from pter |
End:
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33,765,335 bp from pter |
Size:
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82,007 bases |
Orientation:
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minus strand |
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Proteins
for URB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPA1P_HUMAN, O60287 (See
protein sequence)Recommended Name: Nucleolar pre-ribosomal-associated protein 1 Size: 2271 amino acids; 254389 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: D3DSE5 Q96NX1 Q9NYQ1Explore the universe of human proteins at neXtProt for URB1: NX_O60287
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60287
URB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055640.2
ENSEMBL proteins: ENSP00000372199
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
URB1 for ontologies About GeneDecksing
URB1 Antibody Products:
Assay Products for URB1: |
Protein
Domains /
Families
for URB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
URB1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60287ProtoNet protein and cluster: O60287 |
Function
for URB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URB1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: URB1 (NM_014825) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for URB1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat URB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URB1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003674 | molecular_function |
ND | -- |
URB1 for ontologies About GeneDecksing
|
Pathways & Interactions
for URB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for URB1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for URB1 (O602872, 3 ENSP000003721994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- |
URB1 for ontologies About GeneDecksing
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Drugs & Compounds
for URB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for URB1
Search CenterWatch for drugs/clinical trials and news about URB1 / NPA1P
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Transcripts
for URB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for URB1 gene: NM_014825.2 Unigene Cluster for URB1: URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Hs.473611 [show with all ESTs]Unigene Representative Sequence: NM_0148253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382751(uc002ypn.2) ENST00000480196 ENST00000492603
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URB1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: URB1 (NM_014825) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for URB1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat URB1 |
Additional cDNA sequence: AB011111.2 AF231919.1 AF432264.1 BC041033.1 BC062356.1 13 DOTS entries: DT.212590 DT.92042754 DT.75181672 DT.40115247 DT.65284211 DT.86821102 DT.95267660 DT.100682870 DT.121138528 DT.40261222 DT.65284811 DT.91662163 DT.95128681
GeneLoc Exon Structure
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Expression
for URB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| URB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAACTGTG
About this image
See URB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for URB1
SOURCE GeneReport for Unigene cluster: Hs.473611
SABiosciences Custom PCR Arrays for URB1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for URB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat URB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URB1 |
Orthologs
for URB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for URB1 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for URB1 (if available)
TreeFam Gene Tree for URB1 (if available) |
Paralogs
for URB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for URB1 gene
URB1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for URB1
PGOHUM00000250160
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Genomic Variants
for URB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for URB1 (33683329 - 33765335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for URB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing URB1 |
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Disorders
/ Diseases
for URB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 URB1 for disorders About MalaCards
URB1 for disorders About GeneDecksing
OMIM gene information: 608865
OMIM disorders: --
Export disorders for URB1 gene to outside databases
|
Publications
for URB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for URB1 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with URB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
- NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T....Nishimoto T. (2006)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PubMed id 10773462)1, 2 Slavov D.... Gardiner K. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for URB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing URB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing URB1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing URB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for URB1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for URB1 gene:
Search GeneIP for patents involving URB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for URB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for URB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for URB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for URB1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for URB1 | | OriGene 3'-UTR Clone for URB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for URB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for URB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for URB1 | | OriGene Custom Protein Services for URB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat URB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing URB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat URB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat URB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat URB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat URB1 |
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| | | | Search Tocris compounds for URB1 |
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 | | | URB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for URB1 |
|  |  |  | | | | Search ThermoFisher Antibodies for URB1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat URB1 |
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